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DE10309349A1 Apparatus for the analysis of an analyte such as a foodstuff, feces, water or fermenter sample, comprises a semiconductor chip carrier with immobilized receptors specific for particular ligands, and a pH sensor  
An analytical apparatus comprising a semiconductor chip with receptors for specific ligands which may be present in the sample, and further comprising at least one pH sensor, is new. An apparatus...
DE10313098A1 Test system for finding active ingredients against prion induced diseases and drugs for the prevention and treatment of this disease  
The Invention relates to a test system for the discovery of active substances, which the inhibition of axon growth by infectious prions cancel, with the following components: a) a culture held in...
DE10312846A1 Test system for identifying substances FLOW The neurite outgrowth  
The invention relates to a method for the search or testing of active substances which affect the growth and survival of nerve cells, wherein a cell is contacted with at least one substance and...
DE10311769A1 Test methods for determining the intracellular concentration of cyclic nucleotides  
The invention describes a method for the quantitative optical analysis of the intracellular concentration of the cyclic nucleotides cGMP and cAMP. Here, find cell lines using recombinantly a...
DE10311563A1 Replication assay for the detection of antiviral substances with HTS methods  
The present invention relates to an HTS-test procedures on the basis of the Hepatitis C Virus (HCV) virus analog of bovine viral diarrhea (BVDV) in an in vitro test with infectious BVDV...
DE10311984A1 Using neutral endopeptidase-associated molecules for treatment, diagnosis, prophylaxis and monitoring of eating and metabolic disorders and dementia, also for drug development  
Use of NEP (= neutral endopeptidase)-associated molecules (I) to prepare a composition for diagnosis, prophylaxis, (secondary) treatment, and/or monitoring of non-immunological, non-hypertensive...
DE10310758A1 Identifying compounds that modulate sensory neuron specific receptors, useful for treating pain, also nucleic acid encoding the receptors, related proteins and their modulators  
Identifying substances (A) that modulate the extra- and/or intra-cellular functions of receptors of the SNSR (sensory neuron specific receptor) family, especially the SNSR-L2 and -L3 receptors of...
DE10307390A1 For the cellular testing of a number of substances, e.g. molecular bonds with DNA and proteins and peptides, spots are placed in micro-arrays without physical separation for biological assay  
For testing a number of substances, in cellular tests, they are deposited on to flat surfaces (1) as spots (2) with a covalent attachment to the surfaces. The spots have a diameter of 100-500...
DE10026789B4 Cartilage replacement and process for its preparation  
Method for propagating differentiated cartilage cells, the differentiated cartilage cells while preserving their differentiation embedded in a three-dimensional, gel-like biomatrix containing 1.5...
DE10306616A1 Kit for detection of microorganisms on skin, useful e.g. for diagnosis of infection, comprises specific oligonucleotides for in situ hybridization  
Kit for detecting microorganisms (A) contains at least one oligonucleotide (ON) specific for at least one species, or group of species, that is present on the skin. An independent claim is also...
DE10303973A1 A method for detection of fertility enhancing or contraceptive agents  
The present invention relates to a method for the detection of changes of cellular messengers in sperms in a stopped-flow measurement apparatus or detecting the motility or the change in swimming...
DE19920811B4 A device to carry out investigations on cell cultures  
Apparatus for carrying out investigations on cell cultures that are in a liquid culture medium, the apparatus comprising at least one receptacle for the culture medium and the cell culture and...
DE10302405A1 Detecting effect of substances on beta-cell function and mass, for identifying agents for treating late stages of diabetes type II, comprises immunoblotting and mitogen-activated protein kinase and pull-down assays  
Method for detecting the effect of substances on the function and mass of insulin-producing beta cells (A). Method for detecting the effect of substances on the function and mass of...
DE10260927A1 Method for determining the enzymatic status of human skin in vitro  
The present invention relates to a method for determining the enzymatic status of human skin in vitro, test kits for determining the enzymatic status of human skin as well as the use of enzymes to...
DE10261834A1 High throughput screening suitable method of identifying agents  
The present invention relates to a high-throughput screening suitable method for the identification of active agents.
DE10260929A1 A method of controlling based on microbial interaction  
The present invention relates to a novel method for controlling processes based on microbial interaction processes using certain receptor molecules, receptor molecules, as well as uses of this...
DE10260891A1 Screening method for identifying active substances against halitosis, gingivitis or periodontitis  
The present invention relates to a screening method for identifying active substances against halitosis, gingivitis or periodontitis, test kits for detecting active substances against halitosis,...
