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7186559 |
Apparatus and method for electroporation of biological samples
The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a...
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7141425 |
Apparatus and method for electroporation of biological samples
The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a...
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7029916 |
Apparatus and method for flow electroporation of biological samples
The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a...
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6773669 |
Flow electroporation chamber and method
The present invention relates to a method and apparatus for the encapsulation of substances and drugs into cells and platelets. The present invention is also related to the incorporation of...
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EP0690671B1 |
METHOD AND APPARATUS FOR ENCAPSULATION OF BIOLOGICALLY-ACTIVE SUBSTANCES IN CELLS
Abstract not available for EP0690671 Abstract of corresponding document: WO9421117 The present invention relates to a method and apparatus for the encapsulation of biologically-active substances...
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6278004 |
Stabilized phospholipidic composition
A method for the stabilization of a phospholipidic composition as well as a method for the production of a stabilized phospholipidic composition comprising at least one phospholipide as well as a...
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6242417 |
Stabilized compositions containing hemoglobin
The present invention relates to a hemoglobin compositions stabilized against the formation of aggregates. The present invention further relates to methods of making such hemoglobin compositions.
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6172039 |
Expression of recombinant hemoglobin and hemoglobin variants in yeast
The invention is directed to a substantially pure mammalian globin chain or heme-binding fragment thereof. The invention is further directed to recombinant DNA vectors capable of expressing at...
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6074605 |
Flow electroporation chamber and method
The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cell, characterized by an optionally automated, continuous-flow,...
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6020308 |
Methods for improving therapeutic effectiveness of treatment of vascularization disorders
The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as as an adjunct to treatment of inappropriate tissue...
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5840851 |
Purification of hemoglobin
The present invention generally relates to methods for purifying hemoglobin solutions and to hemoglobin solutions obtained by the methods. In one aspect, such methods include removing contaminants...
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5788958 |
Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as an antitumor therapy to reduce tumor blood flow and...
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5759517 |
Hemoglobins as drug delivery agents
A tracer, such as a radioisotope, is conjugated to a hemoglobin-like protein, such as normal hemoglobin, for use as an in vitro diagnostic imaging agent.
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5720921 |
Flow electroporation chamber and method
The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow,...
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5688526 |
Hemoglobin-encapsulating liposome and method for making the same
A hemoglobin-encapsulating liposome having encapsulated thererin a hemoglobin solution having added thereto a substrate for an enzymatic reaction which produces reduced-form nicotinamide adenine...
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5679777 |
Hemoglobins as drug delivery agents
The invention relates to methods and compositions for delivering drugs to the body by binding them to hemoglobin. This technique stabilizes the drug and extends its half-life in the body. The drug...
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5674528 |
Hemoglobin-encapsulated liposome
A hemoglobin-encapsulated liposome is provided. The hemoglobin-encapsulated liposome comprises a liposome and an enzymatically active hemoglobin solution encapsulated therein. The hemoglobin...
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5665869 |
Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
The present invention relates to a method for the production of a substantially protoporphyrin IX free hemoglobin solution comprising: rapidly heating a crude protoporphyrin IX-containing...
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5661124 |
Blood substitutes
The present invention provides blood substitutes comprised of recombinantly produced mutant hemoglobin having an osmolarity greater than 303 milliosmoles per liter and less than 800 milliosmoles...
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5631219 |
Method of stimulating hematopoiesis with hemoglobin
The present invention relates to a method for stimulating hematopoiesis in a mammal comprising administration of a therapeutically effective amount of a hemoglobin, including recombinant...
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5612310 |
Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
The present invention is directed to administration of a nitric oxide scavenger or a nitric oxide synthase inhibitor to enhance the effectiveness of tumor therapy with hypoxic or acidic...
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5612207 |
Method and apparatus for encapsulation of biologically-active substances in cells
The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in a red blood cell, characterized by an optionally automated, continuous-flow,...
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5578564 |
Nickel-free hemoglobin and methods for producing such hemoglobin
According to the present invention removal of nickel from a nickel-containing hemoglobin solution is accomplished by exposing the nickel-containing hemoglobin solution to a chelating agent,...
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5563254 |
Polynucleotides encoding genetically engineered mutant hemoglobins
The present invention provides for polynucleotides capable of producing recombinant hemoglobins that have a P 50 of 26-36 torr. This invention makes possible the commercial production of wholly...
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5554638 |
Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as an antitumor therapy to reduce tumor blood flow and...
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4853370 |
Substitute for human blood and a method of making the same
The method of this invention yields a two phase liquid aqueous system which replicates the two phase heterogeneous physico-chemical system of naturally securing whole human blood. The method...
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4752586 |
Apparatus for encapsulating biological active substances into erythrocytes
This invention relates to a process for the encapsulation in human or animal erythrocytes of at least one substance having a biological activity, characterized in that the primary compartment of at...
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4738952 |
Substitute for human blood and a method of making the same
The method of this invention yields a two phase liquid aqueous system which replicates the two phase heterogeneous physiochemical system of naturally occurring whole human blood. The method...
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EP0152453A1 |
METHOD AND APPARATUS FOR ALTERING RED BLOOD CELL FUNCTION AND SURVIVAL.
Abstract not available for EP0152453 Abstract of corresponding document: US4478824 Method and apparatus for creating reversible intracellular hypertonicity in red blood cells of mammals in order...
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