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DE102018108612A1 METHOD FOR INCREASING PERSISTENCE OF ADOPTIVELY INFUNDED T CELLS  
The present disclosure provides methods for improving the effectiveness of T cells. In one aspect, the disclosure further provides methods of enhancing T-cell persistence for adoptive cell...
DE102018120149A1 Pharmaceutical component and use thereof for inhibiting the genesis and metastasis of a breast cancer tumor  
The invention relates to a pharmaceutical component and the use thereof for inhibiting the genesis and metastasis of a breast cancer tumor, wherein the pharmaceutical component is a GR agonist...
DE102018107224A1 Peptides and combinations of peptides of non-canonical origin for use in immunotherapy against various cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic procedures. In particular, the present invention relates to the immunotherapy of cancer....
DE102018000901A1 Pyrrolizidine derivatives of the lycopsamine type as a prodrug in liver cancer cells  
Retronecin monoesters and lecopsamine-type Necin monoesters as cytostatic agents in malignant diseases of tissues in which cytochrome P450 is expressed.
DE102018222807A1 Degradable embolic microspheres with high drug loading capacity and process for their preparation  
The present invention discloses a method for producing degradable drug loading embolization microspheres and a resulting product, the method comprising the steps of: dissolving a degradable...
DE102017125888A1 New engineered T cell receptors and their use in immunotherapy  
The present invention relates to antigen-recognizing constructs against COL6A3 antigens. In particular, the invention provides novel engineered T cell receptor (TCR) based molecules which are...
DE202019102378U1 baking mix  
Baking mix for use as part of a prescription drug for the manufacture of cannabis-containing cookies in a pharmacy, comprising Flour, Soda and Sucrose.
DE212017000199U1 Vegetable juice for treating adult cancer and suppressing tumor growth in children  
Vegetable juice for the treatment of adult cancer and suppression of tumor growth in children with curative effects on the whole organism, comprising the fresh raw juice of vegetables in the...
DE102018119271A1 PHARMACEUTICAL COMPOSITION SUITABLE FOR THE TREATMENT AND / OR PREVENTION OF CANCER  
A composition is provided which is suitable for the treatment and / or prevention of colon cancer, the composition comprising a carbonaceous material and an active particle residing on the...
DE102018119270A1 PHARMACEUTICAL COMPOSITION SUITABLE FOR THE TREATMENT AND / OR PREVENTION OF GAS CANCER  
There is provided a composition suitable for the treatment and / or prevention of gastric cancer, the composition comprising a carbonaceous material and an active particle residing on the...
DE112017002816T5 SELECTIVE CHANGE OF MICROBIOTA FOR IMMUNOMODULATION  
The invention relates to methods for modulating immune cells in a patient by altering the microbiota of the patient. The invention further relates to methods of modulating treatments or therapies...
DE102018111140A1 Pharmaceutical product for use in tumor therapy  
The invention relates to a pharmaceutical product comprising at least one growth hormone and at least one thyroid hormone, and which, when given to a tumor patient or a person with an increased...
DE102017116370A1 Silica nanoparticles for therapeutic application  
The invention relates to the use of nanoparticles comprising a surface of silica for use as a medicament, in particular for the treatment of diseases which are based on the overexpression of EGFR,...
DE202018005685U1 Implant for filling with active ingredients  
Implant, consisting of a tissue bag that has low permeability to bacteria, but allows enzymes to diffuse through.
DE102017005815A1 Vaccine for the treatment of a malignancy  
Disclosed are methods of providing a medicament for treating a malignancy and cell membranes provided thereby, and the use thereof, wherein the individual communication structure between the...
DE102016115246C5 NEW T-CELL RECEPTORS AND THEIR USE IN IMMUNOTHERAPY  
The present invention relates to antigen-recognizing constructs against COL6A3 antigens. In particular, the invention provides new T cell receptor (TCR) based molecules that are selective and...
DE102017005546A1 Combination therapy for the treatment of macular degeneration  
Combination Therapeutic for the Treatment of Macular Degeneration A combination therapeutic comprising nicotinamide adenine dinucleotide hydride (NADH) or a salt thereof and at least one...
DE102017110933A1 Immunostimulant high purity oligosaccharides  
The present invention relates to a high purity oligosaccharide for use as an immunostimulant, a pharmaceutical composition comprising the high purity oligosaccharide of the invention, the use of...
