Matches 1 - 50 out of 87 1 2 >
Match Document Document Title
EP1944310A2 Modified oligonucleotides for mismatch discrimination  
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor...
7393645 Compositions for the electronic detection of analytes utilizing monolayers  
The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
7384749 Electrodes linked via conductive oligomers to nucleic acids  
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
7381533 Electrodes linked via oligomers to nucleic acids  
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
7381525 AC/DC voltage apparatus for detection of nucleic acids  
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
7368549 Tm leveling compositions  
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor...
7348146 Single nucleotide polymorphism analysis of highly polymorphic target sequences  
Methods and probes are provided for the analysis of target sequences having two or more polymorphisms wherein one of the polymorphisms is to be distinguished and another polymorphism is to be masked.
7338805 Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules  
The present invention relates to a temperature-stable labeling reagent of formula: in which R 1 represents H or an alkyl, aryl or substituted aryl group, R 2 represents a detectable...
7312087 Devices and methods for biochip multiplexing  
The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a...
7297518 Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension  
The invention provides methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension. Some applications of the invention utilize total internal reflection fluorescence...
7267939 Detection of analytes using reorganization energy  
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
7220549 Stabilizing a nucleic acid for nucleic acid sequencing  
The invention provides methods for sequencing a nucleic acid comprising stabilizing a primer/target nucleic acid duplex on a substrate. Methods of the invention generally contemplate the use of a...
7205105 Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis  
Oligonucleotide probes/conjugates are provided along with method for their use in assays to monitor amplification wherein the signal produced does not rely on 5′ nuclease digestion.
7172897 Devices and methods for biochip multiplexing  
The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising...
7169560 Short cycle methods for sequencing polynucleotides  
The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.
7160678 Compositions for the electronic detection of analytes utilizing monolayers  
The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
7125668 Electrodes linked via conductive oligomers to nucleic acids  
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
7118907 Single molecule detection systems and methods  
A microfluidic system is provided that includes a substrate, a first microchannel disposed in the substrate for providing a reactant to a reaction zone, a second microchannel disposed in the...
7090804 Amplification of nucleic acids with electronic detection  
The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification....
7087148 Binding acceleration techniques for the detection of analytes  
The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer...
7064197 System, array and non-porous solid support comprising fixed or immobilized nucleic acids  
Nucleic acids are fixed or immobilized to non-porous solid supports (substrates), and include systems containing such supports and arrays with fixed or immobilized nucleic acids. These compositions...
7060441 Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling  
A single- or double-stranded deoxyribonucleic acid (DNA) is fragmented and labeled by chemically fragmenting the DNA by creating at least one abasic site on the DNA, and attaching a marker to at...
7045610 Modified oligonucleotides for mismatch discrimination  
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor...
7045285 Electronic transfer moieties attached to peptide nucleic acids  
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
7033760 Metallic solid supports modified with nucleic acids  
The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization...
7018523 Detection of analytes using reorganization energy  
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
7014992 Conductive oligomers attached to electrodes and nucleoside analogs  
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
6949367 Modified oligonucleotides for mismatch discrimination  
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor...
6942771 Microfluidic systems in the electrochemical detection of target analytes  
The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
6921640 Process for labeling a ribonucleic acid  
The present invention relates to a process for labeling a synthetic or natural ribonucleic acid (RNA). It also relates to RNA fragments, which have been labeled by fragmenting the RNA to free a...
6911345 Methods and apparatus for analyzing polynucleotide sequences  
The present invention provides an apparatus for analyzing the sequences of polynucleotides. The apparatus comprises (a) flow cell which has at least one microfabricated multilayer elastomeric...
6902891 Process for labeling a nucleic acid  
A process of fragmenting and labeling a synthetic or natural nucleic acid, comprising the steps of providing a mixture containing a nucleic acid, a labeling agent containing a detectable label, and...
6884584 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders  
Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI 3 ), and an oligonucleotide form unusually stable hybrids with...
6833267 Tissue collection devices containing biosensors  
The present disclosure provides tissue collection devices comprising biosensors that can be used for the detection of target analytes, such as nucleic acids and proteins, including antibodies and...
6818395 Methods and apparatus for analyzing polynucleotide sequences  
Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.
6809196 Molecular recognition at surfaces derivatized with self-assembled monolayers  
An article suitable for use as a biosensor includes a molecule of a formula X—R—Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres...
6761816 Printed circuit boards with monolayers and capture ligands  
The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer...
6750357 Rhodamine-based fluorophores useful as labeling reagents  
Fluorescent dyes based on rhodamine are derivatized to form labeled conjugates that fluoresce upon excitation with light of an appropriate wavelength. Particularly preferred embodiments are certain...
6740518 Signal detection techniques for the detection of analytes  
The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the...
6686150 Amplification of nucleic acids with electronic detection  
The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification....
6683173 Tm leveling methods  
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor...
6613516 Preparation of nucleic acid samples  
The presently claimed invention provides methods, compositions, and apparatus for studying nucleic acids. Specifically, the present invention provides a novel enrichment and labeling strategy for...
6548259 Multiparametric fluorescence in situ hybridization  
The invention relates to a set of combinatorially labeled oligonucleotide probes each member thereof: (i) having a predetermined label distinguishable from the label of any other member of said...
6541617 Detection of target analytes using particles and electrodes  
The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are...
6528266 Nucleic acid mediated electron transfer  
The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties...
6506563 Multiparametric fluorescence in situ hybridization  
The invention relates to a set of combinatorially labeled oligonucleotide probes each member thereof: (i) having a predetermined label distinguishable from the label of any other member of said...
6492346 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders  
Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI 3 ), and an oligonucleotide form unusually stable hybrids with...
6489114 Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby  
A process is provided for labeling with signal amplification a ribonucleic acid (RNA), comprising fragmenting the RNA to form RNA fragments, fixing a first ligand to a terminal phosphate located at...
6485906 Oligonucleotides containing pyrazolo&lsqb 3,4-d&rsqb pyrimidines for hybridization and mismatch discrimination  
Oligonucleotides in which one or more purine residues are substituted by pyrazolo[3,4-d]pyrimidines exhibit improved hybridization properties. Oligonucleotides containing pyrazolo[3,4-d]pyrimidine...
6479240 Electrodes linked via conductive oligomers to nucleic acids  
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
Matches 1 - 50 out of 87 1 2 >