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7411044 |
Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating...
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EP1894573A2 |
Methods and compositions for oxygen transport comprising a high oxygen affinity
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such...
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EP1465643B1 |
METHODS AND COMPOSITIONS FOR OXYGEN TRANSPORT WITH HIGH OXYGEN AFFINITY
Abstract not available for EP1465643 Abstract of corresponding document: WO03059363 The present invention relates to blood products, and more particularly to compositions comprising a modified...
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7271145 |
Methods and compositions for oxygen transport comprising modified hemoglobin in plasma
The present invention relates to blood products, and more particularly to compositions comprising a modified hemoglobin in plasma.
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7202341 |
Stabilized hemoglobin solutions
A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture...
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7135554 |
Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric...
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7135553 |
Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating...
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7101846 |
Methods and compositions for optimization of oxygen transport by cell-free systems
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof....
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7041800 |
Preserving a hemoglobin blood substitute with a transparent overwrap
The invention relates to a method for preserving the stability of a hemoglobin blood substitute comprising maintaining the hemoglobin blood substitute in an atmosphere substantially free of oxygen....
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7041799 |
Preserving a hemoglobin blood substitute with a transparent overwrap
The invention relates to a method for preserving the stability of a hemoglobin blood substitute comprising maintaining the hemoglobin blood substitute in an atmosphere substantially free of oxygen....
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7001715 |
Purification of red blood cells by separation and diafiltration
Red blood cells are purified by separating whole blood, such as by centrifugation, to form a red blood cell fraction and a liquid fraction. The whole blood can be defibrinated or treated to prevent...
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6991624 |
Methods and compositions for use in perfusion applications
Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or...
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6986984 |
Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
Red blood cells are purified by defibrinating whole blood and then filtering the defibrinated whole blood, whereby at least a portion of a plasma component is separated from the red blood cells to...
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EP1011710B1 |
METHODS AND COMPOSITIONS FOR OPTIMIZATION OF OXYGEN TRANSPORT BY CELL-FREE SYSTEMS
Abstract not available for EP1011710 Abstract of corresponding document: US6054427 Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of...
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6844317 |
Methods for oxygen transport comprising a high oxygen affinity modified hemoglobin
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such...
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EP1465643A1 |
METHODS AND COMPOSITIONS FOR OXYGEN TRANSPORT WITH HIGH OXYGEN AFFINITY
Abstract not available for EP1465643 Abstract of corresponding document: WO03059363 The present invention relates to blood products, and more particularly to compositions comprising a modified...
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6753006 |
Paclitaxel-containing formulations
In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of a pharmaceutically active agent, wherein the agent is associated with a...
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6680305 |
Physiologically acceptable aqueous solutions and methods for their use
Physiologically acceptable aqueous solutions and methods for their use are provided. The subject solutions comprise: electrolytes; a dynamic buffering system and an oncotic agent; and do not...
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6669965 |
Method of treating atherosclerosis
A method of treating or preventing atherosclerosis in a mammalian subject comprises: (a) extracting the aliquot of blood from the subject; (b) treating the aliquot of blood ex vivo with at least...
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6627393 |
Solutions for use as plasma expanders and substitutes
An artificial plasma-like substance having at least one water soluble polysaccharide oncotic agent selected from the group consisting of high molecular weight hydroxyethyl starch, low molecular...
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6610832 |
Preserving a hemoglobin blood substitute with a transparent overwrap
The invention relates to a method for preserving the stability of a hemoglobin blood substitute comprising maintaining the hemoglobin blood substitute in an atmosphere substantially free of oxygen....
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6569467 |
Treatment of autoimmune diseases
An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the...
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EP0862440B1 |
THERAPEUTIC USE OF HEMOGLOBIN IN PROMOTING WOUND HEALING
Abstract not available for EP0862440 Abstract of corresponding document: WO9715313 A method for enhancing wound repair comprises administration of a therapeutic dose of hemoglobin in an amount...
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6518010 |
Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
Red blood cells are purified by defibrinating whole blood and then filtering the defibrinated whole blood, whereby at least a portion of a plasma component is separated from the red blood cells to...