DE10195824T5 A method for determining the ability of the reaction, the reaction of the lymphocytes in the blood to specific antigen  
A method for determining the ability of the reaction of the lymphocytes in the blood to a specific antigen, comprising the steps of: the T-lymphocyte is in the peripheral blood of the recipient...
DE10053521B4 Method for the detection of apoptotic and necrotic cells  
A method for the detection of apoptotic and necrotic cells in a cell suspension me the steps of: a) contacting a cell suspension of the extracted first sample with a lectin which is capable of...
DE10260264A1 Screening for agents that inhibit or promote cell proliferation or have antiinflammatory activity, useful e.g. for treating tumors, based on activation or inhibition of the promoter of the guanylate-binding protein-1 gene  
Identifying agents (I) with proliferation-inhibiting, antiangiogenic, antiinflammatory and/or invasion-inhibiting activity, is new. Method for identifying agents (I) with proliferation-inhibiting,...
DE10014685B4 A method for identifying cell-specific target structures  
A method for identifying cell-specific target structures comprising the steps of a) automated application of a reagent solution Y1 having at least one marker molecule, to an object X1, the cells...
DE10257102A1 Preparing high purity cell types from stem cells, useful in drug screening and as transplantation material, by differentiation in an actively aerated bioreactor  
Preparing high purity cell types (A) from stem cells (SC) comprises differentiation in an actively aerated bioreactor. Independent claims are also included for the following: (1) preparing...
DE10256669A1 Mixture of at least two fusion proteins as well as their preparation and use  
The present invention relates to a protein mixture containing at least a first fusion protein comprising a protein or protein fragment, an interaction domain and a protein translocation sequence...
DE10256042A1 A process for the selection of cells that produce the specific binding molecules  
The present invention relates to a method for the selection of cells expressing specific binding molecules. The method can be applied to all cells, which are able to express specifically binding...
DE10320633A1 A method of identifying a possible modification of at least one biological parameter using living cells that were exposed to a stimulus, and living cells that were not exposed to this stimulus  
An object of the present invention is a method for identifying a possible modification of at least one biological parameter. The present invention relates generally to a method for identifying a...
DE10320602A1 A method for identifying a possible modification of at least one biological parameter using young and old living cells  
An object of the present invention is a method for identifying a possible modification of at least one biological parameter. The present invention relates generally to a method for identifying a...
DE10253526A1 Endothelial cells as a diagnostic tool in cardiovascular disease  
The invention relates to a method for immunocytochemical determination of apoptotic endothelial cells and / or endothelial progenitor cells in samples such as. For example, from peripheral blood,...
DE10147638B4 Leukocyte inactivation module (LIM)  
Module for reducing the activity of a Leukocytenzelle which comprises a carrier and a ligand that is bound to the support and is suitable for interacting with a receptor of the Leukocytenzelle.
DE10251879A1 Medium for measuring effect of tumor therapy on individual cells, useful for selecting treatments, has low buffering capacity in which acidification caused by metabolism of carbon sources is monitored  
Medium (A) for measuring the effects of a tumor therapy on suspensions of individual cells comprises the essential amino acids, vitamins, salts and carbon sources and, the new features, contains...
DE10202887B4 Cell analysis method  
Cell analysis method in which - Individual cells (5) or a small number of cells (5) in a Zellösungstropfen (7) with the help of the pulse transfer of surface sound waves on the surface of a...
DE10054639B4 Using RanBPM as co-modulator of steroid hormone receptors  
The use of RanBPM in a screening method as a co-modulator for influencing steroid hormone receptors.
DE10246811A1 Determining the risk of developing breast cancer, by analyzing peripheral blood lymphocytes, treated with mitogens, for the rate of micronuclei formation in binuclear cells  
Determining the risk of developing breast cancer based on spontaneous development of micronuclei in mitogen-treated lymphocyte cultures, is new. Method for determining the risk of developing...
DE10136702B4 System for cell- and development-specific selection of differentiating embryonic stem cells, adult stem cells and embryonic germ cells  
Embryonic stem cells, embryonic germ-line cells and/or adult stem cells (A) that contain at least one each of reporter gene (RG1) and resistance gene (RG2) under control of the same promoter and...
DE19710287B4 Microbiological biosensor, procedures for its preparation and its use  
Microbiological biosensor for the determination of heavy metal ions and substrates comprising a physical transducer and a yeast transformant of a strain of the species Saccharomyces cerevisiae,...
