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7397546 Systems and methods for reducing detected intensity non-uniformity in a laser beam  
A method of increasing the spatial uniformity of the detected intensity of a beam of light from a laser in a system including the laser and a light detector. In one embodiment the method includes...
7387891 Optical instrument including excitation source  
An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed...
7384806 Method for characterizing defects on semiconductor wafers  
A method is described for characterizing defects on a test surface of a semiconductor wafer using a confocal-microscope-based automatic defect characterization (ADC) system. The surface to be...
7378280 Apparatus and methods for conducting assays and high throughput screening  
The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and...
7378236 Method for analyzing gene expression patterns  
A method and device for detecting or monitoring the treatment status of a selected physiological state or disease condition. The device has a subarray of genes which show a statistically...
7364895 Bioarray chip reaction apparatus and its manufacture  
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO...
7361906 Biopolymer array substrate thickness dependent automated focus-distance determination method for biopolymer array scanners  
A method and system for determining a biopolymer array substrate thickness dependent optimal focus distance for scanning a molecular array by a molecular array scanner are provided. A reference...
7336812 System for microvolume laser scanning cytometry  
The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of...
7331511 Biopolymeric array scanners capable of automatic scale factor selection for a plurality of different dyes, and methods for making and using the same  
Biopolymeric array scanners that are capable of automatically selecting a dye specific scale factor to employ for a plurality of different dyes, as wells as methods for making and using the same,...
7323298 Microarray for determining the relative abundances of polynuceotide sequences  
A method of determining the relative amounts of individual polynucleotides in a complex mixture of different-sequence polynucleotides is disclosed. The polynucleotides, after fluorescent labeling,...
7312919 Wide field of view and high speed scanning microscopy  
A wide field of view scanning microscope includes a light source, a light detector, optics, a scanning assembly, a translation system, and a data collection control and processing unit. The...
7310547 Fluorescent fiberoptic probe for tissue health discrimination  
A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the...
7309867 Methods and apparatus for characterization of tissue samples  
The invention provides methods for determining the probability that a given region of a tissue sample contains tissue of a given category, such as CIN 1 (cervical intraepithelial neoplasia, grade...
7297518 Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension  
The invention provides methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension. Some applications of the invention utilize total internal reflection fluorescence...
7282723 Methods and apparatus for processing spectral data for use in tissue characterization  
The invention provides methods for processing tissue-derived spectral data for use in a tissue classification algorithm. Methods of the invention comprise application of spectral and/or image masks...
7280207 Time-delay integration in a flow cytometry system  
An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for...
7265833 Electrophoretic system with multi-notch filter and laser excitation source  
Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for...
7260248 Image processing using measures of similarity  
The invention provides methods of relating a plurality of images based on measures of similarity. The methods of the invention are useful in the segmentation of a sequence of colposcopic images of...
7259845 Disposable optical cuvette cartridge with low fluorescence material  
A disposable cuvette cartridge for optical measurements is formed from three flexible thin layers. The middle layer is an adhesive sheet with cut out regions, typically between 30 and 50, serving...
7253404 Median filter for liquid chromatography-mass spectrometry data  
High-intensity, spiked noise is reduced in chromatography-mass spectrometry data by applying a nonlinear filter such as a moving median filter to the data. The filter is applied to individual mass...
EP1813683A1 Method for polymerase chain reaction in a microfluidic device  
A method of performing polymerase chain reaction in a microfluidic device is provided. The microfluidic device has a central axis of rotation, a central reservoir, one or more radially-arranged...
7248360 Polychronic laser scanning system and method of use  
A system for laser scanning provides spectral flexibility needed for the spectroscopic monitoring of highly multiplexed samples, such as cellular and particle assays in whole blood or other...
7241419 Circuits for the control of output current in an electronic device for performing active biological operations  
A circuit for control of an output current in a multiple unit cell array includes an array of unit cells arranged in rows and columns. Each unit cell includes a column select transistor being...
7227633 Optical substrate for enhanced detectability of fluorescence  
A sample substrate adapted for use with fluorescence excitation light with a first wavelength. A reflector is disposed on a base. The reflector includes a reflecting multilayer interference coating...
7223568 Methods for determining nucleotide sequences of single nucleic acid molecules  
The present invention relates to a method for determining a nucleotide sequence of a nucleic acid by detecting a single dye molecule.
