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7408062 Rigidized trimethine cyanine dyes  
Disclosed are analogues of trimethine cyanine dyes, which are useful for importing fluorescent properties to target materials by covalent and non-covalent association.
7381572 Reagents and procedures for multi-label high-specificity labeling  
A detectable complex and methods for use thereof are provided herein. The detectable complex includes: at least one target material; a first peptide tag bound to the at least one target material;...
7282373 Ultra-high specificity fluorescent labeling  
A self-assembled relay probe for detecting a target material is provided including: a first peptide tag bound to the target material; and a first fluorescent conjugate including a first...
7282339 Competitive immunoassay  
The present invention provides ligand-detection reagents, ligand analogs and methods for determining the presence of a ligand in a sample. The ligand-detection reagent comprises a ligand-binding...
EP1816475A1 Use of cyanine dyes for the diagnosis of disease associated with angiogenesis  
This invention relates to the use of conjugates of cyanine dyes with an angiogenesis specific binding component preferably with an EB-D fibronectin specific binding component for the diagnosis of...
EP1801165A2 Modified carbocyanine dyes and their conjugates  
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described....
EP1019721B1 CHROMOPHORES IN THE PREPARATION OF NOVEL TANDEM CONJUGATES  
Abstract not available for EP1019721 Abstract of corresponding document: US6133429 The inventors herein disclose new heterobifunctional chromophores that are capable of coupling with two distinct...
EP1792897A2 Intercalators having affinity for DNA and methods of use  
Intercalator compounds are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds...
EP1770129A2 Modified carbocyanine dyes and their conjugates  
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described....
7141655 Reagents and procedures for high-specificity labeling  
A molecule with two pendant phenylarsine moieties according to the general structural Formula (I) and tautomers, acids, and salts thereof: wherein: (i) R 1 or R 2 , are each independently O...
6977305 Modified carbocyanine dyes and their conjugates  
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described....
6974873 Modified carbocyanine dyes and their conjugates  
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described....
6877359 Liquid leak detection  
Liquid leaks from a vessel cause shorts between at least one elongate sensing wire and another conductor when the fluid absorbs into the porous sheath of the sensing wire. The other conductor may...
6747159 Symmetric, monofunctionalised polymethine dyes labelling reagents  
A symmetric cyanine of the formula: wherein: X is selected from the group consisting of O, S and C(CH 3 ) 2 ; W represents non-metal atoms required to form a benzo-condensed or a...
6716994 Mobility-Modifying Cyanine Dyes  
The present invention provides a novel class of fluorescent cyanine dye compounds that are modified at one of the hetercyclic ring nitrogen atoms with a mobility-modifying moiety that permits the...
6593148 Cyanine dye compounds and labeling methods  
A novel cyanine dye having the formula is useful for labeling biological and nonbiological molecules.
6540977 Cyanidin compositions and therapeutic and diagnostic uses therefor  
Compositions comprising cyaniding reagents for binding to FcγRI receptors, and methods and kits for use therefor are provided.
6437141 Cyanine dyes and synthesis methods thereof  
A cyanine dye having the formula wherein R 1 -R 8 are each independently selected from a group consisting of hydrogen, C 1 -C 6 alkyl group, and C 0 -C 4 alkyl group having a hydrophilic...
6372445 Chromophores in the preparation of novel tandem conjugates  
The inventors herein disclose new heterobifunctional chromophores that are capable of coupling with two distinct moieties. One moiety may be either a signal-enhancing agent or a blocking agent. The...
6342326 Synthesis and use of acyl fluorides of cyanine dyes  
This invention provides dyes, particularly cyanine and related dyes, with acyl fluoride activating groups, the dyes having the general formula wherein: each dotted line represents carbon atoms...
6335450 Efficient cyclic-bridged cyanine dyes  
This invention provides cyclic-bridged dyes, particularly cyclic-bridged cyanine dyes, of the general formula: In this formula, each dotted line represents carbon atoms necessary to form a fused...
6331632 Cyanine dye phosphoramidites  
This invention provides dye phosphoramidites, particularly phosphoramidites of cyanine and related dyes, of the general formula: ##STR1## In this formula, each dotted line represents carbon atoms...
EP1112254A2 CYANINE DYES AND SYNTHESIS METHODS THEREOF  
Abstract not available for EP1112254 Abstract of corresponding document: US6114350 A cyanine dye having the formula wherein R1-R8 are each independently selected from a group consisting of...
6224644 Cyanine dyes and synthesis methods thereof  
A cyanine dye having the formula ##STR1## wherein R 1 -R 8 are each independently selected from a group consisting of hydrogen, C 1 -C 6 alkyl group, and C 0 -C 4 alkyl group having a...
6207421 DNA sequencing and DNA terminators  
A universal terminator includes a heterocycle other than naturally occuring DNA heterocycles such as adenine, cytosine, guanine and thymine. In terminating strand synthesis, the hybridized...
