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DE10035106A1 A method for detecting the effect of a substance on living cells  
The invention relates to a method and a device for automatically establishing the effect of cell-influencing substances or active ingredients on living cells, cell systems and cell compartments....
DE10034804A1 Using VLCFAE for identifying herbicidally active compounds  
The invention relates to the use of nucleic acids that encode plant polypeptides having the biological activity of Very Long Chain Fatty Acid elongases and the use of the polypeptides encoded for...
DE10031179A1 Introducing active molecules into the nucleus of eukaryotic cells, useful for transfection and gene therapy, by applying controlled electrical pulse  
Introducing a biologically active molecule (I) into the nucleus of eukaryotic cells, comprising applying an electrical pulse of field strength 2-10 kV/cm; duration at least 10 Micros and current...
DE10033353A1 Identifying compounds that modify activity of signal transduction pathways, useful potentially as therapeutic agents, by screening with cells that contain hybrid G proteins  
Identifying (M1) compounds (A) that modify, in an organism, the activity of at least one signal transduction pathway that depends on a G protein coupled receptor (GPCR). Cells that contain at...
DE10032730A1 Microtiter plate for carrying out tests on biological cells, e.g. using pharmaceuticals, has array of projections which act as test sites and have binding agents on their surfaces to which cells can be bound  
Microtiter plate (10) for carrying out tests on biological cells (23) has an array of projections (25) which act as test sites. These have binding agents on their surfaces to which the cells can...
DE10032568A1 Apparatus and method for electrically contacting located in a liquid in suspension biological cells  
The invention relates to a device for making electrical contact with biological cells (11), suspended in a fluid (14), comprising a substrate with at least one opening and a means of immobilising...
DE10123987A1 Rapid detection of fungicides by thin-layer chromatography, useful e.g. in testing foods, uses quenching of fluorescence or an optical brightener for detection  
Bioautographic detection of fungicides (I) by applying a fungal suspension to a dried, developed thin-layer chromatography plate (A); incubating the plate and determining zones of inhibition by...
DE10028692A1 Method for investigating membrane-biocompartments  
In a method for investigating biocompartments (1) a is the biocompartments (1) containing the measuring chamber (2) continuously or in portions flows through the culture medium. In one adjacent to...
DE10030193A1 Test kit for determining total protein and globulins, useful for diagnosing kidney disease, comprises copper sulfate as additional precipitant and polysaccharide  
A test kit for determining total protein (A) and globulins (B) in a biological fluid, comprising reagents that precipitate (A) and permit visual evaluation of the results of a precipitation...
DE10062623A1 Cartilage replacement, useful particularly for repairing joint defects, comprises differentiated and proliferating chondrocytes in collagen-based biomatrix  
Cartilage replacement (A) prepared by (i) incorporating dedifferentiated cartilage cells (B) into a three-dimensional, gel-like biomatrix containing at least 1.5 mg/ml collagen in buffered,...
DE10028118A1 A process for the determination of the confluence of a cell layer on porous biomaterials  
The invention relates to a novel method, permitting the semiquantitative determination of the confluence of a cell layer on the total surface of a porous biomaterial, without irreversible damage...
DE10027308A1 Analyzing endogenous or exogenous cell activation for the diagnosis of e.g systemic inflammation comprises measuring assembly of CD14-containing receptor cluster  
Analyzing exogenous and endogenous cell activation comprises measuring the assembly of receptors into a CD14-containing receptor cluster (RC), is new. Independent claims are also included for the...
DE10026833A1 A method for identifying compounds for modulating the activity of a tumor suppressor  
The invention relates to a method for identifying compounds which alter the activity of the intracellular tumour suppressor gene nf2, whereby the activity of the protein NF2 that is coded by the...
DE10026789A1 Cartilage replacement and process for its preparation  
The invention relates to methods for cultivating cartilage cells, to methods for the redifferentiation of dedifferentiated cartilage cells and to cartilage transplants.
DE10016077A1 Automated testing of activity of cell-modifying agents useful for selecting cytostatic agents for particular treatments  
Automated detection of an activity of a cell-modifying agent (A) on living cells. The process comprises: (a) measuring data (MD) that represents cellular activity of live cells contacted with (A);...
DE10027119A1 Photolithographic exposure unit for e.g. manufacturing DNA chips, scans target areas of biological material selectively with highly-focused flying spot illumination  
Photolithographic exposure unit for manufacturing DNA chips comprising highly-focused light from a source controlled by a deflection- or positioning unit, directing the light spot onto each...
DE10022362A1 Methods of finding modulators of enzymes of the carotenoid biosynthesis pathway  
The invention relates to nucleic acids encoding Carotene for Zeta synthase from tobacco, which encoded polypeptides and to methods of finding modulators of the activity of zeta-carotene synthase,...
