Match Document Document Title
DE102018100619A1 Gentherapeutic treatment of deafness  
The present invention relates to a viral vector, in particular an adeno-associated virus (AAV) vector, and its use in the gene therapy of deafness, especially DFNB93 deafness.
DE102017216292A1 Biomarkers for determining the physical stress of humans and animals and methods for determining the physical stress as well as a kit for carrying out the procedure  
The invention relates to a biomarker for determining the physical physical stress on humans and animals, and to methods for determining physical exercise stress, and to a kit for carrying out the...
DE102017114737A1 New T cell receptors and their use in immunotherapy  
The present invention relates to antigen-recognizing constructs against tumor-associated antigens (TAA), in particular to serine protease inhibitor Kazal type 2 (SPINK2). In particular, the...
DE212017000061U1 Composition for detecting a single-stranded target RNA  
A composition for detecting a single-stranded target RNA in an acellular sample comprising a plurality of RNAs, comprising: (i) a C2c2-guideRNA that hybridizes to the single-stranded target RNA;...
DE212017000062U1 Use for detecting a single-stranded target RNA  
Use of: (i) a C2c2-guideRNA that hybridizes to a single-stranded target RNA; (ii) a labeled detection RNA; and (iii) a C2c2 protein, splits the RNA present in a sample, wherein the C2c2 protein...
DE212017000056U1 Kits for detecting a target RNA in a sample  
A kit for detecting a target RNA in a sample comprising a plurality of RNAs, the kit comprising: (a) a labeled detection RNA; and (b) a C2c2 protein and / or a nucleic acid encoding the C2c2...
DE112004002217B4 Protein-forming complex with a c-Jun protein, nucleic acid encoding the same, and methods using the same  
Use of a protein of the following (a) or (b): (a) a protein comprising any of the amino acid sequences of SEQ ID NOS: 95 to 99, SEQ ID NOS: 1 to 69, SEQ ID NOS: 70 to 87, SEQ ID NOS: SEQ ID NOS:...
DE19742706B4 lipocalin muteins  
Lipocalin mutein based on a polypeptide of the lipocalin family, in which amino acid positions in the range- of at least three of the four peptide loops, which are arranged at one end of...
DE102008049136B4 New regulators of the innate immune system  
Using a CFHR molecule, in particular a CFHR protein, or a functional fragment or functional derivative thereof for the treatment or prophylaxis of inflammatory reactions, wherein the CFHR protein...
DE102004010928B4 Protein for binding of prokaryotic DNA and process for the separation and enrichment of prokaryotic DNA  
A method for separating and / or enriching prokaryotic DNA comprising the steps of: a) contacting a is in solution undergoing prokaryotic DNA with a specific prokaryotic DNA-binding protein that...
DE10311106B4 Peptides to cold intolerance inducing autoantibodies, nucleic acids coding therefor, their use and pharmaceutical compositions comprising  
An isolated nucleic acid molecule selected from the group comprising: a) a nucleic acid molecule comprising, consisting of the following amino acid sequences of a nucleotide sequence coding for a...
DE10164805B4 Method and means for modification of human angiogenesis  
A method of transporting a nucleic acid molecule in eukaryotic cells, cell cultures or tissue, in particular cells and tissues of mammals, wherein human embryonic stem cells are excluded, and...
DE10004815B4 Human intestinal sodium phosphate cotransporter  
Npt2B polypeptide having an amino acid sequence which is identical to the sequence SEQ ID NO. 01 and sodium phosphate co-transporter having activity.
DE19932688B4 Design of beta-sheet proteins of the gamma-II-crystallin antibody-like  
Mutagenized gamma-II-crystallin protein with β-sheet structure, characterized by the following features: - An antibody-like binding property to a binding partner, - Amino acids, which are located...
DE10163130B4 Apoptotic active peptides and pharmaceutical compositions comprising  
apoptotic selected active peptide from the group consisting of: and their pharmaceutically acceptable salts thereof.
DE10138876B4 Genetically modified cyclic nucleotide-gated ion channels, and their use  
Genetically modified cyclic nucleotide-gated ion channels (CNG channels) from Subunits, which at the position corresponding to the threonine T537 in the α3 subunit complies with cattle, so changes...
DE10101430B4 Soluble cyclic analogues for modulating the amyloidogenesis  
peptide having the biological activity of a Modulator of amyloidogenesis with an amino acid sequence selected from the group of sequences consisting of SEQ ID NO. 2 to SEQ ID NO. 19, wherein the...
