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EP1978029A2 Secreted and transmembrane polypeptides and nucleic acids endoding the same  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7432057 Genetic test for PSE-susceptible turkeys  
This invention relates to methods and compounds for the improvement of turkey meat and turkey populations, but not limited to, a genetic screen to select for turkeys that produce a better quality...
7431921 Interferon beta-like molecules  
The invention relates to a conjugate exhibiting interferon β (IFNB) activity and comprising at least one first non-polypeptide moiety covalently attached to an IFNB polypeptide, the amino acid...
EP1956030A1 Secreted and transmembrane polypeptides and nucleic acids endoding the same  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
EP1953173A1 Secreted and transmembrane polypeptides and nucleic acids endoding the same  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
EP1944317A2 Secreted and transmembrane polypeptides and nucleic acids encoding the same  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
7399839 Monopegylated growth hormone proteins  
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the...
EP1927659A1 Wisp polypeptides and therapeutical applications thereof  
The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising...
7375086 Modulators of Nod2 signaling  
The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying...
7371371 Interleukin-2 mutants with reduced toxicity  
Interleukin-2 (IL-2) mutants having reduced toxicity, which include full-length IL-2, truncated forms of IL-2 and forms of IL-2 that are linked to another molecule are disclosed herein. Particular...
7357925 Method for treating disorders and diseases treatable with human fibroblast interferon  
PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys 17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A...
7351855 Chemically defined non-polymeric valency platform molecules and conjugates thereof  
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
7351689 Use of IL-28 and IL-29 to treat cancer and autoimmune disorders  
Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29...
7345154 Cysteine variants of erythropoietin  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
7345149 Cysteine substitution variants of beta interferon  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
EP1897947A2 IL-17 homologous polypeptides and therapeutic uses thereof  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein a re vectors and host cells comprising those nucleic acid...
EP1897946A2 IL-17 homologous polypeptides and therapeutic uses thereof  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein a re vectors and host cells comprising those nucleic acid...
EP1897945A2 IL-17 homologous polypeptides and therapeutic uses thereof  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein a re vectors and host cells comprising those nucleic acid...
EP1897944A2 IL-17 homologous polypeptides and therapeutic uses thereof  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein a re'vectors and host cells comprising those nucleic acid...
EP1897943A2 IL-17 homologous polypeptides and therapeutic uses thereof  
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein a re vectors and host cells comprising those nucleic acid...
EP1668031B1 HOMOGENEOUS PREPARATIONS OF IL-29  
Abstract not available for EP1668031 Abstract of corresponding document: WO2005023862 Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the...
7338788 Interferon-β variants and conjugates  
The present invention provides new interferon β conjugates, methods of preparing such conjugates and the use of such conjugates in therapy, in particular for the treatment of multiple sclerosis.
EP1881005A1 Derivatives of growth hormone and related proteins  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific biologically active...
EP1873245A1 Interleukin-8 homologous polypeptides and therapeutic uses thereof  
The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells...
EP1873244A2 Methods and compositions for inhibiting neoplastic cell growth  
The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of...
7314921 Cysteine variants of erythropoietin  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
EP1870464A2 Methods and compositions for inhibiting neoplastic cell growth  
The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of...
EP1867719A2 Methods and compositions for inhibiting neoplastic cell growth  
The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of...
7309781 Cysteine variants of granulocyte colony-stimulating factor  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
EP1865061A2 IL-17 homologous polypeptides and therapeutic uses thereof  
The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host...
7306931 Method for refolding proteins containing free cysteine residues  
The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having free cysteines in which a host cell expressing the protein is exposed to a cysteine...
7301003 Method of preparing polymers having terminal amine groups  
The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a...
EP1012184B1 DERIVATIVES OF GROWTH HORMONE AND RELATED PROTEINS  
Abstract not available for EP1012184 Abstract of corresponding document: WO9903887 The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors....
7270972 Process for producing subunit peptide originating in polymer protein  
It is provided a method for producing a subunit peptide originating from an oligomeric protein having disulfide bonds within a subunit and between subunits. The method comprises producing a subunit...
7270809 Cysteine variants of alpha interferon-2  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
EP1820860A2 Methods and compositions for inhibiting neoplastic cell growth  
The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of...
EP1820859A2 Methods and compositions for inhibiting neoplastic cell growth  
The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of...
7255986 Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets  
The present invention relates to the use of novel nucleotide sequences for the M and N region peptide of the ferret coronavirus and derivative products for the diagnosis and treatment of epizootic...
7253267 Cysteine variants of interleukin-11  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
EP1284987B1 METHODS FOR REFOLDING PROTEINS CONTAINING FREE CYSTEINE RESIDUES  
Abstract not available for EP1284987 Abstract of corresponding document: WO0187925 The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having...
7238344 Interferon-β variants and conjugates  
The present invention provides new interferon β conjugates, methods of preparing such conjugates and the use of such conjugates in therapy, in particular for the treatment of multiple sclerosis.
7235638 Coagulation factor VII derivatives  
The present invention relates to novel human coagulation Factor VII polypeptides, Factor VII derivatives as well as polynucleotide constructs encoding such polypeptides, vectors and host cells...
7235633 Cytokine receptors and nucleic acids encoding the same  
The present invention is directed to novel cytokine receptors having sequence similarity to AF18497_1 and to nucleic acid molecules encoding those cytokine receptors. Also provided herein are...
7235240 Antagonists of interleukin-15  
Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are...
7232885 Termini cysteine-added variants of granulocyte colony stimulating factor  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
EP1783139A2 Human telomerase catalytic subunit  
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
7214779 Termini cysteine-added variants of granulocyte-macrophage colony stimulating factor  
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
7173115 Stra6 polypeptides  
The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides....
7173010 Orphanin FQ receptor  
The present invention provides Orphanin FQ receptor nucleic acids and polypeptides and uses thereof. In particular, the present invention provides nucleic acid sequences of differentially expressed...
7157559 Homogeneous preparations of IL-28 and IL-29  
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
Matches 1 - 50 out of 98 1 2 >