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7351855 Chemically defined non-polymeric valency platform molecules and conjugates thereof  
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
7208156 Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule  
Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when...
7163683 Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule  
Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when...
7138244 Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule  
Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when...
7115581 Chemically-defined non-polymeric valency platform molecules and conjugates thereof  
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
7083959 Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry  
The present invention relates to a method of specifically suppressing an undesired immune response in a mammal suffering from such a response. The method comprises: i) preparing a construct...
7081242 Methods of treating lupus based on antibody affinity and screening methods and compositions for use thereof  
The invention provides methods identifying individuals suitable for treatment for lupus and methods of monitoring treatment, based on measuring antibody affinities, as well as of treating lupus...
6951939 Multivalent platform molecules comprising high molecular weight polyethylene oxide  
Valency platform molecules comprising high molecular weight polyethylene oxide groups are provided, as well as conjugates thereof with biologically active molecules, and methods for their...
6897049 Proteins producing an altered immunogenic response and methods of making and using the same  
The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the...
6858210 Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same  
The present invention provides domain 1 β 2 GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 β 2 GPI polypeptides and...
6458953 Valency platform molecules comprising carbamate linkages  
This invention pertains generally to valency molecules, such as valency platform molecules which act as scaffolds to which one or more molecules may be covalently tethered to form a conjugate. More...
6410775 APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies  
aPL analogs that (a) bind specifically to B cells to which an aPL epitope binds and are disclosed. Optimized analogs lack T cell epitope(s) are useful as conjugates for treating aPL...
6399578 Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same  
This invention provides conjugates useful for xenotransplantation which comprise a galactose α1,3 galactosyl (αGal) epitope conjugated to a valency platform molecule, preferably a chemically...
6245752 Compositions and methods for tolerization in immune complex-mediated disease progression  
Methods and compositions are provided for tolerizing shed antigen-specific B cells involved in an immune complex-mediated disease progression. The composition comprises a substantially...
6207160 aPL immunoreactive peptides, conjugates thereof and methods of treatment for aPL antibody-mediated pathologies  
aPL analogs that (a) bind specifically to B cells to which an aPL epitope binds and are disclosed. Optimized analogs lack T cell epitope(s) are useful as conjugates for treating aPL...
6060056 Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule  
Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when...
6048529 PVA or PEG conjugates of peptides for epitope-specific immunosuppression  
The invention relates to a procedure for synthesis of well-defined conjugates of peptides to the tolerogenic polymer monomethoxypolyethylene glycol (mPEG) or polyvinyl alcohol (PVA). This method...
6031073 Cyclic polypeptides comprising a thioether linkage and methods for their preparation  
This invention relates generally to cyclic polypeptides comprising a thioether linkage and methods for their preparation. More particularly, this invention relates to halogenated polypeptides...
5874409 APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies  
aPL analogs that (a) bind specifically to B cells to which the aPL epitope binds and (b) lack T cell epitope(s), methods preparing and identifying said analogs and methods of treatment using said...
5817752 Cyclic polypeptides comprising a thioether linkage and methods for their preparation  
This invention relates generally to cyclic polypeptides comprising a thioether linkage and methods for their preparation. More particularly, this invention relates to halogenated polypeptides...
Matches 1 - 20 out of 20