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6559152 |
6-substituted pyrazolo&lsqb 3,4-d&rsqb pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II): that are potent inhibitors of...
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6174884 |
1,5-dihydro-pyrazolo[34-D]-pyrimidinone derivatives
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EP0972905A2 |
Glazing panel with a fastening device for a strain-free mounting of the glazing panel
A method for mounting glass facade panels (70) at a spacing from a support wall (14) has struts incorporating ball and socket joints, with one of the joints (15) near to the plane of the glass to...
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5958929 |
6-aryl pyrazolo 3,4-d! pyrimidin-4-ones and compositions and methods of use thereof
6-Aryl pyrazolo 3,4-d!pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or...
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5736548 |
6-aryl pyrazolo 3,4-D! pyrimidin-4-ones and compositions and method of use thereof
6-Aryl pyrazolo 3,4-d!pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or...
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5656629 |
6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof
6-Substituted pyrazolo[3,4 -d]pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure...
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5470974 |
Uncharged polynucleotide-binding polymers
A composition of polymer molecules effective to bind, with substantially uniform binding affinity, to a single-stranded polynucleotide containing a target sequence of bases. The polymer molecules...
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5391739 |
Selective adenosine receptor agents
Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological...
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5294612 |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclylcarboxaldehyde or by...
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5256650 |
Selective adenosine receptor agents
Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological...
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5142047 |
Uncharged polynucleotide-binding polymers
A composition of polymer molecules effective to bind, with substantially uniform binding affinity, to a single-stranded polynucleotide containing a target sequence of bases. The polymer molecules...
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5088513 |
Support leg for stick-shaped walking aids
A support leg for a canelike walking aid includes an adapter part to which a support tube of the walking aid may be fitted, a sole body which can bear on the ground, and a joint device connecting...
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4169948 |
Pyrazolopyrimidines
Novel aminoalkyl purine and pyrazolopyrimidine compounds useful in the inhibition of blood platelet aggregation in animals.
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