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7402441 |
Method of detecting an analyte in a fluid
A method for the detection of an analyte in a fluid, comprising contacting the fluid with a holographic element comprising a medium and a hologram disposed throughout the volume of the medium,...
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7399643 |
Method and apparatus for aligning microbeads in order to interrogate the same
A method and apparatus are provided for aligning optical elements or microbeads, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be...
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7375890 |
Method of manufacturing of a diffraction grating-based optical identification element
A method of manufacturing optical identification elements that includes forming a diffraction grating in a fiber substrate along a longitudinal axis of the substrate. The grating includes a...
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7364858 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection...
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7349158 |
Diffraction grating-based encoded micro-particles for multiplexed experiments
Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a...
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7332285 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection...
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7320865 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection...
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7314763 |
Fluidics-based assay devices
A fluidics-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g.,...
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7312039 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection...
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7285424 |
Membrane-based assay devices
A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g.,...
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7247500 |
Reduction of the hook effect in membrane-based assay devices
A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a chromatographic zone on which is disposed a plurality...
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7223534 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the...
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7223368 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the...
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7214530 |
Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of...
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7190522 |
Chemical synthesis using diffraction grating-based encoded optical elements
An optical identification element having a synthesized chemical attached thereto includes an optical substrate having at least one diffraction grating disposed therein, the grating having a...
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7169550 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of...
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7166434 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention...
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7164533 |
Hybrid random bead/chip based microarray
A method and apparatus f or performing an assay process, featuring providing microbeads in a solution; placing the microbeads on an alignment substrate; reading codes of the microbeads and the...
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7158224 |
Optically active substrates
A device for optical examination of biological materials using radiation of a selected wavelength includes a substrate having a first surface and a second surface opposite to the first surface. The...
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7126755 |
Method and apparatus for labeling using diffraction grating-based encoded optical identification elements
A method and apparatus for labeling an item using diffraction grating-based encoded optical identification elements 8 includes an optical substrate 10 having at least one diffraction grating ...
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7118855 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the...
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7106513 |
Diffraction grating-based encoded particle
An encoded particle 8 includes a particle substrate 10; at least a portion of the substrate having at least one diffraction grating disposed therein, the grating having a resultant refractive...
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7105358 |
Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks
An apparatus to measure micro-forces includes a cantilever palette with a set of cantilever array blocks. Each cantilever array block includes a set of cantilevers, with each cantilever including a...
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7102752 |
Systems to view and analyze the results from diffraction-based diagnostics
An analyzer useful in determining the presence of an analyte using a diffraction based sensing device and methods and systems using this device. The present invention may be used with a variety of...
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7098041 |
Methods to view and analyze the results from diffraction-based diagnostics
An analyzer useful in determining the presence of an analyte using a diffraction based sensing device and methods and systems using this device. The present invention may be used with a variety of...
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7097980 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention...
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7092160 |
Method of manufacturing of diffraction grating-based optical identification element
A method for manufacturing a diffusion grating-based optical identification element is provided. The optical identification element includes a known fiber substrate, having a diffraction grating...
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7091049 |
Enhanced diffraction-based biosensor devices
An enhanced diffraction based biosensor system and method are provided for detecting an analyte of interest in a test medium. The system incorporates at least one additional detection tag substance...
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7083917 |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a...
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7014994 |
Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in...
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6852487 |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a...
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6797470 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention...
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6689316 |
Holographic sensors and their production
A method for the production of a holographic sensor wherein the holographic recording material forming the sensitive element is a polymer matrix, which comprises diffusing into the matrix one or...
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EP1369681A1 |
Hologram used as a sensor
The invention relates to a sensor (9) comprising a hologram (17) supported on or within a holographic support medium (10), A species to be detected is reactive with a substance disposed throughout...
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EP0753139B1 |
HOLOGRAM USED AS A SENSOR
Abstract not available
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6579673 |
Patterned deposition of antibody binding protein for optical diffraction-based biosensors
The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed...
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6399295 |
Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as...
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6268148 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention...
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6221579 |
Patterned binding of functionalized microspheres for optical diffraction-based biosensors
The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as...
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6180288 |
Gel sensors and method of use thereof
The present invention comprises an optically diffracting sensing device whose diffraction pattern changes upon exposure to some stimuli. The diffraction pattern may be two or three dimensional, and...
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6027889 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention...
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5989923 |
Hologram containing sensor
The invention relates to a sensor (9) comprising a hologram (17) supported on or within a holographic support medium (10). A species to be detected is reactive with a substance disposed throughout,...
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5885843 |
Device and method for determining oxygen concentration and pressure in gases
Disclosed are oxygen concentration and/or pressure sensing devices and methods which incorporate photoluminescent silica aerogels. Disclosed sensors include a light proof housing for holding the...
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