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DE10225651A1 A method of identifying agonists or antagonists for the GPR45like / GPR63 receptor  
The invention relates to a method for identifying a compound which modifies the activity of the G protein-coupled receptor GPR45like / GPR63.
DE10225443A1 Binding assay for identifying compounds that react with the mas-like-1 receptor, useful for treating cardiovascular disease, including activators and inhibitors  
Identifying a compound (I) that binds specifically to the G protein-coupled receptor mas-like-1 (R) by (i) treating at least one cell that expresses R on its surface (or a preparation of the cells...
DE10210908A1 Apparatus for applying liquid media and method thereto  
The invention relates to a device for applying liquid media, in particular culture and / or reaction media, as well as a method for generating suitable reaction and / or cultivation conditions.
DE10219031A1 Detecting biologically active compounds, useful for detecting toxins and in drug screening, based on their effect on luminescent bacteria  
Method for detecting biologically active compounds (I) from their effect on luminescent microorganisms (A). Method for detecting biologically active compounds (I) from their effect on luminescent...
DE10217102A1 Method for the characterization of primary tumors  
The invention relates to a method for the detection and characterization of primary tumors or individual regions of primary tumors in which cell clusters of tumor cells located therein are...
DE10214153A1 Method for the detection of microorganisms by means of in situ hybridization and flow cytometry  
The invention relates to a combined method for the specific detection of microorganisms by in situ hybridization and flow cytometry. Above all, the method is characterized by an improved...
DE10216738A1 Helicokinin receptor from insects  
The invention relates to polypeptides which exert the biological activity of a helicokinin receptor, as well as polynucleotides which code for these polypeptides and in particular to their use for...
DE10216243A1 Event Detection - Apparatus and method for measuring the activity of neural networks  
The invention relates to a device for measuring the activity of neural networks with a structured semiconductor substrate, comprising DOLLAR A - a plurality of sensor elements each having at least...
DE10217254A1 Prevention or treatment of tumors comprises treating eukaryotic cells with an agent that modulates the expression and/or function of proteins synthesized and/or secreted by tumors  
Prevention or treatment of tumors comprises treating eukaryotic cells with an agent (I) that modulates the expression and/or function of proteins synthesized and/or secreted by tumors and thereby...
DE10214019A1 Luminescent, spherical, non-autofluorescent silica gel particles with variable emission intensities and frequencies  
The present invention relates to high luminescence spherical, transparent silica gel particles produced by encapsulating one or more different luminescent substances in a silica gel matrix. By...
DE10213762A1 New costimulatory molecule and its use  
The invention relates to a novel costimulation pathway mediated by a member of the semaphorin protein family, namely Sema4A, which is selectively expressed on the surface of dendritic cells....
DE10213332A1 Tryptophanaminotransferase, indole-3-pyruvate decarboxylase and indole-3-acetaldehyde oxidase as new targets for herbicides  
The present invention provides tryptophanaminotransferase, indole-3-pyruvate decarboxylase and indole-3-acetaldehyde oxidase as novel targets for herbicides, test methods for identifying...
DE10217858C1 Separation of groups of cells in an image, useful e.g. for analysis of cancer-screening smears, based on assignment of overlap areas to individual cells  
Method for separating a group of cells, present in an image of a sample, into individual cells for subsequent classification of the cells, where the group comprises several overlapping cells....
DE10211369A1 Screening method for identifying protective substances for the treatment of neurodegenerative and / or ischemic diseases  
The present invention relates to a screening method for identifying protective substances which influence hemoglobin formation in neuronal, myocardial and / or skeletal muscle cells, as well as...
DE10211088A1 Differentially expressed in tumors gene products and their use  
According to the invention, tumor-associated expressed gene products and the nucleic acids coding therefor were identified. The present invention relates to the therapy and diagnosis of diseases...
DE10209245A1 Method and device for detecting microorganisms  
This invention relates to the rapid detection of microorganisms, ie bacteria, fungi, cells and other organisms, by nanotechnology methods and devices. Such organisms, which are more or less...
DE10209788A1 Device and method for determining the relative synthesis power of individual cells and / or position coordinates  
The invention relates to a device and a method for the non-invasive determination of the relative synthesis power of secretory proteins of individual cells and / or the position coordinates of...
DE10207135A1 Detection of specific antibodies useful e.g. for diagnosis of autoimmune hepatitis, comprises using pre-adsorbed test sample and recombinant antigen-expressing cell  
Detecting specific antibodies (sAb) in a biological sample using the corresponding immobilized antigen (Ag), is new. Detecting specific antibodies (sAb) in a biological sample comprises; (a)...
