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7371517 |
High purity X-chromosome bearing and Y-chromosome bearing populations of spermatozoa
Isolated non-naturally occurring populations of spermatozoa ( 15 ) having high purity and technologies to differentiate spermatozoa ( 28 ) based on characteristics such as mass, volume,...
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7315357 |
Imaging and analyzing parameters of small moving objects such as cells
Light from an object such as a cell moving through an imaging system is collected and dispersed so that it is imaged onto a plurality of separate detectors. The light is spectrally dispersed by a...
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7286719 |
Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
A multi-channel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a...
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7221457 |
Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
A flow imaging system is used to implement surface plasmon resonance (SPR) detection to study bio-molecular interactions. The flow imaging system is used to capture SPR absorption spectra of large...
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7221453 |
Optical apparatus
Various optical apparatus provide a source of parallel light ( 7, 75 ). The parallel light ( 7, 75 ) is generally achieved by directing an incident beam at the apex of a prism ( 1, 22, 24, 26, 28...
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7208265 |
Method of cryopreserving selected sperm cells
The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected...
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7195920 |
Collection systems for cytometer sorting of sperm
Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a...
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7190832 |
Computational methods for the segmentation of images of objects from background in a flow imaging instrument
In automated computation-based interpretation of images, the accuracy and reliability of the detection and delineation of objects, known as “object segmentation,” is implemented so as to...
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7169548 |
Sperm cell processing and preservation systems
Methods and apparatus are disclosed for processing sperm cells to accomplish preservation for future use while minimizing the adverse effects of such preservation. Sperm cells may be collected from...
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7094527 |
System for in-vitro fertilization with spermatozoa separated into X-chromosome and Y-chromosome bearing populations
An IVF system for successfully utilizing spermatozoa separated into X-chromosome bearing and into Y-chromosome bearing population for insemination. The IVF system includes fertilization medium that...
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7087877 |
Auto focus for a flow imaging system
A pair of optical gratings are used to modulate light from an object, and the modulated light from either grating is used to determine the velocity of the object. Each optical grating is offset...
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7079708 |
Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
A multichannel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a...
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7057732 |
Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
A flow imaging system is used to implement surface plasmon resonance (SPR) detection to study bio-molecular interactions. The flow imaging system is used to capture SPR absorption spectra of large...
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7006710 |
Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
A multichannel imaging system generates an ensemble of images for each field of view of an object. Each image in the ensemble is intended to contain information from only one source among a...
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6975400 |
Imaging and analyzing parameters of small moving objects such as cells
Light from an object such as a cell moving through an imaging system is collected and dispersed so that it is imaged onto a plurality of separate detectors. The light is spectrally dispersed by a...
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6947136 |
Multipass cavity for illumination and excitation of moving objects
An illumination system for increasing a light signal from an object passing through a reflection cavity. The reflection cavity is defined by spaced-apart, opposed first and second surfaces disposed...
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6947128 |
Alternative detector configuration and mode of operation of a time delay integration particle analyzer
Light from an object moving through an imaging system is collected, dispersed, and imaged onto a time delay integration (TDI) detector that is inclined relative to an axis of motion of the object,...
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6934408 |
Method and apparatus for reading reporter labeled beads
Combinatorially-synthesized deoxyribonucleic acid (DNA) oligonucleotides attached to encoded beads that are hybridized to amplified and labeled genomic DNA or ribonucleic acid (RNA) are analyzed...
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6906792 |
Methods of calibrating an imaging system using calibration beads
When utilized in a flow imaging instrument, calibration beads provide a known data source that can be employed in various self-diagnostic, calibration and quality metric applications for the both...
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6875973 |
Auto focus for a flow imaging system
A pair of optical gratings are used to modulate light from an object, and the modulated light from either optical is used to determine the velocity of the object. Each optical grating is offset...
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6707551 |
Multipass cavity for illumination and excitation of moving objects
An illumination system for increasing a light signal from an object passing through a reflection cavity. The reflection cavity is disposed between spaced-apart, opposed first and second surfaces...
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6671044 |
Imaging and analyzing parameters of small moving objects such as cells in broad flat flow
Light from an object such as a cell moving through an imaging system is collected and dispersed so that it can be imaged onto a time delay and integration (TDI) detector. The light can be emitted...