DE112015007252T5 PROCESS FOR PREPARING A CRACECEPHALUM CREPIDIOID EXTRACT, PRESENTED EXTRACT AND USE OF THE EXTRACT  
The present invention provides a method of preparing a Crassocephalum crepidioides extract and the extract produced thereby. The present invention further relates to a pharmaceutical composition /...
DE102017002810A1 Sialic acid derivatives with CC triple bond and their preparation  
Sialic acid derivatives containing a CC triple bond are described, processes for their preparation, conjugates prepared therefrom, and pharmaceutical compositions containing them.
DE102017105195A1 Process for the differential sequestration of substances of different substance groups using hydrogels containing sulfated or sulfonated components  
The invention relates to a process for the differentiated sequestration of substances of different substance groups A and B in a sulfated and / or sulfonated hydrogel and depletion of substances...
DE102018103030A1 Compounds isolated from Antrodia Camphorate and a method of using the same  
The present invention relates to a compound isolated from Antrodia camphorata, which compound is represented by Formula 1: The compound can be used to inhibit the growth of cancer cells in a...
DE202016008594U1 A novel pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine  
An aqueous composition comprising one or more particles, wherein (A) each particle comprises a complex of at least one double-stranded polyribonucleotide, or a salt or solvate thereof, and at...
DE102017120403B3 Infusion pump kit for the treatment of tumors  
A kit for the treatment of tumors, comprising an implantable infusion pump having a medicament chamber adapted to receive a therapeutic agent having a port adapted to fill the medicament chamber...
DE102007032799B4 Sugary metal complexes and their use  
Sugar-containing metal complexes of substituted polypyridines of general formula I.(L1n)(L2m)(L3O)(L4p)(L5q)M+/-.consisting of ligands L1 to L5, wherein at least one of these ligands L1 to L5 is a...
DE202018103853U1 Composition for application of curcumin  
Composition for the preparation of a preparation for the application of curcumin, characterized in that the composition contains curcumin and / or curcumin derivatives, cyclodextrin, propylene...
DE102017000896A1 Selective release system for tumor therapeutics and tumor diagnostics and biosensor for tumor tissue  
The present invention relates generally to a tumor tissue sensor and a local delivery system of therapeutics / diagnostics for targeted tumor therapy and tumor diagnostics. More specifically, the...
DE212016000236U1 Human endothelin receptor binding antibody and its use  
A specific antibody to human endothelin receptors, characterized in that the antibody comprises one of the following schemes of amino acid sequences: a. CDR3 sequence of a light chain selected...
DE202015009594U1 New dimers of cytidine derivatives  
A cytidine derivative dimer having the following general formula (I),in which: R1 a C1-C10Alkyl, C1-C10 -substituted alkyl, - (CH2)n-Ph or substituted - (CH2)n-Ph is; in - (CH2)n-Ph, n = 0, 1, 2,...
DE112016004398T5 THE ANTIBODIES THAT SPECIFICALLY BIND THE TYPE-1 RECEPTOR OF THE FIBROBLAST GROWTH FACTOR, THE USE OF ANTIBODIES FOR THE TREATMENT OF ONCOLOGICAL DISEASES, A PROCESS FOR THE MANUFACTURE OF THE ANTIBODIES  
The group of inventions relates to biotechnology and medicine and refers to antibodies for the treatment of oncological diseases. The antibodies of the invention specifically bind and block...
DE202017103290U1 Composition for topical application, in particular for bladder instillation  
A composition, in particular a pharmaceutical composition, for use in the prophylactic and / or therapeutic treatment of side effects of BCG therapy (Bacillus-Calmette-Guérin therapy), in...
DE102016123847B3 New T cell receptors and their use in immunotherapy  
The present invention relates to antigen-recognizing constructs against tumor-associated antigens (MAGEA1). In particular, the invention provides new T cell receptor (TCR) based molecules which...
DE112016003047T5 NEW PHARMACEUTICAL COMPOSITION COMPRISING PARTICULAR COMPOSITIONS OF A COMPOUND OF A DOUBLE-STRENGTHED POLYRIBONUCLEOTIDE AND A POLYALKYLENEIMINE  
The present invention relates to compositions comprising particles wherein each of said particles comprises a complex of at least one double stranded polyribonucleotide, such as polyinosin...
DE102014005513B4 Means for the prevention and therapy of tumor diseases  
Agent for the therapy and prevention of tumor diseases, in particular of breast or prostate carcinomas, characterized in that it comprises the steroid hormones estriol, progesterone and...
