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DE10307732A1 New oligonucleotides for specific detection of microorganisms, useful e.g. for detecting or quantifying microbes on the skin, in foods, clinical samples or water, by in situ hybridization  
Oligonucleotides (ON) for specific detection of microorganisms, are (i) are any of 30 sequences reproduced; (ii) have at least 80, best 95, % correspondence with (i); (iii) are derived from (i) or...
DE10303973A1 A method for detection of fertility enhancing or contraceptive agents  
The present invention relates to a method for the detection of changes of cellular messengers in sperms in a stopped-flow measurement apparatus or detecting the motility or the change in swimming...
DE4120345C5 Protein fragments from the central region of the flagellin of Borrelia burgdorferi, as antigens suitable for the specific detection of antibodies as well as methods for their preparation  
Protein fragment from the middle region (amino acid 132 to amino acid 266) of flagellin of Borrelia burgdorferi, characterized in that it consists of the amino acid sequence consists.
DE10303850A1 Screening assay based on the Forkhead transcription factor-dependent SOD-3 promoter used to identify AKT modulating compounds or of upstream regulators, such as insulin / IGF1 receptors  
The present invention relates to the identification and use of the reactant to DAF-2 / IR sod-3 promoter. It describes transgenic C. elegans with sod-3-reporter gene constructs, which are suitable...
DE10303664A1 Recognition molecules for the treatment and detection of tumors  
The invention relates to recognition molecules, which are directed against tumors, pharmaceutical compositions comprising said recognition molecules, method for production of the recognition...
DE10302421A1 New double-stranded interfering RNA, useful for inhibiting hepatitis C virus, has one strand linked to a lipophilic group to improve activity and eliminate the need for transfection auxiliaries  
Double-stranded RNA (I) having a strand (S1) that is complementary, at least in parts, to a target gene (TG) and, the new feature, linked to at least one lipophilic group (A) is new. An...
DE10301519A1 New substituted 9-keto-spinosyn derivatives, useful for control of animal pests and microorganisms, in plant protection and veterinary medicine, also new intermediates  
9-substituted keto-spinosyn derivatives (I) and their salts are new. 9-substituted keto-spinosyn derivatives of formula (I) and their salts are new. X = oxygen, NH or NR4; R1 = hydrogen or an...
DE19823876B4 With different compounds laden component (biochip) as well as methods for its preparation  
Component (biochip) for the detection of substances by their specific spatial addition, the surface of which is loaded in spatially separated regions with different compounds, especially...
DE10260805A1 Method and apparatus for optimizing a nucleotide sequence for expressing a protein  
The invention relates to a method for optimizing a nucleotide sequence for expressing a protein on the basis of the amino acid sequence of the protein, wherein for a specific area, a test sequence...
DE4325471B4 Valve system for the simultaneous synthesis of DNA or peptide sequences  
Valve system comprising a) a valve block (10) having a plurality of feed channels formed within the same (31), b) a plurality of delivery channels (36) extending transversely to the feed channels...
DE10300049A1 New compounds which inhibit factor VIIa  
The present invention relates to novel compounds of formula (I): These compounds are very potent factor VIIa inhibitors and are therefore especially in the treatment and / or prevention of...
DE10261693A1 Production of new or known monomeric uronic acid compounds, useful e.g. as immunosuppressive or antiarthritic agents, by hydrolyzing bacterially produced polyuronic acid  
Production of monomeric uronic acids (or their derivatives) (I) involves (a) fermenting a bacterial strain producing a polyuronic acid (II) formed from (I) units, (b) isolating (II) from the...
DE10232774B4 Cosmetic preparations with antibacterial properties  
Cosmetic preparations, characterized in that it comprises an effective amount of (A) glycyrrhetic acid zinc salt and (B) benzoyl contain.
