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DE10164501A1 Methods and nucleic acids for the analysis of lymphoid cell division disorder  
The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for...
DE10158904A1 Process for the preparation of linear DNA fragments for the in vitro expression of proteins  
The present invention relates to a method for the production of linear DNA fragments for the in vitro expression of proteins, in which a linear DNA fragment containing control elements necessary...
DE10158516A1 Method for detecting hybridization events in nucleic acids  
Disclosed is a method for detecting target nucleic acid by hybridization, wherein a) hybridization is carried out with at least one probe nucleic acid which is bound with one end to a solid phase,...
DE10148828A1 Modulation of the expression of STAT-1-dependent genes  
The present invention relates to decoy oligonucleotides and antisense oligonucleotides having the nucleic acid sequence according to SEQ ID NO: 1 to 43 and their use as medicaments.
DE10159078A1 Heterocyclyl polymethine dyes, useful for optical marking of protein, nucleic acid, oligomer, DNA, RNA, cell, lipid, saccharide, ligand, receptor, vitamin, nucleotide, polymer or pharmaceuticals, also for receptor-ligand analysis  
Marker dyes, useful for optical marking of e.g. proteins, based on tri-, penta- or hepta-methines are new. Marker dyes, useful for optical marking of e.g. proteins, of formulae (I), (II) and (III)...
DE10156910A1 Antitumoral and antineoplastic medicaments, effective against carcinoma, sarcoma, lymphoma and leukemia, comprise new or known nucleoside-sulfur containing phospholipid derivatives  
Nucleoside-sulfur containing phospholipid derivatives (I), which on adminstration to humans directly or indirectly provide (I) or other antitumoral or antiproliferative active metabolites or their...
DE10156467A1 Carrier for synthesis and process for the preparation of biopolymers  
The present invention relates to a support for the synthesis of biopolymers, its use and a process for the preparation of the biopolymers.
DE10154245A1 Genes encoding regulatory proteins  
The invention relates to novel nucleic acid molecules, their use for the construction of genetically improved microorganisms and processes for the preparation of fine chemicals, in particular...
DE10156352A1 Enzymatic synthesis of sugar acrylates  
The invention relates to a method for the enzymatic synthesis of sugar acrylates, to a method for producing polymer sugar acrylates, to the polymers which can be obtained according to said method,...
DE10155862A1 Production of recombinant antibodies by fusion with elastin-like peptides  
The invention relates to a nucleic acid molecule in which a first DNA sequence coding for a recombinant antibody is fused with a second DNA sequence coding for elastin-like peptides in such a way...
DE10153957A1 Method for isolating nucleic acids  
The invention relates to a simplified and rapid method for the isolation of nucleic acids, in particular plasmid DNA from E. coli, whereby after alkaline lysis of the sample, the above is...
DE10152598A1 ARL-2 for fertility control  
It describes a human ARL-2 protein and its use for fertility disorders, therapy and diagnosis.
DE10154399A1 Method for identifying active substances for the modulation of pip92-mediated apoptosis  
The invention concerns methods for identifying active substances involved in the signal cascade of protein pip92-mediated apoptosis, and methods which can be used to identify proteins interacting...
DE10152376A1 New substrates for phospholipase, useful e.g. for diagnosis and drug screening, contain two fluorophores that make a fluorescent energy-transfer pair  
Phospholipase substrates (I) containing two fluorophores are new. Phospholipase substrates of formula (I) are new. A = 1-20C alkylene or alkenylene; B = NH, NHCO, CONH, NHCONH, NHCSNH, oxygen or...
DE10152147A1 Method for applying nucleosides and / or nucleotides on functionalized surfaces and methods for determining coupling yields in the synthesis of nucleotides  
The present invention relates to a method for applying nucleosides and / or nucleotides on functionalized surfaces which are provided with reactive functional groups, wherein the reactive...
DE10152615A1 Zuckerester  
New sugar esters are proposed which are obtained by esterifying sugar acids with alcohols in the presence of lipases.
DE10152017A1 Arrays with hairpin structures  
The invention relates to arrays of nucleic acids immobilized on a carrier, which are present at least partly in the form of secondary structures such as hairpin structures. The invention also...
DE10150677A1 New nucleic acid encoding fungal mitogen-activated protein kinase, useful as target for identifying fungicides for plant protection, is from Fusarium graminearum  
Nucleic acid sequence, encoding a MAP kinase, (I) comprises (a) sequences (S1) or (S2), of 556 and 490 nucleotides, reproduced; (b) a functional equivalent of (a); (c) a fragment of (a); or (d) a...
