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DE102004011687A1 VGLUT specific dsRNA compounds  
The present invention provides dsRNAs ready for the VGLUT are specific and the phenomenon trigger the RNA interference can. Further, host cells containing these dsRNAs are provided. According to a...
DE102004013736A1 A method for enrichment of trehalose with the aid of aluminosilicates  
The Invention relates to a method for enriching trehalose from solutions wherein the enrichment with the aid of an adsorbent is carried out, characterized in that the adsorbent is an...
DE102004012676A1 New glucopyranosyl-substituted benzene derivatives are sodium-dependent glucose cotransporter inhibitors, useful for treating e.g. metabolic disorders (type 1 and type 2 diabetes mellitus or metabolic acidosis)  
Glucopyranosyl-substituted benzene derivatives (I) and their tautomers, sterioisomers andsalts are new. Glucopyranosyl-substituted benzene derivatives of formula (I) and their tautomers,...
DE102004062386A1 Monacolin K biosynthesis genes  
Of the Monascus produced cholesterol inhibitor monacolin K is a secondary Metabolite from the group of polyketides. The invention provides probes prepared that are specific for the gene cluster of...
DE102004062386B4 Monacolin K biosynthesis genes  
An isolated DNA molecule comprising a polynucleotide which it is mkA and which has a nucleotide sequence of SEQ ID NO: 2, wherein said polynucleotide encodes a polypeptide having an activity...
DE102004009977A1 New nucleic acid containing fluorescent tricyclic heterocyclic residue, useful as hybridization probes for detection and quantification of nucleic acids  
Nucleic acid (A) comprising a backbone to which at least one tricyclic heterocyclic group (I) is attached is new. Nucleic acid (A) comprising a backbone to which at least one tricyclic...
DE4126475B4 13-dihydro-3 '- (2-alkoxy-4-morpholinyl) anthracycline, processes for their preparation, their use and compositions containing  
Anthracycline glycoside of the general formula (A) or a pharmaceutically acceptable salt thereof where R1 H, OH or OCH3 is; one of the groups R2 and R3 is OH and the other is H; R4 is H or OH; R5...
DE102005007110A1 Metallic salt of N4-Acylcytidin derivatives and processes for producing N4-Acylcytidin derivatives by using the same  
These Invention relates to a method for producing a high-purity N4-Acylcytidin Derivative. More specifically This invention relates to a compound of formula (1): wherein R1 is a hydrogen atom, an...
DE102004010219B4 HKI10311129, new antibiotic, to processes for its preparation and medicaments containing HKI10311129  
connection (HKI10311129) with molecular weight 1113 and the empirical formula C56H75NO22. wherein the structural formula applies:
DE102004009704A1 New conjugates useful for labeling nucleic acids comprise a label coupled to nucleotide or nucleoside molecules through polymer linkers  
Conjugates (I) comprising a label coupled to 1-100 nucleotide or nucleoside molecules through polymer linkers with a length of 100-20000 atoms are new. Conjugates of formula (I) are new....
DE102004009018A1 Methods for modulating gibberellic acid-dependent processes in plants  
The This invention relates to a method of inhibiting gibberellic acid-dependent processes in transgenic plants by modulating the expression of a negative regulator gibberellic acid-controlled...
DE4041317B4 Method of crystallizing crystal anhydrous fructose from their aqueous solutions  
process to crystallize anhydrous crystalline fructose from water a crystallizer with a productivity of at least 0.5 t / m3 d, comprising: a) preparing a aqueous Solution, containing at least about...
DE102004017793A1 Use of trioxacarcins for treatment and prevention of infectious diseases, also new trioxacarcins for treatment of e.g. tumors, inflammatory and autoimmune diseases  
Use of trioxacarcins (I), or their stereoisomers, tautomers and salts, for preparing a composition for treatment and prevention of infectious diseases caused by fungi, parasites, viruses and...
DE102004008302A1 Preparation of alkoxylated alkyl and/or alkenyl polyglycosides, useful as adjuvants in agro-chemical formulations e.g. in herbicides, comprises reaction of alkylene oxides with alkyl- and alkenyl polyglycosides  
Preparation of alkoxylated alkyl and/or alkenyl polyglycosides (A) comprises reaction of alkylene oxides with alkyl- and alkenyl polyglycosides (I) (in aqueous preparation form with a water...
DE102004006477A1 Process for demonstrating the presence of single nucleotide polymorphism in human genes, comprises using a priming agent  
A process demonstrates the presence of single nucleotide polymorphism (SNP) in human CYP2-genes using a priming agent and/or a probe, where the priming agent effects high-resolution amplification...
DE102004003860A1 Methods for genotyping and pathotyping of Pseudomonas aeruginosa  
The Invention relates to a method for genotyping and pathotyping bacteria of the species Pseudomonas aeruginosa by hybridization assays on a biochip or microarray. The invention further relates...
DE102004002787A1 Flavonoid complexes  
The Invention relates to complexes of certain flavonoid derivatives, preparations, containing such derivatives, corresponding methods for producing the containing flavonoid derivatives or of these...
