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DE102018201920A1 Liquid functionally improved isomalt  
The present invention relates to a liquid isomalt composition comprising 6-O-alpha-D-glucopyranosyl-D-sorbitol (1,6-GPS) and 1-O-alpha-D-glucopyranosyl-D-mannitol (1,1-GPM ) and the other...
DE102018201916A1 Solid functionally improved isomalt  
The present invention relates to a solid isomalt composition comprising 6-O-alpha-D-glucopyranosyl-D-sorbitol (1,6-GPS) and 1-O-alpha-D-glucopyranosyl-D-mannitol (1,1-GPM ) and the other...
DE102017010898A1 New inhibitors of shikimic acid pathway  
The present invention relates to novel inhibitors of the shikimic acid pathway (shikimate route), to pharmaceutical compositions containing these novel inhibitors, to processes for the preparation...
DE102017125888A1 New engineered T cell receptors and their use in immunotherapy  
The present invention relates to antigen-recognizing constructs against COL6A3 antigens. In particular, the invention provides novel engineered T cell receptor (TCR) based molecules which are...
DE102015219343B4 A method of processing seaweed-derived galactose using agarase  
A process for processing galactose, the process comprising: Processing a residue of red algae by steps comprising saccharification of the red algae by hydrolysis with an acid and filtration of the...
DE112017002818T5 Compound for use in an enzymatic reaction and mass spectrometry methods  
A compound used in the conventional enzymatic reactions and mass spectrometry methods must be changed in structure as a substrate compound, such as the length of an alkyl chain contained therein,...
DE102015214603B4 Phosphorus containing aminoglycoside salts  
Compound of Formula 1 wherein the aminoglycoside is selected from the group of aminoglycoside or aminoglycoside group-containing antibiotics, where y is selected from 0.1 to 20, where n is...
DE102017115966A1 Polypeptide molecule with improved dual specificity  
The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain which provide a binding region derived from a T cell receptor...
DE112016005245T5 METHOD FOR THE FRACTIONATION OF LIGNOCELLULOSE-CONTAINING BIOMASS  
This invention aims to develop a process for fractionating lignocellulosic biomass by contacting lignocellulosic biomass with treating liquid in a closed system at a temperature not exceeding 200...
DE102017003004A1 Cationic polymers with D-fructose substituents  
The invention relates to novel cationic polymers which are D-fructose conjugated, whereby they are able to interact selectively with specific structural elements on cell surfaces. The task was to...
DE102017002810A1 Sialic acid derivatives with CC triple bond and their preparation  
Sialic acid derivatives containing a CC triple bond are described, processes for their preparation, conjugates prepared therefrom, and pharmaceutical compositions containing them.
DE102017002252A1 Enzymatic process for the production of fructose  
The present invention relates to a process for the preparation of aqueous solutions of D-fructose from a di-, oligo- or polysaccharide. Current methods are based on the generation of D-glucose...
DE102007032799B4 Sugary metal complexes and their use  
Sugar-containing metal complexes of substituted polypyridines of general formula I.(L1n)(L2m)(L3O)(L4p)(L5q)M+/-.consisting of ligands L1 to L5, wherein at least one of these ligands L1 to L5 is a...
DE102006035020B4 Stabilization of NAD / NADH  
A test element for the determination of an analyte comprising (i) a coenzyme dependent enzyme or a substrate for such an enzyme and (ii) as a coenzyme a compound having the following general...
DE202015009594U1 New dimers of cytidine derivatives  
A cytidine derivative dimer having the following general formula (I),in which: R1 a C1-C10Alkyl, C1-C10 -substituted alkyl, - (CH2)n-Ph or substituted - (CH2)n-Ph is; in - (CH2)n-Ph, n = 0, 1, 2,...
DE102016225419A1 Olfactory signaling after overheating in technical facilities by pyrolysis of perfume derivatives  
The present invention relates to a method for providing a technical device with a warning signal against heating and a kit with which the method can be carried out.
DE10113265B4 Use of a stabilized nucleic acid for the production of a protein  
The invention teaches the use of a linear nucleic acid stabilized against exonuclease degradation in a method of producing a protein encoded by a base sequence of the nucleic acid in a cell-free...
