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7393830 |
Prolactin induced increase in neural stem cell numbers
The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ,...
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7368115 |
Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (PACAP)
The present invention relates to a method of increasing the number and/or differentiation of neural stem cells and/or neural stem cell progeny using pituitary adenylate cyclase-activating...
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EP1870419A2 |
Modulators of beta-amyloid peptide aggregation comprising D-amino acids
Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely...
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EP0954283B1 |
USE OF A NON-ENCAPSULATED ANTICANCER DRUG FOR THE PREPARATION OF A FORMULATION FOR TREATING NEOPLASMS BY INHALATION
Abstract not available for EP0954283 Abstract of corresponding document: WO9829110 A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically...
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7101879 |
Treatments for neurotoxicity in Alzheimer's Disease
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds...
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7067550 |
Treatments for neurotoxicity in Alzheimer's Disease
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds...
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7048934 |
Combined regulation of neural cell production
This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro or in vivo. Also provided are methods of treating or ameliorating...
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7018979 |
Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor
Disclosed are methods of selectively delivering a medicant to an abnormal brain region and/or to a malignant tumor in a mammalian subject, including a human. A medicant is administered...
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7014861 |
Permeabilizing reagents to increase drug delivery and a method of local delivery
A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for...
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6942963 |
Methods for identifying treatments for neurotoxicity in Alzheimer's disease caused by β-amyloid peptides
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds...
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6838279 |
Herpes simplex virus type 1 (HSV-1)-derived vector for selectively inhibiting malignant cells and for expressing desired traits in malignant and non-malignant mammalian cells
Disclosed is an HSV-1-derived vector containing a DNA having a functional LAT promoter, or operative fragment thereof, a deletion in both copies of the HSV-1 LAT gene, and a deletion in both copies...
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6663880 |
Permeabilizing reagents to increase drug delivery and a method of local delivery
A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for...
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6630120 |
Agents to increase the uptake of pharmaceuticals and diagnostic substances into solid tumors
Agents, such as bradykinin agonists, increase the transport of pharmaceutical or diagnostic substances that are initially in the bloodstream of a host animal into the interstitial spaces of...
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6471943 |
Formulation and method for treating neoplasms by inhalation
A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is...
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6419901 |
Method for treating neoplasms by inhalation
A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is...
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6419900 |
Formulation and method for treating neoplasms by inhalation
A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is...
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6348209 |
Formulation and method for treating neoplasms by inhalation
A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is...
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6258780 |
Method and composition for enabling passage through the blood-brain-barrier
A pharmaceutical composition for facilitating passage of compounds through the blood-brain barrier comprising the agent ACHE-I4 readthrough (SEQ ID No:1) splice variant or the I4 peptide (SEQ ID...
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6172043 |
Treatments for neurotoxicity in Alzheimer's disease caused by β amyloid peptides
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds...
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6054114 |
Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro
Novel organometallic compounds for binding amyloid are described. Methods using such compounds for determining by imaging the localization or quantification of amyloid fibrils in a mammal, for...
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6043223 |
Enhanced opening of abnormal brain tissue capillaries
Improved compositions and methods for increasing permeability of abnormal brain tissue to pharmaceutical agents. Cyclic GMP specific phosphodiesterase inhibitors are combined with bradykinin or a...
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5686416 |
Increasing blood-brain barrier permeability with permeabilizer peptides
Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or...
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5585355 |
Method for increasing blood-ocular barrier permeability with permeabilizer peptides
The permeability of the blood-ocular barrier to therapeutic or diagnostic agents in the bloodstream of a host is increased by administering a permeabilizer peptide, preferably bradykinin or a...
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5434137 |
Method for selective opening of abnormal brain tissue capillaries
A method for selectively opening abnormal brain tissue capillaries of a mammal in order to allow selective passage of both low and high molecular weight neuropharmaceutical agents into abnormal...
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