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7407747 Method for drying dye-terminator sequencing reagents  
A dry composition comprising a nucleotide linked to a fluorescent dye is provided. A method of making a dry composition comprising the step of drying a solution comprising a nucleotide linked to a...
7399854 Regents labeled with energy transfer dyes  
Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor...
7388092 Oligonucleotides and analogs labeled with energy transfer dyes  
Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor...
7316899 Portable sensor array system  
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
7262029 Dye-labeled ribonucleotide triphosphates  
The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase...
7256275 Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation  
This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and...
7238789 Sulfonated [8,9] benzophenoxazine dyes and the use of their labelled conjugates  
Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a...
7179906 Asymmetric benzoxanthene dyes  
A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure wherein Y 1 and Y 2 are individually hydroxyl, amino, imminium, or oxygen, R 1...
EP1748078A2 Methods, kits and compositions of combination oligomers  
This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and...
7169939 Energy transfer dyes with enhanced fluorescence  
Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor...
EP1746171A2 Probes and methods for hepatitis C virus typing using single probe analysis  
This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at...
EP1746170A2 Probes and methods for hepatitis C virus typing using multidimensional probe analysis  
This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at...
7022517 Method and apparatus for the delivery of samples to a chemical sensor array  
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
7019128 Propargylethoxyamino nucleotides  
Propargylethoxyamino nucleosides are disclosed having the structure wherein R 1 and R 2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W 1 is...
6908770 Fluid based analysis of multiple analytes by a sensor array  
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
6887690 Dye-labeled ribonucleotide triphosphates  
The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase...
6828159 Carbopyronine fluorescent dyes  
The invention relates to the use of carbopyronine compounds of general formula (I) as marker groups in methods for detecting analytes. The invention also relates to novel carbopyronine compounds...
6764710 Light emitting markers for use with substrates  
A method of determining whether a substrate has been subjected to an energy source. In one embodiment, the method includes the steps of providing a polymeric surface, providing a light emitting...
6713622 4,7-dichlororhodamine dye labeled polynucleotides  
A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures wherein R 1 -R 6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower...
6713298 Method and apparatus for the delivery of samples to a chemical sensor array  
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
6680206 Sensor arrays for the measurement and identification of multiple analytes in solutions  
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
6653462 Nucleotide compounds including a rigid linker  
A nucleoside/tide compound having the structure: NUC-L-S-LB/LG is described wherein NUC is a nucleoside/tide having a nucleobase portion B, L is a rigid linkage, S is a spacer; and LB/LG is a...
6649403 Method of preparing a sensor array  
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
6617445 Asymmetric benzoxanthene dye labelling reagents  
A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure wherein Y 1 and Y 2 are individually hydroxyl, amino, imminium, or oxygen, R 1...
EP1173519B1 NOVEL CARBOPYRONINE FLUORESCENCE DYES  
Abstract not available for EP1173519 Abstract of corresponding document: DE19919119 The invention relates to the use of carbopyronine compounds of general formula (I) as marker groups in methods...
6605434 Direct bacterial lysate sequencing  
The present invention relates to novel methods for sequencing nucleic acid molecules. More specifically, methods are provided for sequencing nucleic acid molecules present in bacterial lysates...
6602702 Detection system based on an analyte reactive particle  
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
6504024 Propargylethoxyamino nucleotide primer extensions  
Propargylethoxyamino nucleosides are disclosed having the structure wherein R 1 and R 2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W 1 is...
6465644 Sulfonated &lsqb 8,9&rsqb benzophenoxazine dyes and the use of their labelled conjugates  
Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a...
6316201 Apparatus and methods for sequencing nucleic acids in microfluidic systems  
The present invention is generally directed to microfluidic systems and methods of using such systems in the determination of the nucleotide sequence of target nucleic acid sequences (referred to...
6303775 Polynucleotides labelled with asymmetric benzoxanthene dyes  
A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein Y 1 and Y 2 are individually hydroxyl, amino, imminium, or...
6248568 Propargylethoxyamino nucleotide primer extensions  
Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R 1 and R 2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W 1 ...
6207421 DNA sequencing and DNA terminators  
A universal terminator includes a heterocycle other than naturally occuring DNA heterocycles such as adenine, cytosine, guanine and thymine. In terminating strand synthesis, the hybridized...
6200748 Tagged extendable primers and extension products  
This invention provides a duplex comprising an oligonucleotide primer and a template, wherein the primer is coupled chemically to a chromophore or fluorophore so as to allow chain extension by a...
6197555 Nucleotide compounds including a rigid linker  
A nucleoside/tide compound having the structure NUC-L-S-LB/LG is described wherein NUC is a nucleoside/tide having a nucleobase portion B, L is a rigid linkage, S is a spacer; and LB/LG is a...
6143151 DNA sequencing  
To sequence long strands of DNA, clone strands having lengths longer than 100 bases are, in one embodiment, marked on one end with biotin. These strands are divided into 4 aliquots and each...
6107044 Apparatus and methods for sequencing nucleic acids in microfluidic systems  
The present invention is generally directed to microfluidic systems and methods of using such systems in the determination of the nucleotide sequence of target nucleic acid sequences (referred to...
6086737 Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor  
To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or...
6080852 4,7-dichlororhodamine dyes  
A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures ##STR1## wherein R 1 -R 6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene,...
6025505 4,7-Dichlororhodamine dyes  
A class of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein R 1 -R 6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene,...
6020481 Asymmetric benzoxanthene dyes  
A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein Y 1 and Y 2 are individually hydroxyl amino, imminium, or oxygen,...
6017712 4,7-dichlororhodamine dyes  
A class of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein R 1 -R 6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene,...
6013445 Massively parallel signature sequencing by ligation of encoded adaptors  
The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose...
6004446 DNA Sequencing  
To sequence DNA, DNA samples marked with flourscent infrared dye are applied at a plurality of locations for electrophoresing in a plurality of channels through a gel electrophoresis slab. The...
5958694 Apparatus and methods for sequencing nucleic acids in microfluidic systems  
The present invention is generally directed to microfluidic systems and methods of using such systems in the determination of the nucleotide sequence of target nucleic acid sequences (referred to...
5948648 Nucleotide compounds including a rigid linker  
A nucleoside/tide compound having the structure NUC--L--S--LB/LG is described wherein NUC is a nucleoside/tide having a nucleobase portion B, L is a rigid linkage, S is a spacer; and LB/LG is a...
5863403 Digital DNA typing  
To sequence DNA automatically, fluorescently marked DNA are electrophoresed in a plurality of channels through a gel electrophoresis slab; wherein the DNA samples are resolved in accordance with...
5861287 Alternative dye-labeled primers for automated DNA sequencing  
Methods for the use of a class of dyes for improved DNA sequencing are provided. A new class of dyes, BODIPY® fluorophores, has been described recently. The parent heterocyclic molecule of the...
5847162 4, 7-Dichlororhodamine dyes  
A class of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein R 1 -R 6 are hydrogen, fluorine, chlorine, lower alkyl lower alkene,...
5840999 Asymmetric benzoxanthene dyes  
A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein Y 1 , and Y 2 are individually hydroxyl, amino, imminium, or...
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