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7422902 |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods...
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7361640 |
Stable lipid-comprising drug delivery complexes and methods for their production
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
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7335509 |
Stable lipid-comprising drug delivery complexes and methods for their production
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
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7323594 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group...
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7285288 |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The...
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7262173 |
Chemosensitizing with liposomes containing oligonucleotides
The invention relates to the use of oligonucleotide containing cationic liposomal formulations to enhance the efficacy of chemotherapy and/or radiotherapy, particularly as a means to sensitize...
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7189874 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group consisting...
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EP1128813B1 |
AN INHALATION SYSTEM
Abstract not available for EP1128813 Abstract of corresponding document: WO0027359 An inhalation system of a composition having lipids and a bioactive agent and an inhalation device.
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7173154 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group...
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7166745 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group...
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7166298 |
Genetic immunization with cationic lipids
A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic...
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7157098 |
Gene therapy of tumors using non-viral delivery system
The present invention provides a pharmaceutical composition, comprising: (a) cationic lipids, wherein said lipids are a liposomal mixture of a diacyl-ethyl-phosphocholine and...
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7145039 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group...
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7115712 |
Cytokine polypeptides
New cytokine polypeptides, and nucleic acids encoding them, are provided. Compositions including these polypeptides and nucleic acids, recombinant cells comprising said polypeptides and nucleic...
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RE39220 |
Peptide-mediated gene transfer
A methodology that allows for highly efficient transfer and stable integration of DNA into both established eukaryotic cell lines and primary cells, including non-dividing cells such as human...
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6977244 |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The...
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6890554 |
Genetic immunization with cationic lipids
A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic...
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6858431 |
Bone mineralization proteins, DNA, vectors expression systems
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that...
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6855549 |
Methods and compositions for increasing the infectivity of gene transfer vectors
The present invention involves methods and compositions for increasing the susceptibility of target cells to transduction by gene transfer vectors. Specifically, it is proposed that increasing...
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EP1489184A1 |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods...
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EP0832271B1 |
LIPID-NUCLEIC ACID PARTICLES PREPARED VIA A HYDROPHOBIC LIPID-NUCLEIC ACID COMPLEX INTERMEDIATE AND USE FOR GENE TRANSFER
Abstract not available for EP0832271 Abstract of corresponding document: WO9640964 Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are...
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6793912 |
Treatment of cancers by inhalation of stable platinum-containing formulations
Disclosed are methods of treating cancers by inhalation of stable platinum-containing formulations.
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6693086 |
Systemic immune activation method using nucleic acid-lipid complexes
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune...
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6620795 |
Mammalian transformation complex comprising a lipid carrier and DNA encoding CFTR
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes or nucleic acid abre...
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6586410 |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods...
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6582694 |
Method for preparing a viral aerosol
A method for preparing a viral aerosol from a dilute viral suspension prepared by dissolving a virus in an aqueous solution containing 6-12 g/l of a monovalent cation salt, or 50-100 g/l of a...
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6559129 |
Cationic liposomal delivery system and therapeutic use thereof
The invention relates to novel cationic lipid formulations and use thereof for treatment of cancer, especially in combination with radiation.
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6555107 |
Lentiviral nucleic acids and uses thereof
The invention provides non-primate lentiviral vectors, packaging cells and packaging plasmids based, for example, on feline and ungulate retroviruses. In particular, the packaging plasmids are...
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6521750 |
Bone mineralization proteins, DNA, vectors, expression systems
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that...
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6468798 |
Expression of cloned genes in the lung by aerosol and liposome-based delivery
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Liposome-nucleic acid complexes are prepared then delivered...
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6444803 |
Bone mineralization proteins, DNA, vectors, expression systems
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that...
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6410328 |
Sensitizing cells to compounds using lipid-mediated gene and compound delivery
The present invention relates to methods and compositions for sensitizing a cell to a prodrug compound.
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6383814 |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from...
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6375980 |
Stabilization of lipid:DNA formulations during nebulization
The present invention provides a liposomal aerosol composition, comprising a pharmaceutical compound, a cationic lipid, a neutral co-lipid; and tryptone. Also provided is a nebulized cationic...
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6372500 |
Episomal expression cassettes for gene therapy
The invention consists of episomal expression cassettes for expression of a transgene in gene therapy. The expression cassettes consist of regulatory elements of the human cytokeratin gene and a...
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6300127 |
Bone mineralization proteins, DNA, vectors, expression systems
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that...
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6271206 |
Sonic nebulized nucleic acid/cationic liposome complexes and methods for pulmonary gene delivery
Compositions and methods are provided for gene delivery to the respiratory tract. In particular, compositions comprising a nebulized nucleic acid/stabilizing agent complex, and methods employing...
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EP1080225A1 |
COMPOSITIONS AND METHODS FOR THE PULMONARY DELIVERY OF NUCLEIC ACIDS
Abstract not available for EP1080225 Abstract of corresponding document: WO9960166 The present invention relates to compositions and methods for the pulmonary delivery of nucleic acids,...
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6158431 |
Portable systems and methods for delivery of therapeutic material to the pulmonary system
A handheld therapeutic material delivery system includes a droplet dispersion chamber, a droplet generating assembly for generating droplets of a fluid containing the therapeutic material and for...
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6156567 |
Truncated transcriptionally active cytomegalovirus promoters
Recombinant adenoviruses, methods of making them, uses for them, including in immunological, immunogenic, vaccine or therapeutic compositions, or, as a vector for cloning, replicating or expressing...
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6124270 |
Use of a cationic amphipathic compound as a transfection agent, vaccine additive or drug
A cationic amphipathic compound of formula (I), ##STR1## wherein A is a single bond, an NH--R' grouping or (a), wherein --R'-- is a straight or branched, optionally substituted, saturated or...
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6121247 |
Therapy for allergic diseases
Administration of an expression gene construct for IFN-γ to an affected organ is an effective means of reversing antigen-induced inflammation. Suitable allergic diseases for treatment include...
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6107286 |
Lipopolyamines as transfection agents and pharamaceutical uses thereof
Cationic lipids of general formula (I), wherein m is an integer from 2 to 6 inclusive; n is an integer from 1 to 9 inclusive, preferably 1-5, where, when n is 2-9, a single R grouping other than...
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5952516 |
Cationic amphiphiles containing multiplesteroid lipophilic groups
Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by...
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5952220 |
Method for preparing a viral aerosol
A method for preparing a viral aerosol from a dilute viral suspension prepared by dissolving a virus in an aqueous solution containing 6-12 g/l of a monovalent cation salt, or 50-100 g/l of a...
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5948925 |
Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids
Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by...
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5942634 |
Cationic amphiphiles for cell transfections
Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by...
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5935568 |
Gene therapy for effector cell regulation
The present invention provides a nucleic acid-based therapeutic composition to treat an animal with disease by controlling the activity of effector cells, including T cells, macrophages, monocytes...
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EP0832271A2 |
LIPID-NUCLEIC ACID PARTICLES PREPARED VIA A HYDROPHOBIC LIPID-NUCLEIC ACID COMPLEX INTERMEDIATE AND USE FOR GENE TRANSFER
Abstract not available for EP0832271 Abstract of corresponding document: WO9640964 Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are...
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