DE112004002217T5 the same protein complex formation with a c-Jun protein, nucleic acid encoding the same and methods using  
inhibitor for a Interaction between a protein with a c-Jun protein interacts and the c-Jun protein, a protein of the following (A) or (b) as an active ingredient comprises: (a) a protein...
DE19955576B4 Transfer compounds, their preparation and their use  
use a carboxy-terminal fragment of the Ki-67 Proteines or active homolog thereof as a transfer protein for the transfer suitable in cells and uptake by, and release from cells is.
DE10109466B4 Method and means for modification of human angiogenesis  
process to induce angiogenic processes in tissues of a mammalian organism, comprising the steps of: - Preparation of a ternary complex by complexing a nucleic acid molecule as a functional...
DE60219221T2 DNA sequences having anti-repressor activity  
The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory...
DE3890998B4 Neutrophilenaktivierungsfaktor, process for its preparation and pharmaceutical composition containing it  
Neutrophilenaktivierungsfaktor (NAF) which is derived from human monocytes and the following amino acid sequence comprising:...
DE19882435B4 Methods of inhibiting cancer cell growth with a pRb2 / p130 expressing vector  
process for inhibiting the growth of tumor cells comprising transfecting the tumor cells with a vector expressing pRb2 / p130, wherein the tumor cells pRb2 / p130-negative cells or cells include,...
DE60124710T2 ANALOG OF SIMILAR GLUCAGON PEPTIDE 1  
Disclosed are glucagon-like peptide-1 (GLP-1) compounds with modifications at one or more of the following positions: 11, 12, 16, 22, 23, 24, 25, 27, 30, 33, 34, 35, 36, or 37. Methods of treating...
DE60215502T2 A method of selecting a transcription-Modulatierenden DNA sequence using a vector with a transcriptional repression active element  
The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory...
DE102004004924B4 A141S and G399S mutation in the Omi / HtrA2 protein in Parkinson's disease  
Nucleic acid molecule encoding for a human Omi / HtrA2 protein the at amino acid position 141 and / or 399 over a the wild-type genetic modification indicated and for corresponding portions...
DE19958198B4 The IGF-1 receptor interacting proteins (IIPs)  
Nucleic acid, thereby in that they for a binding to the IGF-I receptor protein encoded selected from the group: (A) in SEQ ID NO: 5 nucleic acid sequence shown, (B) Nucleic acid sequences, which...
DE19960225B4 Crystalline, in the asymmetric unit at least one involved in catalysis (Sub) -Domaine a human m-calpain polypeptide having, methods for identifying compounds under its use, method of crystallization and method for displaying a 3-dimensional structure of this peptide  
Krystallines Polypeptide, characterized in that the one involved in catalysis Calpain subdomain IIa (sequence section T93 to G209) and / or IIb (sequence section G210 to N342) of at least one...
DE60210297T2 USE OF LONG pentraxin PTX3 FOR TREATING infertility in WOMEN  
The PTX3 gene or equivalent PTX3 activity is required for female fertility. Manipulation of PTX3 activity will regulate female fertility. The effects of female sterility may be ameliorated,...
DE10306085B4 New splice variant of a protein kinase A-anchoring protein, and use of these  
AKAP-coding Nucleic acid molecule the nucleotide sequence SEQ ID No. 1 and all homologues having at least 83%, to the nucleic acid molecule the nucleotide sequence SEQ ID No. are functionally...
DE10328775B4 In vivo test system for the detection of HIV protease activity  
proteinaceous Composition (A) a first fusion protein comprising an interaction domain A fluorophore and a B and (B) a second fusion protein, comprising an interaction domain A 'and a fluorophore...
DE10061110B4 Expression of keratin genes 8 and 18 for the treatment of tumors, especially breast cancer  
medium for gene therapy treatment HER2-expressing solid tumors with simultaneous Inhibition and reduction of tumor metastasis containing K8-specific Nucleic acid (HGNC-id 6446; NCBI Accession...
DE10161899B4 Fusion proteins against Hodgkin's disease  
Fusion proteins characterized in that it a least a specific ligand antigen presenting Cell (APC) selected cytotoxic from CD 153, TNF or its region and at least one domain selected from GTPase, GTP...
DE10161738B4 Fusion proteins to T-cell tumors  
Fusion proteins characterized in that it comprises at least a first component selected from CD 58, CD 72, CD 29, collagen, or laminin, and at least one selected second component from GTPase, GTP...
