Matches 1 - 26 out of 26


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DE102007002386A1 Pharmaceutically active compounds  
The present invention relates to pharmaceutically active compounds from an isoflavone or isoflavone glycoside and covalently with this connected, an amino acid, a peptide or peptide derivative...
DE10306452A1 New peptides containing tyrosine sulfate, phosphate or sulfonate derivatives, useful against unwanted skin and hair pigmentation and for lightening hair color  
Peptides (I) containing tyrosine sulfate, phosphate or sulfonate derivatives are new. Peptides of formula (I) and their salts are new: XO-Ar-CH2-CH(NR'R)-CO-Y (I) Ar : o-, m- or p-phenylene; X :...
DE10234415A1 Isotope-encoded affinity tags 3  
The invention concerns isotopically coded affinity markers (ICAT) for mass spectrometric analysis of proteins, and the preparation and use of said markers.
DE10102878A1 Oligo- or Polyalkylengekoppelte thrombin  
The invention relates to novel, covalent oligo and polyalkylene glycol conjugates containing synthetic inhibitors of trypsin-type serine protease, in particular inhibitors of the haemocoagulation...
DE10054687A1 Inhibitors of transglutaminases  
The invention relates to a chemical compound of formula (I), wherein R<1> means formula (II), (III), (IV) or (V); R<2> means H, alkyl, which can optionally be substituted with halogen or N2, or...
DE10025379A1 Determination of NAALADase Inhibitors  
The present invention relates to a process for determining inhibitors of the enzyme N-acetyl-alpha-linked acidic dipeptidase (NAALADase), in which the enzymatic conversion of a radioactively...
DE10028402A1 New pyridinylamino-alkanoyl-glycyl-beta-alanine derivatives, are integrin inhibitors useful for treating, e.g. thrombosis, cardiac infarction, coronary heart disease, inflammation, tumors, osteoporosis or restenosis  
3-(2-(w-(Pyridinylamino)-alkanoylamino)-ethanoylamino)-3-(he terocyclyl -phenyl)-propionic acid derivatives (I) are new. 3-(2-(omega-(Pyridinylamino)-alkanoylamino)-ethanoylamino)-3 -(heterocy...
DE19940130A1 New effectors of dipeptidyl peptidase IV for topical use  
The invention relates to compounds of general formula (I), wherein A represents an amino acid with at least one functional group in the side chain; while B is a chemical compound covalently bound...
DE19939910A1 New compounds that inhibit tryptase activity  
The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of tryptase...
DE19816915A1 New dipeptide derivatives useful as neuropeptide Y agonists and/or antagonists for treating cardiovascular disorders, coronary, cerebral or renal vasospasms, obesity, bulimia and asthma  
N-Carbamylacyl dipeptide derivatives (I) are new: Peptide derivatives of formula (I) and their salts are new: R<1> = a group of formula (i): n = 1-6, preferably 1-4; Ar = phenyl (optionally mono-...
DE19816903A1 New dipeptide derivatives useful as neuropeptide Y agonists and/or antagonists for treating cardiovascular disorders, coronary, cerebral or renal vasospasms, obesity, bulimia and asthma  
N-(homo)piperazinylcarbonylacyl dipeptide derivatives (I) are new. Dipeptide derivatives of formula (I) and their salts are new: R<3> = a group of formula (i) or (ii): n = 2 or 3; Q, U = CH2, CO...
DE19815812A1 New camptothecin derivatives useful as cytostatic agents for treating cancer  
Camptothecin amino acid or peptide esters (I) are new. Compounds of formula (I) and their salts are new: A = 2-9C alkanoyl optionally substituted by halogen, OH, 1-8C alkoxy, amino, carbonyl...
DE19813137A1 New camptothecin glyco-conjugate compounds  
Camptothecin (CT) glyco-conjugates of formula (I), containing a 3-O-methylated beta -L-fucose residue bonded to the 20-hydroxy group via a thiourea-modified peptide spacer, and their salts,...
DE19801037A1 New camptothecin glyco-conjugate compounds  
Camptothecin (CT) glyco-conjugates of formula (I), containing a 3-O-methylated beta -L-fucose residue bonded to the 20-hydroxy group via a thiourea-modified peptide spacer, and their salts,...
DE19640970A1 Modified cytostatics  
The invention concerns conjugates of cytostatic agents and N-thiocarbonyl-modified amino acids and peptides. The invention further concerns processes for their preparation and their use as...
DE19632948A1 New antiviral effective oxime and nitro-substituted pseudopeptides  
The invention concerns oxime- and nitron-substituted pseudopeptides with an anti-viral action and having general formula (I) in which the substituents are as defined in the description. The...
DE19605772A1 New antiviral formyl-substituted pseudopeptides  
The invention concerns formyl-substituted pseudopeptides with an anti-viral action and having general formula (I) in which the substituents are as defined in the description. The invention also...
DE19605769A1 New antiviral effective pseudopeptides with Mercaptal- or thioether  
The invention concerns pseudopeptides with an anti-viral action, the pseudopeptides containing a mercaptal or thioether group and having general formula (I) in which the substituents are as...
DE19512484A1 Carbohydrate-modified cytostatics  
The invention relates to cytostatics which are made tumour-specific by modification with sugar. Suitable spacers ensure serum-stability and intracellular effect at the same time.
DE19509729A1 17-difluoromethylene Estratrienes  
The invention concerns novel 17-difluoromethylene-oestratrienes of general formula (I), in which: R<1> is a hydrogen atom or a C1-C10 alkyl group; R<5> is a methyl or ethyl group; R<2> is a...
DE19505933A1 amides method for producing L-aspartyl-D-alanine-N- (thietane-3-yl)  
The invention concerns a method of producing L-aspartyl-D-alanine-N-(thiethane-3-yl)-amides of general formula (I) by reacting D-alanine-thiethane amides of general formula (II) with oxazolidinone...
DE19504504A1 New orally active thrombin inhibiting peptide cpds.  
Novel thrombin inhibitors consist of N-terminal sulphonylated peptidic p-amidino-benzamide cpds. of formula (I): R1-SO2-A-B-NH-D-C(=NH)(NH2) (I) and their stereoisomers and acid addn. salts. The...
DE4443390A1 New dipeptide p-Amidinobenzylamide with N-terminal sulfonyl or Aminosulfonylresten  
The invention pertains to compounds of formula (I), wherein R<1>, A and B are as indicated in the description, and to their preparation. The new compounds can be used for combatting diseases.
DE4301452A1 New di:phenyl:acetyl-argininamide derivs.  
N2-(Diphenylacetyl)-N-((hetero)ar(alkyl)yl)-argininamide derivs. of formula (I) and their diastereomers, enantiomers and salts are new: n = 0-4; Ar1, Ar2 = phenyl (opt. substd. by 1 or 2 of F, Cl,...
DE4207254A1 4-OXO-2-THIOXOIMIDAZOLIDIN DERIVATIVES  
4-oxo-2-thioxoimidazolidine derivates have the general formula (I), in which R<1> to R<4> and Y have the definition given in the description. Also disclosed is a process for preparing these...
DE4030350A1 New retro:virus protease-inhibiting oligopeptide derivs. - for treatment of retro-viral infection e.g. AIDS  
Peptides of formula (I) and their salts are new, where Y = O, S, CHR5''R6'' or NR7, l = 0-1. A = D-(E)n-(F)o-(G)p-, A' = D'-(E')n'-(F')o'-(G')p'-, E,E',F,F',G,G' = natural or other amino acid,...

Matches 1 - 26 out of 26