DE102016116121A1 Process for the epimerization of saccharides  
The invention relates to a process for the epimerization of saccharides by heating a saccharide dissolved in a solvent in the presence of a metal-containing catalyst, wherein an aldose is...
DE102016124844B3 DNA probes for in situ hybridization of chromosomes  
Kit, probe mixtures and probes for detecting chromosomal aberration. A gene probe obtained by a method comprising the steps of: (a) assaying genomic portions for sequence regions having...
DE102011118022B4 Antibodies against the prostate-specific stem cell antigen and its use  
The invention relates to recombinant prostate-specific stem cell antigen (PSCA) binding antibodies. The antibody of the invention contains complementarity determining regions (CDR) with the...
DE102007063902B3 Aptamers that bind to a target molecule involved in hemostasis  
Aptamer that binds to a target molecule involved in hemostasis, wherein the aptamer is an aptamer that binds to activated protein C, the aptamer having a dissociation constant KD in the range of ≥...
DE102011018627B4 Modified nucleotides  
Compound of structure (I): or a salt, a conjugated base, a tautomer or a dissociated form thereof, P1 being a phosphate group; P2 is a phosphate group; Nus is a nucleoside structural unit...
DE112012003416B4 adenosine process for the preparation of 2- (4-methoxycarbonylpyrazole-1-yl) and 2- (4-ethoxycarbonyl-1-yl) adenosine  
A process for the preparation of 2- (4-methoxycarbonylpyrazole-1-yl) adenosine of the formula Ia and 2- (4-ethoxycarbonyl-1-yl) adenosine of formula Ib by reaction of 2-Hydrazinoadenosin of...
DE102015009439B4 Triple Target HIV-1 NAT for the detection of all known genotypes  
A primer / probeset for the detection of HIV, in particular HIV-1, comprising at least one primer / probeset 1 consisting of oligonucleotides comprising SEQ ID NOs 1, 2 and 3; Primer / probeset 2...
DE102006012414B4 Chemical process for the production of degraded polygalactomannans  
A process for recovering degraded polygalactomannan comprising the steps of: providing a suspension of a polygalactomannan in an aqueous alcoholic solution having an alcohol concentration between...
DE202017002052U1 Nucleoside pearl necklaces sequencing  
An apparatus for DNA sequencing by passing a single-stranded DNA or RNA strand with anhybridized, chemically modified (nucleo-) bases, nucleosides or nucleotides by a biological or non-biological...
DE102015219651A1 Compositions containing sugar amine and fatty acid  
Compositions comprising a) one or more sugar amines of the formula (I) Wherein R1 and R2 are independently H, CH3 Or 2-hydroxyethyl and / or one or more corresponding protonated sugar amines with...
DE102007041476B4 Aptamers that bind to a target molecule involved in hemostasis  
Aptamer which binds to a target molecule involved in haemostasis, said aptamer being a thrombin-binding fusion aptamer comprising at least two aptamers binding to thrombin and at least one linker,...
DE202008018643U1 Nucleosidphosphoramidat prodrugs  
A compound according to the following formula: Wherein (a) R1 Is hydrogen, methyl, ethyl, n-propyl, i-propyl or a substituted or unsubstituted phenyl, the substituent of the substituted phenyl...
DE102015011780A1 New glutaminyl cyclase inhibitors  
The invention relates to a compound of formula (I) for use as a glutaminyl cyclase inhibitor, a compound-containing composition for use as a QC inhibitor, and methods of preparation.
DE102015214603A1 Phosphorhaltige Aminoglycosid-Salze  
Aufgabe ist es, Aminoglycosid-Verbindungen bereitzustellen, die eine retardierende Aminoglycosid-Freisetzung über klinisch relevante Zeiträume in therapeutisch wirksamen Konzentrationen...
DE112012003470B4 Process for the preparation of 2- [4 - [(methylamino) carbonyl] -1-H-pyrazol-1-yl] adenosine monohydrate  
Process for the preparation of 2- [4 - [(methylamino) carbonyl] -1-H-pyrazol-1-yl] adenosine monohydrate of the formula I Comprising the following steps: a) reacting 2-...