DE102005014687A1 A composition comprising beta-defensin 2  
object of the present invention are compositions containing β-defensin 2 and / or its derivatives, especially human β-defensin 2. The compositions are selected in particular for cosmetic and / or...
DE19917195B4 Peptide to induce an immune response against tumor cells containing this pharmzeutische compositions, uses thereof, nucleic acid coding therefor and these nucleic acid expression vector containing  
Peptide, characterized in that it comprises the sequence according to SEQ ID No .: 1: Ser Thr Ala Pro Pro Val His Asn Val has.
DE60115613T2 PRODUCTION OF RECOMBINANT muteins OF COAGULATION FACTOR VIII IN HUMAN CELL LINES  
The present invention relates to an improved method for the production of recombinant human blood clotting factors, in particular of factor VIII and factor IX. An immortalized human cell line can...
DE19941897B4 IL-6 receptor protein beta-chain (gp130) of the IL-6 receptor protein-encoding DNA for these proteins, derived RNA, peptide with the amino acids 771-811 of the beta-chain or parts thereof and their uses  
IL-6 Receptor protein in the beta chain deletion the range of the amino acids 771-811 or comprising portions of this range, so that the specific Binding of Hck tyrosine kinase is inhibited to gp130.
DE10347710B4 Recombinant vaccines and their use  
Fusion molecule, the Antigen, a transmembrane region and the cytoplasmic region a chain of an MHC molecule includes.
DE102004043782A1 Polypeptides and methods for the specific binding of prions  
The Invention relates to polypeptides with at least one sequence motif, the specific pathological to the isoform of a prion protein bind, and the uses thereof and a process for specific binding...
DE20023745U1 Method of modulating expression of an endogenous cellular gene in a cell to prevent gene activation or prevent repression of gene expression comprising contacting a target sequence with a zinc finger protein  
Modulating expression of an endogenous cellular gene in a cell comprises contacting a first target site in the endogenous cellular gene with a first zinc finger protein (ZFP). ACTIVITY :...
DE10247755B4 Selective, local activation of members of the TNF receptor family by systemically inactive non-antibody TNF ligand fusion proteins  
polypeptide comprising a portion (1), which contains a cell surface molecule binding domain, a Section (2), which is a peptide linker, and a portion (3), of a per se biologically inactive / active...
DE10226674B4 A method for testing the hormonal effect of substances  
process for testing the hormonal effect of substances, in which a) Cells transfected with two vectors, wherein the one Vector DNA for the androgen receptor or a fragment thereof, and the other...
DE102004026135A1 An MHC molecules binding tumor associated peptides  
The Invention relates to a tumor-associated peptide with an amino acid sequence the selected is selected from the group consisting of SEQ ID NO. 1 to SEQ ID NO. 577 of the attached sequence...
DE102004025805A1 Cosmetic compound for incorporation in pharmaceutical products for treatment of e.g. human skin, hair and nails  
A cosmetic compound for the treatment of materials incorporating keratin incorporates a polypeptide sequence (i) in a cosmetic-compatible medium. The polypeptide sequence (i) has a binding...
DE102004024617A1 Differentially expressed in tumors gene products and their use  
According to the invention were Tumor-associated gene products expressed and coding the for nucleic acids identified. The present invention relates to the therapy and Diagnosis of diseases in...
DE10347710A1 Recombinant vaccines and their use  
The This invention relates to fusion molecules of antigens, the nucleic acids coding therefor, and the use of such fusion molecules and nucleic acids. Especially the invention relates to fusion...
DE102004018608A1 Double transfected cell lines as in vitro screening tools for creating profiles of pharmaceutical compounds: A model for hepatobiliary elimination  
The present invention relates to several double-transfected cell lines the human NTCP (Na / taurocholate cotransporting protein; SLC10A1) together with human BSEP (Bile Salt Export Pump; ABCB11)...
DE102004018418A1 Diagnosis of inflammatory bowel diseases, particularly ulcerative colitis  
The present invention relates to goblet cell antigen, a method for detection of antibodies against goblet cell antigen, based thereon method for diagnosis inflammatory Intestinal diseases and a...
DE19964269B4 A process for the detection of the proliferation potential of cells  
process for the detection of the proliferation potential of a cancer cell, comprising: (A) Incubating a sample selected from a body fluid one suffering from cancer patients, tumor cells, cell...