DE10150676A1 New chemically-inducible promoters  
The invention relates to methods for the chemically inducible expression of nucleic acid sequences, preferably in plants. Said invention also relates to novel chemically inducible promoters,...
DE10150121A1 Real-time detection of DNA amplification products  
The invention relates to a method for the real-time detection of DNA amplification products. The invention also relates to partially double-stranded oligonucleotides, which are used during the...
DE10139062A1 Process for the fermentative production of L-amino acids using coryneform bacteria  
The invention relates to a process for the preparation of L-amino acids, in which the following steps are carried out: DOLLAR A a) fermentation of the desired L-amino acid-producing coryneform...
DE10249024A1 Preparing aqueous nucleic acid-rich extracts, useful in cosmetics e.g. for reducing aging of skin, includes extraction in presence of cellulase then treatment with protease  
Method for preparing a nucleic acid-rich aqueous extract (A) from plant materials, especially plant embryos or seeds rich in DNA and RNA comprises: (i) extraction in aqueous medium in presence of...
DE10150783A1 Splicing as a target to identify new drugs  
The present invention relates to novel deoxyribonucleic acid (DNA) constructs, vectors and host organisms which contain these DNA constructs and which are suitable for use in certain methods to...
DE10142643A1 Detection of interactions on probe arrays  
The invention relates to a method for detecting interactions between probe molecules on probe arrays, in which the labeling of the target molecules can be dispensed with. Furthermore, the...
DE10125537A1 Identifying herbicides and plant growth regulators, from ability to inhibit specific genes, also use of these genes to prepare herbicide-resistant transgenic plants  
Identifying compounds (A) with herbicidal activity from ability to reduce or block expression or activity of gene products of specific nucleic acid sequences (I) or amino acid sequences (II)...
DE10146589A1 New mutants of formate dehydrogenase from Candida boidinii  
The present invention is concerned with new improved recombinantly produced enzymes, in particular rec-FDHs. By directed evolution, it has been possible to generate catalytically more active and...
DE10145226A1 Production of carrier-bound molecules  
The invention relates to a support for binding assays, whereby the assignment and coupling of trap molecules occurs on the solid phase by simple coating of a surface (support), pretreated in a...
DE10144346A1 TT virus sequences in human tumor tissues, means for their detection and tumor therapy  
Described are DNA sequences comprising the genome of a tumor-associated TT virus, or fragments thereof. The present invention further relates to proteins encoded by said DNA sequences, antibodies...
DE10140651A1 Diagnostic kit, useful for assessing a subject's tolerance of drugs, comprises reagents for determining alleles of genes encoding detoxification enzymes  
Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans. Diagnostic kit (A) for determining tolerance of pharmaceuticals in humans comprises two pairs of oligonucleotide (ON)...
DE10144647A1 New allosterically regulatable hairpin ribozyme, useful for identifying compounds that bind specific targets, has extra sequence between substrate binding and catalytic domains  
Allosterically regulatable hairpin ribozyme (I) is new. Independent claims are also included for: (1) polynucleotide (II) comprises a hairpin ribozyme having a substrate-binding domain A and a...
DE10144355A1 Identifying agents that inhibit the function of specific RNA, useful e.g. for treating human or feline immune deficiency virus, comprises using a target-reporter construct prepared from a reporter ribozyme domain  
Identifying compounds (A1) that bind specifically to a particular RNA target motif (II) so as to inhibit or eliminate its function. Identifying compounds (A1) that bind specifically to a...
DE10144264A1 Aqueous detergent formulation, useful in cosmetics, e.g. shampoo, hair lotion, foam bath or shower formulation, contains N-acylamino-acid and/or salt and polyol and/or polyol fatty acid ester  
Aqueous detergent formulation contains: (a) N-acylamino-acid (I) and/or salt (IA), and (b) polyol (II) and/or polyol fatty acid ester (III). Independent claims are also included for: (A) the...
DE10129484A1 Alkyl and / or alkenyl oligoglycoside preparations with reduced magnesium salt concentrations  
DOLLAR A These alkyl and / or Alkenyloligoglycosid preparations are used with a magnesium salt concentration of less than 10 ppm in surface-active preparations, such as preferably in cosmetic...
DE10129332A1 New sialic acid-binding Ig-like lectin (Siglec) inhibitors with increased activity, useful for e.g. treating inflammation, multiple sclerosis, cancer or viral disease, comprises C-9 amino-substituted neuraminic acid derivatives or analogs  
New sialic acid-binding Ig-like lectin (Siglec) inhibitors comprise of neuraminic acid derivatives (including aza, carba or thia analogs) (I) containing an optionally substituted amino group at...
