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Title:
HYALURONIC ACID BUTYRIC ESTERS WITH A LOW DEGREE OF SUBSTITUTION, PROCEDURE FOR THEIR PREPARATION AND USE
Kind Code:
A1
Abstract:
Abstract not available for EP1781707
Abstract of corresponding document: WO2005092929
The invention relates to hyaluronic acid butyric esters in which the hydroxyl groups of hyaluronic acid are partially esterified with butyric residues, characterised by a degree of substitution with butyric residues (ratio of number of butyric acid residues to disaccharide units GIcNAc-GIcUA of hyaluronic acid) being equal or below 0.1. These esters with low degree of substitution are obtained by means of a process carried out in the homogeneous phase under anhydrous conditions, wherein hyaluronic acid is used in the form of a quaternary nitrogen salt. The esters of the invention have a greater antiproliferative activity than corresponding esters with higher degree of substitution, and are particularly active against primary and metastatic tumours, where said tumours are primary of hepatic origin, or are hepatic metastases. A further aspect of the invention is represented by pharmaceutical compositions, containing as active principle at least one of the esters described.


Inventors:
Perbellini, Alberto (deceased, IT)
Coradini, Danila (Via Pecorini, 7, I-20138 Milano, IT)
Ferlini Deceased., Giovanna-heiress Of The Inventor (Via IV Novembre 14, 37126 Verona, IT)
PERBELLINI, Giulia (heiress of deceased inventor) (Via IV Novembre 14, 37126 Verona, IT)
Application Number:
EP20050718276
Publication Date:
05/09/2007
Filing Date:
03/25/2005
Assignee:
Sintofarm S.p.A. (Via Togliatti 5, 42016 Guastalla, IT)
International Classes:
C08B37/00; A61K47/48; C08B37/08
European Classes:
C08B37/00P2F
View Patent Images:
Other References:
See references of WO 2005092929A1
Attorney, Agent or Firm:
Gervasi, Gemma (Notarbartolo & Gervasi S.p.A., Corso di Porta Vittoria, 9, 20122 Milano, IT)