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7425426 Methods for purification of cells based on product secretion  
The invention provides methods for purifying one or more cells based on the level of one or more products secreted by the cells. In one embodiment, the method involves (a) contacting a plurality of...
7423750 Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion  
Methods and optical systems for scanning of a target sample, including methods and systems using a low mass scan head and methods and systems for conducting a scanned optically transduced assay...
7410793 Optical instrument including excitation source  
An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area...
7405819 Optical substrate for enhanced detectability of fluorescence  
A sample substrate adapted for use with fluorescence excitation light with a first wavelength. A reflector is disposed on a base. The reflector includes a reflecting multilayer interference coating...
7387891 Optical instrument including excitation source  
An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed...
7371517 High purity X-chromosome bearing and Y-chromosome bearing populations of spermatozoa  
Isolated non-naturally occurring populations of spermatozoa ( 15 ) having high purity and technologies to differentiate spermatozoa ( 28 ) based on characteristics such as mass, volume,...
7369227 Imaging fluorescence signals using telecentricity  
The present invention relates to the field of DNA analysis. In particular, the present invention is directed to a device for the parallel imaging of fluorescence intensities at a plurality of sites...
7312919 Wide field of view and high speed scanning microscopy  
A wide field of view scanning microscope includes a light source, a light detector, optics, a scanning assembly, a translation system, and a data collection control and processing unit. The...
7300795 Optoinjection methods  
Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the...
7285789 Optical device for surface-generated fluorescence  
A sample substrate adapted for use with electromagnetic excitation light includes a base and a layer system. The layer system includes a multilayer interference coating with at least two layers...
7253946 Microscope with extended field of vision  
An optical system is provided for creating a mosaic image of a large field of view through a microscope at fast refresh rates of about 25 Hz with a high resolution that is free of blurring or...
7227633 Optical substrate for enhanced detectability of fluorescence  
A sample substrate adapted for use with fluorescence excitation light with a first wavelength. A reflector is disposed on a base. The reflector includes a reflecting multilayer interference coating...
7221453 Optical apparatus  
Various optical apparatus provide a source of parallel light ( 7, 75 ). The parallel light ( 7, 75 ) is generally achieved by directing an incident beam at the apex of a prism ( 1, 22, 24, 26, 28...
7208265 Method of cryopreserving selected sperm cells  
The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected...
7195920 Collection systems for cytometer sorting of sperm  
Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a...
7169548 Sperm cell processing and preservation systems  
Methods and apparatus are disclosed for processing sperm cells to accomplish preservation for future use while minimizing the adverse effects of such preservation. Sperm cells may be collected from...
7129070 Targeted system for removing tumor cells from cell populations  
A method is presented for killing a first population of cells within a mixture of viable cells by providing the mixture of viable cells, contacting the cells with a label, illuminating a portion of...
7094527 System for in-vitro fertilization with spermatozoa separated into X-chromosome and Y-chromosome bearing populations  
An IVF system for successfully utilizing spermatozoa separated into X-chromosome bearing and into Y-chromosome bearing population for insemination. The IVF system includes fertilization medium that...
7092557 Method and device for selectively targeting cells within a three-dimensional specimen  
The invention provides an apparatus for electromagnetically affecting a particle of interest in a specimen. The apparatus includes (a) a stage capable of supporting the specimen; (b) a detector...
7024316 Transiently dynamic flow cytometer analysis system  
A flow cytometry apparatus and methods to process information incident to particles or cells entrained in a sheath fluid stream allowing assessment, differentiation, assignment, and separation of...
7008789 Instrument for monitoring polymerase chain reaction of DNA  
An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of...
6992761 Broad range light detection system  
Broad-range light-detection systems, including components and methods of use thereof. These systems may include apparatus and methods for detecting light with increased speed and/or detection...
6984828 Quantified fluorescence microscopy  
The present invention relates to calibration apparatuses, methods or tools used in microscopy. A calibration tool for fluorescent microscopy includes a support, a solid surface layer including a...
6982431 Sample analysis systems  
Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation...
6825921 Multi-mode light detection system  
Apparatus and methods for combining multiple modes and methods of optical detection, postprocessing, and/or feedback loops in bioanalytical measurements. The methods may include (1) positioning a...
6818437 Instrument for monitoring polymerase chain reaction of DNA  
An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of...
