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DE10220894A1 Promoters with altered transcription efficiency  
The present invention relates to a deoxyribonucleic acid (DNA) comprising at least one promoter sequence derived from a wild-type promoter of a methylotrophic yeast whose transcription efficiency...
DE20121966U1 Designing primers and probes for analyzing diseases associated with cytosine methylation state e.g. arthritis, cancer, aging, arteriosclerosis comprising fragments of chemically modified genes associated with cell cycle  
A nucleic acid, (I), comprising a sequence of 18 bases, of a segment of chemically pretreated DNA (CP DNA) of genes associated with cell cycle having a sequence taken from 424 sequences (Ss) and...
DE10220188A1 New antagonists of calcitonin gene-related peptide or amylin, useful for treating or preventing e.g. migraine or inflammation, are specific binding nucleic acids  
An antagonist (I) of CGRP (calcitonin gene-related peptide), especially a nucleic acid, preferably one that binds to CGRP, is new. Independent claims are also included for: (1) antagonist (Ia) of...
DE10218554A1 Syringe for purifying liquid or isolating substances from it, especially nucleic acids or proteins from blood, plasma or urine, has filter above its inlet, on which purifying agent is placed  
Syringe (12) for purifying a liquid and/or isolating substances from it has a filter (26) positioned above its inlet/outlet (24). Purifying agent (28) is placed on the filter on the side opposite...
DE10218476A1 Medicaments, cosmetics and dermatological compositions for a wide variety of skin treatments contain lignans or their glycosides  
Cosmetic and/or dermatological compositions contain lignans (or their glycosides) in addition to conventional ingredients.
DE10217994A1 A coupling product from (sic) chemical compounds of hyperbranched polysaccharide completely catabolized in the body under control of the body enzymes useful for parenteral pharmaceutically active materials  
A coupling product from (sic) chemical compounds of (sic) hyperbranched polysaccharide, i.e. from alpha-1,4-glycoside linked anhydroglucose units with alpha-1,6-glycosidal branching anhydroglucose...
DE10216426A1 Beta-L-2'-deoxy-thymidine preparation, for use as antiviral agent, from L-arabinose in 4-stage process via new oxazolidine derivative and thymidine derivative intermediates  
Preparation of beta-L-2'-deoxy-thymidine (I) involves: (a) reacting L-arabinose with cyanamide and optionally protecting the product; (b) reacting the obtained oxazoline compound (II) with a...
DE10214395A1 Parallel sequencing of nucleic acid segments, useful for detecting single-nucleotide polymorphisms, by single-base extensions with labeled nucleotide  
Parallel sequence analysis of segments of a complete nucleic acid sequence, using sequence-specific primers, is new. Parallel sequence analysis of segments of a complete nucleic acid sequence,...
DE10212397A1 Repressor of skeletal muscle differentiation, encoding nucleic acid and its use in diagnostics and therapy  
Disclosed are polypeptide sequences which play a role in the regulation of skeletal muscle differentiation, as well as nucleic acids coding therefor and their use in diagnostics and therapy. Uses...
DE10248451A1 Fredericamycin derivatives  
The invention relates to novel Fredericamycin derivatives, medicaments containing these or their salts, and the use of Fredericamycin derivatives for the treatment of diseases, in particular tumors.
DE20303420U1 Fischer-Tropsch and corresponding Guerbet alcohol mixtures, derivatives and compositions are useful e.g. in polymer, oil, cosmetic, pharmaceutical, detergent or functional fluid containing polymer surfactant and/or hydraulic fluid  
Alcohol mixtures (I) comprising Fischer-Tropsch alcohols and derivatives comprise alcohols containing (wt.%): (a) over 20% to 80% primary alcohols with a linear aliphatic chain; (b) over 10% to...
DE10209203A1 Composition useful for preparing DNA chips comprises compound with labile functional group and a sensitizer that acts by triplet-triplet energy transfer  
Chemical composition (A) comprises a molecule (I) having a labile functional group (LFG) and a compound (II) that has a triplet state energy higher than, or very close to, that of LFG. An...
DE10209071A1 Standardized polynucleotide system, useful for quantitative, real-time determination of nucleic acid, comprises stabilized standards, primers and probe  
Standardized polynucleotide system (A) comprises at least one carrier nucleic acid (cNA); at least 3 oligonucleotides (ON), as primers and target-specific, fluorescently labeled probe; optionally...
DE10210527A1 Alleles of the aceA gene from coryneform bacteria  
The invention relates to allelic aceA gene from coryneform bacteria encoding isocitrate lyases, and to processes for the fermentative production of L-lysine using bacteria containing these alleles.
DE10209564A1 Antitumoral and antineoplastic medicaments, effective against carcinoma, sarcoma, lymphoma and leukemia, comprise new or known nucleoside-sulfur containing phospholipid derivatives  
Nucleoside-sulfur containing phospholipid derivatives (I), which on adminstration to humans directly or indirectly provide (I) or other antitumoral or antiproliferative active metabolites or their...