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6628385 |
High efficiency, large field scanning microscope
A fluorescent optical imaging system ( 10 ) produces two separate spots (S 1 and S 2 ) on a sample ( 12 ) by a pair of excitation laser beams (B 1 and B 2 ) that are generated by first and second...
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6608682 |
Imaging and analyzing parameters of small moving objects such as cells
Light from an object such as a cell moving through an imaging system is collected and dispersed so that it is imaged onto a plurality of separate detectors. The light is spectrally dispersed by a...
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6608680 |
TDI imaging system for kinetic studies
Light from an object such as a cell moving through an imaging system is collected, and imaged onto a time delay integration (TDI) detector, producing a pixelated output signal in response to the...
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6589792 |
Method and apparatus for flow cytometry
A flow cytometer ( 20 ) capable of utilizing an imaging system including a sensor ( 88 ) to determine various properties of the flow cytometer ( 20 ). Importantly, the imaging allows for...
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6583865 |
Alternative detector configuration and mode of operation of a time delay integration particle analyzer
Light from an object moving through an imaging system is collected, dispersed, and imaged onto a time delay integration (TDI) detector that is inclined relative to an axis of motion of the object,...
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6580504 |
Multipass cavity for illumination and excitation of moving objects
An illumination system for increasing a light signal from an object passing through a reflection cavity. The reflection cavity is disposed between spaced-apart, opposed first and second surfaces...
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6563583 |
Multipass cavity for illumination and excitation of moving objects
A multipass cavity system employs a beam of light that is reflected back and forth between reflective surfaces a plurality of times, illuminating a different portion of the field of view with each...
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6532061 |
Measuring the velocity of small moving objects such as cells
Frequency domain velocity measurements and time domain velocity measurements are made using light from cells or other objects. An optical grating is used to modulate the light from an object so...
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6507391 |
Measuring the velocity of small moving objects such as cells
Frequency domain velocity measurements and time domain velocity measurements are made using light from cells or other objects. An optical grating is used to modulate the light from an object so...
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6473176 |
Imaging and analyzing parameters of small moving objects such as cells
Light from an object such as a cell moving through an imaging system is collected and dispersed so that it can be imaged onto a detector. The light can be emitted from a luminous object or can be...
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6249341 |
Imaging and analyzing parameters of small moving objects such as cells
Light from an object such as a cell moving through an imaging system is collected and dispersed so that it can be imaged onto a time delay and integration (TDI) detector. The light can be emitted...
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6248590 |
Method and apparatus for flow cytometry
A flow cytometer capable of utilizing an imaging system to determine various properties of the flow cytometer. Importantly, the imaging allows for determination of a drop delay time. Other...
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6211955 |
Imaging and analyzing parameters of small moving objects such as cells
Light from an object such as a cell moving through an imaging system is collected and dispersed so that it can be imaged onto a time delay and integration (TDI) detector. The light can be emitted...
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6194731 |
Bio-particle fluorescence detector
Biological aerosols are detected in real time by passing air, which may contain the aerosols, through a duct having a pair of photodetectors adjacent the duct for detecting fluorescence of the...
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6115119 |
Device and method for studying particles in a fluid
The present invention provides a device for studying particles in a fluid that advantageously allows particles having a broad range of particle size, e.g., in the 3-1000 μm range, to be readily...
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5844685 |
Reference laser beam sampling apparatus
Apparatus for sampling a laser beam used in an analytical instrument, e.g., a clinical hematology or flow cytometer instrument, for measuring absorption by particles suspended in a stream moving...
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5824269 |
Flow cytometer
A flowcytometer includes a sheath flow cell for forming a sample stream containing particles; a detector for detecting the particle at a first area to generate a signal representative of the...
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5726745 |
Process and apparatus for preparing a blood sample for analysis of white blood cells
A process and apparatus for preparing blood for analysis of white blood cells involves: preparing a mixture made up of blood and a lysing agent, emitting luminous radiation in the direction...
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5644388 |
Imaging flow cytometer nearly simultaneously capturing a plurality of images
A sample liquid containing particles are caused to flow through a transparent flow cell. An image capturing device is used to capture different images for a single particle existing in an image...
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5633503 |
Particle analyzer
A particle analyzer includes a flow cell for enclosing a sample liquid containing particles in a sheathed flow to form a flat flow of the sample liquid; an exciting light source for emitting light...
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