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DE10044373A1 A new reagent for the labeling of nucleic acids  
The present invention is a labeling reagent, wherein the marker is bound via amide formation and a linker attached to the remainder of the molecule, essentially characterized in that the N atom of...
DE10043674A1 New antisense oligonucleotides and ribozymes, useful for treating e.g. pain and for diagnosis, are directed against mRNA for vanilloid-family receptors  
Oligonucleotide (ON) containing, or corresponding to: (a) any of 135 sequences (A) fully defined in the specification; or (b) a sequence that differs from (A) by a single base change, provided...
DE10133427A1 For sigH gene coding nucleotide sequences  
The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a...
DE10133426A1 For SIGC gene coding nucleotide sequences  
The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical to a polynucleotide coding for a...
DE10109690A1 New codes for the metY gene nucleotide  
The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to...
DE10043702A1 New antisense oligonucleotides and ribozymes, useful for treating e.g. pain and for diagnosis, are directed against mRNA for vanilloid-family receptors  
Oligonucleotide (ON) containing, or corresponding to: (a) any of 135 sequences (A) fully defined in the specification; or (b) a sequence that differs from (A) by a single base change, provided...
DE10043331A1 New polynucleotide from coryneform bacteria, useful when overexpressed for increasing fermentative amino acid production, encodes sigma factor D  
Isolated polynucleotide (I) from coryneform bacteria, representing the sigD gene is: (i) 70% identical with a sequence that encodes a 188 amino acid sequence S1, reproduced; (ii) encodes a...
DE10042742A1 New encoding the lipA gene nucleotide  
The invention relates to isolated polynucleotides comprising a polynucleotide sequence selected from the group DOLLAR A a) polynucleotide which is identical to at least 70% with a polynucleotide...
DE10042739A1 New codes for the gene nucleotide lipB  
The invention relates to isolated polynucleotides comprising a polynucleotide sequence selected from the group DOLLAR A a) polynucleotide which is identical to at least 70% with a polynucleotide...
DE10041766A1 Methods for labeling of chemical substances  
The invention relates to a method for marking and detecting chemical substances, which bind specifically to a receptor. The sequence of a DNA-, RNA- or PNA-oligomer single strand is used as a...
DE10041541A1 New nucleic acid encoding moth allergens, related polypeptides and antibodies, useful in the diagnosis and treatment of arthropod allergies  
A nucleic acid (I) encoding an allergenic polypeptide (II), is new. A nucleic acid (I) encoding an allergenic polypeptide (II) comprises: (a) a sequence (1; 1294 bp), (3; 1092 bp), (5; 2230 bp) or...
DE10123071A1 New codes for the gene nucleotide ccpA2  
The invention relates to isolated polynucleotides comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a...
DE10042051A1 New codes for the cstA gene nucleotide  
The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a...
DE10041542A1 A new strategy for the synthesis of polymers on surfaces  
The invention relates to a novel method for synthesising polymers, particularly biopolymers such as nuclear acids, peptides and saccharides, on the surface of solid supports. The inventive method...
DE10041539A1 New Amiditderivate for synthesizing polymers on surfaces  
The invention relates to novel amidite derivatives and the use thereof as linker elements for synthesising polymers, especially biopolymers such as nucleic acids, peptides and saccharides, on the...
DE10040052A1 Use of proton pump inhibitors for the treatment of inflammation, in particular musculoskeletal disorders  
Based on the knowledge that rheumatism and prosthetic loosening fibroblasts and osteoblasts express membrane-bound proton pumps which contribute to bone destruction by acidifying the extracellular...
DE10040857A1 The nucleic acid library or protein or peptide library  
The invention relates to a nucleic acid library or protein or peptide library in the form of a two-dimensionally resolved grid-type arrangement with a plurality of grid elements. Every grid...
DE10036469A1 Ultraspiracle (USP) protein from Heliothis virescens  
The invention relates to nucleic acids which code for polypeptides having the biological activity of ultraspiracle protein, as well as such polypeptides per se. Furthermore, the invention relates...
DE10034729A1 Regulatory sequences from meristematic cells  
The present invention relates to regulatory nucleic acid sequences, which allow specific expression of transgenes in meristematic cells.
DE10039049A1 Novel polynucleotide from Coryneform bacteria coding for lysR3 gene, useful as a probe for detecting DNA to isolate nucleic acids coding for transcription regulator lysR3 or for producing L-amino acids, e.g., L-lysine and L-valine  
An isolated polynucleotide (I) from Coryneform bacteria comprising a polynucleotide sequence coding for the lysR3 gene, comprising a polynucleotide having at least 70% identity to a polynucleotide...