6804385 Method and device for selectively targeting cells within a three-dimensional specimen  
The invention provides an apparatus for electromagnetically affecting a particle of interest in a specimen. The apparatus includes (a) a stage capable of supporting the specimen; (b) a detector...
6741344 Method and apparatus for detection of fluorescently labeled materials  
Fluorescently marked targets bind to a substrate 230 synthesized with polymer sequences at known locations. The targets are detected by exposing selected regions of the substrate 230 to light...
6680796 Microscope assemblage  
A microscope assemblage, in particular a confocal laser scanning microscope, has a light source ( 1 ), for illumination of a specimen ( 6 ). An objective ( 5 ) is provided for guiding the...
6654165 Optical arrangement  
An optical arrangement in the beam path of a light source suitable for fluorescence excitation, preferably in the beam path of a confocal laser scanning microscope, with at least one spectrally...
6642018 Method for inducing a response in one or more targeted cells  
A method and apparatus is disclosed for selectively identifying, and targeting with an energy beam, specific cells within a mixed cell population, for the purpose of inducing a response in the...
6597000 Systems and methods for detection of labeled materials  
Labeled targets on a support synthesized with polymer sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, can be detected by...
6580081 Arrangement for the detection of fluorescene radiation of matrix-shaped speciman carriers  
An arrangement for the detection of the fluorescence radiation of matrix-shaped specimen carriers with a large number of individual specimens, in particular, for the analysis of chemical and...
6576476 Chemiluminescence detection method and device  
A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay...
6534308 Method and apparatus for selectively targeting specific cells within a mixed cell population  
This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a mixed cell population, for the purpose of inducing a response...
6514722 Method and apparatus for selectively targeting specific cells within a cell population  
This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a cell population, for the purpose of inducing a response in the...
6510001 Optical arrangement with a spectrally selective element  
An optical arrangement in the beam path of a light source suitable for fluorescence excitation, preferably in the beam path of a confocal laser scanning microscope, with at least one spectrally...
6499366 Sample feeder  
Devices for automatically feeding sample containers into and out of an analyzer. The device may include (1) a first station that receives and initiates transport of a sample container into an...
6498335 Broad range light detection system  
A broad-range light-detection system. In some embodiments, the system includes apparatus and methods for detecting light with high accuracy over a broad range of intensities. In other embodiments,...
6483582 Apparatus and methods for time-resolved spectroscopic measurements  
Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a...
6472671 Quantified fluorescence microscopy  
A calibration tool for fluorescent microscopy comprises a support on which is carried a solid surface layer comprised of effective fluorophores, and a thin mask of non-fluorescent material defining...
6469311 Detection device for light transmitted from a sensed volume  
A high-throughput light detection instrument and method are described. In some embodiments, switch mechanisms and optical relay structures permit different light sources and/or detectors to be...
6466316 Apparatus and methods for spectroscopic measurements  
Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a...
6455861 Fluorescence polarization assay system and method  
An instrument is disclosed for fluorescence assays which is capable of reading many independent samples at the same time. This instrument provides enhanced throughput relative to single-sample...
6441379 Imaging system for an optical scanner  
An imaging system comprises a radiation device for providing excitation radiation of at least two different wavelengths, an objective lens for focusing the excitation wavelengths onto a sample to...
6355938 Phosphor screen scanning systems  
A system for scanning an imaging plate, comprising: a continuous belt drive; a first scanning head mounted to the belt drive; a second scanning head mounted to the belt drive; and a laser...
6355934 Imaging system for an optical scanner  
An imaging system comprises three or more sources for providing excitation radiation of different wavelengths, an objective lens for focusing one or more of the exitation wavelengths onto a sample...
EP1168031A2 Microscope arrangement  
The construction permits rotation of the illuminating beam (2) into the objective pupil, or the object (6) can be moved along at least one dimension.
6335824 Wide field of view and high speed scanning microscopy  
Limited rotation, micro-lens scanning of DNA arrays, microscope slides, biological materials, etc., is performed by arcuate and translational motion. A scanning system includes an objective lens...
6326605 Broad range light detection system  
A broad-range light-detection system. In some embodiments, the system includes apparatus and methods for detecting light with high accuracy over a broad range of intensities. In other embodiments,...
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