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DE10155518A1 Detection of apoptosis induction, useful for testing cytostatic agents, comprises staining cells with a fluorochrome compound and measuring the cells by flow cytometry while stimulating the fluorochrome compound  
Detection of apoptosis induction, comprising: (a) fixing cells to be studied; (b) permeabilizing the outer membrane to maintain organelle structure; (c) staining cells with a fluorochrome...
DE10155185A1 Method for the characterization and / or identification of mechanisms of action of antimicrobial test substances  
The invention relates to a method for the characterisation and/or identification of active mechanisms of antibacterial test substances, by means of IR (infrared) analyses, FT-IR (Fourier Transform...
DE10152598A1 ARL-2 for fertility control  
It describes a human ARL-2 protein and its use for fertility disorders, therapy and diagnosis.
DE10154399A1 Method for identifying active substances for the modulation of pip92-mediated apoptosis  
The invention concerns methods for identifying active substances involved in the signal cascade of protein pip92-mediated apoptosis, and methods which can be used to identify proteins interacting...
DE10152376A1 New substrates for phospholipase, useful e.g. for diagnosis and drug screening, contain two fluorophores that make a fluorescent energy-transfer pair  
Phospholipase substrates (I) containing two fluorophores are new. Phospholipase substrates of formula (I) are new. A = 1-20C alkylene or alkenylene; B = NH, NHCO, CONH, NHCONH, NHCSNH, oxygen or...
DE10151511A1 ee3 protein family and underlying DNA sequences  
The invention relates to (i) DNA sequences, (ii) expression vectors, comprising said DNA sequences, (iv) host cells, comprising said expression vectors, (v) genetic products, coded by said...
DE10150677A1 New nucleic acid encoding fungal mitogen-activated protein kinase, useful as target for identifying fungicides for plant protection, is from Fusarium graminearum  
Nucleic acid sequence, encoding a MAP kinase, (I) comprises (a) sequences (S1) or (S2), of 556 and 490 nucleotides, reproduced; (b) a functional equivalent of (a); (c) a fragment of (a); or (d) a...
DE10139874A1 Human Mater proteins  
Two human MATER proteins and their use for fertility disorders, therapy and diagnosis are described.
DE10150971A1 Measuring the receptor capacity of cells, useful in a drug screening system for drugs that treat central nervous system disorders, comprises measuring the change in charging current upon stimulation of receptors by their agonists  
Measuring the receptor capacity of whole transfixed cells, comprising using a capacitative assembly comprising: (a) a silicon wafer, with gold deposition and a coating of octadecylmercaptane, as a...
DE10150060A1 Measuring system for the measurement of physiological and/or metabolic parameters in biological cells, comprises measuring the electrical activity through sensors sensitive to a magnetic field without interference  
Measuring system to measure or study physiological and/or metabolic parameters in biological cells, or cell components, by measuring their electrical activity, using at least one sensor which is...
DE10147638A1 Module for suppressing leukocyte activity, useful e.g. in association with heart-lung machines, comprises a carrier linked to a ligand specific for the leukocyte receptor  
Module (A) for suppressing the activity of leukocytes, comprising: (a) a carrier; and (b) a ligand bound to the carrier that can interact with a receptor on leukocytes, is new.
DE10147020A1 New telomerase-immortalized cell line, useful e.g. for examining the effects of xenobiotics, is produced by transfection of human endometrial cells  
New telomerase-immortalized cell line (A), produced from a human endometrial cell, isolated from uterine tissue in the proliferation phase of the cycle, and transfected with the eukaryotic...
DE10147975A1 Testing the functional differentiation capacity of cells, useful for checking suitability of vascular transplants, comprises determining hydraulic conductivity and profibrinolytic properties  
Testing the functional differentiation capacity of cells, which in the course of biotechnological applications become established on organic or plastic, porous, or hollow organs, is new. Testing...
DE10143757A1 In situ determination of tissue characteristics, useful e.g. for diagnosis of tumors, by using specific detection agents that are transiently labeled  
In situ determination (M) of at least two coincident biochemical, genotypical and/or phenotypical characteristics in a tissue and/or extracellular matrix, comprising using at least two detection...
DE20202129U1 Test kit for diagnosing neuroimmunological health disorders comprises at least one harmful substance at subtoxic concentration, a lymphocyte incubation device and a unit for detecting (pro)inflammatory and regulatory cytokines  
Test kit for diagnosing neuroimmunological health disorders comprises at least one harmful substance at subtoxic concentration, an incubation device for lymphocytes or lymphoid cells, and a unit...
DE10143237A1 Production of Artificial Internal Ribosomal Entry Point Elements (Ires Elements)  
A method of creating a nucleic acid sequence having an adenine-rich nucleic acid block of at least 25 nucleotides in length is provided, whereby said nucleic acid sequence is capable of causing...
DE10227248A1 Expressing functional membrane receptor in baculovirus, useful for identifying modulators of receptor-ligand interactions  
Expressing a functional membrane receptor (A) by culturing a host infected with at least one type of recombinant baculovirus (B) containing a gene for an interacting protein (I) and a gene...
