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DE102013019618A1 Tri- and tetracyclic compounds for the treatment of incontinence  
Tri- or tetracyclic compounds of formula (I) wherein: X is = CH- or -CH2-; R1 CH3 or C2H5; R2 CH3 or C2H5; R3 H or CH3; R4 is H, CN or halogen; can be used for the prevention and / or treatment of...
DE102010033527A1 Quetiapine tablets  
The present invention relates to a tablet comprising a matrix of a mixture of at least two sugar alcohols, wherein the matrix contains, as active ingredient quetiapine or a salt thereof.
DE69229688C5 containing ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a beta-adrenergic antagonist  
The usage of (A) 0.05 to 5% (wt./wt.) (S, S) - (-) - 5,6-Dihydro-4-ethylamino-6-methyl-4H-thieno [2,3-b ] thiopyran-2-sulfonamide-7,7-dioxide or an ophthalmologically acceptable salt thereof, and...
DE102006053637B4 Last fluoro-substituted 1,4-Benzothiepin-1,1-dioxide derivatives, pharmaceutical compositions containing them and their use  
Compounds of the formula I, which mean X NH; R1 (C1-C6) Alkyl; R4 F; R4 'H, F; R2, R2 ', R3, R3', R5, R5 'independently of one another H, F, Cl, Br, I, OH, - (CH2) -OH, CH2F, CHF2, CF3, NO2, N3,...
DE102006053637A1 New fluorine-substituted 1,4-benzothiepine-1,1-dioxide, a process for their production, medicaments containing these compounds and their use  
The Invention relates to the compounds of formula I and physiologically acceptable Salts. The compounds are suitable for. B. as hypolipidemic agents.
DE102006053636A1 New substituted with cyclohexyl 1,4-Benzothiepin 1,1-dioxide derivatives, processes for their preparation, pharmaceutical compositions containing them and their use  
The Invention relates to the compounds of formula I and physiologically acceptable Salts. The compounds are suitable for. B. as hypolipidemic agents.
DE102006053636B4 New with cyclohexyl substituted 1,4-Benzothiepin-1,1-dioxide derivatives and their use  
compounds of formula I, which mean X NH; R1 (C1-C4) Alkyl; R2 ', R3 ', R4', R5 ', R6' H; R2, R3, R4, R5, R6 independently OH, O- (C1-C6) Alkyl, OSO3H, NH2, NH- (C1-C6) -alkyl, N ((C1-C6) Alkyl)2...
DE102006053635A1 New substituted with benzyl 1,4-Benzothiepin-1,1-dioxide derivatives, processes for their preparation, pharmaceutical compositions containing them and their use  
The Invention relates to the compounds of formula I and physiologically acceptable Salts. The connection is suitable for. B. as hypolipidemic agents.
DE102006053635B4 New substituted with benzyl 1,4-Benzothiepin-1,1-dioxide derivatives, pharmaceutical compositions containing them and their use  
Compounds of formula and the pharmaceutically acceptable salts thereof.
DE102005023944A1 Substituted benzofused cycloheptanone derivatives and their use for producing medicaments  
The present invention relates to substituted benzofused cycloheptanone derivatives, processes for their preparation, medicaments comprising these compounds, and the use of these compounds for...
DE102005022020A1 New dibenzocycloheptane compounds are tumor necrosis factor-alpha inhibitors useful to treat e.g. cancer, rheumatic arthritis, gout, septic shock, osteoporosis, naturopathic pain, HIV-propagation and periodontal diseases  
Dibenzocycloheptane compounds (I) and their salt and solvate and its salts, are new. Dibenzocycloheptane compounds of formula (I) and their salt and solvate and its salts, are new. Either X, Y1 :...
DE102004039382A1 A spirocyclic cyclohexane derivatives  
The present invention relates to spirocyclic cyclohexane derivatives, Processes for their preparation, pharmaceutical compositions containing these compounds, and the use of spirocyclic...