DE102004002351A1 New RNA aptamers specific for lipopolysaccharide-binding protein, useful for diagnosis and treatment of sepsis, inhibit the lipopolysaccharide-induced signaling cascade  
RNA aptamers (I), or their alleles and/or derivatives, that bind specifically to lipopolysaccharide-binding protein (LBP) are new. An independent claim is also included for a method for preparing...
DE10360456A1 Tumor antigens and their use  
The present invention relates to tumor antigens squamous, nucleic acids, encoding them, and antibodies, which are directed against this. The invention further relates to A method of generating...
DE10358077A1 A method for increasing the sensitivity of tumor cells  
The Invention relates to a method for increasing the sensitivity of tumor cells opposite to a potentially apoptosis or necrosis triggering cellular effector, wherein a substrate conversion by a...
DE102004054432A1 Solvent-free production of carbohydrate partial esters for use in cosmetics, pharmaceuticals and food involves transesterification of glycoses with fatty acid esters in presence of emulsifiers and an alkali catalyst mixture  
Solvent-free production of carbohydrate partial esters of average esterification degree 1-4 in presence of an alkali metal carbonate/alkali metal hypophosphite catalyst mixture is effected by...
DE102004034228A1 A process for preparing a pyrimidine nucleoside compound and a new pyrimidine nucleoside compound  
process for preparing a Pyrimidinnukleosidverbindung, comprising: Reacting a sugar phosphate with a pyrimidine base derivative under Using an enzyme having activity Cytosinnukleosidphosphorylase...
DE10361133A1 Glucopyranosyloxy-substituted aromatics, pharmaceutical compositions containing them, their use and processes for their preparation  
The present invention relates to glucopyranosyloxy-substituted aromatics of the general formula, in theR1 to R6 and R7a, R7b, R7c the claim 1 are defined, the tautomers, the stereoisomers, the...
DE10359351A1 DNA sequence and recombinant production of Group 4 Major allergens from cereals  
The This invention relates to the provision of DNA sequences Group 4 Major allergens from cereals. The invention also includes fragments, Combinations of partial sequences and point mutants having...
DE102004059710A1 Preparing a biological sample containing DNA for automatic isolation comprising concentrating and stabilizing in a lysis bonding buffer system without using large samples or centrifuges  
Concentrating and stabilizing biological material containing DNA, and especially blood samples comprising partially treating the sample material in a cell lysis bonding buffer system, and bonding...
DE102004045139A1 Dendrimer-based DNA extraction procedure and biochips  
The present invention provides a dendrimer-based biochip ready wherein a flow channel, by a biopolymer molecules containing solution supplied is formed in the substrate of the biochip, a plurality...
DE10359960A1 New glucopyranosyloxy-pyrazole derivatives are sodium dependent glucose cotransporter inhibitors used for treating and preventing metabolic disorders, particularly diabetes  
Glucopyranosyloxy-pyrazole derivatives (I), are new. Glucopyranosyloxy-pyrazole derivatives of formula (I), their tautomers, stereoisomers, mixtures and salts are new. [Image] R 1>pyrrolidin-3-yl,...
DE10359023A1 A process for producing 2-keto-L-gulonic esters  
process for the production of 2-keto-L-gulonic acid-C1-C10-alkyl esters by esterifying 2-keto-L-gulonsäureanhydrat with an anhydrous C1-C10alkyl alcohol in the presence of an acidic homogeneous...
DE10358407A1 Antiapoptorisch effective aptamers (for the treatment of cardiovascular diseases)  
The present invention relates to anti-apoptotic effective aptamers. The corresponding sequences are shown. Possible therapeutic and diagnostic Uses are described, including atherosclerosis,...
DE10357677A1 Primers and probes for the detection of genital HPV genotypes  
The present invention relates to oligonucleotides as primers for suitable amplification of DNA of genital human papilloma viruses (HPV) are oligonucleotides that genital as probes to type HPV...
DE20023659U1 Molecular markers to test the phenotypic stability of cell populations and cell populations for autologous transplantation  
Diagnostic Tool for identifying cells that are capable of, to produce non-vascularized cartilage in vivo stable, comprising DNA probes hybridizing at least two of the markers at the mRNA selected...
DE10357301A1 Compounds for the modulation of the glycolysis enzyme and / or transaminase-complex  
The Invention relates to compounds for modulating the glycolytic enzyme complex and transaminase-complex, to pharmaceutical compositions containing such compounds and use of such compounds for the...
DE10356837A1 New conjugates useful for modifying nucleic acid chains comprise nucleotide or nucleoside molecules coupled to a label through water-soluble polymer linkers  
Conjugates (I) comprising 1-100 nucleotide or nucleoside molecules coupled to a label through water-soluble polymer linkers are new. Nucleotide or nucleoside conjugates of formula (I) are new:...
DE10353621A1 Oligonucleotide-peptide used in nucleic acid analysis, is made by covalent bonding of defined marker-peptide chain to oligonucleotide  
A defined marker-peptide chain covalently-bonded to the oligonucleotide, is new. The antibody is obtained by immunizing an animal by injection of the marker peptide defining the oligonucleotide,...
