Title:
HIV-1 VIRUS TAT-PROTEIN MUTANTS
Kind Code:
A1
Abstract:
Abstract not available for EP1463819
Abstract of corresponding document: US2005164164
The invention relates to the use of a protein mutation method for preparing detoxified and immunogenic mutants of the wild-type HIV-1 virus Tat-protein. The invention also relates to a method for preparing detoxified and immunogenic mutants of the wild-type HIV-1 virus Tat-protein, comprising a first step in which wild-type Tat-protein mutants are prepared, a second step in which detoxified mutants having no transcellular activity but an altered nuclear localization are screened, and a third step in which immunogenic mutants capable of inducing antibodies directed against both mutants and the wild Tat protein are screened. Steps two and three are reversible.
Abstract of corresponding document: US2005164164
The invention relates to the use of a protein mutation method for preparing detoxified and immunogenic mutants of the wild-type HIV-1 virus Tat-protein. The invention also relates to a method for preparing detoxified and immunogenic mutants of the wild-type HIV-1 virus Tat-protein, comprising a first step in which wild-type Tat-protein mutants are prepared, a second step in which detoxified mutants having no transcellular activity but an altered nuclear localization are screened, and a third step in which immunogenic mutants capable of inducing antibodies directed against both mutants and the wild Tat protein are screened. Steps two and three are reversible.
Inventors:
Guillon, Christophe (FR)
Chedal-bornu, Aurelie (FR)
Verrier, Bernard (FR)
Mandrand, Bernard (FR)
Chedal-bornu, Aurelie (FR)
Verrier, Bernard (FR)
Mandrand, Bernard (FR)
Application Number:
EP20030709864
Publication Date:
10/06/2004
Filing Date:
01/09/2003
View Patent Images:
Export Citation:
Assignee:
Biomerieux SA. (FR)
International Classes:
A61K39/21; A61K39/21; A61P31/00; A61P31/18; C07K14/005; C07K14/16; C12N15/40; C12N15/48; C12N15/49; (IPC1-7): C12N15/49; A61K39/21; C07K14/16; C07K16/10; C12N5/10; G01N33/53; G01N33/566
European Classes:
A61K39/21; C07K14/16F
Other References:
See references of WO 03057885A1