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6902924 |
Human kinases and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6902923 |
Human kinase proteins and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6902921 |
Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
The present invention relates to the field of DNA recombinant technology. More specifically, this invention relates to fusion proteins comprising an ATP generating polypeptide joined to a...
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6902891 |
Process for labeling a nucleic acid
A process of fragmenting and labeling a synthetic or natural nucleic acid, comprising the steps of providing a mixture containing a nucleic acid, a labeling agent containing a detectable label, and...
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6902702 |
Devices and methods for producing microarrays of biological samples
The present invention is directed to systems and methods for producing microarrays of biological samples using an improved slide platform, vacuum manifold, and variable pin contact velocity. Slides...
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6900013 |
Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
The present invention recognizes that identifying genes expressed during developmental processes, stress responses, and disease states can advance understanding of these biological functions, and...
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6897073 |
Non-specific binding resistant protein arrays and methods for making the same
Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an...
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6897025 |
Genetic analysis systems and methods
Improved systems and methods for performing genetic analyses. Full genomic DNA scans are performed on the genetic DNA from a plurality of individuals to identify genetic variants. For those...
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6897015 |
Device and method of use for detection and characterization of pathogens and biological materials
The present invention includes a method and apparatus for the detection of a target material. The method and apparatus includes providing a substrate with a surface and forming a domains of...
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6887715 |
Methods and compositions for producing biopolymeric arrays
Methods and compositions are provided for producing arrays of polymeric binding agents. In the subject methods, the individual polymers of the array are synthesized using solid phase synthesis...
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6887685 |
Human thymosin protein and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6887431 |
Bead dispensing system
A bead dispensing system is provided for delivering small amounts of substances onto substrates. The system can include, for example, a movable support structure having an array of spaced-apart...
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6887362 |
Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates...
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6884626 |
Redrawn capillary imaging reservoir
Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively...
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6884578 |
Genes differentially expressed in secretory versus proliferative endometrium
The present invention compares expression profiles from matched samples to identify differential gene expression. Samples are matched according to physiological, pharmacological and/or disease...
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6882742 |
Method and apparatus for providing a bioinformatics database
System and method for organizing information relating to polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information relating to sample...
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6881836 |
Photocleavable protecting groups and methods for their use
Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally...
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6881586 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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6881571 |
Qualitative differential screening
The invention concerns a method for identifying and/or cloning nucleic acid regions representing qualitative differences associated with alternative splicing events and/or with insertions,...
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6881563 |
Human proteases and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6875858 |
Functionalized polynucleotide compound, optionally marked and method for detecting a target nucleic acid
The invention relates to a functionalized compound of general formula (I):
in which W represents a nucleotide analog, L represents a linker arm comprising at least four atoms, R 1 ...
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6875587 |
Human protease inhibitor and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications
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6872522 |
Broad specificity affinity arrays: a qualitative approach to complex sample discrimination
Described is a method for discriminating complex biological samples using an array of discrete biological sensing elements immobilized onto a solid support in which constituents bound to the sensor...
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6872521 |
Polymerase signaling assay
The present invention relates to the field of nucleic acid sequence analysis. The invention provides methods for performing a polymerase signal assay (PSA) to analyze nucleotide sequences using...
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6867048 |
Multiplexed active biologic array
A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method,...
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6867025 |
Human hydroxylases and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in industrial, therapeutic, diagnostic, and pharmacogenomic applications.
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6864201 |
Preparation and screening of crystalline zeolite and hydrothermally-synthesized materials
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is...
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6864101 |
Combinatorial strategies for polymer synthesis
A method for producing polymer arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a monomer in a single coupling step of less than 5 nl to occupy a...
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6864079 |
Human kinase and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6864059 |
Biotin containing C-glycoside nucleic acid labeling compounds
Nucleic acid labeling compounds including the following structure are disclosed:
wherein A is a triphosphate group with apporpriate counterions, said counterions selected from the group...
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6864050 |
Single-phase amplification of nucleic acids
The amplification of nucleic acids in a single phase can reliably provide products at relatively low cost and labor. A single-phase amplification can also increase the amount of nucleic acids while...
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6861241 |
Human kinase and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6861240 |
Human kinases and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6861214 |
Immobilization of biopolymers to aminated substrates by direct adsorption
An assay article for detection biopolymers contained in a sample is described. The assay article includes a substrate and a biopolymer directly adsorbed on the surface of the substrate. A plurality...
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6859735 |
Computer systems for identifying pathways of drug action
The present invention provides methods and computer systems for identifying and representing the biological pathways of drug action on a cell The present invention also provides methods and...
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6858711 |
Labeling reagents
The present invention provides a simplified method for identifying differences in nucleic acid abundances (e.g., expression levels) between two or more samples. The methods involve providing an...
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6858419 |
Human kinases and polynucleotides encoding the same, and uses thereof
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6852844 |
Human protocadherin proteins and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6852840 |
Human kielin-like proteins and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6852521 |
Human proteases and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6852487 |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a...
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6849462 |
Combinatorial strategies for polymer synthesis
A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less...
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6849443 |
Human kinases and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6849409 |
Cellular kinases involved in Cytomegalovirus infection and their inhibition
The role of certain cellular kinases active during Human Cytomegalovirus infection is disclosed. These cellular kinases are useful to detect HCMV infection, and can be used to screen for cellular...
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6849127 |
Apparatus and method for spotting a substrate
The present invention provides a method and apparatus for dispensing a small volume of a selected liquid, such as a biological sample or reagent, onto a substrate. The device includes a tube...
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6844433 |
Nucleic acid labeling compounds
Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a...
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6844165 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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6844151 |
Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
The present invention provides methods for producing arrays having associated modified nucleic acid structures, e.g. acid stable and/or end-blocked nucleic acids such as 2′-O—R...
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6841377 |
Human kinase and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenmic applications.
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6841258 |
High density, miniaturized arrays and methods of manufacturing same
High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates....
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