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DE10148828B4 Modulating the expression of STAT-1-dependent genes  
Pharmaceutical A composition comprising a double stranded DNA oligonucleotide, a strand of DNA a sequence according to SEQ ID NO: 1 to 32 or 34 to 40 or has a single-stranded nucleic acid molecule...
DE10346721A1 New oligonucleotides, useful for treating cancer, especially of the pancreas, are not species specific but induce apoptosis or inhibit proliferation  
Oligonucleotide (ON) that includes an arrangement of at least 6, preferably 8, consecutive nucleotides (nt) from (S1) is new. Oligonucleotide (ON) that includes an arrangement of at least 6,...
DE10345021A1 Verfahren zur nichtinvasiven Früherkennung von Dickdarmkrebs und/oder Darmkrebsvorläuferzellen  
Die Erfindung betrifft ein Verfahren zur nichtinvasiven Früherkennung von Dickdarmkrebs und/oder Dickdarmkrebsvorläuferzellen, Primer, mit denen Mutationsanalysen in ausgewählten Regionen der Gene...
DE10344799A1 Identifying surface-associated antigens for tumor diagnosis and therapy  
According to the invention were Tumor-associated gene and the nucleic acids encoding them identified. The present invention relates to the therapy and diagnosis of Diseases in which aberrant these...
DE10344967A1 New cyclodextrin derivatives, used for giving fiber, e.g. textile or hair, or skin temporary binding or release finish, e.g. for odor or perfume, are prepared from reactive derivative and alkoxylate with ethoxylate and/or propoxylate units  
New cyclodextrin derivatives (I) have 1-3 substituents comprising an optionally etherified or esterified alkoxylate group of 1-150 ethylene and/or propylene glycol units, linked to the...
DE10344967B4 Alkoxyl group-containing cyclodextrin derivatives; Processes for their preparation and their use  
Cyclodextrin derivative of the formula (I) A [-Z1-XZ2- (EO / PO)n-R1]m (I)wherein A represents an m-valent cyclodextrin residue which is formed of a cyclodextrin molecule by removal of m hydroxyl...
DE10342292A1 New macrolide oxazolidinone derivatives useful for treating bacterial infections  
Macrolide oxazolidinone derivatives (I) are new. Macrolide oxazolidinone derivatives of formula (I) and their salts, solvates and hydrates are new. [Image] R1, R2 : H, optionally protected OH or...
DE10341812A1 Differentially expressed in tumors gene products and their use  
According to the invention were Tumor-associated gene products expressed and coding the for nucleic acids identified. The present invention relates to the therapy and Diagnosis of diseases in...
DE10340068A1 New inhibitors of non-ribosomal peptide synthetase adenylation domains useful in therapeutic compositions comprise aminoacyl sulfamoyl adenosine derivatives  
New inhibitors of non-ribosomal peptide synthetase adenylation domains (NRPS A domains) comprise aminoacyl sulfamoyl adenosine derivatives (I) that are not hydrolyzable and specifically bind to...
DE10339609A1 Oligonucleotide, method and system for the detection of antibiotic resistance-mediating genes in microorganisms by means of the real-time PCR  
oligonucleotide Method and system for the detection of antibiotic resistance-imparting Genes in microorganisms by means of the Real Time-PCR, comprising:- Using a first primer nucleotide sequence...
DE10339549A1 New glucopyranosyloxy-pyrazole derivatives are sodium dependent glucose cotransporter inhibitors used for treating and preventing metabolic disorders, particularly diabetes  
Glucopyranosyloxy-pyrazole derivatives (I), are new. Glucopyranosyloxy-pyrazole derivatives of formula (I), their tautomers, stereoisomers, mixtures and salts are new. [Image] R 1>pyrrolidin-3-yl,...
DE102004022065A1 Screening procedures for hydantoin racemases  
The present invention relates to a method for screening and hydantoin racemases new hydantoin racemases they nucleic acid sequences encoding and a method for mutagenesis.Hydantoin racemases are...
DE19755642B4 Markierter Primer für die Polymerasekettenreaktion  
Verwendung einer Polymerasekettenreaktion, bei der – mindestens einer der Primer an den beiden Enden seines Oliganukleotid-Stranges mit zwei unterschiedlichen Fluereszenzfarbstoffen, einem...
DE10006462B4 Production of non-cariogenic sugar in transgenic plants  
Recombinant Nucleic acid molecule which a) regulatory sequences of an active in plant cells promoter; b) operatively linked thereto a DNA sequence encoding a protein with the enzymatic activity a...
DE10333509B4 Directed against VEGF recognition molecules and the use of these  
Recognition molecule directed, against the gene of the Vascular Endothelial Growth Factor, characterized in that that the recognition molecule, which is a nucleic acid construct selected of an...
DE10333509A1 New recognition molecules for the vascular endothelial growth factor gene, useful for treatment, diagnosis and monitoring of solid tumors and leukemia  
Recognition molecule (I), directed against the gene for vascular endothelial growth factor (VEGF) is new. It interacts specifically with the mRNA of VEGF in the target sequence region 600-990 of M...