DE10159264A1 Use of acetoacetyl-CoA thiolase to identify new fungicidally active substances  
The invention relates to nucleic acids which code for polypeptides from fungi with the biological activity of acetoacetyl-CoA-thiolase, the polypeptides encoded by them and their use as targets...
DE10232507C1 Sequence-controlled synthesis of nucleic acids, useful for making synthetic genes, comprises hybridizing primers to both strands then filling in gaps using a nucleic acid polymerase system  
Sequence-controlled preparation of a nucleic acid product (NP), comprising hybridizing primers to both strands then filling in gaps using a nucleic acid polymerase system, is new....
DE10206845A1 Surfactant alcohols and their ethers are obtained by a modified process involving metathesis of an olefin mixture, followed by dimerization and derivatization  
Production of surfactant alcohols or their ethers by derivatization of 10-20C olefins or mixtures, comprises: (i) metathesizing a 4C olefin mixture; (ii) removing the 5-8C olefins; (iii)...
DE20308345U1 Injection solution, for use in pyrosequencing equipment, comprises a buffer, deoxynucleotide and an alkaline pH which permits longer sequencing  
An injection solution for use in pyrosequencing equipment comprises: (1) a deoxynucleotide; (2) a buffer; and (3) an alkaline pH which permits longer sequencing, is new.
DE10205607A1 New nucleic acid encoding fatty acid elongase, useful for producing polyunsaturated fatty acids as oils, lipids or free fatty acids  
Isolated nucleic acid (I) that encodes a polypeptide (II) able to extend 16 or 18 carbon fatty acids having at least two double bonds by at least 2 carbon atoms, where the fatty acids...
DE10205500A1 Dyeing of hair in intense orange and red-gold to violet shades uses a mixture of a hydrolysate-containing preparation with 1,2,4-trihydroxynaphthalene glycoside (i.e. Lawson) derivative dye carriers, some of which are new  
A composition for dyeing keratinous fibers is obtained by mixing directly before use (A) a dye carrier containing a 1,2,4-trihydroxynaphthalene glycoside (i.e. Lawson) derivative and (B) a...
DE10204843A1 New nucleic acid from Arabidopsis thaliana, useful e.g. for detecting the presence or expression of corresponding genes, involved in metabolism and detoxification  
Nucleic acid (I) for qualitative or quantitative detection of Arabidopsis thaliana genes, or fragments, or derived RNA, comprises one of 275 fully defined sequences given in the specification, or...
DE10204072A1 Novel compounds that inhibit factor Xa activity  
The invention relates to the compounds of formula (I) or to the pharmaceutically acceptable salts, solvates, hydrates or pharmaceutically acceptable formulations thereof. The inventive compounds...
DE10204000A1 Sialysed carbohydrates  
The invention relates to the use of sialic carbohydrates of general formula (I), containing at least one carbohydrate unit of general formula (II) for the immune modulation, immune suppression and...
DE10203999A1 Cycloglycane  
The use of, in particular homopolymeric, cycloglycans with an annular base structure of 2 to 40 monosaccharides in the ring for the prevention of the invasion and infection of mammalian cells by...
DE10201858A1 Separating nucleic acids from a cell lysate, useful for recovering plasmids from bacteria, comprises passing the lysate through a filter material covering the whole inside surface of a holder  
Separating nucleic acids (NA) from other cell components, comprising: (a) lysis and precipitation of lysate components so that NA remains in solution; and (b) filtering the lysate in a separation...
DE10202419A1 A method of inhibiting the expression of a chromosome aberrated target gene  
The invention relates to a method for increasing the efficiency of an inhibitor of a tyrosine kinase activity in a cell. The tyrosine kinase is encoded by a gene produced by mutation. In order to...
DE10154290A1 Method for detecting periodontitis and caries associated bacteria  
The present invention relates to the field of diagnostics of microorganisms, in particular the detection of bacteria associated with the disease of periodontitis or caries. The invention relates...
DE10154290B4 A method for detecting periodontal disease and caries-associated bacteria  
A method for detecting periodontal disease or tooth decay associated bacteria by amplification and hybridization, comprising the steps of A) amplifying nucleic acid to fragments from the genome of...
DE10203713A1 New nucleic acid encoding fatty acid elongase, useful for producing polyunsaturated fatty acids as oils, lipids or free fatty acids  
Isolated nucleic acid (I) that encodes a polypeptide (II) able to extend 16 or 18 carbon fatty acids having at least two double bonds by at least 2 carbon atoms, where the fatty acids...
DE10201732A1 New immunogenic preparation, useful for preparing a composition for treating or preventing infections caused by HIV, Hepatitis B or C virus, Rous-Sarcoma virus or Chlamydia pneumoniae  
An immunogenic preparation comprising mature mRNA coding for at least one antigen of a pathogenic agent, is new. An Independent claim is also included for a vaccine comprising the immunogenic...
DE10201354A1 Novel alk(en)yloligoglycoside betaine quaternary ester useful as an emulsifier, hair conditioner and washing softener  
Alk(en)yloligoglycoside betaine quaternary ester (I) free of ethylene- and/or propylene-oxide is new. Alk(en)yloligoglycoside betaine quaternary ester of formula (I) is new; R1O(G)nOCOCR2R3NR4R5R6...