DE10303218A1 Determining intracellular degradation of cell-permeable substance, useful e.g. for optimizing properties of vaccinating peptides, by measuring concentration of degradation products  
Determining intracellular degradation of a cell-permeable substance (I) comprises adding (I) to a medium being used to grow cells and measuring the accumulation of degradation products (II) of...
DE10159264A1 Use of acetoacetyl-CoA thiolase to identify new fungicidally active substances  
The invention relates to nucleic acids which code for polypeptides from fungi with the biological activity of acetoacetyl-CoA-thiolase, the polypeptides encoded by them and their use as targets...
DE10204531A1 cover element  
The invention relates to a lid element that is placed on cell culture vessels in which cells are stored in a liquid medium. The aim of the invention is to provide a lid element which allows to...
DE10202887A1 Cell analysis method comprises applying single cell in drop of solution to functionalized position connected to contact and measuring electrical parameters between contact and second contact on patch pipette  
Cell analysis method comprises applying a single cell (5) or a small number of cells in a drop (7) of cell solution to a measuring position on a solid substrate (1) which is functionalized to hold...
DE19932958C2 A device for binding molecules, molecular groups, molecular parts and / or cells  
The present invention relates to a device for binding molecules, molecular groups, molecular parts and / or cells in a liquid (62) to target structures (12), said apparatus comprising at least one...
DE10203686A1 Method for carrying out electrical measurements on biological membrane bodies  
The present invention relates to a method for performing electrical measurements on biological membrane bodies located on a support. The required for the measurement electrically conductive access...
DE10202710A1 Method for detecting the biocompatibility of polymers  
Disclosed is a method for detecting the biocompatibility of polymers, according to which the apoptosis rate and mitogenicity of cells are measured in the presence of the polymers.
DE10202416A1 Spectroscopic examination of human or animal cell substructures using optical fiber, suffuses tissues with blood and illuminates in near infra red  
Spectroscopic examination of human or animal cell substructures using optical fibre, is new. The tissue to be investigated, is suffused with blood. This ensures presence of hemoglobin in the cells...
DE10200541A1 Microtiter plate, for use in fluorescence analysis of cell samples, has cylindrical wells whose walls are at angle to its base  
Microtiter plate comprises cylindrical wells (2) whose walls (9) are at an angle to its base (4).
DE10200549A1 Sorting and counting of biological particles, comprises marking with paramagnetic or dielectric nanoparticles, to be passed a sensor which registers field changes to give signals which can be counted electronically  
Sorting and counting biological particles, where the non-agglutinate particles are marked with paramagnetic or dielectric nano particles of 5-500 nm. The marking is through bi-functional...
DE10162814A1 Reconstructed hair follicle model  
Described is a skin / hair equivalent, in particular a hair model with reconstructed papillae (pseudo-papillae, PP) in a reconstructed dermis (pseudo-dermis, PD) and its preparation and its use,...
DE10164556A1 Test system for the search or testing of active substances that influence the growth and / or survival of nerve cells  
The invention relates to a test system for identifying or testing active substances, which affect the growth and the survival of nerve cells. According to said system, a cell is brought into...
DE10163986A1 In vitro selection of specific binding agents, useful potentially as pharmaceuticals and diagnostic agents, discriminates again non-specific, high-affinity agents  
In vitro method for selecting agents (A), present in a library of molecules, that bind to a target molecule (TM). In vitro method for selecting agents (A), present in a library of molecules, that...
DE10163640A1 Detection of interactions between at least two specific biomolecules  
Disclosed is a method for detecting interaction between at least two specific biomolecules, whereby biomolecules fixed in cells are immobilized in an electric field and then incubated with a...
DE10161412A1 Method for determining the activity of ornithine decarboxylase and for identifying effectors of ornithine decarboxylase activity  
The present invention relates to a method for the determination of the activity of ornithine decarboxylase and for the identification of effectors of ornithine decarboxylase activity, the...
DE10157475A1 Method and means for influencing intercellular communication and intercellular organelle transport  
The invention relates to a method for the investigation of intercellular communication and intercellular transport, wherein cells in culture after singulation are examined for intercellular...
DE10158517A1 Method for analyzing translation-controlled gene expression  
The invention relates to a method for analyzing gene expression, enabling a reliable correlation of the amount of mRNA transcribed by the gene to be examined, taking into account the translation...