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6506725 |
Ultra pure hemoglobin solutions and blood-substitutes
A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free hemoglobin solution and process for preparing same. The process comprises fractionating whole blood,...
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6506549 |
Plasma expanders and blood substitutes
Solutions are described which are useful as plasma expanders and blood substitutes in mammals, including primates, and methods for using the solutions.
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6458762 |
Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
Administration of low doses of hemoglobin minimizes damage to the myocardium after blockage and significantly reduces reperfusion injury. Hemoglobin exerts a pharmacological effect by increasing...
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6444418 |
Plasma-like solution
Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved...
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6432918 |
Methods and compositions for optimization of oxygen transport by cell-free systems
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof....
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6410218 |
Plasma-like solution
Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved...
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6406839 |
Methods for using a plasma-like solution
Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved...
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6387612 |
Method of preparing a terminally heat sterilized plasma-like solution
Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved...
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6350729 |
Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
The invention is directed to a method for the prophylaxis or treatment of an animal for deleterious physiological effects such as systemic hypotension caused by nitric oxide production induced by a...
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6323175 |
Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
Compositions and processes to alleviate oxygen toxicity are disclosed based on the addition of nitroxides to physio-logically compatible macromolecules. In particular, hemoglobin-based red cell...
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6300322 |
Plasma-like solution
Artificial plasma-like solutions and methods for their use are provided. The subject solutions include: electrolytes and an oncotic agent. The subject solutions find use in a variety of...
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6288027 |
Preserving a hemoglobin blood substitute with a transparent overwrap
The invention relates to a method for preserving the stability of a hemoglobin blood substitute comprising maintaining the hemoglobin blood substitute in an atmosphere substantially free of oxygen....
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6284452 |
Methods of using plasma expanders and blood substitutes
A blood substitute solution and methods for its use are provided. The subject solution contains: subphysiological amounts of potassium ion, 0-10 mM magnesium ion, 70-160 mM sodium ion, 0.5-4.0 mM...
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6271351 |
Method for preserving a hemoglobin blood substitute
The invention relates to a method for preserving the stability of a hemoglobin blood substitute comprising maintaining the hemoglobin blood substitute in an atmosphere substantially free of oxygen....
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EP0581883B1 |
BLOOD SUBSTITUTES AND ORGAN PRESERVATIVE SOLUTIONS
Abstract not available for EP0581883 Abstract of corresponding document: WO9218136 The present invention relates to the field of compositions of matter, disclosing compositions of matter which as...
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6242417 |
Stabilized compositions containing hemoglobin
The present invention relates to a hemoglobin compositions stabilized against the formation of aggregates. The present invention further relates to methods of making such hemoglobin compositions.
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6218099 |
Methods and compositions for use in perfusion applications
Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or...
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6172039 |
Expression of recombinant hemoglobin and hemoglobin variants in yeast
The invention is directed to a substantially pure mammalian globin chain or heme-binding fragment thereof. The invention is further directed to recombinant DNA vectors capable of expressing at...
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6133425 |
Acellular red blood cell substitute
An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically...
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6124114 |
Hemoglobins with intersubunit dislufide bonds
Cysteine substitution mutants of alpha and/or beta globin mutants are produced by recombinant DNA techniques and used in the construction, intracellularly or otherwise, of mutant hemoglobins in...
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6117838 |
Use of hemoglobin in the treatment of hypotension
A method of treating a mammal suffering from hypotension by administering intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.
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6103690 |
Prevention or inhibition of pathogenic syndromes caused by nitric oxide overproduction using iron-containing hemoprotein
The invention is directed to a method for the prophylaxis or treatment of an animal for deleterious physiological effects such as systemic hypotension caused by nitric oxide production induced by a...
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6080538 |
Plasma like solution and methods of use
Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved...
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6054427 |
Methods and compositions for optimization of oxygen transport by cell-free systems
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof....
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6020308 |
Methods for improving therapeutic effectiveness of treatment of vascularization disorders
The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as as an adjunct to treatment of inappropriate tissue...
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5968726 |
Plasma-like solution
Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved...
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