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7385025 |
Metallopeptide compounds
Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (α-MSH), gamma-melanocyte stimulating hormone (γ-MSH), or bombesin sequence of length n residues,...
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7361640 |
Stable lipid-comprising drug delivery complexes and methods for their production
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
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7335509 |
Stable lipid-comprising drug delivery complexes and methods for their production
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
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7335359 |
Glycosylated specificity exchangers
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and...
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7332166 |
Glycosylated specificity exchangers
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and...
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7318926 |
Glycosylated specificity exchangers
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and...
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7238345 |
Recombinant microorganism expressing meningococcal class 1 outer membrane protein
Outer-membrane vesicles, Class 1 outer membrane proteins of Neisseria meningitidis, fragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal...
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7235715 |
Virus-resistant transgenic plants expressing L3
Disclosed are transgenic plants containing an exogenous nucleic acid encoding an L3 protein. The plant exhibits increased resistance to viruses and/or fungi that infect plants. The L3 proteins...
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7179618 |
Streptavidin proteins
Streptavidin-metallothionein chimeric proteins with biological recognition specificity in which the streptavidin moiety provides high affinity biotin binding and the metallothionein moiety provides...
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RE39220 |
Peptide-mediated gene transfer
A methodology that allows for highly efficient transfer and stable integration of DNA into both established eukaryotic cell lines and primary cells, including non-dividing cells such as human...
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7083777 |
Immunomodulating polymers
A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the...
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7058658 |
Molecular database for antibody characterization
The invention relates to a cumulative, evolving molecular database of monospecific probes and their characteristics. In particular, the invention relates to a computer repository of histograms...
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7053074 |
Prevention of ovarian cancer by administration of a Vitamin D compound
The present invention relates to methods for preventing the development of epithelial ovarian cancer by administering a Vitamin D compound in an amount capable of increasing apoptosis in...
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7026285 |
Immunomodulating polymers
Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing...
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7019111 |
Glycosylated ligand/receptor specificity exchangers specific for bacterial adhesion receptors
The present invention generally relates to compositions and methods for preventing and treating human diseases including, but not limited to, pathogens such as bacteria, yeast, parasites, fungus,...
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6933366 |
Specificity exchangers that redirect antibodies to bacterial adhesion receptors
Specificity exchangers and methods of making and using specificity exchangers are disclosed. Specificity exchangers are useful for preventing and treating human diseases including cancer and those...
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6872548 |
Scaffolded fusion polypeptides and compositions and methods for making the same
The present invention provides soluble forms of integral membrane proteins, or domains or portions thereof, that retain the biological activity of the integral membrane protein, domain or portion...
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6667389 |
Technetium-99m labeled peptides for imaging
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for...
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6660842 |
Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
The present invention generally relates to compositions and methods for preventing and treating human diseases including, but not limited to, pathogens such as bacteria, yeast, parasites, fungus,...
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EP0759037B1 |
ANTIGEN/ANTIBODY SPECIFICITY EXCHANGER
Abstract not available for EP0759037 Abstract of corresponding document: US5869232 PCT No. PCT/SE95/00468 Sec. 371 Date Dec. 27, 1996 Sec. 102(e) Date Dec. 27, 1996 PCT Filed Apr. 27, 1995 PCT...
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6482596 |
Method for measuring antigen concentration
This invention provides a method for measuring an antigen concentration in a sample, which comprises: preparing VH-domain polypeptide and VL-domain polypeptide of an antibody specific to the...
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6469143 |
Antigen/antibody specificity exchanger
An antigen/antibody specificity exchanger is disclosed. It comprises: A) an amino-acid sequence corresponding to an amino-acid sequence of an antibody which specifically binds to a certain antigen,...
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6458775 |
NAALADase inhibitors useful as pharmaceutical compounds and compositions
The present invention relates to N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use...
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6417324 |
Synthetic peptides that bind to the hepatitis B virus core and e antigens
The present invention relates generally to the field of virology. More particularly, the invention relates to the discovery that peptides, which bind to the Hepatitis B virus (HBV) core and e...
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6413948 |
Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors
The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical...
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6395718 |
Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
The present disclosure relates to a method of inhibiting angiogenesis comprising administering a N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) inhibitor to a patient in need thereof, and a...
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6391590 |
Recombinant streptavidin-metallothionein chimeric protein having biological recognition specificity
Streptavidin-metallothionein chimeric proteins with biological recognition specificity in which the streptavidin moiety provides high affinity biotin binding and the metallothionein moiety provides...
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6384022 |
Prodrugs of NAALAdase inhibitors
The present invention relates to prodrugs of NAALADase inhibitors, pharmaceutical compositions comprising the same, and methods of using the same to treat glutamate abnormalities and prostate...
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6372726 |
Methods of cancer treatment using NAALADase inhibitors
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to...
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6331285 |
Structurally determined cyclic metallo-constructs and applications
A metallo-construct, which may be a peptide, is provided for use as a biological, therapeutic, diagnostic imaging, or radiotherapeutic agent, and for use in library or combinatorial chemistry...
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6313159 |
Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
The present invention relates to metabotropic glutamate receptor ligand derivatives and methods of using the same to inhibit NAALADase enzyme activity, to effect neuronal activities, to inhibit...
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6288046 |
Phosphonic acid derivatives
The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such...
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6271245 |
Hydroxamic acid derivatives
The present invention relates to hydroxamic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such...
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6265609 |
Thio-substituted pentanedioic acid derivatives
The present invention relate to thio-substituted pentanedioic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions...
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6245895 |
Antigen/antibody specificity exchanger
An antigen/antibody specificity exchanger is disclosed. It comprises: A) an amino-acid sequence corresponding to an amino-acid sequence of an antibody which specifically binds to a certain antigen,...
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6241965 |
Somatostatin derivatives and their radiolabelled products
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labelled radiodiagnostic agents. Specifically, the invention relates to...
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6200752 |
Method and composition for detecting the presence of a nucleic acid sequence in a sample
A method for detecting the presence of a nucleic acid sequence in a sample includes the step of coupling a fluorescent metal-ligand complex to an oligonucleotide having a sequence complementary to...
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6113878 |
Technetium-99m labeled peptides for imaging
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for...
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6071965 |
Phosphinic alkanoic acid derivatives
The present invention relate to phosphinic alkanoic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the...
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6054444 |
Phosphonic acid derivatives
The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such...
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6051206 |
Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled...
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6040137 |
Antigen/antibody specification exchanger
An antigen/antibody specificity exchanger is disclosed. The exchanger comprises an amino-acid sequence of an antibody which specifically binds to a certain antigen linked to an amino-acid sequence...
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6028216 |
Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives
The present invention relates to asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives.
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6027711 |
Structurally determined metallo-constructs and applications
A metallo-construct, which may be a peptide, is provided for use as a biological, therapeutic, diagnostic imaging, or radiotherapeutic agent, and for use in library or combinatorial chemistry...
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6017903 |
Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical...
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6017512 |
Radiolabeled peptides
This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled...
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6017509 |
Radiolabeled somatostatin receptor-binding peptides
This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled...
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6011021 |
Methods of cancer treatment using naaladase inhibitors
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to...
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6004946 |
Treatment of global and focal ischemia using naaladase inhibitors
The present invention includes compositions and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions...
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5985855 |
Treatment of global and focal ischemia using NAALADase inhibitors
The present invention includes compositions and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions...
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