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DE10101319A1 Morphometric tissue or cell preparation  
The invention relates to a morphometric tissue or cell preparation, which may be obtained by carrying out the following method steps: a) cells are cultivated in a three-dimensional matrix, over a...
DE10100807A1 Method for analysis of hard tissue, especially for diagnosing fungal infection of finger-or toe nails, comprises cutting particles from tissue, staining and examining them under microscope  
Particles (6) from tissue are cut using a rotary cutter, stained and examined under a microscope.
DE10059631A1 T cell epitopes of the papillomavirus L1 and E7 protein and their use in diagnostics and therapy  
The present invention relates to a papillomavirus T cell epitope having an amino acid sequence DOLLAR A YLPPVPVSKVVSTDEYVART, STDEYVARTNIYYHAGTSRL, VGHPYFPIKKPNNNKILVPK, GLQYRVFRIHLPDPNKFGFP,...
DE10037759A1 screening procedures  
The invention relates to a method for identifying pain-related or pain-regulating substances, related polynucleotides, peptides, proteins, vectors and cells, characterized compounds identified,...
DE10108264A1 Stem cells, method for their expansion in vitro and the use thereof  
Disclosed is a method for expanding stem cells in vitro, wherein the stem cells during the expansion continuously or intermittently a microcurrent and / or an electromagnetic field constant and /...
DE10063179A1 Detecting tumor cells and their precursors in cervical smears, by simultaneous detection of two markers, suitable for automation and providing an objective diagnosis  
Detecting (M1) tumor cells and their precursors in cervical smears by simultaneous detection of at least two molecular markers in a cell. An Independent claim is also included for a kit for (M1).
DE10063112A1 A method for increasing the clinical specificity in the detection of tumors and their precursors by simultaneous measurement of at least two different molecular markers  
The present invention relates to an automatable method for improved diagnosis of pathologically altered cells by simultaneously staining of at least two different molecular markers that...
DE10063111A1 Replication assay for the detection of antiviral substances  
The invention relates to a replication assay for detecting anti-virally active inhibitors in the form of a single-well assay. Said assay consists of a combination of a natural virus isolation...
DE10062422A1 Using acetyl-CoA carboxylase for identifying insecticidally effective use  
The invention relates to nucleic acids, which code for polypeptides from insects having the biological activity of acetyl-CoA carboxylases, to polypeptides coded thereby, and to their use for...
DE10061872A1 Yeast strain for testing the genotoxicity and cytotoxicity of complex environmental contaminations  
The invention relates to modified yeast strains and to methods for constructing yeast strains, as well as to their use for testing the geno- and/or cytotoxicity of complex environmental contamination.
DE10061161A1 New human androgen receptor variants  
There are new variants of the androgen receptor, AR42 and AR32, and describes their use.
DE10061347A1 Apparatus for the measurement of ion flows in single cells, where the wall of the micro measurement chamber acts as a reference diode to work with the patch pipette to study the cells under conditions of ischemia and/or stimulation  
Apparatus to measure the ion flows, at a single cell, having a micro measurement chamber (1) with a shape and dimensions to match the cell (4) under study, and the wall acts as a Ag/AgCl reference...
DE10060880A1 Determining chemotaxis activity of leukocytes, useful for diagnosing e.g. immune defects comprises measuring expression of cell-adhesion molecules  
Determining the chemotaxis activity of leukocytes in a sample by determining expression of a cell-adhesion molecule (I), is new. Independent claims are also included for the following: (1) similar...
DE10056899A1 New promoter from Saccharomyces cerevisiae YNL279W gene, useful e.g. for identifying modulators of G protein-coupled receptors, is responsive to pheromone alpha  
Recombinant DNA fragment (I) contains the promoter (P) of the Saccharomyces cerevisiae gene YNL279W which regulates transcription of functionally linked structural genes. Independent claims are...
DE10057755A1 New nucleic acid encoding plant phosphomevalonate kinase, useful for identifying modulators, potentially useful as herbicides and growth regulators  
A nucleic acid (I) that encodes a plant phosphomevalonate kinase (PMVK), excluding the known fully defined partial sequences (S3-5) of 611, 728 and 571 base pairs as given in the specification, is...
DE10137442A1 Selection of microorganism degrading lipophilic volatile organic compound and continuous biodegradation e.g. of (halo)hydrocarbon uses pH to control nutrients, nitrogen source and organic compound without need to add organic separately  
In selection of microorganisms that degrade (almost) water-insoluble, volatile, lipophilic organic compounds (VOC) or continuous biodegradation of VOC in aerated bioreactor in chemostatic and...
