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DE102018004759A1 Diagnosis of a neuroautoimmune disease  
The present invention relates to a method for diagnosing a disease, comprising the step of detecting an antibody that binds to a polypeptide selected from the group comprising NSF, STX1B and VAMP2...
DE102009033281B4 Method for the detection of autoantibodies in paraneoplastic neurological syndromes  
Polypeptide, characterized in that it comprises the amino acid sequences according to SEQ ID NO: 5, 6 and 7, but not the amino acid sequence according to SEQ ID NO: 1.
DE102011008153B4 Process for the preparation of a monoclonal antibody against oligomeric alpha-synuclein  
A method for producing a monoclonal antibody against pathological oligomeric alpha-synuclein by Immunization of mice or in vitro cell cultures with the peptide TKEGWHGVATVAE of the...
DE102016108017A1 Loaded protein containers for the construction of nanostructured materials  
The invention relates to an arrangement of protein containers having positive and / or negative total charge of the outer surface, wherein the protein containers are formed from ferritin...
DE112004002217B4 Protein-forming complex with a c-Jun protein, nucleic acid encoding the same, and methods using the same  
Use of a protein of the following (a) or (b): (a) a protein comprising any of the amino acid sequences of SEQ ID NOS: 95 to 99, SEQ ID NOS: 1 to 69, SEQ ID NOS: 70 to 87, SEQ ID NOS: SEQ ID NOS:...
DE102013202206B4 Method for inhibiting protein SWAP-70  
A method of identifying a substance which inhibits the activity of SWAP-70, the method comprising: (i) contacting: (a) a test substance with (b) SWAP- 70, (ii) detecting the degree of dimerization...
DE102005029845B4 Verfahren zur Diagnose von rheumatischen Erkrankungen  
Polypeptid abgeleitet von nativem Vimentin mit der SEQ ID No. 1, dadurch gekennzeichnet, dass es gegenüber der nativen Sequenz in mindestens einer der Positionen 16, 17, 19, 41, 58, 59, 60, 68,...
DE102015108523A1 Peptid-Biomarker für Krebs  
Die vorliegende Erfindung betrifft Biomarker-Peptide zur Verwendung in der Diagnose, Prognose, und/oder Prädiktion von Tumoren, sowie Verfahren zur Identifizierung/Quantifizierung von gegen die...
DE102007000564B4 Process for coating carriers with collagen fibrillar matrices  
A method for coating carriers with collagen fibrillary matrices of defined structure and morphology from flowing solutions, wherein the collagen solution is moved through a microchannel, the...
DE102014222898A1 Preparation and isolation of a native human dermal extracellular matrix  
The present invention relates to functionalized extracellular matrices composites of functionalized extracellular matrices and carriers, processes for their preparation and uses thereof.
DE102010033575B4 ASPP2 splice variant  
Method for the in vitro determination of the presence or a predisposition of a patient for the development of cancer, characterized in that in a biological sample from the patient the presence of...
DE102009036995B4 Collagen-based matrix for use as a restorative material and method for producing the same  
A method for preparing a collagen-based matrix which comprises: - To form a 0.05-1 mm thick uniform membrane, followed by lyophilization at -60 to as a first step applying the atelocollagen...
DE102013202206A1 Method for inhibiting the protein SWAP 70  
The invention relates to the field of biomedical and pharmacological research, especially in the field of immunology, allergy, cancer, bone diseases and autoimmune diseases. The invention is based...
DE102010039019B4 Antibodies against 6-sulfo LacNAc positive human dendritic cells and their use  
Composition comprising a) at least one anti-SLAN antibody which specifically binds to human dendritic cells, the surface of the P selectin glycoprotein ligand 1 (PSGL-1) with the O-linked glycan...
DE102005051789B4 The botulinum neurotoxin A receptor protein and its applications  
Polypeptide consisting of an amino acid sequence that is identical to at least 70% with the amino acid sequence of the synaptic vesicle glycoprotein 2C of Homo sapiens, wherein the polypeptide...
DE102010025935B4 collagen  
From an individual of the species Rhopilema derived collagen with a ratio of proline to hydroxyproline of at least 1.9: 1 and a glycosylation measured by the ratio of Dissacchariden to...
DE102012022013A1 Peptides that bind to amino-terminally truncated amyloid-beta-peptide and their use  
The invention relates to peptides which bind to amino-terminally truncated pEAβ3-42, present its exposed glutamic acid residue at position 3 or 11 in cyclized Pyroglutamatform. Four oligopeptides...
DE102012108598A1 New, of D3 derived D-enantiomeric peptides and their use  
The present invention relates to novel D-enantiomeric A-beta Oligomerbindende peptides, homologs, fragments, parts, and polymers thereof and to their use.