DE102015219343A1 A process for preparing galactose derived from marine algae using agarase  
A method for preparing galactose by means of an enzymatic treatment of a red algal residue is provided. The process for preparing galactose comprises: preparing a residue; Treating the residue...
DE102015008536A1 Discontinuous oligonucleotide ligands  
The present invention relates to an oligonucleotide conjugate K of the structure Or a pharmaceutically active salt thereof wherein RNA1, RNA2, RNA3, and RNA4 are each strands of a ribonucleic acid...
DE19549875B4 Use of magnetic particles for the isolation of nucleic acids  
Magnetic particles with an outer glass surface which is substantially pore-free or has pores of a diameter of less than 10 nm and ferromagnetic particles having a glass surface are preferred for...
DE112015001085T5 Antibodies, uses and procedures  
The present invention relates to anti-human OX40L antibodies, new medical uses and methods.
DE102015216558A1 PROCEDURE AND TEST KIT FOR FAST ISOLATION OF NUCLEIC ACIDS BY SMOKE SURFACES  
The invention relates to a method for isolating nucleic acids from nucleic acid-containing samples, characterized in that free nucleic acids released by lysis are bound to a solid phase with a...
DE102014018527A1 CYCLO - nucleosides  
The present invention relates to Cyclo-nucleosides of formula (I) R is hydrogen, alkyl or acyl, R1 is hydrogen or alkyl, X is hydrogen or the group OR, and Y is oxygen or NH.
DE10328887B4 alkaline protease  
Alkaline protease with a prepro sequence, the prepro sequence is a mutated sequence of the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having a strength at least 80%, 87%...
DE102015008631A1 Medicines for cancer therapy  
The present invention relates to novel chemical compounds, in particular benzophenone derivatives which are suitable as active ingredients in the drug treatment of cancer.
DE202014010612U1 Double Run cassette  
Cassette (1) for synthesizing a plurality of batches of a [18F] -labelled positron emission tomography (PET) -Tracers, said cartridge comprising: (i) an anion exchange column (3, 4) for each of...
DE19858588B4 The dye-labeled oligonucleotide for labeling a nucleic acid molecule  
The dye-labeled oligonucleotide for labeling a a target sequence section comprising a nucleic acid molecule, wherein the dye-labeled oligonucleotide comprises the following components: a) - a loop...
DE102014013397A1 Perlenketten sequencing  
There will be described using labeled nucleotides, a method for sequencing nucleic acids. Firstly, the nucleotides on the ribose or deoxyribose may be labeled and be integrated by means of a...
DE102014112055A1 Di- and triphosphate prodrugs  
The invention relates to prodrugs as useful compounds, in particular Nukleosiddi- triphosphate and prodrugs, and a method for preparing these compounds. Object of the present invention is to...
DE102014210662A1 Device and method for obtaining and glycoglycerolipids glycosphingolipids from lipoid phase  
The present invention relates to an apparatus and method for conserving and hydrolysefreien separating glycoglycerolipids and of glycoglycerolipids and glycosphingolipids from a lipoid phase which...
DE102014208194A1 Purification of epidaunorubicin  
The present invention relates to a method for the purification of epidaunorubicin, in particular the separation of the impurity epi-Feudomycin as it occurs as a by-product of the biotechnological...
DE102014001464A1 RNAi technology  
Ribonucleic acids (RNAs) can be blocked by small inhibitory RNAs. In this way, genes off. This mechanism known as RNA interference was first described by Andrew Fire and Craig Mello. For the...
DE112013004650T5 Multiplexpyrosequenzierung using nichtinterferierender, noise-terminating Polynukleotididentifikationstags  
The present disclosure relates generally to a multiplexing method for analyzing samples, comprising the Polynukleotidamplifikation to production of amplified products, wherein one or more target...
DE102013111487A1 The bispecific antibody fragment and pharmaceutical combination preparation with such a  
The invention relates to a bispecific antibody fragment (10) with a first detection point (12) and at least a second detection point (14), which specifically recognize each at least one structure...
DE19547958B4 Anthracycline derivatives  
Anthracyclinanalogon the formula A wherein R1 a hydrogen atom or a hydroxy or methoxy group; R2 and R3 are each hydroxy groups or one of R2 and R3 a hydroxy group and the other is a hydrogen atom;...