7220549 Stabilizing a nucleic acid for nucleic acid sequencing  
The invention provides methods for sequencing a nucleic acid comprising stabilizing a primer/target nucleic acid duplex on a substrate. Methods of the invention generally contemplate the use of a...
7197401 Peak selection in multidimensional data  
An automatic peak selection method for multidimensional data that selects peaks from very noisy data such as two-dimensional liquid chromatography-mass spectrometry (LC-MS) data is described. Such...
EP0880690B1 FLUORESCENCE IMAGING SYSTEM COMPATIBLE WITH MACRO AND MICRO SCANNING OBJECTIVES  
Abstract not available for EP0880690 Abstract of corresponding document: WO9728439 Provided is a coaxial illumination and collection laser scanning system designed to provide substantially uniform...
7187810 Methods and systems for correcting image misalignment  
The invention provides methods of determining a correction for a misalignment between at least two images in a sequence of images due at least in part to sample movement. The methods are applied,...
7169560 Short cycle methods for sequencing polynucleotides  
The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.
7154605 Method for characterizing defects on semiconductor wafers  
A method is described for characterizing defects on a test surface of a semiconductor wafer using a confocal-microscope-based automatic defect characterization (ADC) system. The surface to be...
EP0628164B1 CAPILLARY ARRAY CONFOCAL FLUORESCENCE SCANNER AND METHOD  
Abstract not available for EP0628164 Abstract of corresponding document: WO9317325 A laser-excited capillary array scanner including a plurality of capillaries (21) having a parallel,...
7136518 Methods and apparatus for displaying diagnostic data  
The invention provides methods for displaying diagnostic results obtained from a tissue sample. In general, the invention assigns tissue-class probability values to discrete regions of a patient...
7127282 Optical methods and systems for rapid screening of the cervix  
A method and a system is provided for discriminating between healthy cervical tissue and pathologic cervical tissue based on the fluorescence response of the tissue to laser excitation (LIF) and...
7118910 Microfluidic device and methods of using same  
A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high...
7103401 Colonic polyp discrimination by tissue fluorescence and fiberoptic probe  
A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the...
7090758 Capillary array electrophoresis scanner  
An improved rotary confocal fluorescence scanner capable of detecting analytes separated on over a 1,000 capillaries simultaneously. This system uses a confocal microscope objective and mirror...
7089123 Array scanner control system  
An optical scanning system adapted to physically adjust scanner settings in response to control feature readings is disclosed. The scanner and methodology finds particular use in reading of...
7087732 Nucleotides and analogs having photoremovable protecting groups  
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
7075100 Confocal scanner system and method  
A radiation image that has been stored in an image plate ( 19 ), such as a photostimulable phosphor screen is read by stimulating an information-bearing target area ( 13 ) with stimulating light (...
7067783 Method for improved focus control in molecular array scanning by using a symmetrical filter to determine in-focus-distance  
Automated methods and systems for determining an in-focus-distance for a position on the surface of a molecular array substrate using a molecular array scanner are provided. A signal from a first...
7050208 Scanning microscopy, fluorescence detection, and laser beam positioning  
High speed, wide area microscopic scanning or laser positioning is accomplished with an inertia-less deflector (for example an acousto-optic or electro-optic deflector) combined with a high speed...
7013220 Biopolymer array scanner with real-time saturation detection  
Optical scanner system approaches are described in which signal saturation data is produced in real-time. The data generated may be used for tuning a subsequent scan, in protection of optical...
7008789 Instrument for monitoring polymerase chain reaction of DNA  
An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of...
6995901 Optical analysis systems  
A system for the optical analysis of a sample. An illumination source illuminates the sample, exciting fluorescence. The fluorescence is collected by an objective lens, which transmits the...
6992761 Broad range light detection system  
Broad-range light-detection systems, including components and methods of use thereof. These systems may include apparatus and methods for detecting light with increased speed and/or detection...
6991765 Apparatus and methods for infrared calorimetric measurements  
Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical...
6984828 Quantified fluorescence microscopy  
The present invention relates to calibration apparatuses, methods or tools used in microscopy. A calibration tool for fluorescent microscopy includes a support, a solid surface layer including a...
6982431 Sample analysis systems  
Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation...
EP1610117A2 Light scanning device  
The light scanning device has a light emission device (10) for providing stimulation light (11) directed onto the surface of the sample (22) via a focussing lens (34,44), with an optical lens...
Matches 1 - 50 out of 240 1 2 3 4 5 >