DE10333508A1 New recognition molecules for the prothrombin gene, useful for treatment, diagnosis and monitoring of thromboembolic disease, target a specific region in prothrombin mRNA  
Recognition molecule (I), directed against the gene for human prothrombin (hPT) is new. It interacts specifically with the mRNA of hPT in the target sequence region 489-1932 of NM 000506. An...
DE10247476B4 A method for concentrating and isolating Oregonin  
process for enrichment and isolation of Oregonin of formula I alder bark by extraction in 50-120 ° C hot water, Filtration, selective deposition of the overnight cooled extract acrylate-adsorber,...
DE10328813A1 Method for investigating cytosine methylation in DNA sequences by means triplexbildender oligomers  
It is a method for examination of locations of cytosine methylations in DNA sequences described. It triplex oligomers are used, the preferred in positions triplex structures form at which cytosine...
DE10106370B4 Oligonucleotide probes for the detection of periodontal bacteria by means of in situ hybridization  
oligonucleotide probes for species-specific detection of periodontal pathogenic bacteria of the species Actinobacillus actinomycetemcomitans by in situ hybridization, wherein the oligonucleotide...
DE10329240A1 Method for analysis of cytosine methylation status of Cancer-testis antigens for an individualized immunotherapy  
described is a method for determining the points of a tumor immunotherapy, said method comprising:a) removes a DNA sample,b) the methylation state at least each of a CpG position within more...
DE10325200A1 Preparation of saccharide esters  
It is provided a process for the preparation of saccharide esters by reacting saccharides with activated carboxylic acids in an aprotic dipolar solvent and described in the absence of a basic...
DE102004028318A1 Preparation of aldoses  
A Aldose having n-1 carbon atoms is from an aldonic acid with n carbon atoms using hypochlorous acid or a hypochlorite with a high yield and safely and at a low cost by treating the reaction...
DE19747642B4 A process for producing isomelezitose-containing sweeteners, of isomelezitose and isomaltulose  
process for the preparation of a sweetener, being enzymatically in a first method step saccharose converting at a temperature of 50 to 60 ° C and in a second Step the Saccharidgemisch obtained...
DE19624345B4 Acylated carbohydrates with at least one etherified with the carbohydrate carboxyalkyl group, processes for their preparation and their use in detergents  
Acylated etherified carbohydrates having at least one with the carbohydrate Carboxyalkyl group of the general formula KH (-O-CHR1COOH)n (-O-CO-R2)m in the KH (carbohydrate) is a monosaccharide,...
DE10324063A1 Preparing nucleotides on controlled pore glass, useful for making libraries for screening to identify aptamers, by coupling protected deoxyphosphoramidite directly to amino groups on the glass  
Preparing nucleotides (I) bound to porous glass (controlled pore glass; CPG) comprising functionalizing the surface of CPG with amino groups; coupling a protected deoxyphosphoramidite (I) directly...
DE29724846U1 Preparation of 6-O-methyl erythromycin A crystal Form II - from erythromycin, treating with solvent, and isolating, useful as an antibiotic  
Preparation of 6-O-methylerythromycin A crystal form II comprising: (a) converting erythromycin A to 6-O-methylerythromycin A; (b) treating 6-O-methylerythromycin A with a solvent selected from...
DE10362249B4 C1-selective oxidation of oligosaccharides and the use of a carbon supported gold catalyst for this oxidation  
Process for the selective oxidation of the C1-aldehyde group of a used as starting material oligosaccharide, oligosaccharide mixture or an oligosaccharide or composition containing an...
DE10319917B4 Process for the selective carbohydrate oxidation using a supported gold catalysts  
process for the selective oxidation of carbohydrates, carbohydrate blend or composition containing the same, wherein an aqueous solution of Carbohydrate, the mixture or composition in the presence...
DE10319917A1 Process for the selective carbohydrate oxidation using a supported gold catalysts  
The This invention relates to a process for the selective oxidation a carbohydrate in the presence of a gold catalyst, the distributed nanodispersed Gold particles comprises on a metal oxide...
DE10320070A1 Water-soluble or water-based polymers of monoethylenically unsaturated saccharide  
Water-soluble or water-based polymers of monoethylenically unsaturated Saccharide, the(A) 5 to 100 wt .-% of at least one Ester selected from the group of Monoacrylsäure- and monomethacrylic of...
DE10320519A1 A method for detecting infectious (+) - strand RNA viruses, in particular infectious enterovirus  
It A method for detecting infectious (+) - strand RNA viruses, in particular Enteroviruses, described in a sample. In this case, first a Cell culture with the sample inoculated, then the...
DE19545870B4 A process for the preparation of the (meth) acrylic acid esters of carbohydrates  
process acrylic acid esters for the preparation of (meth) carbohydrates with at least one free hydroxyl group in molecule selected from the group consisting of sucrose, sugar alcohols and...
DE10316701A1 New nucleic acid, and derived proteins, useful for diagnosis of bronchial cancer and in screening for therapeutic and diagnostic agents  
Isolated nucleic acid (I) associated with bronchial cancer comprising 489 defined sequences given in the specification, is new. Independent claims are also included for: (1) protein or peptide...