DE10356406A1 Medicaments with calcium ion channel inhibiting action, useful e.g. for treating hypertension, cardiomyopathy, ataxia, migraine or epilepsy, containing new or known collybolide compounds  
New medicaments contain collybolide compounds (I) (i.e. 5-hydroxy-2-(2-hydroxyethyl)-cyclohexane-1,3-dicarboxylic acid dilactone derivatives). Most of the compounds (I) are new. Medicaments...
DE19549755B4 Non-solvated crystalline pharmaceutical - comprises 6-hydroxy-2-(4-hydroxyphenyl)-3- (4-(2-piperidino-ethoxy) benzoyl)-benzo(b)-thiophene hydrochloride  
Non-solvated crystalline 6-hydroxy-2-(4-hydroxyphenyl) -3-(4-(2-piperidino-ethoxy) benzoyl)benzo(b)thiophene (I') hydrochloride with a defined X-ray diffraction pattern obtd. with copper radiation...
DE19534745B4 thiophene process for the preparation of 6-hydroxy-2- (4-hydroxyphenyl) -3- [4- (2-piperidinoethoxy) benzoyl] benzo [b]  
A process for preparing a compound of formula with acylating a benzothiophene of formula in which R4 for C1-C4 Alkoxy, and R5 for C1-C4 Alkyl, with an acylating agent of formula in which R6...
DE10216737A1 Control of parasites in animals  
The present invention relates to the systemic and non-systemic control of parasites in animals by means of phenylketoenol derivatives.
DE10207586A1 Preparation of N-methyl-3-hydroxy-3- (2-thienyl) propanamine via novel carbamate-containing thiophene derivatives as intermediates  
A new synthetic route for N-methyl-3-hydroxy-3- (2-thienyl) propanamine IV is described which can serve as a starting compound for the production of duloxetine. The synthesis of...
DE10142456A1 Synergistic mixture containing benzothiepine derivative, useful for treating or preventing disorders of lipid metabolism, includes e.g. cholesterol resorption inhibitor  
A composition comprises a benzothiepin-1,1-dioxide derivative (I) or its salt or functional derivative and another active agent (II). A composition comprises a benzothiepin-1,1-dioxide derivative...
DE10123163A1 Substituted cyclohexane-1,4-diamine derivatives  
The present invention relates to substituted cyclohexane-1,4-diamine derivatives, processes for their preparation, pharmaceutical compositions containing these compounds and the use of substituted...
DE10111039A1 Use of active compound combinations of alpha-lipoic acid and dermatologically acceptable substances which light absorption in the UV-A region and / or UV-B range show, for the preparation of cosmetic or dermatological preparations for the treatment and / or prophylaxis of the symptoms of intrinsic and / or extrinsic skin aging and for the treatment and prophylaxis of the harmful effects of becoming ultraviolet radiation on the skin  
The invention relates to the use of active-ingredient combinations consisting of a) alpha -lipoic acid and b) one or more dermatologically compatible substances that absorb light in the UV-A...
DE10064402A1 New diphenyl-azetidinone derivatives useful for the treatment of hyperlipidemia, arteriosclerosis and hypercholesterolemia  
Diphenyl-azetidinone derivatives are new. The diphenyl-azetidinone derivatives are compounds of formula (I) and their salts: R<1>-R<6> = 0-15C alkylene-L (with 1 or more C optionally replaced by...
DE10061876A1 Arylated furan and thiophenecarboxamides, processes for their preparation, their use as a medicament as well as pharmaceutical compositions containing them  
The invention relates to arylated furane and thiophene carboxylic acid amides, a method for the production thereof, the use thereof as medicaments, in addition to pharmaceutical preparations...
DE10049481A1 Substituted C-cyclohexylmethylamine derivatives  
The invention relates to substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds and the use of substituted...
DE10033459A1 New aminomethyl-substituted bicyclic compounds, useful for treating urinary incontinence, pruritis, tinnitus, diarrhea or especially pain  
Aminomethyl-substituted benzo-cycloalkene or benzo-heterocyclic compounds (I) are new. Also new are tertiary alcohol intermediates (II). Bicyclic compounds of formula (I) and their salts are new....
