2-AMINOETHYL-BENZOFURAN DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USE THEREOF
Kind Code:
A1
Abstract not available for EP0888324
Abstract of corresponding document: US6063810
PCT No. PCT/FR97/00383 Sec. 371 Date Aug. 31, 1998 Sec. 102(e) Date Aug. 31, 1998 PCT Filed Mar. 5, 1997 PCT Pub. No. WO97/32870 PCT Pub. Date Sep. 12, 1997Compounds of formula (I), wherein A is a hydrogen atom or a hydroxyl group; B is a hydrogen atom or a C1-8 alkyl, C1-8 alkenyl, C1-8 fluoroalkyl or C1-8 perfluoroalkyl group; each of R1, R2 and R5, which are the same or different, is a hydrogen atom, a halogen such as chlorine, bromine or fluorine, a C1-8 alkyl, C1-8 alkenyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C6, C10 or C14 aryl, C1-6 alkoxycarbonyl, C1-6 hydroxyalkyl, C1-6 alkoxyalkyl, C1-6 alkoxy, C1-8 fluoroalkyl or C1-8 perfluoroalkyl group, or R1 and R2 taken together form a C3-8 cycloalkyl, C3-8 cycloalkenyl or C6, C10 or C14 aryl ring, except for compounds in which R1 and R2 are both hydrogen; each of R3 and R4, which are the same or different, is a hydrogen atom or a C1-8 alkyl, C1-8 alkenyl, C3-8 cycloalkyl or C3-8 cycloalkenyl group, or R3 and R4 taken together form a C2-6 cycloalkyl or C3-6 cycloalkenyl ring, e.g., piperidyl, azetidinyl or pyrrolidyl; in the form of enantiomers, diastereoisomers or mixtures thereof, including racemic mixtures;, as well as pharmaceutically acceptable acid addition salts thereof. The compounds may be used in therapy.
Abstract of corresponding document: US6063810
PCT No. PCT/FR97/00383 Sec. 371 Date Aug. 31, 1998 Sec. 102(e) Date Aug. 31, 1998 PCT Filed Mar. 5, 1997 PCT Pub. No. WO97/32870 PCT Pub. Date Sep. 12, 1997Compounds of formula (I), wherein A is a hydrogen atom or a hydroxyl group; B is a hydrogen atom or a C1-8 alkyl, C1-8 alkenyl, C1-8 fluoroalkyl or C1-8 perfluoroalkyl group; each of R1, R2 and R5, which are the same or different, is a hydrogen atom, a halogen such as chlorine, bromine or fluorine, a C1-8 alkyl, C1-8 alkenyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C6, C10 or C14 aryl, C1-6 alkoxycarbonyl, C1-6 hydroxyalkyl, C1-6 alkoxyalkyl, C1-6 alkoxy, C1-8 fluoroalkyl or C1-8 perfluoroalkyl group, or R1 and R2 taken together form a C3-8 cycloalkyl, C3-8 cycloalkenyl or C6, C10 or C14 aryl ring, except for compounds in which R1 and R2 are both hydrogen; each of R3 and R4, which are the same or different, is a hydrogen atom or a C1-8 alkyl, C1-8 alkenyl, C3-8 cycloalkyl or C3-8 cycloalkenyl group, or R3 and R4 taken together form a C2-6 cycloalkyl or C3-6 cycloalkenyl ring, e.g., piperidyl, azetidinyl or pyrrolidyl; in the form of enantiomers, diastereoisomers or mixtures thereof, including racemic mixtures;, as well as pharmaceutically acceptable acid addition salts thereof. The compounds may be used in therapy.
Inventors:
Philippo, Christophe (FR)
Courtemanche, Gilles (FR)
Fett, Eykmar (FR)
Orts, Marie Claire (FR)
Bovy, Philippe (FR)
O'connor, Stephen Eric (FR)
Galzin, Anne Marie (FR)
Courtemanche, Gilles (FR)
Fett, Eykmar (FR)
Orts, Marie Claire (FR)
Bovy, Philippe (FR)
O'connor, Stephen Eric (FR)
Galzin, Anne Marie (FR)
Application Number:
EP19970908303
Publication Date:
01/07/1999
Filing Date:
03/05/1997
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Export Citation:
Assignee:
Synthelabo (FR)
International Classes:
A61K31/00; A61K31/00; A61K31/34; A61K31/34; A61K31/343; A61K31/343; A61K31/395; A61K31/395; A61K31/397; A61K31/397; A61K31/4427; A61K31/443; A61K31/445; A61K31/445; A61K31/4453; A61K31/4453; A61P1/00; A61P1/00; A61P9/00; A61P9/00; A61P9/14; A61P11/00; A61P11/00; A61P11/02; A61P25/00; A61P25/06; C07D307/00; C07D307/79; C07D307/85; C07D307/91; C07D405/00; C07D405/06; (IPC1-7): C07D307/79; C07D307/85; C07D307/91; C07D407/04
European Classes:
C07D307/79B
Other References:
See references of WO 9732870A1