DE10352433B4 Polypeptide a Silicatein ß from Suberites domuncula, nucleic acid coding therefor, their uses, this nucleic acid vector comprising and expressing this polypeptide host cell  
Polypeptide a Silicatein β from Suberites domuncula according to SEQ ID NO. 1, recombinant polypeptide comprising an amino acid sequence of β-Silicatein domain identical to the sequence shown in...
DE10352433A1 Enzymatic synthesis, modification and elimination of silicon (IV) -and other metal (IV) -compounds  
The This invention relates to the use of recombinant or from natural sources insulated Silicatein β and of Silicatein β fusion proteins and Silicatein β-related Enzymes for the synthesis,...
DE10350256A1 PIM-1-specific siRNA compounds  
The present invention provides dsRNAs ready for the PIM-1 kinase specific. Furthermore, these host cells containing provided. According to a another aspect of these containing medicinal products,...
DE10349441A1 Selecting nucleic acid that binds target molecules, useful potentially as therapeutic agents, by screening short sequences with two fixed regions flanking a random region  
Selecting a nucleic acid (I), especially an aptamer, that binds a target molecule (II), is new. Selecting a nucleic acid (I), especially an aptamer, that binds a target molecule (II) comprises:...
DE10057841B4 A method for the detection of protozoa of the genus Naegleria  
oligonucleotide probes for the detection of protozoa of the genus Naegleria in a sample by in situ hybridization, wherein the oligonucleotide probes specific bind to the 18S ribosomal sequences...
DE10350965A1 Method using activated linker with specified functionality to modify components for coupling with thio-esters through chemical ligation, employs specified linker structure  
Method using an activated linker with specified functionality to modify components for coupling with thio-esters through chemical ligation, is new. Method using an activated linker with specified...
DE4444606B4 Process for the preparation of sennosides A and B.  
process for the preparation of sennosides A and B, in which rheinanthrone-8-glucoside with oxygen or an oxygen source to the sennosides A and B is oxidized, characterized in that the oxidation...
DE10348407A1 Prognostic and diagnostic markers for cell proliferative disorders of breast tissues  
The present invention relates to modified and genomic sequences, Oligonucleotides and / or PNA-oligomers for detecting the cytosine methylation state of genomic DNA and a method for prognosis and...
DE10346627A1 Single-chain antibody against the 37 kDa / 67 kDa laminin as tools for diagnosis and therapy of prion diseases and cancer, their preparation and use  
described are single chain antibodies, called. "single-chain" antibodies, specific both the 37 kDa precursor form of the laminin receptor (37 kDa LRP) as well as the 67 kDa high-affinity form of...
DE10148828B4 Modulating the expression of STAT-1-dependent genes  
Pharmaceutical A composition comprising a double stranded DNA oligonucleotide, a strand of DNA a sequence according to SEQ ID NO: 1 to 32 or 34 to 40 or has a single-stranded nucleic acid molecule...
DE10346721A1 New oligonucleotides, useful for treating cancer, especially of the pancreas, are not species specific but induce apoptosis or inhibit proliferation  
Oligonucleotide (ON) that includes an arrangement of at least 6, preferably 8, consecutive nucleotides (nt) from (S1) is new. Oligonucleotide (ON) that includes an arrangement of at least 6,...
DE10345021A1 Verfahren zur nichtinvasiven Früherkennung von Dickdarmkrebs und/oder Darmkrebsvorläuferzellen  
Die Erfindung betrifft ein Verfahren zur nichtinvasiven Früherkennung von Dickdarmkrebs und/oder Dickdarmkrebsvorläuferzellen, Primer, mit denen Mutationsanalysen in ausgewählten Regionen der Gene...
DE10344799A1 Identifying surface-associated antigens for tumor diagnosis and therapy  
According to the invention were Tumor-associated gene and the nucleic acids encoding them identified. The present invention relates to the therapy and diagnosis of Diseases in which aberrant these...
DE10344967B4 Alkoxyl group-containing cyclodextrin derivatives; Processes for their preparation and their use  
Cyclodextrin derivative of the formula (I) A [-Z1-XZ2- (EO / PO)n-R1]m (I)wherein A represents an m-valent cyclodextrin residue which is formed of a cyclodextrin molecule by removal of m hydroxyl...
DE10344967A1 New cyclodextrin derivatives, used for giving fiber, e.g. textile or hair, or skin temporary binding or release finish, e.g. for odor or perfume, are prepared from reactive derivative and alkoxylate with ethoxylate and/or propoxylate units  
New cyclodextrin derivatives (I) have 1-3 substituents comprising an optionally etherified or esterified alkoxylate group of 1-150 ethylene and/or propylene glycol units, linked to the...
DE10342292A1 New macrolide oxazolidinone derivatives useful for treating bacterial infections  
Macrolide oxazolidinone derivatives (I) are new. Macrolide oxazolidinone derivatives of formula (I) and their salts, solvates and hydrates are new. [Image] R1, R2 : H, optionally protected OH or...