DE10021688A1 New DNA sequences involved in isoprenoid biosynthesis, useful in screening for compounds with e.g. antimicrobial and herbicidal activity  
DNA sequence (I) that encodes one of sequences (5) or (14), of 539 and 343 amino acids (aa), respectively, or their analogs or derivatives in which one or more aa are deleted, inserted or...
DE10020072A1 Apparatus and method for the treatment and study of living organisms and tissues under temperate conditions  
The invention relates to an apparatus and a method for the treatment and investigation of living organisms and tissue under temperature-controlled conditions. DOLLAR A Physiological and...
DE10020704A1 Biochip for archiving and medical laboratory analysis of biological sample material, process for its preparation and its use in diagnostic procedures  
A biochip for diagnostic use comprises a sample support consisting of a solid matrix, to whose surface the sample material to be analysed, originating from a biological organism, is bonded.
DE10020507A1 Solution for the preservation of human liver cells, preserved human liver cells, their preparation and use  
The invention relates to a solution for the preservation of human liver cells preserved human liver cells, their preparation and their use for the detection or identification of liver active...
DE10019918A1 Method and apparatus for the comminution of microorganisms  
The invention relates to a method and a device (1) for comminuting micro-organisms contained in the sewage sludge of a sewage treatment works. According to said method, a volume containing the...
DE10019136A1 Polyamide nucleic acid derivatives, compositions and methods for their preparation  
The invention relates to PNA derivatives which carry a phosphoryl radical on the N terminus of the PNA backbone, for example a phosphate or a substituted phosphoryl radical, substituted phosphoryl...
DE10019135A1 Polyamide nucleic acid derivatives, compositions and methods for their preparation  
The invention relates to PNA derivatives that carry one or more phosphoryl groups at the C terminus or at the C and N terminus of the PNA backbone, said phosphoryl groups optionally carrying one...
DE10014708A1 A method for identifying and enriching cell-specific target structures  
The present invention relates to a method for identifying and enriching cell-specific target structures, especially for identifying cell-specific protein combination patterns on the surface of...
DE10014685A1 A method for identifying cell-specific target structures  
The present invention relates to a method for identifying cell-specific target structures, wherein the automated a reagent solution Y1 having at least one marker molecule to an object X1 is...
DE10118156A1 Apparatus for observing biological material comprises microscope slide with well in which substance is placed which has focusing mark underneath from which focus is shifted by specified amounts for particular materials  
Apparatus for observing a material (12) comprises: (a) a microscope slide (7) with a well (8) in which the substance is placed and which has a transparent section; (b) an optical system for...
DE10018433A1 Sensor system used for determining the quality of tap water, comprises a chamber having an inlet and an outlet, a substrate on which algae is grown, oxygen sensors, pH sensors, and optionally temperature sensors  
Sensor system comprising a chamber (9) having an inlet and an outlet; a substrate (6) on which algae is grown, oxygen sensors (4, 11), pH sensors (3, 13), and optionally temperature sensors (15),...
DE10017519A1 Detecting beer spoilage bacteria, from presence of the HorA membrane transporter responsible for hop resistance  
Method for detecting beer-spoilage bacteria (A), particularly lactic acid bacteria, by detecting the activity of the HorA membrane transporter.
DE10016527A1 A method for diagnosing cancer and / or neurodegenerative disease states as well as products for  
The invention relates to a method for diagnosing cancerous diseases and/or neuro-degenerative pathological conditions. According to said method, proteins with domains rich in glutaminic...
DE10013619A1 New polypeptide subunit of invertebrate ligand-controlled anion channel, useful in screening for potential plant-protection agents, especially insecticides  
Polypeptide subunit(s) of invertebrate ligand controlled anion channel, useful in screening for potential plant-protection agents, are new. Polypeptides (I), involved in assembly of a...
DE10006174A1 Isoform of neuregulin-beta with acidic isoelectric point, useful as indicator or target, e.g. in screening for potential neurological agents  
An isoform (I) of neuregulinbeta that has an isoelectric point (pI) not over 7, is new. - ACTIVITY : Neurological. - MECHANISM OF ACTION : (I) Is involved in regulation of neuronal processes.
DE10013618A1 New polypeptides from Drosophila melanogaster have biological activity of peptide receptor, useful to find new compounds for plant protection and insecticides  
New polypeptides (P1) fromDrosophila melanogasterhaving the biological activity of a peptide receptor, are new. A polypeptide having the biological activity of a peptide receptor and at least 70%...
DE10013580A1 Receptor for Latrotoxin from insects  
The invention relates to polypeptides which exert the biological activity of latrotoxin receptors, as well as nucleic acids encoding these polypeptides, and in particular the use thereof for...