DE10039044A1 Novel polynucleotide from Coryneform bacteria coding for lysR1 gene, useful as hybridization probe for detecting DNA coding for transcription regulator lysR1  
An isolated polynucleotide (I) from Coryneform bacteria containing a polynucleotide sequence coding for the lysR1 gene, comprising a polynucleotide having at least 70% identity to a polynucleotide...
DE10039043A1 New codes for the luxR gene nucleotide  
Isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical with a polynucleotide that codes for a polypeptide containing...
DE10037769A1 Diagnosis of diseases associated with CD24  
The invention relates to the chemically modified genomic sequence of the CD24 gene, to oligonucleotides oriented against the sequence and/or PNA oligomers for detecting the cytosine methylation...
DE10038237A1 A method for detecting mutations in nucleotide sequences  
The invention relates to a method for simultaneously detecting mutations in different nucleotide sequences and for determining the transcription rate of mutated and non-mutated nucleotide...
DE10037612A1 New phosphopentose isomerase gene from Coryneform bacteria, useful for transforming cells for improved fermentative production of L-amino acids, especially lysine  
Isolated polynucleotide (I) from Coryneform bacteria contains a sequence that is at least 70% identical with a sequence encoding a 157 amino acid (aa) polypeptide (II), encodes a polypeptide at...
DE10037611A1 New ribulose-phosphate 3-epimerase gene from coryneform bacteria, useful for transforming cells for improved fermentative production of L-amino acids, especially lysine  
An isolated polynucleotide (I) from coryneform bacteria containing a sequence that: (a) is at least 70% identical to a sequence encoding a 219 amino acid (aa) polypeptide (II); (b) encodes a...
DE10036486A1 A method for the separation of nucleic acids in solution doppelstränigen in single stranded nucleic acids  
The invention relates to a method for unraveling double-stranded nucleic acids located in an aqueous solution into single-stranded nucleic acids. The invention is characterized in that the...
DE10037111A1 Producing a recombinant protein in a prokaryotic host cell  
The invention relates to advantageous processes for preparing heterologous proteins in prokaryotic host cells by improved codon use and/or expression of tRNAs which code for codons occurring...
DE10036743A1 A method for determining a partial nucleotide sequence of a nucleic acid molecule  
The invention relates to a method for determining a partial nucleotide sequence of a nucleic acid molecule, comprising the following steps: (a) incubating a primer which hybridizes to the nucleic...
DE10035084A1 A nucleic acid molecule encoding a plant AMP deaminase  
The isolation and cloning of a gene coding for the AMP deaminase from Arabidopsis thaliana nucleic acid sequence will be described. The nucleic acid sequence containing the isolated nucleic acid...
DE10032529A1 Diagnosis of important genetic parameters within the major histocompatibility complex (MHC)  
The present invention describes nucleic acids for diagnosing a set of genetic parameters within the major histocompatibility complex (MHC), comprising an at least 20 base pairs long reverse...
DE10034804A1 Using VLCFAE for identifying herbicidally active compounds  
The invention relates to the use of nucleic acids that encode plant polypeptides having the biological activity of Very Long Chain Fatty Acid elongases and the use of the polypeptides encoded for...
DE10033091A1 Polymer chip  
A polymer chip is disclosed, comprising a number of probes, whereby various probes are arranged at a different probe site on a support and each probe comprises an oligomer sequence. Said oligomer...
DE10126344A1 Apoptosis-inducing DNA sequences  
The invention relates to novel apoptosis-associated and especially apoptosis-inducing nucleic acid sequences, polypeptides which are coded by said sequences, and the use of the same for preparing...
DE10033991A1 A process for the isolation of nucleic acids  
The invention relates to a method for isolating nucleic acids from a solution, wherein the nucleic acids are adsorbed on a surface containing SiO2 in the presence of alkali halides and alcohol....
DE10033353A1 Identifying compounds that modify activity of signal transduction pathways, useful potentially as therapeutic agents, by screening with cells that contain hybrid G proteins  
Identifying (M1) compounds (A) that modify, in an organism, the activity of at least one signal transduction pathway that depends on a G protein coupled receptor (GPCR). Cells that contain at...