DE102012108599A1 New peptide containing amino acid sequences and their homologues and polymers and their homologues, useful to inhibit fibril formation of amyloid-beta peptides and to bind aggregated amyloid beta peptides to treat Alzheimers disease  
Peptide containing at least one amino acid sequence consisting of SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3 and its homologues, fragments and parts and polymers having SEQ ID NO: 1, SEQ ID NO: 2...
DE102006059574B4 Methods and reagents for specific detection of autoantibodies in patients with autoimmune blistering skin diseases  
Polypeptides which react specifically with autoantibodies to BP180, characterized in that they contain more than one polypeptide of SEQ ID NO 1 or more than a polypeptide of a part-sequence of at...
DE102012105416A1 Modifying glycosylation profile of a glycosylation site contained in a target peptide, comprises recombinantly producing a fusion protein made of a mint protein and the target peptide, which contains predetermined glycosylation site  
Modifying glycosylation profile of a glycosylation site contained in a target peptide, comprises recombinantly producing a fusion protein made of a mint protein and the target peptide, which...
DE102008033381B4 Modulation of the immune response by the receptor NKp65 and its ligands  
Use of a substance for blocking the NKp65 receptor complex for the manufacture of a medicament for the treatment and / or prevention of inflammatory and autoimmune diseases, in particular of the...
DE102012102998B4 New polymer comprising two substances that bind to amyloid-beta-oligomers, useful for treating Alzheimer's disease, Parkinson's disease, Creutzfeldt Jakob disease or diabetes  
Polymer comprising at least two substances (monomers) that bind to amyloid-beta -oligomers is new. Independent claims are included for: (1) a Kit comprising the polymer; (2) a sensor comprising...
DE102012102998A1 New polymer comprising two substances that bind to amyloid-beta-oligomers, useful for treating Alzheimer's disease, Parkinson's disease, Creutzfeldt Jakob disease or diabetes  
Polymer comprising at least two substances (monomers) that bind to amyloid-beta -oligomers is new. Independent claims are included for: (1) a Kit comprising the polymer; (2) a sensor comprising...
DE19742706B4 lipocalin muteins  
Lipocalin mutein based on a polypeptide of the lipocalin family, in which amino acid positions in the range- of at least three of the four peptide loops, which are arranged at one end of...
DE19941756B4 Methods of using oligomeric nucleic acid-protein conjugates as reagents for immunological detection methods in particular, the Immuno-PCR  
Oligomers protein-nucleic acid conjugates, formed by self-assembly, consisting of a.) nucleic acids which are associated with at least two binding molecules, and b.) proteins which have at least...
DE102006043891B4 A serum-free medium for the differentiation of stem cells  
Synthetic composition, comprising: a) that the amino acid sequence of a polypeptide SEQ ID NO: 1, b) a polypeptide that has the amino acid sequence of SEQ ID NO: 3, c) a polypeptide that has the...
DE112010001777T5 VERWENDUNG VON SILINTAPHIN FÜR DIE STRUKTUR-GERICHTETE HERSTELLUNG VON (NANO)COMPOSIT-MATERIALIEN IN MEDIZIN UND (NANO)TECHNOLOGIE  
Die vorliegende Erfindung betrifft die Anwendung von Silintaphin-1 bei der nachhaltigen Herstellung von hierarchisch geordneten Silicastrukturen in einem Nano- bis Makromaßstab bei...
DE102011105694A1 Cellular proteins ( "host factors") that are essential for the replication of RNA viruses  
Animal and human pathogenic flaviviruses need for their propagation in the host cell proteins, which produces the cell itself. These proteins are referred to as "host factors". The interactions of...
DE10028725B4 Primary structure of the HNA-2a (formerly NB1) antigen  
Nucleotide sequence comprising a nucleotide sequence SEQ ID NO 1 which encodes an HNA-2a antigen, for use as a diagnostic agent, which reacts with alloantibodies which are specific HNA-2a.
DE102010039018B4 Anti-La antibodies and their use for Immunotargeting  
A recombinant antibody comprising a.) a binding unit of an antibody which specifically binds to an epitope of a human nuclear antigen, preferably human La, binds, and b.) a binding moiety - An...
DE102006030566B4 Methods and reagents for diagnosis of inflammatory liver disease  
A method for diagnosing autoimmune hepatitis, characterized in that a biological sample of a patient associated with at least a fragment of Myosin-9 and / or Filamin A contact and the binding of...
DE102004031579B4 Peptides to inhibit the interaction of protein kinase A and protein kinase A anchor proteins, these nucleic acid molecule comprising, vector, host cell against these directional recognition molecule containing these pharmaceutical composition containing them and their use kit  
Polypeptide, wherein the polypeptide is selected from a group consisting of amino acid sequences SEQ ID no. 20 to 27.
