Matches 1 - 50 out of 67 1 2 >


Match Document Document Title
DE102010055566A1 New compounds conjugating gyrase-inhibiting substances with catechol structural units, are gyrase inhibitors, useful as biologically active substances, and for treating bacterial infection  
Compounds (Q) conjugating gyrase-inhibiting substances with catechol structural units, are new. An independent claim is included for the preparation of (Q). ACTIVITY : Antibacterial. MECHANISM OF...
DE102008017590A1 Glucopyranosidderivate  
New compounds of formula I whereinX has the meaning given in claim 1, useful as antidiabetic agents.
DE102007052119A1 New coumermycin A1-derivative, useful as biologically active substance and as antibiotics or cytostatics, and for preventing diseases caused by bacteria or tumor  
Coumermycin A1-derivative (I), is new. Coumermycin A1-derivative of formula (I), is new. R1, R2 : CH 3, halo or H, preferably H, F, Cl, Br or I, where both R1, R2 are not simultaneously CH 3. An...
DE102006053637B4 Last fluoro-substituted 1,4-Benzothiepin-1,1-dioxide derivatives, pharmaceutical compositions containing them and their use  
Compounds of the formula I, which mean X NH; R1 (C1-C6) Alkyl; R4 F; R4 'H, F; R2, R2 ', R3, R3', R5, R5 'independently of one another H, F, Cl, Br, I, OH, - (CH2) -OH, CH2F, CHF2, CF3, NO2, N3,...
DE102006053637A1 New fluorine-substituted 1,4-benzothiepine-1,1-dioxide, a process for their production, medicaments containing these compounds and their use  
The Invention relates to the compounds of formula I and physiologically acceptable Salts. The compounds are suitable for. B. as hypolipidemic agents.
DE102006053635A1 New substituted with benzyl 1,4-Benzothiepin-1,1-dioxide derivatives, processes for their preparation, pharmaceutical compositions containing them and their use  
The Invention relates to the compounds of formula I and physiologically acceptable Salts. The connection is suitable for. B. as hypolipidemic agents.
DE102006053635B4 New substituted with benzyl 1,4-Benzothiepin-1,1-dioxide derivatives, pharmaceutical compositions containing them and their use  
Compounds of formula and the pharmaceutically acceptable salts thereof.
DE102005042828A1 Selected CGPR antagonists, process for their preparation and their use as medicaments  
object the present invention relates to the CGRP-antagonists of general Formulas I, in which R1, R2 and R3 are as defined in claim 1, their Tautomers, the isomers, the diastereomers, deren...
DE102005033903A1 New perfluoroalkyl-containing metal complexes, useful for production of contrast agents for use in e.g. NMR and X-ray diagnostics, necrosis imaging and in radiodiagnostics and radiotherapy  
Perfluoroalkyl-containing metal complexes (I) are new. Perfluoroalkyl-containing metal complexes of formula K1>-L(Q-R)-N(A)-X-Rf (I), are new. R : mono- or oligosaccharide bound with one hydroxy...
DE102005033903B4 Perfluoroalkyl-containing complexes, processes for their preparation, and their use and pharmaceutical compositions containing them  
perfluoroalkyl Metal complexes having N-alkyl group of the general formula I in which R either one about 1-OH-bonded mono- or oligosaccharide represents the optional is peralkylated, in this case...
DE19948651B4 Para- and diamagnetic perfluorinated compounds containing pharmaceutical formulations, their preparation and use  
Galenic Formulation, characterized in that it comprises paramagnetic perfluoroalkyl- Compounds according to general formula I RF-A (I)where RF a straight-chain or branched perfluoroalkyl radical...
DE10258007B4 Aromatic Fluorglycosidderivate, medicaments containing these compounds and methods for making these medicines  
compounds of formula I, which mean R1, R2 OH, F or H; R3 OH or F, where one of R1, R2, R3 F must be; AO, NH, CH2, S or a Binding; R4, R5, R6 hydrogen, F, Cl, Br, I, OH, CF3, NO2, CN, COOH, CO...