DE202017006287U1 Drug for external lesional and intralesional therapy of the basal cell carcinoma  
Medicament for externally lesional and intralesional therapy of the basalioma, characterized in that it contains the active ingredient forskolin, either in pure form or as part of a plant extract,...
DE102016123859B3 New T cell receptors and their use in immunotherapy  
The present invention relates to antigen-recognizing constructs against a tumor-associated antigen (TAA) derived from the target protein DDB1 and CUL4-associated factor 4-like 2 (DCAF4L2). In...
DE102016113143A1 cancer drug  
An anticancer drug is formed by a pyrimidine base having N-1 glycosidically linked glucose or gluconic acid, the pyrimidine base being substituted in its 5-position with a furfural group.
DE102016113018A1 Pharmaceutical use of beta-D-mannuronic acid  
The invention relates to a uronic acid monomer for use in a method of treating Alzheimer's disease, cancer, oxidative stress disorders or a viral disease wherein the uronic acid monomer is...
DE202012013584U1 Pharmaceutical formulation containing curcumin  
Pharmaceutical formulation, characterized in that it contains curcumin and / or a curcumin derivative, an alcohol, an acid and a solubilizer and contains at most 12% by weight of water.
DE112012000807B4 Pyrrolo [2,1-c] [1,4] naphthodiazepine-linked piperazine compounds and process for their preparation  
The present invention provides compounds of general formula A which can be used as potential antitumor agents against five human cancer cell lines. The present invention further provides a process...
DE102016014603A1 Synthetic ayahuasca  
According to the invention, two or more of the active ingredients contained in ayahuasca (extract from parts of the plants Banisteriopsis caapi and Psychotria viridis and / or Diplopterys...
DE102016121540A1 The use of compositions of water / alcohol extracts of timber cultivated fruit bodies and solid cultured mycelia of Antrodia cinnamomea as additives for anti-cancer agents  
The present invention relates to a use of a Antrodia cinnamomea composition consisting of 50-99% (w / w) water / alcohol extract of solid cultured mycelia of Antrodia cinnamomea and 1-50% (W / W)...
DE102016115246B3 NEW T-CELL RECEPTORS AND THEIR USE IN IMMUNOTHERAPY  
The present invention relates to antigen-recognizing constructs against COL6A3 antigens. In particular, the invention provides new T cell receptor (TCR) based molecules which are selective and...
DE112016000927T5 Screening and treatment methods with USP4 inhibitors  
The present application relates to materials and methods for exploiting synthetic lethality and / or chemo-sensitization in DNA damage response (DDR) signaling pathways. In particular, the...
DE102017005091A1 Substituted 3,4-dihydropyrido [2,3-b] pyrazine-2 (1H) -one  
The present invention relates to BET protein-inhibiting, in particular BRD4-inhibitory substituted substituted 3,4-dihydropyrido [2,3-b] pyrazine-2 (1H) -ones of the general formula I. in the R1,...
DE102017005089A1 Substituted 3,4-dihydroquinoxaline-2 (1H) -one  
The present invention relates to BET protein-inhibiting, in particular BRD4-inhibitory substituted 3,4-dihydroquinoxaline-2 (1H) -ones of the general formula I. in the R1, R2, R3, R4, R4, R5 and...
DE102017110957A1 Zoledronic acid, calcium and vitamin D pharmaceutical compositions useful in the treatment and / or prophylaxis of bone metabolism disorders and therapy-induced hypocalcemia  
The present invention includes pharmaceutical compositions comprising zoledronic acid, calcium and vitamin D which are useful for the treatment and / or prophylaxis of bone metabolism disorders...
DE102016005550A1 Adjuvant for the induction of a cellular immune response  
The present invention relates to the use of a water-soluble synthetic lipopeptide producible under GMP conditions as a universal adjuvant for the induction of a systemic cellular immune response....
DE102016205389A1 Photocatalytically active particles with a modified surface and processes for the preparation of dispersions of these particles  
The present invention relates to photocatalytically activated particles having a particle surface which is modified with at least one carboxylic acid derivative having at least one ethoxy group...
DE102016104470A1 A composition for promoting the activity of sirtuins  
The invention relates to a composition containing as active ingredient ectoine, hydroxyectoin and / or salts, esters or amides of these compounds for promoting the activity of sirtuins, in...