DE10054639A1 Specific coactivator for human nuclear receptors  
The invention relates to the use of a cloned gene which codes for a protein which in humans, acts as a co-activator of hormone receptors, especially of the androgen receptor; as an important...
DE10055703A1 Ex vivo blood lavage with oligomeric carbohydrates for removal of pathogens, hapten-containing antibody aggregates and amyloids, useful in treatment of e.g. multiple sclerosis and Alzheimer's disease  
Preventing cell destruction and eliminating amyloids from body-specific cells, comprising removing pathogens and hapten-containing antibody aggregates from the serum by an ex vivo blood lavage and...
DE10054878A1 Sodium channels of the type of peripheral nerves  
The present invention provides cell lines expressing one or more recombinant peripheral nerve (PN) sodium channels, preferably a human PN sodium channel. The invention also provides methods for...
DE10053521A1 Method for the detection of apoptotic and necrotic cells  
The invention relates to a method for the identification of apoptotic and necrotic cells in a cell suspension, comprising the following steps: a) contacting a first sample taken from said cell...
DE10053224A1 A process for the exposure of peptides and polypeptides on the cell surface of bacteria  
The inventive method allows peptides or polypeptides to be exposed on the surface of gram-negative host bacteria using specific intimin-based anchor modules. Intimins with shortened carboxy...
DE10048375A1 Multifunctional and multiparametric biochip arrangement  
There is provided a biochip having a sensor unit for measuring of constituents of body fluids or cell cultures, in particular for measuring the constituents of capillary, venous and arterial...
DE10052583B4 Method for optimizing the multiplex molecular diagnosis of tissue micro arrays by means of Virtual Cell Nucleus Imageing  
Method for calculation of optimization strategies for the multiplex molecular diagnosis of Micro tissue arrays, characterized in that for to be examined cell type / cell types, a computer model of...
DE10135996A1 Identifying metastatic tumor cells and screening for antitumor agents, comprises hybridization to specific cDNA sequences  
Identifying metastatic tumor cells (A) comprising testing them for hybridization to at least one cDNA sequence (I) not defined in the specification, or the derived complete gene, functional...
DE10046647A1 Determining hormonal activity of materials, useful for diagnosis or detecting abuse of anabolics, comprises detecting expression of reporter gene product in transfected cells  
Determining the peptide hormone- or steroid hormone- activity of a material or mixture in cells, by detecting the expression of a reporter gene in transfected cells, is new. Starting cells, with...
DE10043470A1 Identification of cell-specific proteins, useful for development of highly selective therapeutic agents, e.g. for controlling migration of cancer cells  
Identifying cell-specific proteins (A) comprising: (a) determining cell-specific protein combination patterns (B) of n cells; (b) comparing (B) of healthy and diseased/physiologically altered...
DE10041596A1 Apparatus and method for spatially resolved Examine networked cells and / or cell systems and use of the drug investigation  
The invention relates to an apparatus and method for spatially resolved Examining crosslinked cells and / or cell systems and their use for diagnostic use, and for drug analysis.
DE10042177A1 New acetylcholine receptor subunit, useful for identifying plant-protection and therapeutic agents, comprises segment of insect subunit inserted into vertebrate subunit  
Modified acetylcholine receptor (ACR) subunit (I) in which at least one amino acid (aa), in the region of an alpha -subunit of a vertebrate ACR that is homologous with a 45 aa sequence (S1),...
DE10041515A1 A process for preparing ready to use antigen-loaded or -unbeladener, cryopreserved mature dendritic cells  
The invention relates to a method for producing ready to use, antigen loaded or unloaded, cryoconserved mature dendritic cells especially for the production of a vaccine containing said dendritic...
DE10041411A1 Screening methods for finding the endocytosis promoting adjuvants  
The invention relates to a screening method for discovering auxiliary agents promoting the endocytosis of low molecular and/or macro-molecular compounds, especially nucleic acids, in cells. The...
DE10038169A1 Synthetic particles for labeling of a substance  
The invention relates to a synthetic particles for labeling a substance, comprising a plurality of solid-form identification substances 10, 12 and at least one identification of substances 10,...
DE10036469A1 Ultraspiracle (USP) protein from Heliothis virescens  
The invention relates to nucleic acids which code for polypeptides having the biological activity of ultraspiracle protein, as well as such polypeptides per se. Furthermore, the invention relates...
DE10053879A1 Gene expression, genome alteration and reporter expression in myofibroblasts and myofibroblast-like cells  
The invention relates to specific regulatory sequence regions of the alpha smooth muscle actin gene (alpha-SMA gene), Funsionskonstrukte, where such regulatory sequence regions of the alpha-SMA...
