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7402730 Knockout animals manifesting hyperlipidemia  
Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal...
EP1944321A2 Methods and compositions for determining the purity of chemically synthesized nucleic acids  
This application describes a.n antibody that specifically binds to a synthetic oligomer (e.g. an oligonucleotide or oligopeptidc) having a organic protecting group covalently bound thereto, which...
7399584 Method of comparing a target nucleic acid and a reference nucleic acid  
The invention provides methods of comparing a target nucleic acid with a reference nucleic acid using nucleic acid arrays.
7393903 Devices and methods for the rapid, reliable detection and determination of acrylamide concentration in food substances and prevention of acrylamide formation in the same  
The present invention includes a device and associated analytical method to use for the sensitive detection and accurate, rapid determination of acrylamide in food substances. The present invention...
7387865 Composition containing a photoacid generator monomer, substrate coated with the composition, method for synthesizing a compound on a substrate using the composition, and microarray produced according to the method  
A composition containing a photoacid generator monomer and surfactant, and a method for synthesizing a compound on a substrate using the composition are provided. The method includes bonding a...
EP1930439A1 Neurotrophic factors  
The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides, as well as...
7384606 Bead dispensing system  
A bead dispensing system is provided for delivering small amounts of substances onto substrates. The system can include, for example, a movable support structure having an array of spaced-apart...
7378236 Method for analyzing gene expression patterns  
A method and device for detecting or monitoring the treatment status of a selected physiological state or disease condition. The device has a subarray of genes which show a statistically...
7374932 Human kinases and polynucleotides encoding the same, and uses thereof  
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
7371563 Peelable and resealable devices for biochemical assays  
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat...
7371516 Methods for determining the specificity and sensitivity of oligonucleo tides for hybridization  
The present invention provides materials and methods which may be used to evaluate one or more different probes and select probes that are optimized for sensitivity and specificity for a particular...
7368242 Method and kits for multiplex hybridization assays  
The invention provides a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The invention also...
7365179 Multiplexed analytical platform  
The invention provides a system and reagents for carrying out multiplexed analytical measurements using the hybridization of oligonucleotide tags to addressable solid phase supports to obtain...
7364920 Method for gold deposition  
A method for depositing gold on a substrate is provided. By this aspect nucleation centers are bound, deposited or formed at one or more sites on the substrate, the substrate is then contacted with...
7364859 Methods of using bioelastomers  
Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of...
7364858 Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions  
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection...
7361749 Sequence-determined DNA encoding methyltransferases  
The present invention provides DNA molecules that constitute portions of the genome of a plant. The DNA molecules are useful for expressing a gene product, either as a promoter or as a structural...
7361309 Matrix storage and dispensing system  
The present invention provides a system and process providing variable access to, as well as quick and accurate dispensing of, numerous selected reagents from a mass storage arrangement. According...
7358049 Gene chip technology for determining memory genes  
The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during...
EP1499749B1 HUMAN PAPILLOMA VIRUS DETECTION WITH DNA MICROARRAY  
7354721 Highly sensitive proteomic analysis methods, and kits and systems for practicing the same  
Methods of determining whether a sample includes one or more analytes, particularly proteinaceous analytes, of interest are provided. In the subject methods, an array of binding agents, where each...
7351578 Use of multiple recombination sites with unique specificity in recombinational cloning  
The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit...
7351575 Methods for processing biological materials using peelable and resealable devices  
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat...
7351376 Integrated active flux microfluidic devices and methods  
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be...
7347975 Bead dispensing system  
A bead dispensing system is provided for delivering small amounts of substances onto substrates. The system can include, for example, a movable support structure having an array of spaced-apart...
EP1900824A1 Gene expression signature for the prognosis, diagnosis and therapy of prostate cancer and uses thereof  
Provided is a method for monitoring the presence and/or progression of prostate tumor in an individual, by measuring the expression level of marker genes out of a novel signature of 39 genes. The...
7344832 Method and apparatus for molecular analysis in small sample volumes  
The interrogation of extremely small sample volumes can be accomplished with the present invention. Provided are probes having disposed thereon a plurality of domains forming an array, which is...
7338764 Polynucleotide microarray including two or more groups of probe polynucleotides immobilized on substrate according to melting temperature and method for detecting target polynucleotides using the same  
Provided is a polynucleotide microarray including two or more groups of spots on which probe polynucleotides are immobilized, wherein the probe polynucleotides of each group have melting...
7338763 Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays  
The invention relates to a method and a kit for the specific identification and/or quantification of one or several among at least 7 organisms or parts thereof, in a biological sample being...
7335762 Apparatus and method for sequencing a nucleic acid  
Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting...
7332285 Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions  
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection...
7332271 Apparatus and methods for parallel processing of micro-volume liquid reactions  
Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an...
7329496 Sequencing of surface immobilized polymers utilizing microflourescence detection  
Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine...
7329484 Retentate chromatography and protein chip arrays with applications in biology and medicine  
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
EP1882748A2 A population of nucleic acids including a subpopulation of LNA oligomers  
The present application discloses LNA-2,6-diaminopurine (LNA-D) and LNA-2-aminopurine (LNA-2AP) of the formulae and corresponding methods for the preparation thereof, as well as LNA oligomers...
EP1882520A1 Patterned spot microarray using photocatalyst and a method of manufacturing the same  
Provided is a method of preparing a patterned spot microarray using a photocatalyst, the method including coating the photocatalyst on a substrate to form a photocatalyst layer; coating a material...
7323307 Identification of molecular sequence signatures and methods involving the same  
Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets...
7323305 Methods of amplifying and sequencing nucleic acids  
An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing,...
7323298 Microarray for determining the relative abundances of polynuceotide sequences  
A method of determining the relative amounts of individual polynucleotides in a complex mixture of different-sequence polynucleotides is disclosed. The polynucleotides, after fluorescent labeling,...
EP1881063A1 Stem cell populations and methods of use  
The invention provides populations of expanded CD34-expressing cells and methods of use. Particular embodiments provide for defined culture media useful for growing these cells, and grafts...
7320865 Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions  
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection...
7314708 Method and apparatus for electronic synthesis of molecular structures  
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic...
7314542 Methods and materials for optimization of electronic transportation and hybridization reactions  
Methods for the transport and hybridization of a nucleic acid on an electrode device by providing a low conductivity buffer with a reducing agent to the device. The low conductivity buffer may also...
EP1870157A2 Focused acoustic energy in the preparation and screening of combinatorial libraries  
A spatial array comprising a plurality of different ascertainable compositions of matter on a substrate surface divided into a plurality of discrete surface sites, each site containing one...
7312376 Regulatory regions from Papaveraceae  
Regulatory regions suitable for regulating expression of a heterologous nucleic acid are described, as well as nucleic acid constructs that include these regulatory regions. Also disclosed are...
7312079 Variants of FAM3C  
Polynucleotide and polypeptide sequences that encode novel variant FAM3C proteins are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
7312039 Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions  
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection...
EP1865076A1 Detection of lymph node metastasis from gastric carcinoma  
Methods, compositions and articles are directed to diagnosing the lymph node metastasis from gastric carcinoma, differentiating between negative lymph nodes and lymph nodes with metastasis from...
7302289 Readable probe array for in-vivo use  
A disposable high density optically readable polydeoxynucleotide array with integral fluorescence excitation and fluorescence emission channels is described. The compact array size allows...
7300757 Electronic systems and component devices for macroscopic and microscopic molecular biological reaction, analyses, and diagnostics  
This invention pertains to the design, fabrication, and uses of an electronic system which can actively carry out and control multi-step and multiplex reactions in macroscopic or microscopic...
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