DE10032350A1 New coryneform bacterium in which the mdhA gene is attenuated, preferably eliminated, useful for fermentative production of L-amino acids such as L-lysine  
A coryneform bacterium (I) in which the mdhA gene is attenuated, preferably eliminated, is new. Independent claims are also included for the following: (1) a polynucleotide (II) from coryneform...
DE10032173A1 New encoding the plsC gene nucleotide  
This invention relates to a coryneform bacterium, the plsC gene of which is enhanced, and to an isolated polynucleotide which encodes 1-acyl-SN-glycerol-3-phosphate acyltransferase from coryneform...
DE10032174A1 Novel coryneform bacterium in which the gpsA gene encoding glycerol-3-phosphate dehydrogenase is enhanced, useful for fermentative production of L-amino acids such as L-lysine and L-glutamate  
A coryneform bacterium (I) in which the gpsA gene encoding glycerol-3-phosphate dehydrogenase is enhanced, is new. An independent claim is also included for a polynucleotide (II) which is isolated...
DE10031932A1 Calpain protease 12  
The invention relates to calpain protease 12 (Capn12), which is characterized in that it has an amino acid sequence comprising amino acids 1 - 342 of SEQ ID NO: 1 or an amino acid sequence...
DE10031236A1 Use of carboxylic acids and other additives in combination with cationic compounds to stabilize the nucleic acids in biological materials  
The invention relates to the use of compositions for isolating and/or stabilising nucleic acids in or from micro-organisms such as prokaryots, fungi, protozoa or algae. The composition comprises a...
DE10030647A1 Preparing fine chemicals, particularly Vitamins E and K, useful as antioxidants e.g. in foods or medicine, by growing organisms with altered shikimate biosynthesis pathway  
Preparation of fine chemicals (I) by culturing organisms in which the shikimate pathway (SP) has been altered relative to the wild type. Independent claims are also included for the following: (a)...
DE10030149A1 Use of novel polypeptide or its variant or nucleic acid encoding the polypeptide for diagnosing and/or preventing and/or treating skin disorders and/or treatment in wound healing or for identifying active substances  
Use of a polypeptide or its variant (I) or nucleic acid encoding (I) or its variant for the diagnosis and/or prevention and/or treatment of skin disorders and/or treatment in wound healing or for...
DE10022334A1 Protein production in yeast Arxula  
The invention relates to novel transcriptional promoters for heterologous gene expression, and methods for their use. DOLLAR A Such transcriptional promoters are used in combination with...
DE10030588A1 Synthesizing carrier bound arrays of oligomers, useful for performing parallel polymerase chain reactions, e.g. for gene expression analysis, includes reversal of orientation  
Synthesis of a carrier-bound array (1) of oligomers (2), particularly oligo(ribo)nucleotides, with free ends (A), particularly 3'-hydroxy, and with (i) ends (B), particularly 5'-hydroxy,...
DE10029131A1 New nucleic acid encoding protein kinase of the mitogenic signaling pathway, useful for identifying cytostatic agents, includes the sequence of a glycolytic enzyme binding site  
Nucleic acid (I) that codes for at least a partial sequence (A) of a protein kinase of the mitogenic signaling pathway (PKm), is new. It can be a silent mutation of the sequence, or it can...
DE10029194A1 New isolated nucleic acid encoding L-pantolactone hydrolase, useful for production of optically pure D-pantolactone from its racemate  
Isolated nucleic acid (I) that encodes a polypeptide (II) with L-pantolactone hydrolase activity is (i) a 810 bp sequence (1); (ii) equivalents of (i) within the degeneracy of the genetic code;...
DE10028257A1 Analysis chip used e.g. in DNA sequencing, comprises baseplate carrying array of electronically-addressable points, with matching perforated plate attached to it  
An analysis chip, comprising a baseplate (D) partially-coated with an electrically-conductive material in the form of an array of points (B), is new. Individual points are connected together...
DE10024171A1 Neuronal serine threonine protein kinase  
The present invention relates to a gene and the protein encoded thereby, which is involved in the formation of the consequence of local ischemia. The new protein is a serine-threonine protein...
DE10019058A1 Designing primers and probes for analyzing diseases associated with cytosine methylation state e.g. arthritis, cancer, aging, arteriosclerosis comprising fragments of chemically modified genes associated with cell cycle  
A nucleic acid, (I), comprising a sequence of 18 bases, of a segment of chemically pretreated DNA (CP DNA) of genes associated with cell cycle having a sequence taken from 424 sequences (Ss) and...