Matches 1 - 50 out of 188 1 2 3 4 >
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7427685 Therapeutic substituted cyclopentanes  
Therapeutic compounds according to one of the structures below are disclosed herein.
7425534 Compositions and methods for modulating muscle cell and tissue contractility  
The present invention relates to compositions and methods comprising one or more domains of urokinase-type plasminogen activator (uPA) in an amount effective to modulate one or more of the...
7423177 Carboxamide derivatives as therapeutic agents  
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of...
7420055 Aryl sulfonamides  
Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9....
7413866 Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors  
The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of a chemokine receptor but not a second topology of the receptor. Such agents...
EP1950206A1 Benzoxazocines and their use as monoamine-reuptake inhibitors  
A compound of the general formula (1): wherein one of W, X, Y and Z is N or CR 4 and the others are each CH; and R 4 is a specified substituent. These compounds inhibit monoamine reuptake, and...
7378438 Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders  
The present invention relates to multifunctional β-agonist compounds comprising a reactive oxygen species scavenger group and a nitric oxide donor, and their use for the treatment of respiratory...
7378111 Regulation of GSK-3α activity for the treatment or prevention of Alzheimer's disease  
Provided is a novel use of therapeutic concentrations of an inhibitor of glycogen synthase kinase-3 (GSK-3), including lithium or any other GSK-3 inhibitor, to block, reduce or inhibit processing...
7374891 Methods to identify compounds that modulate rage  
Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE...
EP1920782A1 Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof  
The present invention relates to the field of prevention and treatment of disorders associated with the occurrence of certain carbohydrate epitopes. More particularly, the present invention relates...
EP1920781A1 Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors  
The present invention relates to the field of prevention and treatment of gastrointestinal disorders. More particularly, the present invention relates to the prevention and treatment of...
7371846 CD4-independent HIV envelope proteins as vaccines and therapeutics  
The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
7361678 Azole derivatives and fused bicyclic azole derivatives as therapeutic agents  
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of...
7358229 Deuterated cyclosporin analogs and their use as immunomodulating agents  
Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The...
7335653 Bis-aryl sulfonamides  
Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the...
7332472 Cyclosporine analogue mixtures and their use as immunomodulating agents  
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the...
7329684 Benzimidazole derivatives as therapeutic agents  
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of...
7326698 Prostaglandin analogs  
Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. A, X, J, and E are as described herein. These compounds are useful for treating diseases.
7323477 7-((1H-imidazol-4-yl)methyl)-5,6,7,8-tetrahydroquinoline  
A compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also...
EP1878721A1 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors  
A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are...
EP1875909A2 Use of antagonists of PYY receptors for treating irritable bowel syndrome  
The present invention concerns the use of antagonists of peptide YY receptors for treating irritable bowel syndrome (IBS) in a human subject. The antagonists may be used in conjunction with...
EP1862181A2 Combination therapy using an 11B-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders  
Combination therapy comprising the administration of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent useful for treating, preventing and reducing the risk of...
7300932 Pyrrolo[1,2-b]pyridazine derivatives  
Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the...
EP1854487A2 Combinations of an 11-beta-hydroxysteroid dehaydrogenase type 1 inhibitor and a glucocorticoid receptor agonist  
Combination therapy comprising the administration of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist for treating some forms of cancer, diseases and...
7294472 Method for identifying modulators of G protein coupled receptor signaling  
This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which...
7282489 Compositions and methods for performing reverse gene therapy  
The invention relates to compositions and methods for reverse gene therapy, wherein a gene therapy vector encoding a gene product (e.g. a protein) which is usually only expressed in cells of an...
EP1816138A1 Cyclosporine analogue mixtures and their use as immunomodulating agents  
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A . The mixtures possess enhanced efficacy and reduced toxicity over the...
7253007 Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors  
Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.
7247611 Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator  
The invention includes compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator.
EP1808177A2 Methods of treatment of mitochondrial disorders  
In accordance with the present invention, there are provided methods for the treatment of mitochondrial disorders. Invention methods include the administration of a pyrimidine-based nucleoside such...
EP1808168A1 Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level  
The present invention concerns combination of an amount of a GPR1 19 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering...
7244727 Fused bicyclic nitrogen-containing heterocycles  
Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the...
7244412 Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia  
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
EP1798223A2 Aryl Sulfonamides  
Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9....
7227035 Bis-aryl sulfonamides  
Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the...
EP1787982A2 11Beta-Hydroxysteroid dehydrogenase type 1 active compounds  
A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are...
EP1785424A2 Fused 1,2,4-triazoles and pharmaceutical uses thereof  
The use of fused 1,2,4-triazoles for modulating the activity of 11 β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions has been...
EP1782859A2 Pharmaceutical use of substituted pyrazolo [1,5- a]pyrimidines  
The use of substituted pyrazolo[1,5- a ]pyrimidines for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions...
EP1782823A2 IL-21 peptides and nucleic acids  
The invention relates to an IL-21 polypeptide having the sequence of residues 30-162 of IL-21 and nucleic acid encoding such polypeptides. Also disclosed is the formulation of pharmaceutical...
7214482 Steroid-activated nuclear receptors and uses therefor  
A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR...
7208279 Method for identifying inhibitors of G protein coupled receptor signaling  
This invention relates to methods for identifying peptides and other compounds which block G protein coupled receptor mediated signaling with high affinity and specificity. Assays developed in...
7183324 2,3,4-substituted cyclopentanones as therapeutic agents  
Disclosed herein are compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein Y, A, B, J, and E are further described. Methods, compositions, and medicaments...
7183310 Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents  
A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising ...
7169807 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists  
A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, wherein the dashed line represents the presence or absence of a double bond; J is C═O or CHOH; A is —(CH 2...
EP1743891A1 Heterocyclic compounds and methods for modulating CXCR3 function  
Compounds and compositions are provided that bind the CXCR3 chemokine receptor and which are useful for treating diseases associated with CXCR3 activity, such as multiple sclerosis.
7160694 Nucleic acids encoding TANGO405 and functional fragments and uses thereof  
The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis,...
7157464 Substituted piperazines  
Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1....
7141648 Synthesis of cyclosporin analogs  
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the...
7141417 Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene  
The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The...
EP1721615A1 Pharmaceutical compositions comprising sodium or potassium arsenite for the treatment of urogenital cancer and its metastasis  
The present application relates to pharmaceutical compositions and methods for treatment of urogenital diseases and bone metastasis in a human, which pharmaceutical composition contains an...
Matches 1 - 50 out of 188 1 2 3 4 >