DE10138876A1 Genetically modified cyclic nucleotide-driven ion channels and their use  
The present invention relates to genetically modified cyclic nucleotide-gated ion channels whose subunits are altered to have a higher sensitivity for cAMP and / or a higher selectivity for cAMP...
DE10138912A1 Use of active substances for the prophylaxis and / or therapy of viral diseases and test system for finding such active substances  
The invention relates to the use of at least one active substance for producing a pharmaceutical composition for the prophylaxis and/or treatment of at least one virus disease. The invention is...
DE10131899A1 In vitro screening assay for gamma-secretase  
According to the screening method of the present invention, substances capable of modulating gamma-secretase activity are obtained by incubating a source and a substrate for gamma-secretase...
DE10138766A1 Identifying macrocyclic polyketides, useful e.g. as cytostatic agents, using biosensor cells containing reporter gene controlled by polyketide responsive promoter  
Identifying macrocyclic polyketides (I) by exposing (I), or a mixture containing them, to a biosensor, is new. Independent claims are also included for the following: (1) host cell (A) that...
DE10136472A1 Device for detecting living cells or organelles, useful especially for detecting Salmonella, contains magnetic particles fixed to specific binding agents and a metabolic sensor  
Device (A) for detecting living microorganisms, eukaryotic cells and organelles (B) in a sample that contains magnetic particles (P) having, fixed to their surface, specific binding molecules (I)...
DE10128541A1 Screening procedure with BNPI and DNPI  
The invention relates to a method for finding pain-regulating substances using BNPI and / or DNPI and the use of compounds identified thereby, BNPI and / or DNPI-binding agents, antibodies...
DE10136722A1 Inhibiting adhesion of particles to surfaces, useful e.g. for preventing cell adhesion in microanalytical systems, comprises adding polyol to a working solution  
Inhibiting (M) adhesion of particles, preferably cells or their components, present in a solution, to a surface, comprising adding at least one polyol (I) to the solution, is new. An Independent...
DE10135787A1 New nucleic acid for producing a recombinant polypeptide, for use as a probe, or for the treatment of steroidal hormone dependent illnesses  
A nucleic acid (I): (a) encoding a polypeptide of Seq. ID No. 2 (2055 amino acids, given in the specification); (b) of Seq. ID No. 1 (6995 base pairs, given in the specification); (c) that...
DE10135091A1 Method, device and microscope slide for microdissection  
The invention relates to a specimen holder (100) for dissecting a preparation and to the production of the specimen holder itself. The specimen holder (100) comprises a supporting substrate (103),...
DE10133273A1 Apparatus and method for detecting photosynthesis inhibition  
A method, system and test strip for detecting photosynthesis inhibition in substances by providing cells or parts of cells with an intact photosystem, inserting said cells or cell parts into a...
DE10112505C1 Sensor arrangement and apparatus for amperometric and / or potentiometric, pharmacological active site and / or drug testing and process for amperometric and / or potentiometric, pharmacological active site and / or drug testing  
To amperometric and / or potentiometric, pharmacological active site and / or material testing particularly reliable and nevertheless be able to perform in a short time at low cost, a sensor...
DE10132280A1 Method for the detection of mutagenic substances  
The invention relates to a method and means for the rapid identification of mutations. The test strains used in the invention contain a reporter system and a selection marker. An antibiotic...
DE20023055U1 Photolithographic exposure unit for e.g. manufacturing DNA chips, scans target areas of biological material selectively with highly-focused flying spot illumination  
Photolithographic exposure unit for manufacturing DNA chips comprising highly-focused light from a source controlled by a deflection- or positioning unit, directing the light spot onto each...
DE10130041A1 Delaying senescence of cells, useful for extending life of cultures, by appropriate selection of source cells and culture conditions  
Retarding senescence of cells which exhibit senescence-specific markers (SSM) with sequences that originate in the line of inheritance from source cells, is new. Retarding senescence of cells...
DE10131458A1 Method for the identification of compounds for the therapy of aging processes of the cardiovascular system  
The invention relates to a method for identifying a compound that modifies the activity of the urotensin II receptors by influencing those genes or gene products that are associated with the...
DE10129693A1 Method for extracorporeal qualitative and / or quantitative detection of neurotoxic substances in the blood plasma of an individual  
The invention relates to a method for the extra-corporeal qualitative and/or quantitative recording of neuro-toxic substances in the blood plasma of an individual. According to said method, a...
DE10128552A1 For cell analysis, the cells are fixed on a carrier to be colored with a dye for a digital image, and colored with a separate dye for another digital image for automatic image processing analysis  
Cell analysis comprising fixing cells to a carrier and coloring with first dye for a digital image to be taken and stored in memory. The cells are then colored with a second dye of visually...