DE112010002967T5 New fatty acid desaturases and -elongasen and applications thereof  
The invention provides isolated nucleic acid molecules encoding the fatty acid desaturases and new -elongasen from the organism Emiliana huxleyi. The invention also provides recombinant expression...
DE10352433B4 Polypeptide a Silicatein ß from Suberites domuncula, nucleic acid coding therefor, their uses, this nucleic acid vector comprising and expressing this polypeptide host cell  
Polypeptide a Silicatein β from Suberites domuncula according to SEQ ID NO. 1, recombinant polypeptide comprising an amino acid sequence of β-Silicatein domain identical to the sequence shown in...
DE112010000887T5 Plants having enhanced yield-related traits and processes for their preparation  
The present invention relates to plants with improved properties, wherein the expression of calreticulin, BET1-like polypeptides, DUS1-like polypeptides, ES43-like polypeptides, HON5-like...
DE102011008153A1 Preparing monoclonal antibody comprises immunizing mice with alpha synuclein peptide, removing and fusing B-lymphocytes with myeloma cell line, selecting fusion product peptide in cell culture vessel, selecting immunoglobulin and isolating  
Preparing monoclonal antibody coupled against oligomeric alpha synuclein comprises: immunizing mice or other animals or in-vitro cell cultures with peptide of the alpha synucleins; removing...
DE102009058169B4 Protein or polypeptide to bind to tubulin and / or Mikrotubulistrukturen  
Protein or polypeptide comprising an amino acid sequence selected from the group consisting of e) an amino acid sequence according to SEQ ID NO: 3 or a partial sequence thereof; orf) any one of...
DE10237517B4 A process for the enrichment or depletion of biomolecules from liquid or fluid media using Schichtdoppelhydroxiden and use of other on a layered double hydroxide or incorporated biomolecules as inorganic Vector  
A process for the removal or recovery or purification of at least one biomolecule, which contains, as building blocks nucleotides, nucleosides, amino acids, monosaccharides and / or fatty acids...
DE102010037469A1 Process for reducing the endotoxin content in a collagen-containing material  
The present invention relates to a process for reducing the endotoxin content in a collagen containing material comprising the steps of: - Treating the collagen-containing material with liquor; -...
DE102010039019A1 Antibodies against 6-sulfo LacNAc positive human dendritic cells and their use  
The invention relates to a composition containing at least one anti-SLAN antibody. Furthermore, the invention relates to the diagnostic and therapeutic use of this composition. The object of the...
DE102010039018A1 Anti-La antibodies and their use for Immunotargeting  
The invention relates to antibodies against the human La protein and their application for Immunotargeting, in particular of tumor cells. The object of the invention is the provision of improved...
DE102010039015A1 Linker peptide and its use in fusion proteins  
The invention relates to linker peptides, fusion proteins and fusion protein complexes containing them, processes for the production of fusion proteins and their use. The object of the invention...
DE102010033575A1 ASPP2 splice variant  
Disclosed is a method for the in vitro determination of the presence or a predisposition of a patient for the development of cancer, in a biological sample from the patient the presence of a...
DE19925052B4 Protein complexes for the targeted transport of (poly) peptides and nucleic acids and site-specific integration of DNA vectors  
Transport system to protein complex-based composition comprising a recombinase, z. B. HIV-1 integrase (10) which is fused to a sequence-specific DNA-binding domain (DBD) (6), which replaces a...
DE102010025935A1 Collagen with specified proline to hydroxyproline ratio and glycosylation degree as measured by the ratio of disaccharides to monosaccharides, useful as wound gel for treating wounds, and for tissue engineering  
Collagen with a ratio of proline to hydroxyproline of at least 1.9:1 and a glycosylation degree as measured by the ratio of disaccharides to monosaccharides of at least 75:1, is claimed. An...
DE112009002313T5 Electric submersible pump with uniformly loaded thrust bearings  
A rotary pump having thrust bearings, comprising a system for balancing the load on the axial bearing. The thrust bearings are each supported on pistons that are in fluid communication with a...
DE102004010928B4 Protein for binding of prokaryotic DNA and process for the separation and enrichment of prokaryotic DNA  
A method for separating and / or enriching prokaryotic DNA comprising the steps of: a) contacting a is in solution undergoing prokaryotic DNA with a specific prokaryotic DNA-binding protein that...
DE102010019336A1 Agents for the treatment of Alzheimer's dementia  
The invention relates to agents for treatment of Alzheimer's dementia. According to the invention, a peptide is provided by SEQ ID NO. 1 is available which binds to Aβ oligomers and thus leads to...
DE102010009876A1 Crosslinkers for hydrogels  
The invention relates to biocompatible hydrogels and provides novel peptidic crosslinkers in the form of a linear molecule ready which has a molecular weight of 3 to about 60 kDa, about two- to...