DE10242663A1 Identifying inhibitors of metastasis or lymphangiogenesis, useful for treating cancer, by in vivo testing for inhibiting the activation of vascular endothelial growth factor receptor-3  
Identifying in vivo inhibitors (I) that slow down and/or inhibit formation of metastases and/or lymphangiogenesis, by selecting agents for their effect on specific activation of the...
DE10240118A1 Characterizing and identifying proteins specific for renal cell carcinoma, useful for diagnosis, prognosis, prevention and treatment, comprises comparing proteome patterns of healthy and diseased tissue  
Characterizing and/or identifying proteins (I), specific for renal cell carcinoma (RCC) comprises preparing two extracts (E1, E2) containing soluble proteins, with E1 being from RCC, separating...
DE10130155B3 Reporter gene construct for the detection of HIV-Rev-Tat and HIV  
The present invention relates to a reporter gene construct for the detection of the HIV rev and HIV-Tat proteins. The invention further relates to a Functionality Test method for recombinantly...
DE10236101A1 Functional tests at test cells, e.g. pharmascreening, catch molecules are immobilized in an array of points to bond with reference particles and test cells for measurement  
To perform functional tests at test cells, an array is prepared on a carrier plate (10) of separate measurement points (11) where catch molecules (19,21,22) are immobilized to bond with the test...
DE10235967A1 Identifying compounds active against non-viral microbes, potentially useful as antibacterial agents, by incubation with eukaryotic cells and the microbe  
Method for discovering agents (I) that are active against non-viral microbes (A) comprises incubating together a test compound, eukaryotic cells and (A), then determining viability of the cells....
DE10251709C5 Screening method for agents to stimulate the human beta-defensins of type 2 and / or type 3  
Screening methods for agents that are capable of stimulating the direct or indirect expression of human β-defensins of type 2 and / or type 3 and not capable of stimulating or significant...
DE10251709B4 Screening method for agents to stimulate the human beta-defensins of type 2 and / or type 3  
The Invention relates to screening methods for drugs designed to stimulate the direct or indirect expression of human beta-defensins from Type 2 and / or human beta-defensins are capable of the...
DE10251709A1 Agents for stimulating the human beta-defensins of type 2 and / or type 3, and cosmetic or pharmaceutical compositions containing such active  
The invention relates to agents that are capable of stimulating the direct or indirect expression of human beta defensins of type 2 and / or human beta-defensins type. 3 The invention therefore...
DE10235310B4 A method for determining allergenic potency of products  
A method for the qualitative and / or quantitative determination of the allergenic potency of products by means of granulocytes and / or mast cells, according to the principle of fluorescence...
DE10235310A1 Determining the allergenic potency of products, useful e.g. for diagnosis, comprises measuring changes in intracellular calcium of isolated granulocytes or mast cells  
Method for qualitative or quantitative determination of the allergenic potency of products (A), using granulocytes and/or mast cells, based on the principal of fluorescence ratio imaging (FRI)....
DE10233516A1 Cellular method for identifying modulators of target molecules, useful in screening for pharmaceuticals, from effects of test compounds on both cell growth and reporter expression  
A cellular method for identifying compounds (I) that can modify the activity of a target molecule (II) which affects cell replication, is new. At least one cell, containing a reporter gene (RG) is...
DE10112515B4 A method for detecting cytosine methylation patterns with high sensitivity  
A method for detecting Cytasin methylation in DNA samples, characterized in that one performs the steps of: treating a genomic DNA sample, which comprises to be examined DNA and sequence homology...
DE19964268B4 A method for screening a compound which inhibits the interaction between IGF-1R and IIP-one of the polypeptides 1 to IIP-10  
A method for screening a compound that enhances the interaction between IGF-1R and one of the polypeptides selected from the group consisting of IIP-1 (SEQ ID NO: 2), IIP-5 (Zfp 38), IIP-6 (SEQ ID...
DE10227001A1 A method for identifying fungicidally active compounds  
The invention relates to a method for identifying fungicides, the use of a phosphomannomutase for identifying fungicides, and the use of inhibitors of phosphomannomutase as fungicides.
DE10226675A1 A method for testing the hormonal effect of substances  
There is provided a method for testing the hormonal effect, especially the androgenic or antiandrogenic effect, described by substances, wherein a) cells transfected with two vectors, where a...
DE10226674A1 A method for testing the hormonal effect of substances  
There is provided a method for testing the hormonal effect, especially the androgenic or antiandrogenic effect, described by substances, wherein a) cells transfected with two vectors, where a...