DE10128510A1 New nucleic acid array useful for monitoring mRNA expression of Corynebacterium glutamicum during fermentation, comprising nucleic acid from Corynebacterium glutamicum  
A nucleic acid array comprising (a) - (e) is new: (a) one of the 2179 nucleic acid sequences fully defined in the specification; (b) a genetic code degenerate of (a); (c) a sequence which...
DE10125033A1 Use of Sjoegren syndrome antigens as apoptotic targets, useful for diagnosis, treatment, e.g. of cancer or neurodegeneration, and drug screening  
Use of SS-A(Ro) and/or SS-B(La) (Sjoegren syndrome antigens A and B) nucleic acid (I), and (poly)peptides (II) derived from them, as targets for diagnosis and/or modulation of apoptosis....
DE10123958A1 Identifying ligands for G protein-coupled receptors, useful for treating cardiovascular disease, by using calcium-sensitive fluorophores in cells expressing G alpha proteins  
Method for identifying a ligand (I) of a G protein-coupled receptor (GPCR), is new. Method for identifying a ligand (I) of a G protein-coupled receptor (GPCR) comprises first transforming a cell,...
DE19936035C2 Lymphozytenproliferationstestkit  
It is possible to detect on lymphocytes before and after stimulation with PHA and / or protein A and / or NGF to the cell surface marker CD69 and to determine a stimulation index. DOLLAR A The...
DE10114682A1 Using raf to inhibit bacterial porin factors  
The invention relates to a nucleic acid encoding for at least a partial sequence of a protein kinase of the mitogenic signaling cascade, especially c-raf, wherein the partial sequence interacts...
DE10106826C1 Medium for culturing tumor cells  
describes a medium for the cultivation of tumor cells, which comprises the following constituents, for example in RPMI 1640 medium, comprises: (a) fetal calf serum (FCS), (b)...
DE10112515A1 Detecting methylation status of test DNA in a mixture, useful for diagnosis and prognosis of disease, comprises bisulfite treatment then selective amplification of test DNA  
Detecting cytosine methylation in DNA samples by: (i) chemically treating a genomic sample to convert all non-methylated cytosines to uracil while leaving methylated cytosines unchanged; (ii)...
DE10217066A1 Composition useful for treatment of central nervous system disorders, e.g. Alzheimer's disease comprises modulator of neuron-specific calcium sensor-1  
Pharmaceutical composition (A) comprises an agonist/activator or antagonist/inhibitor (I) of the neuron-specific calcium sensor-1 (NSC1) and a carrier. Independent claims are also included for the...
DE19931276C2 Process for the preparation of sample bodies having biofilm loading and method for quantifying the loading of sample bodies with a biofilm, and the use of the created by the production test specimens  
The invention is based on the idea, first to prepare a specimen with a predetermined homogeneous biofilm load. Subsequently, the pre-defined loading of the specimen is assigned a load reference...
DE10201458A1 New proteins involved in isoprenoid biosynthesis, useful in screening for inhibitors, also new intermediates, potential therapeutic agents, nucleic acids and antibodies  
A protein (P1) capable of enzymatic conversion of 2C-methyl-D-erythritol-2,4-cyclodiphosphate (I) to 1-hydroxy-2-methyl-2-butenyl-4-diphosphate (II), especially the (E) form, is new. Independent...
DE10117723A1 Carrier for biological or synthetic samples has a sample holding plate with reservoirs and a dosing plate with projections, fitted with membranes, of an optically transparent material with trouble-free light beam transparency  
A carrier for biological or synthetic samples having a sample holding plate (10) with a number of reservoirs (13) and a dosing plate (20) with a number of projections (21), each with a membrane...
DE10133930A1 Detecting diseased cells, useful e.g. for diagnosis of cancer, by transfection with construct that expresses reporter when disease-related transcription factor is overexpressed  
Detecting (M) disease-associated cells (A) in body samples by transfection/infection of them with a nucleic acid construct (B) that contains: (a) a promoter having at least one DNA-binding site...
DE10115073A1 Use of inhibitors of IKK-ß and method for finding such inhibitors  
The invention relates to the use of an IKK-ss inhibitor for the production of a medicament for the treatment or prevention of atheroscleroses. A screening method for the discovery of IKK-ss...
DE10112360A1 Transformed blood cells and their use for drug screening  
The invention relates to transformed blood cells and to their use in active ingredient screening. The field of application of the invention are the pharmaceutical industry and medicine. The aim of...
DE10109855A1 Polypeptides of a p53 protein specific murine alpha / beta T-cell receptor nucleic acids encoding these, and their use  
The invention relates to polypeptides of a murine alpha / beta T-cell receptor mediating a p53 protein-specific T-cell response or functional variants or parts thereof or nucleic acids coding...
DE10109854A1 Polypeptides of hdm2 protein specific murine alpha / beta T-cell receptor nucleic acids encoding these, and their use  
The invention relates to polypeptides from a murine alpha / beta T-cell receptor, mediating a hdm2 protein-specific T-cell response, or functional variants or parts thereof, or nucleic acids...