DE10035433A1 Gentle high enrichment of fetal cells from pripherem blood and using the same  
The invention relates to a method for highly enriching foetal cells as products, whereby after a sample of maternal blood is taken and the centrifugation of blood fractions occurs, a cocktail of...
DE10034281A1 Dosimetry and dosimetry device for deposited from a gas phase on cell layers aerosol particles  
The present invention provides a dosimetry and for a Dosimetrievorrichtung from a gas phase deposited on cell layers 2 aerosol particles. There is a gas flow generated 1 in a cell chamber 10...
DE10033268A1 A process for the examination of cells in a culture liquid  
In a method for the examination of cells (20, 38) in a culture liquid, in particular in-situ microscopy in a bioreactor, cells within a sample volume (12) whose thickness (d) in the optical axis...
DE10126055A1 biosensor  
Provided is a compact biosensor which is particularly suitable for measuring the biological oxygen demand. It contains microorganisms altering the biological parameters, and sensors, which are...
DE10035227A1 Selection and use of lipogenesis inhibitors for the treatment and prevention of obesity  
Compounds for the treatment and/or prevention of obesity are selected on the basis of their capability to inhibit de novo lipogenesis in mammals. An independent claim is also included for the use...
DE10035106A1 A method for detecting the effect of a substance on living cells  
The invention relates to a method and a device for automatically establishing the effect of cell-influencing substances or active ingredients on living cells, cell systems and cell compartments....
DE10034804A1 Using VLCFAE for identifying herbicidally active compounds  
The invention relates to the use of nucleic acids that encode plant polypeptides having the biological activity of Very Long Chain Fatty Acid elongases and the use of the polypeptides encoded for...
DE10031179A1 Introducing active molecules into the nucleus of eukaryotic cells, useful for transfection and gene therapy, by applying controlled electrical pulse  
Introducing a biologically active molecule (I) into the nucleus of eukaryotic cells, comprising applying an electrical pulse of field strength 2-10 kV/cm; duration at least 10 Micros and current...
DE10033353A1 Identifying compounds that modify activity of signal transduction pathways, useful potentially as therapeutic agents, by screening with cells that contain hybrid G proteins  
Identifying (M1) compounds (A) that modify, in an organism, the activity of at least one signal transduction pathway that depends on a G protein coupled receptor (GPCR). Cells that contain at...
DE10032730A1 Microtiter plate for carrying out tests on biological cells, e.g. using pharmaceuticals, has array of projections which act as test sites and have binding agents on their surfaces to which cells can be bound  
Microtiter plate (10) for carrying out tests on biological cells (23) has an array of projections (25) which act as test sites. These have binding agents on their surfaces to which the cells can...
DE10032568A1 Apparatus and method for electrically contacting located in a liquid in suspension biological cells  
The invention relates to a device for making electrical contact with biological cells (11), suspended in a fluid (14), comprising a substrate with at least one opening and a means of immobilising...
DE10123987A1 Rapid detection of fungicides by thin-layer chromatography, useful e.g. in testing foods, uses quenching of fluorescence or an optical brightener for detection  
Bioautographic detection of fungicides (I) by applying a fungal suspension to a dried, developed thin-layer chromatography plate (A); incubating the plate and determining zones of inhibition by...
DE10028692A1 Method for investigating membrane-biocompartments  
In a method for investigating biocompartments (1) a is the biocompartments (1) containing the measuring chamber (2) continuously or in portions flows through the culture medium. In one adjacent to...
DE10030193A1 Test kit for determining total protein and globulins, useful for diagnosing kidney disease, comprises copper sulfate as additional precipitant and polysaccharide  
A test kit for determining total protein (A) and globulins (B) in a biological fluid, comprising reagents that precipitate (A) and permit visual evaluation of the results of a precipitation...
DE10062623A1 Cartilage replacement, useful particularly for repairing joint defects, comprises differentiated and proliferating chondrocytes in collagen-based biomatrix  
Cartilage replacement (A) prepared by (i) incorporating dedifferentiated cartilage cells (B) into a three-dimensional, gel-like biomatrix containing at least 1.5 mg/ml collagen in buffered,...
DE10028118A1 A process for the determination of the confluence of a cell layer on porous biomaterials  
The invention relates to a novel method, permitting the semiquantitative determination of the confluence of a cell layer on the total surface of a porous biomaterial, without irreversible damage...
DE10027308A1 Analyzing endogenous or exogenous cell activation for the diagnosis of e.g systemic inflammation comprises measuring assembly of CD14-containing receptor cluster  
Analyzing exogenous and endogenous cell activation comprises measuring the assembly of receptors into a CD14-containing receptor cluster (RC), is new. Independent claims are also included for the...