DE10200410A1 New antisense oligonucleotide, useful for treatment of tumors, inhibits translation of mRNA from the pituitary-tumor transforming gene-1  
Antisense oligonucleotide (AON) designed to inhibit translation of PTTG-1 (pituitary-tumor transforming gene-1) mRNA in human cells is new.
DE19948651A1 Nuclear magnetic resonance imaging contrast agent formulations containing perfluoroalkylated paramagnetic and diamagnetic compounds, having high organ specificity, especially for the lymph nodes  
Galenic formulations (A) contain paramagnetic perfluoroalkylated compounds (I) and diamagnetic perfluoroalkylated compounds (II). (II) include new cyclodextrin complexes (B). Galenic formulations...
DE10200386A1 Genetic sequence encoded by creatinine deiminase and its use  
The present invention relates to genetic sequences encoded by proteins or polypeptides having creatinine deiminase activity. Furthermore, the invention relates to the use of these proteins or...
DE10200252A1 Preparation of desclarithromycin from erythromycin, for use as antibiotic intermediate, comprises five stage process via new silylated and/or N-oxide intermediates  
Preparation of desclarithromycin (I) involves: (1) reacting erythromycin A with silylating agent to give silylated derivative (IX); (2) oxidizing to give silylated N-oxide (X); (3) ethylating...
DE10164197A1 Controllable enhancement of hybridization detection sensitivity  
The present invention is a method of enhancing the sensitivity of hybridization detection of nucleic acids and controlling this enhancement. For this purpose, those oligonucleotides are...
DE10164147A1 New macrocyclic antibacterials, useful for treating or preventing infections in human or veterinary medicine, also new intermediates  
Antibacterial macrocyclic compounds (I) and their salts, solvates and hydrates are new. Antibacterial macrocyclic compounds of formula (I) and their salts, solvates and hydrates are new. R5 = H,...
DE10163240A1 Process for bleaching surface-active compounds  
Disclosed is a method for bleaching aqueous alkyl polyglycoside preparations with the aid of peroxygen compounds, characterized in that the bleaching is carried out in the presence of 4-15 %...
DE10162728A1 New alkaline protease from Bacillus gibsonii (DSM 14393) and detergents and cleaners containing this new alkaline protease  
The invention relates to a novel alkali subtilisin-type protease formed by Bacillus gibsonii (DSM 14393), in addition to sufficiently related proteins and the derivatives thereof. The invention...
DE10161625A1 Methods and nucleic acids for the analysis of pulmonary cell division disorder  
The present invention relates to the chemically modified genomic sequence of genes associated with lung cell division disorders, to oligonucleotides directed against the sequence and / or PNA...
DE19964220C2 Modified nucleic acid oligomer, useful for sequencing by hybridization, is substituted by redox agent to allow electrical detection of hybridization  
Nucleic acid oligomer (I) modified by a redox-active substance (II) that is oxidizable and reducible selectively at a potential (phi) of 2 to -2 V, relative to the standard hydrogen electrode, is...
DE10163579A1 Process for the oxidation of organic compounds, e.g. for production of esters from ethers, uses a liquid multi-phase ruthenium catalyst system and an oxygen atom donor and is carried out using an aqueous phase of neutral or alkaline pH  
A process for the oxidation of organic compounds using a liquid multi-phase catalyst system comprising at least one ruthenium-containing compound and an oxygen atom donor, is characterized in that...
DE10163514A1 Storage system for nucleic acid samples comprises a polymer matrix and a storage film, with pores/cavities of dimensions to take the samples which are protected and held in a small space  
The storage system for nucleic acid samples has at least one polymer matrix (1), of a material which is porous and/or forms cavities and/or is hydrophilic. The pores/cavities have dimensions...
DE10162730A1 Alleles of the glk gene from coryneform bacteria  
The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such...
DE10162729A1 Alleles of the sigA gene from coryneform bacteria  
The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain...
DE10159904A1 Oligonucleotide assembly, method for nucleotide detection and apparatus therefor  
The present invention relates to an oligonucleotide assembly having a substrate having at least one field, wherein in the at least one field oligonucleotides are immobilized with field-specific...
DE10142328A1 Use of fructose-1,6-bisphosphate aldolase to identify new fungicidally active substances  
The invention relates to nucleic acids which code for polypeptides from fungi with the biological activity of fructose-1,6-bisphosphates aldolases, the polypeptides encoded therefrom and their use...
DE10160151A1 Inhibiting expression of target gene, useful e.g. for inhibiting oncogenes, by administering double-stranded RNA complementary to the target and having an overhang  
Inhibiting expression of a target gene (I) in a cell by introducing an inhibitory RNA (dsRNA1) having a double-stranded structure of at most 49 consecutive bases, is new. At least part of one...
DE10107186A1 New form of the PHGPx protein as a diagnostic marker in male infertility  
This invention relates to a novel form of the PHGPx protein, sperm nucleus glutathione peroxidase (snGPx) and parts thereof which play a role in spermatogenesis of mammals and the nucleic acids...