DE102004028241A1 New fluoroglycoside derivatives of pyrazoles, pharmaceutical compositions containing them and their use  
The Invention relates to substituted fluoroglycoside derivatives of pyrazoles of formula I, wherein the radicals given the have meanings, and their physiologically tolerable Salts and processes...
DE102004028241B4 New fluoroglycoside derivatives of pyrazoles, pharmaceutical compositions containing them and the preparation of these drugs  
compounds of formula I, which mean R1 and R2 independently of one another, F or H, where one of the radicals R1 or R2 must be F; A O, NH, CH2, S or a bond; R3 Hydrogen, F, Cl, Br, I, OH, CF3, NO2,...
DE4205306B4 Acid amides, drugs with the same and method for the preparation of acid amides  
amides of the general formula (I) ' in which R '1 and R '2 equal or different and are Hydrogen or füir straight-chain or branched alkyl having up to 4 carbon atoms to stand, R '3 represents...
DE102004012676A1 New glucopyranosyl-substituted benzene derivatives are sodium-dependent glucose cotransporter inhibitors, useful for treating e.g. metabolic disorders (type 1 and type 2 diabetes mellitus or metabolic acidosis)  
Glucopyranosyl-substituted benzene derivatives (I) and their tautomers, sterioisomers andsalts are new. Glucopyranosyl-substituted benzene derivatives of formula (I) and their tautomers,...
DE10361133A1 Glucopyranosyloxy-substituted aromatics, pharmaceutical compositions containing them, their use and processes for their preparation  
The present invention relates to glucopyranosyloxy-substituted aromatics of the general formula, in theR1 to R6 and R7a, R7b, R7c the claim 1 are defined, the tautomers, the stereoisomers, the...
DE10260592A1 New 2-(1-((hetero)aryl(oxy))-ethyl)-nitrobenzene derivatives, useful for introducing intramolecular triplet sensitized photolabile protecting groups into synthons for light-controlled biopolymer production  
2-(1-((Hetero)aryl or (hetero)aryloxy)-ethyl)-nitrobenzene derivatives (I) are new. Also new are nucleotide synthon compounds (II) containing a photolabile protecting group derived from (I)....
DE10218476A1 Medicaments, cosmetics and dermatological compositions for a wide variety of skin treatments contain lignans or their glycosides  
Cosmetic and/or dermatological compositions contain lignans (or their glycosides) in addition to conventional ingredients.
DE10248451A1 Fredericamycin derivatives  
The invention relates to novel Fredericamycin derivatives, medicaments containing these or their salts, and the use of Fredericamycin derivatives for the treatment of diseases, in particular tumors.
DE10204072A1 Novel compounds that inhibit factor Xa activity  
The invention relates to the compounds of formula (I) or to the pharmaceutically acceptable salts, solvates, hydrates or pharmaceutically acceptable formulations thereof. The inventive compounds...
DE19948651A1 Nuclear magnetic resonance imaging contrast agent formulations containing perfluoroalkylated paramagnetic and diamagnetic compounds, having high organ specificity, especially for the lymph nodes  
Galenic formulations (A) contain paramagnetic perfluoroalkylated compounds (I) and diamagnetic perfluoroalkylated compounds (II). (II) include new cyclodextrin complexes (B). Galenic formulations...
DE10129888A1 Process for the preparation of perbenzylated 1-O-glycosides  
The invention relates to a method for producing perbenzylated 1-O-glycosides of general formula I or the salts thereof. In said formula, Sugar<1> represents a monosaccharide functionalised in the...
DE10129677A1 Preparation of perbenzylated 1-O-glycoside used e.g. as pharmaceutical intermediate, by reacting perbenzylated 1-hydroxy-sugar with alkylating agent in organic solvent then deprotecting  
Preparation of perbenzylated 1-O-glycoside compounds (I) involves reacting a perbenzylated 1-hydroxy-sugar (II) with an alkylating agent (III) in a water-miscible organic solvent in the presence...
DE10129256A1 Antiviral glycoconjugates  
The invention relates to acetyl- or benzoyl-protected bromoalkyl- beta -D-glucosides and glycoconjugates that can be structured by reacting the acetyl- or benzoyl-protected bromoalkyl- beta...
