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7435390 |
Nucleic acid synthesizers
The present invention relates to nucleic acid synthesizers and methods of using and modifying nucleic acid synthesizers. For example, the present invention provides highly efficient, reliable, and...
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7355037 |
Thermolabile hydroxyl protecting groups and methods of use
Provided is a hydroxyl-protected alcohol of the formula R—O—Pg, wherein Pg is a protecting group of the formula:
wherein Y, Z, W, R 1 , R 1a , R 2 , R 2a , R 3 , R 3a , R 4 , R 4a , a,...
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7351855 |
Chemically defined non-polymeric valency platform molecules and conjugates thereof
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
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7115581 |
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
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7067641 |
Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III)
wherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy,...
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6965041 |
N-acylphosphoramidites and their use in oligonucleotide synthesis
The present invention provides a compound of formula (I), (II), or (III), wherein R 1 , R 2 , R 2′ , R 3 , and R 3′ are the same or different and each is H an alkyl, an alkenyl, an alkynyl, a...
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6951939 |
Multivalent platform molecules comprising high molecular weight polyethylene oxide
Valency platform molecules comprising high molecular weight polyethylene oxide groups are provided, as well as conjugates thereof with biologically active molecules, and methods for their...
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6932943 |
Nucleic acid synthesizers
The present invention relates to nucleic acid synthesizers and methods of using and modifying nucleic acid synthesizers. For example, the present invention provides highly efficient, reliable, and...
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6900048 |
Biopolymer arrays and their fabrication
A method of fabricating an addressable array of biopolymers on a substrate using a biomonomer with a first linking group which must be activated for linking to a substrate bound moiety, and...
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6762298 |
Thermolabile phosphorus protecting groups, associated intermediates and methods of use
The invention provides a method of thermally deprotecting the internucleosidic phosphorus linkage of an oligonucleotide, which method comprises heating a protected oligonucleotide in a fluid medium...
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6306599 |
Biopolymer arrays and their fabrication
A method of fabricating an addressable array of biopolymers on a substrate using a biomonomer with a first linking group which must be activated for linking to a substrate bound moiety, and...
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6184347 |
Minimization of blooming in high-density arrays by using reactive wash reagents
A wash reagent employed for the bulk washing of the surface of a high-density array to remove unreacted reactants from cells of the array while, at the same time, reacting with the unreacted...
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5902878 |
Modified phosphoramidite process for the production of modified nucleic acids
The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce...
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