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7425218 |
Nitric oxide-releasing medical devices
An implant or intravascular stent comprising a polymeric composition capable of releasing nitric oxide under physiological conditions. The polymeric composition comprises a polymer and at least one...
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7226586 |
Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene...
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7204940 |
Conductive polymer-based material
Disclosed are polymer-based coatings and materials comprising (i) a polymeric composition including a polymer having side chains along a backbone forming the polymer, at least two of the side...
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7081524 |
O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
The present invention provides O 2 -substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates) of the formula
in which R and R...
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6951902 |
Two dimensional polymer that generates nitric oxide
A polymeric composition that generates nitric oxide and a process for rendering the surface of a substrate nonthrombogenic by applying a coating of the polymeric composition to the substrate are...
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6936639 |
Nitroxyl progenitors in the treatment of heart failure
Administration of an HNO/NO − donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart...
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6911433 |
O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates
Provided are O 2 -glycosylated 1-substituted diazen-1-ium-1,2-diolates (O 2 -glycosylated diazeniumdiolates) having the formula:
in which R is a saccharide, which is attached to the O 2 of...
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6887485 |
Nitric oxide-releasing metallic medical devices
Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian...
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EP0929538B1 |
O?2 -ARYLATED OR O?2 -GLYCOSYLATED 1-SUBSTITUTED DIAZEN-1-IUM-1,2-DIOLATES AND O?2 -SUBSTITUTED 1- (2-CARBOXYLATO)PYRROLIDIN-1-YL]DIAZEN-1-IUM-1,2-DIOLATES
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6703046 |
Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene...
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6610660 |
O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-&lsqb (2-carboxylato) pyrrolidin-1-yl&rsqb diazen-1-ium-1,2-diolates
Diazeniumdiolates, wherein the N 1 position is substituted by an inorganic or organic moiety and the O 2 -oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also...
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6451337 |
Chitosan-based nitric oxide donor compositions
A chitosan-based polymeric nitric oxide donor composition comprising a modified chitosan polymer and a nitric oxide [N 2 O 2 ] dimer, wherein the nitric oxide [N 2 O 2 ] dimer is bonded directly to...
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EP0752866B1 |
MEDICAMENTS FOR TREATING RESTENOSIS, COMPRISING NITRIC OXIDE RELEASING POLYMERS
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6379660 |
Nitric oxide-releasing 1-&lsqb (2-carboxylato)pyrrolidin-1-yl&rsqb diazen-1-ium-1,2-diolates and composition comprising same
A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to...
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6290981 |
Use of nitric oxide-releasing agents to treat impotency
A method of treatment for impotency is provided. The method involves the administration of nitric oxide by a nitric oxide-releasing agent capable of providing a penile erection-inducing amount of...
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6270779 |
Nitric oxide-releasing metallic medical devices
Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian...
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6261594 |
Chitosan-based nitric oxide donor compositions
A chitosan-based polymeric nitric oxide donor composition comprising a modified chitosan polymer and a nitric oxide [N2O2] dimer, wherein the nitric oxide [N2O2] dimer is bonded directly to the...
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6255277 |
Localized use of nitric oxide-adducts to prevent internal tissue damage
A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or...
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6200558 |
Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to...
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6147068 |
Lipophilic polyamine esters for the site specific delivery of nitric oxide in pharmaceutical use
A pharmaceutical composition of matter for delivering nitric oxide. The composition is an amine that was reacted with nitric oxide. The composition of matter is lipophilic and insoluble and...
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6110453 |
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical compositions including...
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6103275 |
Systems and methods for topical treatment with nitric oxide
A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate...
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5962520 |
Hydrolytically unstable, biocompatible polymer
A hydrolytically unstable, biocompatible polymer capable of carrying and releasing a pharmaceutical compound when introduced into physiological media. In a preferred embodiment, the polymer...
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5958427 |
Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
The invention is directed to nitric oxide (NO) donor compounds and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a...
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5910316 |
Use of nitric oxide-releasing agents to treat impotency
A method of treatment for impotency is provided. The method involves the administration of nitric oxide by a nitric oxide-releasing agent capable of providing a penile erection-inducing amount of...
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5840759 |
Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5837736 |
Nitric oxide-releasing compounds to sensitive cancerous cells to chemotherapeutic agents
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5814666 |
Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
This invention relates to compositions capable of releasing nitric oxide and therapeutic methods of use thereof for the treatment of microorganism-related disease states. The composition comprises...
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5731305 |
Anti-hypertension compositions of secondary amine-nitric oxide adducts and use thereof
There are disclosed anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component in the anti-hypertensive compositions is a compound of the formula...
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5721365 |
N-substituted piperazine NONOates
There are disclosed N-substituted piperazine NONOate compounds having the structure: ##STR1## wherein M is a pharmaceutically acceptable cation, x is the valence of the cation, and R is selected...
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5718892 |
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical compositions including...
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5714511 |
Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically...
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5698738 |
N-nitroso-N-substituted hydroxylamines as nitric oxide donors
Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an ortho-substituted aryl, a...
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5698535 |
SIN-1A cyclodextrin inclusion complexes
New inclusion complexes which are stable in their so-lid state formed of SIN-1A and cyclodextrins or cyclodextrin derivatives and optionally also containing ions as catalyst or stabilizer. The...
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5691423 |
Polysaccharide-bound nitric oxide-nucleophile adducts
A polymeric composition capable of releasing nitric oxide comprises a polysaccharide including a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical...
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EP0605622B1 |
OXYGEN SUBSTITUTED DERIVATIVES OF NUCLEOPHILE-NITRIC OXIDE ADDUCTS AS NITRIC OXIDE DONOR PRODRUGS
Abstract not available for EP0605622 Abstract of corresponding document: WO9307114 There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical...
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5676963 |
Implants, prostheses, and stents comprising polymer-bound nitric oxide/nucleophile adducts capable of releasing nitric oxide
Implants, prostheses, and stents comprising a polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the...
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5650447 |
Nitric oxide-releasing polymers to treat restenosis and related disorders
Methods of amelioration, treatment and prevention for restenosis and related disorders are provided. Methods involve the administration of nitric oxide by a nitric oxide delivery means comprising a...
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5650442 |
Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5525357 |
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical compositions including...
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5519020 |
Polymeric wound healing accelerators
The invention describes water insoluble polymeric NONOate complexes which are capable of accelerating wound repair through the controlled therapeutic release of NO. The composition is additionally...
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5482925 |
Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents
Novel complexes of nitric oxide (NO) and amines are described where the amine is a known cardiovascular agent having at least one or more primary or secondary amino groups and whereby the resulting...
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5405919 |
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical compositions including...
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5389675 |
Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents
Mixed ligand metal complexes of nitric oxide-nucleophile adducts, useful as cardiovascular agents of the formula KA, wherein A is [(M) x x ' (L) y (R 1 R 2 N-N 2 O 2 ) x ], and K is a...
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5385940 |
Treatment of stroke with nitric-oxide releasing compounds
A method for treatment of stroke in a patient, involving administering to the patient a nitric oxide-releasing compound. A preferred compound of the invention is L-arginine.
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5366997 |
Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular...
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5208233 |
Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
There are disclosed anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component in the anti-hypertensive compositions is a compound of the formula...
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5185376 |
Therapeutic inhibition of platelet aggregation by nucleophile-nitric oxide complexes and derivatives thereof
A method of inhibiting platelet aggregation in vivo with physiologically compatible compounds containing at least one N-oxo-N-nitrosoamine moiety in a molecule thereof, wherein the physiologically...
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