DE10155518A1 Detection of apoptosis induction, useful for testing cytostatic agents, comprises staining cells with a fluorochrome compound and measuring the cells by flow cytometry while stimulating the fluorochrome compound  
Detection of apoptosis induction, comprising: (a) fixing cells to be studied; (b) permeabilizing the outer membrane to maintain organelle structure; (c) staining cells with a fluorochrome...
DE10155185A1 Method for the characterization and / or identification of mechanisms of action of antimicrobial test substances  
The invention relates to a method for the characterisation and/or identification of active mechanisms of antibacterial test substances, by means of IR (infrared) analyses, FT-IR (Fourier Transform...
DE10152598A1 ARL-2 for fertility control  
It describes a human ARL-2 protein and its use for fertility disorders, therapy and diagnosis.
DE10154399A1 Method for identifying active substances for the modulation of pip92-mediated apoptosis  
The invention concerns methods for identifying active substances involved in the signal cascade of protein pip92-mediated apoptosis, and methods which can be used to identify proteins interacting...
DE10152376A1 New substrates for phospholipase, useful e.g. for diagnosis and drug screening, contain two fluorophores that make a fluorescent energy-transfer pair  
Phospholipase substrates (I) containing two fluorophores are new. Phospholipase substrates of formula (I) are new. A = 1-20C alkylene or alkenylene; B = NH, NHCO, CONH, NHCONH, NHCSNH, oxygen or...
DE10151511A1 ee3 protein family and underlying DNA sequences  
The invention relates to (i) DNA sequences, (ii) expression vectors, comprising said DNA sequences, (iv) host cells, comprising said expression vectors, (v) genetic products, coded by said...
DE10150677A1 New nucleic acid encoding fungal mitogen-activated protein kinase, useful as target for identifying fungicides for plant protection, is from Fusarium graminearum  
Nucleic acid sequence, encoding a MAP kinase, (I) comprises (a) sequences (S1) or (S2), of 556 and 490 nucleotides, reproduced; (b) a functional equivalent of (a); (c) a fragment of (a); or (d) a...
DE10139874A1 Human Mater proteins  
Two human MATER proteins and their use for fertility disorders, therapy and diagnosis are described.
DE10150971A1 Measuring the receptor capacity of cells, useful in a drug screening system for drugs that treat central nervous system disorders, comprises measuring the change in charging current upon stimulation of receptors by their agonists  
Measuring the receptor capacity of whole transfixed cells, comprising using a capacitative assembly comprising: (a) a silicon wafer, with gold deposition and a coating of octadecylmercaptane, as a...
DE10150060A1 Measuring system for the measurement of physiological and/or metabolic parameters in biological cells, comprises measuring the electrical activity through sensors sensitive to a magnetic field without interference  
Measuring system to measure or study physiological and/or metabolic parameters in biological cells, or cell components, by measuring their electrical activity, using at least one sensor which is...
DE10147638A1 Module for suppressing leukocyte activity, useful e.g. in association with heart-lung machines, comprises a carrier linked to a ligand specific for the leukocyte receptor  
Module (A) for suppressing the activity of leukocytes, comprising: (a) a carrier; and (b) a ligand bound to the carrier that can interact with a receptor on leukocytes, is new.
DE10147020A1 New telomerase-immortalized cell line, useful e.g. for examining the effects of xenobiotics, is produced by transfection of human endometrial cells  
New telomerase-immortalized cell line (A), produced from a human endometrial cell, isolated from uterine tissue in the proliferation phase of the cycle, and transfected with the eukaryotic...
DE10147975A1 Testing the functional differentiation capacity of cells, useful for checking suitability of vascular transplants, comprises determining hydraulic conductivity and profibrinolytic properties  
Testing the functional differentiation capacity of cells, which in the course of biotechnological applications become established on organic or plastic, porous, or hollow organs, is new. Testing...
DE10143757A1 In situ determination of tissue characteristics, useful e.g. for diagnosis of tumors, by using specific detection agents that are transiently labeled  
In situ determination (M) of at least two coincident biochemical, genotypical and/or phenotypical characteristics in a tissue and/or extracellular matrix, comprising using at least two detection...
DE20202129U1 Test kit for diagnosing neuroimmunological health disorders comprises at least one harmful substance at subtoxic concentration, a lymphocyte incubation device and a unit for detecting (pro)inflammatory and regulatory cytokines  
Test kit for diagnosing neuroimmunological health disorders comprises at least one harmful substance at subtoxic concentration, an incubation device for lymphocytes or lymphoid cells, and a unit...