DE10142743A1 Nucleotide chip containing probes against dimorphism-specific transcripts, useful for diagnosing Candida infections and transition from yeast to hyphal forms  
Nucleotide chip (A) comprises a solid carrier on which is fixed at least one nucleic acid (NA) suitable for identifying a transcript of a gene that encodes a dimorphism-specific protein....
DE10141300A1 Labelable compounds for easy synthesis of 3 '- [.18.F] fluoro-3'-deoxythymidine and methods for its preparation  
Disclosed are compounds of formula (I), wherein R represents Br, J or R<1>-SO3, wherein R<1> is an unsubstituted or substituted C1-C5-alkyl or an unsubstituted phenyl, X is O or NR'', wherein R''...
DE10139283A1 Methods and nucleic acids for the analysis of colon cancer  
The present invention relates to chemically modified genomic sequences, oligonucleotides and / or PNA oligomers for detecting the cytosine methylation status of genomic DNA as well as two methods...
DE10139730A1 Process for preparing CNA  
The invention relates to a novel method for producing CNA oligomers and artificial supramolecular CNA-p-RNA pairing systems. The invention also relates to the use of the same, especially in...
DE10138686A1 Use of a polyester composition as hydraulic fluid  
The present invention relates to the use of polyesters consisting of at least one carbohydrate and at least one carboxylic acid and mixtures thereof as hydraulic fluid.
DE10138092A1 Process for the immobilization of compounds and arrangement of immobilized compounds  
The present invention relates to a method for the immobilization of compounds on a surface comprising the steps DOLLAR A - providing a compound to be immobilized as a first reactant and a surface...
DE10137374A1 Process for the production of arachidonic acid in transgenic organisms  
The invention relates to a process for the production of arachidonic acid in transgenic organisms, in particular in transgenic plants and yeasts. Furthermore, the invention relates to DNA...
DE10139455A1 New polynucleotide sequences from Ashbya gossypii, useful for improving response of A. gossypii to external factors and particularly for improving production of vitamin B2  
Polynucleotide (I) encodes a protein (II) that is associated with transmembrane transport and/or is a transmembrane protein and is isolatable from Ashbya gossypii. Independent claims are also...
DE10136656A1 Biochip useful e.g. for determining gene expression patterns, and for selecting probes, comprises probes specific for genes active in rat liver  
A biochip has many probe positions, each containing many molecules of a nucleic acid probe (I), where one (I) has a length of 20 bases identical with, or complementary to, a segment of a rat liver...
DE10135098A1 Process for the preparation of peracylated 1-O-glycosides  
The invention relates to a process for the preparation of peracylated 1-O-glycosides of the general formula I or their salts DOLLAR F1 in the DOLLAR A sugar · 1 · a 1-OH-position-functionalized...
DE10134660A1 New isolated nucleic acid encoding desaturase enzymes from pomegranate, useful for recombinant production of unsaturated fatty acids, for e.g. the production of food, animal feeds and pharmaceuticals  
New isolated nucleic acid (I) encoding a polypeptide (II) with desaturase activity comprises: (a) a 1464 bp sequence (2); (b) a sequence deduced by reverse translation from a 374 amino acid (aa)...
DE10133915A1 New oligoribonucleotide derivatives for targeted inhibition of gene expression  
The invention relates to oligoribonucleotide derivatives that have, at the 3' end, a 2'5'-linked oligoribonucleotide radical without a 5' phosphate radical and to their use for the targeted...
DE10133858A1 Synthetic double-stranded oligonucleotides for targeted inhibition of gene expression  
The invention relates to oligonucleotide derivatives which are at least partially double stranded and which comprise a 2'5' linked oligonucleotide radical on at last one 3'- end. The invention...
DE10133779A1 Preparation of polynucleotides useful in gene technology involves reacting free 5'-hydroxy group of a oligonucleotide with a hydroxy group  
Preparation of polynucleotides involves: (a) reacting free 5'-hydroxy group of a oligonucleotide with a hydroxy group; (b) optionally oxidizing the product; (c) removing the 3'-hydroxy protecting...
DE10132025A1 Stepwise synthesis of biopolymers, useful e.g. for preparing DNA chips, using synthons containing protecting group that requires photoactivation before cleavage  
Stepwise synthesis of biopolymers (A) using protected synthons (B) where at least one (B) carries a two-stage protecting group (PG). PG is activated in a light-irradiation step and cleaved in a...
DE10128508A1 Methods and nucleic acids for the differentiation of prostate tumors  
The present invention relates to chemically modified genomic sequences, oligonucleotides and / or PNA oligomers for detecting the cytosine methylation state of genomic DNA and a method for...