DE19830430A1 New sulfur-substituted sulfonylamino-carboxylic acid N-arylamide derivatives useful as guanylate cyclase activators in treatment of e.g. cardiovascular disorders, asthma and diabetes  
Sulfur-substituted sulfonylamino-carboxylic acid N-arylamide derivatives (I) are new. Sulfur-substituted sulfonylamino-carboxylic acid N-arylamide derivatives of formula (I) and their salts are...
DE19827907A1 Synergistic composition for treating infant or adult respiratory distress syndrome  
A composition for treating infant respiratory distress syndrome (IRDS) and adult respiratory distress syndrome (ARDS) contains a 4-(2,6-dichloroanilino)-3-thiopheneacetic acid derivative (I) and a...
DE19825804A1 1,4-benzothiazepine 1,1-dioxide derivatives, processes for their preparation, pharmaceutical compositions containing them and their use  
The invention relates to substituted benzo(b)thiepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention relates to compounds of formula (I), wherein R<1>, R<2>, R<3>,...
DE19814084A1 D2 agonist-containing transdermal therapeutic system for the treatment of Parkinson's disease and process for its preparation  
The invention relates to a transdermal therapeutic system comprising a back layer which is inert with respect to the constituents of the matrix, a self-adhesive matrix layer containing an...
DE19814083A1 A process for the production of transdermal therapeutic systems using basic alkali metal salts for the conversion of active substance salts into the free bases  
The invention relates to a method for producing transdermal systems with free active agent bases. The invention is characterized in that, during the production of the system, the free active agent...
DE19804251A1 Biphenylsulfonylcyanamide, processes for their preparation and their use as a medicament  
The invention relates to compounds of formula (I) in which the symbols have the meanings given in the description. The compounds have excellent antiarrhythmic properties and comprise a...
DE19752952A1 thienopyrimidines  
The invention relates to thienopyrimidines of formula (I) wherein R<1>, R<2>, R<3>, R<4>, X and n have the meanings given in claim 1, and to their physiologically compatible salts. Said...
DE19749977A1 New bis-ureido-diphenylalkane or diphenyl ether derivative interleukin-4 inhibitors  
Alkylene- or oxy-bis-(1-phenyl-3-substituted urea) compounds (I) are new. Bis-urea compounds of formula (I) are new. A = CH2 or O; X = 2-exo-norbornyl, 2-(pyrid-2- or 3-yl)-ethyl, benzyl, 2-, 3-...
DE19738604A1 Use of Na<+>/H<+> exchange inhibitors  
Co-administration of a cytostatic agent and a Na<+>/H<+> exchange inhibitor during cancer therapy reduces the cytostatic's cardiotoxicity, allowing it to be administered in higher doses. The use...
DE19723722A1 Nonsteroidal gestagens  
The invention relates to non-steroidal gestagens of general formula (I), wherein R<1> and R<2> are the same or different and stand for a hydrogen atom, a C1-C5 alkyl group or a halogen atom, or...
DE19757627A1 Azulene derivatives, processes for their preparation and pharmaceutical composition containing these compounds  
Compounds of formula (I): wherein R 1 is a substituted or unsubstituted benzene ring or a heteroaromatic ring, R 2 and R 3 are hydrogen or lower alkyl, R 4 is hydrogen or lower alkoxy, R 5 is...
DE3546907C2 New 2-aryl-6-substd. benzofuran, benzothiophene and benzimidazole cpds  
Aromatic heterocycles of formula (I) and their salts are new. R1 = Me, CH2OH or COR3; R2 = H or Me; Ar = gp. (II) or (III) 4-(lower alkyl)phenyl or 3-R7-4-OR6-phenyl; Y = CH or N; X = O, S or NR8;...
DE19644228A1 thienopyrimidines  
The invention relates to thienopyrimidine of the formula (I) as well as to their physiologically acceptable salts, wherein R<1>, R<2>, R<3>, R<4>, X and n have the meaning cited in Claim 1. Said...
