DATABASE WPI Derwent Publications Ltd., London, GB; AN 2002-508794 XP002331088 YAMAJI ET AL.: "Aggrecanase and encoded polynucleotide involved in causing joint diseases" & WO 02/50258 A (YAMANOUCHI PHARMACEUTICAL CO. LTD) 27 June 2002 (2002-06-27) -& DATABASE EMBL 29 August 2002 (2002-08-29), YAMAJI ET AL.: "Aggrecanase and encoded polynucleotide involved in causing joint diseases" XP002331089 Database accession no. ABB81460
See also references of WO 03018764A2