DE10129028A1 Soluble Cdk inhibitory indirubin derivatives  
The invention relates to indirubin derivatives of formula (I) that, by establishing a basic side chain in the 5-position, contain a radically increased solubility with a simultaneous improvement...
DE10064398A1 New 1,2-diphenyl-3-(3-hydroxy-3-phenylpropyl)-azetidin-2-one derivatives, useful for treating lipid metabolism disorders, e.g. hyperlipidemia, hypercholesterolemia, arteriosclerosis or insulin resistance  
1,2-Diphenyl-3-(3-hydroxy-3-phenylpropyl)-azetidin-2-one derivatives (I) are new. Azetidinones of formula (I) and their salts are new. R1 - R6 = -Q-L, H, halo, CF3, NO2, COOH, COOT, CONH2, CONHT',...
DE10040381C1 Perfluoroalkyl-containing complexes with sugar residues, processes for their preparation and their use  
Perfluoroalkyl complexes with sugar residues of the general formula I DOLLAR F1 wherein R is a bound on the 1-OH or 1-SH-position mono- or oligosaccharide, R¶f¶ represents a perfluorinated carbon...
DE10041221A1 Process for the preparation of water-soluble saccharide and Saccharidkonjugaten by Diels-Alder reaction and their use as therapeutic or diagnostic agents  
The invention relates to a method for producing saccharide compounds in a very simple manner. The inventive method comprises the following steps: (a) attaching at least one saccharide to a cyclic...
DE10066210B4 Use of perfluoroalkyl-metal complexes as contrast agents in MR imaging for displaying plaques  
use of perfluoroalkyl-metal complexes that a critical micelle concentration <10-3 minor, a hydrodynamic micelle diameter> 1 nm and a proton relaxivity in plasma> 10 l / mmol · s, as contrast...
DE10025329A1 New 6-hydroxy-2,3-dihydro-1H-indole derivatives and analogs, useful in cancer therapy, especially used in low toxicity glycoside or acetal prodrug form for antibody directed enzyme prodrug therapy  
6-Hydroxy-2,3-dihydro-1H-indole, 5-hydroxy-1,2-dihydro-3H-pyrrolo (3,2-e) indole, 5-hydroxy-1,2-dihydro-3H-benz (e) indole and 6-hydroxy-1,2,3,4-tetrahydro-benzo (f) quinoline derivatives (I)-(IV)...
DE10005275A1 novel glycoconjugates  
The invention concerns cytostatic agents which are more tumor-specific as a result of modification with carbohydrates. Urea or dicarboxylic acid units as appropriate spacers ensure serum stability...
DE19916108C1 With sugar residues substituted 1,4-benzothiazepine-1,1-dioxide derivatives, processes for their preparation and their use  
The invention relates to substituted 1,4-benzothiazepine-1,1-dioxide derivatives and their acid addition salts. DOLLAR A are 1,4-benzothiazepine-1,1-dioxide derivatives of the formula I, DOLLAR F1...
DE19912636A1 Bicyclic heterocycles, process for their preparation and their use as herbicides and pharmaceutical agents  
The invention relates to compounds of formula (I), their tautomers, their salts and their water addition products, the radicals and symbols A, D, E, G and L having the meanings given in claim no....
DE19909979A1 Process for the preparation of glycoconjugates of 20 (S) -camptothecin  
The invention relates to a method for producing glyco-conjugates of 20(S)-camptothecin in which a 3-O-methylated beta -L-fucose building block is linked to the 20 hydroxyl group of a camptothecin...
DE19845405C2 Aryl-substituted propanolamine derivatives and their use  
The invention relates to substituted propanolamine derivatives and pharmaceutically acceptable salts thereof. Are compounds of the formula I, DOLLAR F1 in which the radicals have the meanings...
DE19850572A1 Preparation of new or known luteolin compounds by reducing flavonoids with sodium dithionite, used e.g. as nutritional supplements, cosmetic UV filters or cardiovascular drugs  
Preparation of luteolin (or its O-(hydroxyalkyl) derivatives) (I) involves reducing a flavonoid (II) containing a disaccharide residue, using sodium dithionite in aqueous alkaline medium. Some...