DE19642451A1 Aminothiophencarbons√§ureamide  
Aminothiophene carboxylic acid amides having formula (I) and their physiologically harmless salts, wherein R<1>, R<2>, R<3>, R<4>, R<5>, A and n have the meaning given in claim 1, demonstrate...
DE19642323A1 New 1-substituted-(substituted (hetero)aryl)- fused pyrazole compounds  
1-(Benzyl or heterocyclylmethyl)-3-(substituted (hetero)aromatic)-fused pyrazole compounds of formula (I) are new. X = O, S NH or CH=CH, and the X-containing ring is optionally substituted by R14;...
DE19636769A1 3-substituted pyrido [4 ', 3': 4,5] thieno [2,3-d] pyrimidine derivatives, their preparation and use  
The invention concerns 3-substituted 3,4,5,6,7,8-hexahydro-pyrido[4,3':4,5]thieno-[2,3-d]pyrimidi ne derivatives of formula (I) in which: R<1> designates a hydrogen atom, a C1-C4 alkyl group, an...
DE19624290A1 Pyrrolizine derivatives to lower lipid levels,  
Use of pyrrolizine derivatives of formula (I), as well as their optical isomers, salts or esters, to treat diseases which respond to lowering of lipid levels is claimed: where two of R1-R3 = H,...
DE19604231A1 The pharmaceutical combination product and its use for the treatment of gynecological disorders  
A combined pharmaceutical preparation contains LHRH-analogous substances and anti-estrogens with tissue-selective estrogenic effect. Also disclosed is the use of this combined pharmaceutical...
DE19600707A1 New bi:cyclic anhydride derivatives of active agents  
Bicyclic anhydride-active agent compounds of formulae (I) and (II) are new. B = -Wt-Xg-A; k, l, m, n, g = 0 or 1; W = methylene, preferably substituted by (i) 1-6C alkyl (optionally unsaturated)...
DE19548708A1 Cyclic sulfones  
Cyclic sulphones of formula (I) are disclosed, in which: R<1> and R<2> each independently of one another stand for H, A, CF3, CH2F, CHF2, C2F5, Hal, OH, OA, NH2, NHA, NA2, NO2 or CN; X stands for...
DE19534744A1 New pharmaceutical product  
The present invention is directed to a novel chemical process for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)-benzoyl]benzo[b]thioph enes. The present invention is also directed to crystalline...
DE19526187A1 7-diazo-beta-lactam derivatives and process for their preparation  
Novel 7-diazo-1,1-dioxo-cephem-4-ketones are converted to 1,1-dioxo-cephem-4-ketones substituted at C-7 which are potent protease inhibitors, in particular human leukocyte elastase (HLE) inhibitors.
DE4414316A1 New benzo-fused heterocyclyl-carbonyl-guanidine derivs.  
Benzo-fused 5-membered heterocyclic cpds. of formula (I) and their salts are new: X = N or CR6; Y = O, S or NR7; A + B = a bond, or A=B=H when X=CR6 and Y = NR7; R1-R6 = substits. such that (a)...
DE4412333A1 Microbicidal agents on the basis of dibromo-thiophene-carboxylic acid derivatives  
The invention concerns novel microbicidal agents based on, in part known, dibromo-thiophene-carboxylkic acid derivatives of formula (I), in which R stands for the groupings -XR<1>, -NR<2>R<3>,...
DE4410420A1 3-Aryl-4-hydroxy- DELTA ¬∑ 3 ¬∑ -dihydrothiophenone derivatives  
The invention concerns 3-aryl-4-hydroxy- DELTA <3>-dihydrothiophenone derivatives of the formula (I) in which A, B, G, S, X, Y, Z and n are as defined in the description, methods of preparing...
DE4404399A1 Medicament contg. tiaprofenic acid enantiomer(s)  
An analgesic and/or antiinflammatory medicament for use in humans and animals contains: (a) sepd. enantiomers of tiaprofenic acid alone or as a mixt. obtd. by mixing the sepd. enantiomers; and (b)...

Matches 1 - 50 out of 95 1 2 >