Matches 1 - 29 out of 29
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7356446 Method and apparatus for analyzing multi-channel chromatogram  
A method for analyzing a multi-channel chromatogram is realized for accurately resolving overlapping peaks on a multi-channel chromatogram to permit analysis of the composition of a sample. First,...
7222059 Electrophoretic trace simulator  
A simulated electrophoretic trace is prepared by first obtaining an input file containing an input base sequence comprising a string of letters (A, C, G and/or T) in an order corresponding to the...
7110886 Method and apparatus for analyzing multi-channel chromatogram  
A method for analyzing a multi-channel chromatogram is realized for accurately resolving overlapping peaks on a multi-channel chromatogram to permit analysis of the composition of a sample. First,...
6934638 Method and apparatus for analyzing multi-channel chromatogram  
A method for analyzing a multichannel chromatogram is realized for accurately resolving overlapping peaks on a multichannel chromatogram to permit analysis of the composition of a sample.
6554987 Method and apparatus for alignment of signals for use in DNA base-calling  
Data traces from four channels of an automated electrophoresis detection apparatus are aligned by identifying peaks in each of the four data traces; optionally normalizing the data traces to...
6427126 Automatic sequencer/genotyper having extended spectral response  
An advanced imaging spectrograph system and method are provided for very high throughput identification, sequencing and/or genotyping of DNA and other molecules. The system is based on the...
6393368 Method and apparatus for analyzing multi-channel chromatogram  
A method for analyzing a multichannel chromatogram is realized for accurately resolving overlapping peaks on a multichannel chromatogram to permit analysis of the composition of a sample. First,...
6334099 Methods for normalization of experimental data  
Methods for normalization of experimental data with experiment-to-experiment variability. The experimental data may include biotechnology data or other data where experiment-to-experiment...
6303303 Method and system for DNA sequence determination and mutation detection  
Normalization of experimental fragment patterns for nucleic acid polymers having putatively known sequences starts with obtaining at least one raw fragment pattern for the experimental sample. The...
6270963 Method for testing for mutations in DNA from a patient sample  
A hierarchy of at least two assay techniques is utilized in testing for disease-associated mutations. The first assay in the hierarchy is selected to provide a highly specific test for the...
6208941 Method and apparatus for analysis of chromatographic migration patterns  
The present invention includes a method and apparatus for the detection and analysis of information-containing signals in chromatographic data using iterative blind deconvolution and fuzzy logic...
6054036 Electrophoresis gels and gel holders having fiber spacers and method of making same  
Gel holders for electrophoresis gels are made using clad fibers, particularly glass fibers as spacers between substrates. A plurality of fibers with a high-melting interior core and a low-melting...
6014213 High dynamic range apparatus for separation and detection of polynucleotide fragments  
A high dynamic range apparatus for separation and detection of polynucleotide fragments has a housing adapted to receive an electrophoresis gel holder containing an electrophoresis gel loaded with...
6007689 Apparatus for preparing gels for use in electrophoretic separations and similar applications  
An apparatus for the rapid preparation of electrophoresis gels comprises: (a) a housing; (b) a support fixture removably disposed within the housing and adapted to receive a gel holder having an...
6005663 Automated electrophoresis and fluorescence detection apparatus and method  
Improved detection methods and apparatus which may be used individually or in combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short...
5981186 Method and apparatus for DNA-sequencing using reduced number of sequencing mixtures  
The sequence of a target nucleic acid polymer can be determined by (a) performing a first chain-extension sequencing reaction on the target nucleic acid polymer in a reaction mixture containing...
5916747 Method and apparatus for alignment of signals for use in DNA based-calling  
Data traces from four channels of an automated electrophoresis detection apparatus are aligned by identifying peaks in each of the four data traces; normalizing the heights of the peaks in each of...
5885431 Microgels for use in medical diagnosis and methods of making and using same  
An electrophoresis microgel is formed in a gel holder. The gel holder comprises a top substrate, a bottom substrate and a spacer disposed between the top substrate and the bottom substrate. The...
5853979 Method and system for DNA sequence determination and mutation detection with reference to a standard  
Normalization of experimental fragment patterns for nucleic acid polymers having putatively known sequences starts with obtaining at least one raw fragment pattern for the experimental sample. The...
5834189 Method for evaluation of polymorphic genetic sequences, and the use thereof in identification of HLA types  
The allelic type of a polymorphic genetic locus in a sample is identified by first combining the sample with a sequencing reaction mixture containing a polymerase, nucleotide feedstocks, one type...
5710628 Automated electrophoresis and fluorescence detection apparatus and method  
Improved detection methods and apparatus which may be used individually or in various combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in...
5627022 Microgels for use in medical diagnosis and holders useful in fabricating same  
An electrophoresis microgel is formed in a gel holder. The gel holder comprises a top substrate, a bottom substrate and a spacer disposed between the top substrate and the bottom substrate. The...
5618398 Electrophoresis gels and gel holders having fiber spacers and method of making same  
Gel holders for electrophoresis gels are made using clad fibers, particularly glass fibers as spacers between substrates. A plurality of fibers with an high-melting interior core and a low-melting...
5599434 Electrophoresis gels and gel holders having adhesive affixed fiber spacers and method of making same  
Gel holders for electrophoresis gels are made using fibers, particularly glass fibers, which are affixed to the substrates forming the gel holder using an adhesive. These gel holders can be made by...
5552283 Method, reagents and kit for diagnosis and targeted screening for P53 mutations  
Rapid and cost effective diagnosis of p53 mutations of a sample of patients is achieved by employing a selected plurality of diagnostic tools, in a hierarchy of increasing accuracy and cost per...
5545527 Method for testing for mutations in DNA from a patient sample  
A hierarchy of at least two assay techniques is utilized in testing for disease-associated mutations. The first assay in the hierarchy is selected to provide a highly specific test for the...
5507934 Apparatus for preparing gels for use in electrophoretic separations and similar applications  
An apparatus for the rapid filling and polymerization of electrophoresis gels comprises: (a) a housing; (b) a filling fixture removably disposed within the housing and adapted to receive a...
5442574 Method and apparatus for determining a base line of a measurement  
A method and apparatus for determining a base line of a measurement curve wherein after preparing a template having an arc upward convex, a CPU of the data processing system moves, without...
5365455 Method and apparatus for automatic nucleic acid sequence determination  
A method and system for automated nucleic acid sequence determination of a polynucleotide, wherein a nucleic acid sequencing ladder comprises signals corresponding to oligonucleotides formed from...
Matches 1 - 29 out of 29