DE19850570A1 Production of new or known tri-O-hydroxyalkyl quercetin or isoquercetin derivatives, e.g. useful as food supplements, comprises enzymatic hydrolysis of tri-O-hydroxyalkyl rutin derivatives in an aqueous medium  
The production of tri-O-hydroxyalkyl quercetin or isoquercetin derivatives (I) comprises enzymatic hydrolysis of tri-O-hydroxyalkyl rutin derivatives (II) in an aqueous medium. The production of...
DE19850282A1 Preparation of new or known tris-hydroxyalkyl quercetin and isoquercetin derivatives by enzymatic cleavage of rutin derivatives, used e.g. as nutritional supplements, cosmetic UV filters or cardiovascular drugs  
Preparation of tris-hydroxyalkyl quercetin or isoquercetin derivatives (I) involves enzymatic cleavage of a tris-hydroxyalkyl rutin compound (II) containing a disaccharide residue. Some (I), i.e....
DE19845405A1 Aryl-substituted propanolamine derivatives and their use  
The invention relates to aryl-substituted propanolamine derivatives and their pharmaceutically acceptable salts and functional derivatives. The invention relates to compounds of formula (I),...
DE19829305A1 One step preparation of alpha-hydroxycarboxylic acid sugar monoesters and also of novel lactides useful as surfactants or emulsifiers  
Preparation is claimed of alpha -hydroxycarboxylic acid sugar monoesters and also of certain lactides, the lactides also being claimed as novel compounds used in surfactant or emulsifier mixtures....
DE19825804A1 1,4-benzothiazepine 1,1-dioxide derivatives, processes for their preparation, pharmaceutical compositions containing them and their use  
The invention relates to substituted benzo(b)thiepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention relates to compounds of formula (I), wherein R<1>, R<2>, R<3>,...
DE19821038A1 New acarviosin glycoside, prepared by biotransformation of acarbose, used as saccharase inhibitor for treating diabetes  
A new glycoside (I) is formed from the acarviosin of acarbose and rutin.- DETAILED DESCRIPTION - The glycoside of formula (I) is new.- An INDEPENDENT CLAIM is included for the preparation of (I).-...
DE19813137A1 New camptothecin glyco-conjugate compounds  
Camptothecin (CT) glyco-conjugates of formula (I), containing a 3-O-methylated beta -L-fucose residue bonded to the 20-hydroxy group via a thiourea-modified peptide spacer, and their salts,...
DE19801037A1 New camptothecin glyco-conjugate compounds  
Camptothecin (CT) glyco-conjugates of formula (I), containing a 3-O-methylated beta -L-fucose residue bonded to the 20-hydroxy group via a thiourea-modified peptide spacer, and their salts,...
DE19652386A1 A process for the production of metal  
The invention relates to a method for producing metal complex carboxylic acid amides characterized in that a metal complex carboxylic acid mixture consisting of metal complex carboxylic acid and...
DE19649971A1 Optical diagnostic agents for the diagnosis of neurodegenerative diseases by means of near-infrared radiation (NIR radiation)  
The invention relates to compounds of formula (I): Fm(-A1) (-Bn) (-WO) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600 - 1200 nm; A is a beta -amyloid...
DE19643764A1 Glycoconjugates of modified camptothecin derivatives (20-0-link)  
Disclosed are glycoconjugates from modified camptothecin derivates, where at least a glucidic component is linked to the 20-hydroxyl group of a camptothecin derivate. Also disclosed are their...
DE19627067A1 Preparation of N-(2-amino-acylamino-2-desoxy-hexosyl)-amide derivative  
Preparation of N-(2-aminoacylamino-2-desoxy-hexosyl)-amides of formula (I) comprises (a) reacting protected 2-( alpha -aminoacylamino)-2-desoxy-hexopyranose compounds of formula (II) with...
DE19615576A1 New mono: and di:glucoside of glabridin  
Monoglucoside and diglucoside derivatives (I) (especially the alpha -D-glucosides) of glabridin are new. Also claimed are cosmetic preparations containing (I).

Matches 1 - 50 out of 67 1 2 >