Title:
METHODS FOR PREVENTING RESTENOSIS USING TOCOTRIENOLS
Kind Code:
A1


Inventors:
Lane, Ronald H. (US)
Schneider, Frederick H. (US)
Application Number:
EP19980960259
Publication Date:
09/27/2000
Filing Date:
11/17/1998
Assignee:
LIPOGENICS INC (US)
International Classes:
C07D311/22; A61F2/06; A61K31/352; A61K31/353; A61K31/355; A61K31/60; A61P9/00; C07D311/58; (IPC1-7): A61K31/355; A61K31/60
European Classes:
A61K31/355
View Patent Images:
Foreign References:
55917721997-01-07Tocotrienols and tocotrienol-like compounds and methods for their use
DE4333794A11995-04-06
Other References:
KARPEN C W ET AL: "TOCOTRIENOL-INDUCED INHIBITION OF PLATELET THROMBUS FORMATION AND PLATELET AGGREGATION IN A STENOSEL CORONARY ARTERY CANINE MODEL" CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 4, PART 2, no. 90, 14 November 1994 (1994-11-14), page 1181 XP008004384 ISSN: 0009-7322
TOMEO ET AL.: "Antioxidant effects of vitamin E and gamma-tocotrienol in hyperlipidemic subjects with carotid artery stenosis - A preliminary report" CLIN. RES., vol. 42, no. 1, - 1994 page 29a XP008004386
TOMEO A C ET AL: "ANTIOXIDANT EFFECTS OF PV IN HYPERLIPIDEMIC SUBJECTS WITH CAROTID ARTERY STENOSIS" CLINICAL RESEARCH, THOROFARE, NJ, US, vol. 2, no. 42, 29 April 1994 (1994-04-29), page 158A XP008004385 ISSN: 0009-9279
KOOYENGA D ET AL: "ANTIOXIDANT EFFECTS OF TOCOTRIENOLS IN PATIENTS WITH CAROTID STENOSIS" JOURNAL OF INVESTIGATIVE MEDICINE, AMERICAN FEDERATION FOR CLINICAL RESEARCH,, US, vol. 3, no. 44, 3 May 1996 (1996-05-03), page 245A XP008004383 ISSN: 1081-5589
PACKER L: "INTERACTIONS AMONG ANTIOXIDANTS IN HEALTH AND DISEASE: VITAMIN E AND ITS REDOX CYCLE" PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY & MEDICINE, ACADEMIC PRESS INC. NEW YORK, US, vol. 2, no. 200, June 1992 (1992-06), pages 271-276, XP001073940 ISSN: 0037-9727
AZZI A ET AL: "MODULATION OF CELL PROLIFERATION BY TOCOPHEROLS AND TOCOTRIENOLS: ROLE IN ARTERIOSCLEROSIS" LIPID SOLUBLE ANTIOXIDANTS: BIOCHEMISTRY AND CLINICAL APPLICATIONS, BIRKHAEUSER VERLAG, BASEL, CH, 1992, pages 123-133, XP008004536
QURESHI A A ET AL: "NOVEL TOCOTRIENOLS OF RICE BRAN MODULATE CARDIOVASCULAR DISEASE RISK PARAMETERS OF HYPERCHOLESTEROLEMIC HUMANS" JOURNAL OF NUTRITIONAL BIOCHEMISTRY, BUTTERWORTH PUBLISHERS, STONEHAM, GB, vol. 8, no. 5, May 1997 (1997-05), pages 290-298, XP001026694 ISSN: 0955-2863
GELLER M R ET AL: "Palmvitee-induced carotid plaque regression in humans." STROKE (26, NO. 1, 162, 1995) CODEN: SJCCA7 ISSN: 0039-2499, XP008004540
See also references of WO 9925336A1