DE10259714A1 Method for identifying the polled genotype in cattle, useful in breeding programs, comprises detecting any of seven new microsatellite markers, also new oligonucleotides  
Identifying the polled (hornless) genotype of cattle comprising analyzing DNA for at least one of the genotype-associated microsatellite markers 59A3-A3r, -CSfa, -CSfb, -D3f, -D5f, -D8f, or -F8r...
DE10259713A1 A method for expressing stabilization and improvement of specific effector function of single-chain antigen knower genetic constructs (scARC) and corresponding mutant MDM2 protein specific SCT-cell receptors  
The present invention relates to a process for preparing stabilized single chain antigen recognized genetic constructs (scARC), in which in addition to the conventional V1/2-Li-V2/1-C4/3-sc...
DE10259374A1 Carboxamide-substituted dyes for analytical applications  
The present invention relates to carboxamide-substituted dyes, their preparation and to the use of such dyes as labeling groups in the analysis.
DE10258924A1 coated with the adhesion of biological material mediating substances device  
The invention relates to devices with at least one with tissues and / or fluids of the human or animal body by coming into contact surface. These surfaces are at least partially coated with...
DE10258008A1 New heterocyclic Fluorglycosidderivate, pharmaceutical compositions containing them and their use  
The invention relates to substituted heterocyclic Fluorglycosidderivate of the formula I, wherein the radicals have the meanings indicated, and their physiologically acceptable salts and processes...
DE10361928A1 Analyzing the condition of the uterine mucosa, useful for assessing endometrial receptivity or diagnosing uterine tumor, based on measuring expression of specific beta subunits of chorionic gonadotrophin  
Method for determining defined conditions or alterations in the uterine mucosa, or in the epithelium of other organs, by: (i) isolating mRNA from a blood and/or tissue sample; and (ii) quantifying...
DE10261782A1 New nucleic acid encoding a staphylococcal serine protease, useful for treating bacterial infections or modifying biomolecules, also encoded enzymes and related antibodies  
Nucleic acid molecule (I) encoding a staphylococcal serine protease, is new. (I) is at least 82, best 90, % identical with either a 1623 bp sequence (SEQ ID. 1), defined in the specification, or...
DE10260592A1 New 2-(1-((hetero)aryl(oxy))-ethyl)-nitrobenzene derivatives, useful for introducing intramolecular triplet sensitized photolabile protecting groups into synthons for light-controlled biopolymer production  
2-(1-((Hetero)aryl or (hetero)aryloxy)-ethyl)-nitrobenzene derivatives (I) are new. Also new are nucleotide synthon compounds (II) containing a photolabile protecting group derived from (I)....
DE10260591A1 Stepwise synthesis of biopolymer, e.g. nucleic acid, using synthons having two-stage protecting group activated by cleavage of triplet-sensitized and/or labeled photoactivatable group to allow quality control  
Synthesis of biopolymers (A) by stepwise construction from protected synthons, where at least one of which has a two-stage protecting group (i.e. a group activated by irradiation and cleaved by...
DE10260085A1 Selective extraction of 2-keto-L-gulonic acid from polar solution, especially reaction mixture obtained in preparing ascorbic acid by lactonization, using mixture of tertiary amine and polar organic diluent  
2-Keto-L-gulonic acid (KGA) is extracted from a polar solvent, by contacting the solvent with an extractant (E1) comprising a tertiary amine (I) and a polar organic diluent (II) in a mixing...
DE10259844A1 New mannopyranoside-based peptidomimetic compounds, useful for treatment or diagnosis of e.g. intestinal, autoimmune or tumor diseases, are selective alpha4, beta7-integrin antagonists  
Mannopyranoside-based peptidomimetic compounds (I) are new. Mannopyranoside-based peptidomimetic compounds of formula (I) are new. X = O or CHR15; R1-R5, R15 = 1-30C organic group optionally...