DE10315772A1 Chemical compounds and methods for the intramolecular energy transfer to the elimination of labile functional groups of chemical compounds  
The present invention provided a chemical compound and a A process for the elimination of labile functional groups of molecules by the action of electromagnetic radiation using the chemical...
DE10316268A1 Extraction of 2-keto-L-gulonic acid from a polar solvent comprises extraction of the acid from the polar, preferably aqueous solvent with an extracting agent containing a tertiary amine and a polar organic diluent  
Extraction of 2-keto-L-gulonic acid (I) from a polar solvent comprises extraction of (I) from the polar, preferably aqueous solvent with an extracting agent containing a tertiary amine and a polar...
DE19720496B4 A process for hydrogenating sugars or sugar mixtures to sugar alcohols or sugar alcohol mixtures  
process for hydrogenating sugars or sugar mixtures to sugar alcohols or sugar alcohol mixtures wherein the sugars are ketoses or contained and selected the sugar mixtures ketoses are from the...
DE202004012163U1 System for hybridizing immobilized nucleic acid samples, in sealed hybridizing chambers, has a pressure assembly to build up the chamber pressures over ambient atmospheric levels to prevent the formation of air bubbles  
A system (1) with hybridizing chambers (5), to hybridize immobilized specimens on carriers (27), having chambers which are defined by the gap between the carrier and a cover (26), and which can be...
DE10313791A1 Specific detection of mycobacteria of the M. tuberculosis complex  
Methods and means for the specific detection of mycobacteria of the Mycobacterium tuberculosis complex (TBC), particularly Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium bovis BCG...
DE10312775A1 Microbial production of L-alanine, using microorganisms in which catabolism of pyruvate has been switched off and a gene for L-alanine dehydrogenase has been introduced  
Microbial production of L-alanine comprises anaerobic fermentation of a genetically modified microorganism (A) in which (a) catabolic reactions that start from pyruvate have been switched off and...
DE10005808B4 Process for the preparation of template DNA from refined vegetable food which is suitable for amplifying a region of DNA by the PCR method  
A process for the preparation of a template DNA of a grafted plants food, which was subjected to protein denaturation, comprising the steps of: (A) carrying out a degreasing treatment of the...
DE20220947U1 New pyrrolo(2,3-d)pyrimidine nucleoside analogs useful as immunomodulators for treatment of cancer and autoimmune diseases  
Pyrrolo(2,3-d)pyrimidine nucleoside analogs (I), their salts or prodrugs, are new. Pyrrolo(2,3-d)pyrimidine nucleoside analogs of formula (I), their salts or prodrugs, are new: [Image] A : O, S or...
DE10312625A1 Method for preparing functional peptide nucleic acids, useful e.g. in gene therapy and as detection probes, using protected synthon that allows subsequent reaction with functional carboxylic acid  
Method for producing a functional PNA (peptide nucleic acid) oligomer (A) in which PNA monomer units, containing protected adenine, guanine, cytosine or thymidine, are reacted with Fmoc-omega...
DE10310267A1 Intramolecular transesterification of material, especially plant extract, containing cyclic polyhydroxy compounds, e.g. to prepare bioactive natural products, carried out at elevated temperature and pressure  
Intramolecular transesterification of starting materials containing cyclic polyhydroxy compounds (e.g. phenylethanoids) is carried out at a pressure of 1-20 x 103> Pascals and a temperature of...
DE10308941A1 Monofunctional perylenetetracarboxylic acid bisimides  
The invention relates to novel Perylentetracarbonsäurebisimid derivatives with improved application properties.
DE10308931A1 System and process for the synthesis of polymers  
The present invention relates to an automated polymer synthesis apparatus for synthesis of a polymer chain onto a solid substrate by sequentially adding Polymerbaublöcken and a method for...
DE10012540B4 Oligonucleotides and methods for the specific detection of micro-organisms by the polymerase chain reaction  
Oligonucleotide comprising a sequence selected from the group consisting of: a) 5'-TTA TAC GAC AAA ACT GCA GT-3 '; b) 5'-ATT CGT ATT AGT ATT GTT TGA TG-3 '; c) 5'-ACT ACT AAC AAC AAT ACA GC-3 ';...
DE202004006675U1 Apparatus to purify and isolate nucleic acids, for diagnosis from small samples taken from e.g. blood, has two interconnected hollow bodies with a nucleic acid bonding material at the inlet to the second body  
The apparatus to purify or isolate nucleic acids has a hollow body (100) with an inlet opening (101) for a sample, and an outlet opening (102). A second hollow body (200) has an inlet opening...
DE10310082A1 Protein-binding doxorubicin-peptide derivatives  
The invention relates to low molecular weight doxorubicin-peptide derivatives with MMP-2 or MMP-9 cleavable peptide sequences that contain a protein-binding group.
DE10119203B4 A process for the production of double stranded nucleic acids with single-stranded overhangs of arbitrary length and nucleotide composition  
A process for the production of deoxyribonucleic acid (DNA) by one or two 5 'protruding ends, characterized in that a DNA synthesis with one or two polymerase resistant oligonucleotides is carried...