6197956 Cyanine dyes and synthesis methods thereof  
A cyanine dye having the formula ##STR1## wherein R 1 -R 8 are each independently selected from a group consisting of hydrogen, C 1 -C 6 alkyl group, and C 0 -C 4 alkyl group having a...
6146837 Cyanidin compositions and therapeutic and diagnostic uses therefor  
Compositions comprising cyanidin reagents for binding to FcγRI receptors, and methods and kits for use therefor are provided.
6143151 DNA sequencing  
To sequence long strands of DNA, clone strands having lengths longer than 100 bases are, in one embodiment, marked on one end with biotin. These strands are divided into 4 aliquots and each...
6133429 Chromophores useful for the preparation of novel tandem conjugates  
The inventors herein disclose new heterobifunctional chromophores that are capable of coupling with two distinct moieties. One moiety may be either a signal-enhancing agent or a blocking agent. The...
6114350 Cyanine dyes and synthesis methods thereof  
A cyanine dye having the formula ##STR1## wherein R 1 -R 8 are each independently selected from a group consisting of hydrogen, C 1 -C 6 alkyl group, and C 0 -C 4 alkyl group having a...
6110630 Efficient activated cyanine dyes  
Activating groups based on N-hydroxynaphthalimide, are disclosed herein. The activating groups can mediate the coupling of labeling moieties, such as biotin or cyanine dyes, to a variety of...
6086737 Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor  
To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or...
6015902 Intercalators having affinity for DNA and methods of use  
Intercalator compounds of formula I-T m as defined herein are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains,...
6014213 High dynamic range apparatus for separation and detection of polynucleotide fragments  
A high dynamic range apparatus for separation and detection of polynucleotide fragments has a housing adapted to receive an electrophoresis gel holder containing an electrophoresis gel loaded with...
6005663 Automated electrophoresis and fluorescence detection apparatus and method  
Improved detection methods and apparatus which may be used individually or in combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short...
6004446 DNA Sequencing  
To sequence DNA, DNA samples marked with flourscent infrared dye are applied at a plurality of locations for electrophoresing in a plurality of channels through a gel electrophoresis slab. The...
5986086 Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides  
A chemical compound of the following formula: ##STR1## wherein R 1 is selected from the group consisting of alkyl, aralkyl, and substituted alkyl groups; R 3 is selected from the group consisting...
5877310 Glycoconjugated fluorescent labeling reagents  
Water soluble glycoconjugated fluorescent labeling reagents comprised of a fluorescent dye, one or more sugar or carbohydrate residues that impart water solubility, and a reactive group that allows...
5863403 Digital DNA typing  
To sequence DNA automatically, fluorescently marked DNA are electrophoresed in a plurality of channels through a gel electrophoresis slab; wherein the DNA samples are resolved in accordance with...
5808077 Intercalators having affinity for DNA and methods of use  
Intercalator compounds are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds...
5808044 Indocarbocyanine and benzindocarbocyanine phosphoramidites  
A chemical compound of the following formula is disclosed: ##STR1## where R is selected from the group consisting of H, trityl, 4-O-monomethoxytrityl, 4,4'-O-dimethoxytrityl, and acyl groups, and...
5800995 Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor  
To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or...
5783673 Method of preferential labelling of a phycobiliprotein with an aminereactive dye for use in a multiple color assay and product for such use  
A method for preparing phycobiliprotein/amine-reactive dye conjugates is disclosed in which the conjugates so prepared overcome the energy transfer/fluorescent quenching dilemma encountered in the...
5767287 Compounds and method for synthesizing sulfoindocyanine dyes  
Novel intermediates having an indolenine nucleus which are useful in the synthesis of fluorescent sulfoindocyanine dyes are described. Dyes synthesized using such intermediates do not contain a...
5755943 DNA sequencing  
To sequence DNA, DNA samples marked with flourscent infrared dye are applied at a plurality of locations for electrophoresing in a plurality of channels through a gel electrophoresis slab. The...
5710628 Automated electrophoresis and fluorescence detection apparatus and method  
Improved detection methods and apparatus which may be used individually or in various combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in...
5688966 Compounds and method for synthesizing sulfoindocyanine dyes  
Novel intermediates having an indolenine nucleus which are useful in the synthesis of fluorescent sulfoindocyanine dyes are described. Dyes synthesized using such intermediates do not contain a...
5639874 Method for preparing fluorescent-labeled DNA  
To sequence DNA automatically, DNA marked with near infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab wherein the DNA samples are resolved...
5599932 Intercalators having affinity for DNA and methods of use  
Intercalator compounds are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds...
5556959 Indocarbocyanine-linked phosphoramidites  
A chemical compound of the following formula is disclosed ##STR1## where R is one of H, trityl, 4-0-monomethoxytrityl, 4,4'-O-dimethoxytrityl, or acyl groups and R may be used as a protecting group...
Matches 1 - 50 out of 51 1 2 >