DE10259403A1 A process for the production of alkyl and / or salts Alkenyloliglykosidcarbons√§ure  
Disclosed is a new process for the production of aqueous pastes of alkyl and / or alkenyl oligoglycoside carboxylic acid salts with a reduced content of organic chlorine compounds, which is...
DE10259245A1 Derivatives of Asimadolins with covalently bonded acids  
The present invention relates to derivatives of N-methyl-N - [(1S) -1-phenyl-2 - ((3S) -3-hydroxypyrrolidine-1-yl) -ethyl] -2,2- diphenylacetamide with covalently bound acids and the salts,...
DE10257523A1 Process for the preparation of carboxyl groups, alkyl or alkenyl polyglycosides  
The invention relates to methods for the preparation of acid group-containing alkyl polyglycosides, wherein a reaction mixture containing at least one alkyl polyglycoside, having a at least two...
DE10258258A1 Isolating nucleic acids from liquid samples, for isolating viral nucleic acid from donated blood, by retention on an inorganic oxide carrier, comprises treatment with protease to improve sensitivity and efficiency  
Isolating nucleic acid (NA) from liquid samples comprises: mixing the sample with binding buffer (BB) to give a mixture of pH below 7, treating with a carrier (A) so that NA binds to it,...
DE10254214A1 Oligoribonucleotides for treating degenerative skin symptoms by RNA interference  
Oligoribonucleotides which are able to induce the degradation of the mRNA of connective tissue degrading enzymes, and pharmaceutical and cosmetic compositions for topical application, containing...
DE10253514A1 Production of new or known monomeric uronic acid compounds, useful e.g. as immunosuppressive or antiarthritic agents, by hydrolyzing bacterially produced polyuronic acid  
Production of monomeric uronic acids (or their derivatives) (I) involves (a) fermenting a bacterial strain producing a polyuronic acid (II) formed from (I) units, (b) isolating (II) from the...
DE10253351B4 Novel Pufferfomulierungen for isolation, purification and recovery of long- and short-chain nucleic acids  
process for isolating nucleic acids from a solution characterized by binding to a solid phase, characterized in that one containing the nucleic acid solution with additions is adjusted so that...
DE10253351A1 Isolation of nucleic acid by binding to solid phase, useful e.g. in forensic or diagnostic medicine, uses binding buffer containing monovalent and multivalent ions, eliminates need for alcohol in wash buffer  
Method for isolating nucleic acid (NA) from solution by binding it to a solid phase, comprises treating the NA-containing solution with additives, contacting with the solid phase and optionally...
DE60101056T2 Process for the preparation of ribavirin  
A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said...
DE10251246A1 New antagonists of calcitonin gene-related peptide or amylin, useful for treating or preventing e.g. migraine or inflammation, are specific binding nucleic acids  
An antagonist (I) of CGRP (calcitonin gene-related peptide), especially a nucleic acid, preferably one that binds to CGRP, is new. Independent claims are also included for: (1) antagonist (Ia) of...
DE10262018B4 Compositions, foodstuffs, foods, and beverages, confectionery, pet food, dietary special diet, child nutrition, sweeteners and pharmaceutical compositions containing condensed Palatinose  
The Invention relates to compositions, food, food and beverages, Confectionery, Animal feed, dietary Special diet, Child nutrition, sweeteners and to pharmaceutical compositions containing a new...
DE10262018A1 Condensed palatinose and processes for their preparation  
The invention relates to a novel palatinose condensation product obtained by condensation of the disaccharide palatinose in a melt of palatinose, water and an organic acid.
DE10249795A1 Nucleotide support, useful for assessing genetic risk of arteriosclerosis, comprises probes directed against nine risk-associated genes or their variants  
Nucleotide support (A) for determining the genetic risk of arteriosclerosis comprises oligonucleotide probes (I) for investigating nine specified genes (II) in a patient sample, and each (I) is at...
DE10249552A1 Water soluble iron carbohydrate complexes, their preparation and pharmaceutical compositions containing them  
Water-soluble iron-carbohydrate complex obtainable from an aqueous iron (III) salt solution and an aqueous solution of the product of the oxidation of one or more maltodextrins with an aqueous...
