DEPLETION OF CELLULAR COENZYME-A LEVELS AS A MEANS TO SELECTIVELY KILL CANCER CELLS
Kind Code:
A2
Abstract not available for EP1235568
Abstract of corresponding document: WO0134202
The invention describes a method to inhibit growth or kill cancer cells by acute depletion of free cellular Coenzyme A (CoA). This invention encompasses: any method to selectively decrease CoA in cancer cells by increasing the utilization of CoA and/or reducing its synthesis. As demonstrated herein, depletion of free CoA may be accomplished by inhibiting fatty acid synthase (FAS). This invention also includes depletion of free cellular Coenzyme A by interventions in addition to or alternative to FAS inhibition.
Abstract of corresponding document: WO0134202
The invention describes a method to inhibit growth or kill cancer cells by acute depletion of free cellular Coenzyme A (CoA). This invention encompasses: any method to selectively decrease CoA in cancer cells by increasing the utilization of CoA and/or reducing its synthesis. As demonstrated herein, depletion of free CoA may be accomplished by inhibiting fatty acid synthase (FAS). This invention also includes depletion of free cellular Coenzyme A by interventions in addition to or alternative to FAS inhibition.
Inventors:
Pizer, Ellen S. (US)
Townsend, Craig A. (US)
Kuhajda, Francis P. (US)
Townsend, Craig A. (US)
Kuhajda, Francis P. (US)
Application Number:
EP20000977179
Publication Date:
09/04/2002
Filing Date:
11/13/2000
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Export Citation:
Assignee:
Univ, Johns Hopkins Med (US)
International Classes:
A61K31/00; A61K31/00; A61K31/34; A61K31/34; A61K31/365; A61K31/365; A61K45/00; A61K45/00; A61K45/06; A61P35/00; A61P35/00; A61P43/00; A61P43/00; G01N33/15; G01N33/15; G01N33/50; G01N33/50; (IPC1-7): A61K31/365
European Classes:
A61K31/00; A61K31/34; A61K31/365; A61K45/06; G01N33/50D2D2
Other References:
See references of WO 0134202A2