DE10012220A1 Test system comprising cells expressing different cytochrome P450 2D6 alleles used to investigate genetically caused metabolite toxicity and to determine toxic, mutagenic or carcinogenic effect of compounds  
Test system comprising cells expressing a cytochrome P450 2D6 (hCYP2D6) allele heterolog, and at least three P450 2D6 alleles are expressed in the system, is new. Independent claims are also...
DE19950262C2 Method for performing a flow cytometric Phagozytosetests  
The invention relates to a flow cytometric Phagozytotest for detecting a Phagozytodefekts a patient using a patient blood sample taken. DOLLAR A The known flow cytometric methods have the...
DE10109259A1 Characterizing increased dedifferentiation of cancer cells useful for diagnosing cancer, particularly early cervical cancer, comprises applying body fluids to a foil covered slide and detecting dye-marked cells by laser  
Characterizing increased dedifferentiation and micro-metastasis of cancer cells, comprising applying body fluid cells to a carrier and cytodiagnostically examining its cells using micro-dissection...
DE10010938A1 Inorganic pyrophosphatase of Lepidoptera  
The invention relates to polypeptides which exert the biological activity of inorganic pyrophosphatase, and nucleic acids that encode these polypeptides, and in particular their use for finding...
DE10008373A1 Determining activity of ligand-activatable ion channels comprises measuring resistance or conductivity of two cell samples in conductive liquid, where an active material, e.g. pharmaceutical or insecticide, is added to second sample  
Method for determining the ion channel activity of ligand-activatable ion channels, is new. Method (M1) for determining the ion channel activity of ligand-activatable ion channels comprises: (a)...
DE10026208C1 Cages for laboratory test animals comprises sterile air feed and exhaust air sample collection points leading to indicator cage containing test animal to react to any infectious particles  
An assembly of individual ventilated micro-insulation cages (IVC) has a number of IVC cages for laboratory animals, supplied with sterile air, where samples of the exhaust air are taken from...
DE10009420A1 Determining chemotaxis activity of leukocytes, useful for diagnosing e.g. immune defects comprises measuring expression of cell-adhesion molecules  
Determining the chemotaxis activity of leukocytes in a sample by determining expression of a cell-adhesion molecule (I), is new. Independent claims are also included for the following: (1) similar...
DE10009341A1 A method for antigen-specific stimulation of T lymphocytes  
The invention relates to a method for the antigen-specific stimulation of T-lymphocytes with synthetic peptide libraries, comprising the following steps: a) dividing the whole amino acid sequence...
DE10006309A1 A method for identifying substances that modulate the activity of hyperpolarization-activated cation channels,  
The invention relates to a method for identifying substances which modify the activity of hyperpolarisation-activated cation-channels and to the use of this method.
DE10006175A1 Isoform of neuregulin-beta with acidic isoelectric point, useful as indicator or target, e.g. in screening for potential neurological agents  
An isoform (I) of neuregulinbeta that has an isoelectric point (pI) not over 7, is new. ACTIVITY : Neurological. MECHANISM OF ACTION : (I) Is involved in regulation of neuronal processes.
DE10005735A1 Withdrawing liquid stream containing suspended cells from liquid microsystem, comprises feeding stream at end of exit channel into decoupling stream to form discharge stream which is discharged through outlet  
Withdrawing a liquid stream containing suspended microparticles from a liquid microsystem (10), comprising feeding the stream at the end of an exit channel (14) into a decoupling stream to form a...
DE10004642A1 Biological microsensor has a heating system which is only activated when the temperature level in the reaction chamber needs correction to maintain the bacteria or micro organisms at the level for their activity  
The biological microsensor has a housing for an electrode array, an electrolyte supply, a supply zone for bacterial nutrient and a reaction chamber. The reaction chamber is at the outer wall of...
DE10003673A1 Determining extracellular ion concentrations, useful e.g. for pharmaceutical screening, in the basolateral regions of adherent cells, using immobilized fluorescent dyes  
Method for determining extracellular ion concentrations, and their changes, in the basolateral region of adherent cells. The cells are deposited on a matrix that contains an ion-specific,...
DE10003521A1 Apparatus for producing a three-dimensional matrix body, multi-well plate, solution for cultivating mammalian, method of cultivating a cell culture device for measuring isometric force parameters of cell cultures and methods for measurable following of contractions of incorporated into a carrier cell tissue  
The invention relates to a device for producing a three-dimensional circular muscle body from a carrier substance and from cell cultures incorporated therein comprising a cell culture dish (1) and...
DE10011926A1 Genetically modified fibroblast cells  
Disclosed are genetically modified fibroblast cells having the following characteristics: (a) A gene of the genome thereof is inactivated and/or a component of the signal transduction path is...
DE10003588A1 A method for isolating a portion of a layer of biological material and suitable for this purpose retaining member  
The invention relates to a film (14) comprising a tissue specimen (10) which is placed face down with said tissue specimen (10) onto a microscope object holder (18). Afterwards, the microscope...