DE10249171A1 Polymerase chain reaction method for detecting Salmonella in an animal, environmental or food samples, based on specific amplification of part of the invA gene, also provides indication of virulence  
A PCR method for detecting Salmonella, is new. A PCR method for detecting Salmonella comprises: (a) incubating a sample first in peptone broth and then in Rappaport-Vassiliadis medium; (b)...
DE10248453A1 Chalcomycin derivatives  
The invention relates to novel chalcomycin derivatives, to pharmaceutical compositions containing them or their salts, and the use of the chalcomycin derivatives for the treatment of diseases,...
DE10135098B4 A process for the production of peracylated 1-O-glycosides  
A process for the production of peracylated 1-O-glycosides of general formula I in the sugar1 a functionalized in 1-OH position monosaccharide, R is methyl, ethyl, propyl, isopropyl, t-butyl,...
DE10328887A1 alkaline protease  
The invention relates to an alkaline protease having a prepro, the prepro represents a mutant sequence of the amino acid sequence of SEQ ID NO .: 1 or owned an amino acid sequence having a 80% or...
DE10247476A1 Concentration and isolation of oregonin from alder bark, useful as antioxidant in cosmetic or therapeutic compositions, includes treating hot water extract with adsorber resin  
Improved method for concentration and isolation of oregonin (I) from alder (Alnus) bark. Improved method for concentration and isolation of oregonin (I) from alder (Alnus) bark comprises...
DE10245779A1 Predicting responsiveness of a subject with breast cell proliferative disorder, useful for treating or differentiating breast cell proliferative disorders comprises analyzing methylation pattern of a genomic DNA from the subject  
Predicting the responsiveness of a subject with a cell proliferative disorder of the breast tissues to a therapy comprising analyzing the methylation pattern of a target nucleic acid by contacting...
DE19714255B4 A process for the production of alkyl and / or alkenyl oligoglycosides by acetalization of a direct glucose / fatty alcohol suspension in the presence of acid catalysts  
A process for the production of alkyl and / or alkenyl oligoglycosides by direct acetalization of a glucose / fatty alcohol suspension in the presence of acidic catalysts, wherein the total molar...
DE10247790A1 Solid phase synthesis of labelled oligonucleotide conjugate, by nucleophilic substitution of labile protecting group on terminal hydroxy group with labeling reagent  
A solid phase-supported method for the production of oligonucleotide conjugates (I) involves the reaction of 3'-5'- or 5'-3'-structured oligonucleotide (II), having the terminal hydroxy group...
DE10247073A1 Monomeric uronic acid compound production, for use e.g. as immunosuppressive, antirheumatic or cardiovascular agents, by hydrolyzing bacterially produced polyuronic acid  
Production of monomeric uronic acids (I) involves (a) fermenting a bacterial strain producing a polyuronic acid (II) formed from (I) units, (b) isolating (II) from the supernatant of the...
DE10247073B4 A process for preparing monomeric uronic acids, in particular D-mannuronic acid and D-guluronic acid, and their use as medicaments  
A process for preparing monomeric uronic acids, comprising the steps of: a polyuronic fermenting a producing strain of bacteria, the epimerase gene has been inactivated. b. Isolating the...
DE10246824A1 Analyzing nucleic acid mixture by hybridization to an array, useful e.g. for expression analysis, using sample mixture of labeled restriction fragments of uniform size  
Method for analyzing a nucleic acid (NA) mixture by hybridization to a DNA array of immobilized NA, which uses a labeled NA mixture of reduced complexity as the hybridization sample. Method for...
DE10244456A1 A method for the detection and differentiation of bacteria  
The present invention relates to the field of diagnosis of micro-organisms, in particular the detection of bacteria. The invention relates in particular hybridization methods and amplification...