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5935932 Bradykinin antagonists containing pentafluorophenylalanine  
The present invention provides bradykin antagonists containing pentafluorophenylalanine which are therapeutically useful. Moreover, the present invention provides methods to antagonize bradykinin...
5932703 Macrophage derived chemokine and chemokine analogs  
The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C--C chemokine designated MDC, and polypeptide analogs thereof. Also...
5925730 GnRH antagonists  
Peptides are provided which have improved duration of GnRH antagonistic properties. These antagonists may be used to regulate fertility and to treat steroid-dependent tumors and for other...
5922573 IL-1 receptor antagonists with enhanced inhibitory activity  
DNA molecules that code for IL-1 antagonists with improved biological activity arc described. DNA molecules coding for improved IL-1 antagonists inserted into expression vectors and host cells...
5919903 Low affinity human IL-12 beta2 receptor  
A recombinant human IL-12 receptor complex produced on the surface of a non-human mammalian cell and free from other human proteins, the complex comprising the beta1 receptor protein complexed...
5916569 Human erectile dysfunction and methods of treatment  
This invention is a method for treating human erectile dysfunction using therapeutic amounts of human growth hormone (GH) administered systemically. Severing the parasympathetic nerves that...
5914106 Interleukin-6 receptor agonists  
It is known that the ligands of the group of cytokines similar to Interleuk 6 (IL-6), that is Oncostatin M (OSM), Leukemia Inhibitory Factor (LIF), Ciliary Neurotrophic Factor (CNTF) and...
5910483 Plerocercoid growth factor protein purified from Spirometra mansonoides  
The invention relates to a purified growth factor protein which is obtained from Spirometra mansonoides, and a pharmaceutical composition which includes the same. The protein has a molecular...
5900235 Interleukin-8 as an antiviral and antitumor agent  
Interleukin-8 (IL-8) and analogs thereof is useful in the treatment of viral infections, caused by human and animal viruses, and cancers caused by oncoviruses.
5898030 hGH containing pharmaceutical compositions  
Pharmaceutical compositions containing hGH stabilized by means of saccharose. The formulation is particularly suitable for stabilizing a lyophilisate of recombinant hGH.
5895646 Isolated native primate GM-CSF protein  
A method for purifying CSF protein is described. The method comprises: precipitating the protein with ammonium sulfate at 80% saturation to form a pellet containing the CSF protein; resuspending...
5891998 Interleukin-6 receptor agonists  
Disclosed are interleukin-6 receptor agonists. These receptor agonists were enerated by mutating amino acid positions 175, 176, 177, 181, and/or 183 of human interleukin-6.
5891680 Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12  
Fusion proteins, such as a bio active IL-12 polypeptide, which comprise at least two polypeptide monomers (chains of amino acids) joined through a heterologous polypeptide linker and which are...
5888963 Treatment of bone disorders with adrenomedullin  
A method for promoting bone growth in a patient (e.g., a mammal such as a human) said method including the step of administering a therapeutically effective amount of adrenomedullin or an...
5888974 Hybrid human/animal factor VIII  
A hybrid procoagulant factor VIII is produced by isolation and recombination of human and other nonhuman mammalian factor VIII subunits or domains, or by genetic engineering of the human and...
5889144 Fused somatotropin epitopic peptides that potentiate growth hormone activity  
This invention relates to composite somatotropin peptides comprising somatotropin epitopic amino acid sequences, and fusion proteins thereof, useful in potentiating growth hormone activity. Also...
5889156 TNF deletion muteins  
A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function....
5883073 Single-chain double-alpha peptide  
The invention is directed to a glycosylated or nonglycosylated protein which is composed of the amino acid sequence of a first α subunit common to the glycoprotein hormones linked covalently,...
5883224 Characterization of transfer factors and methods of use  
Characterization of transfer factors is provided in the form of amino acid and nucleic acid sequences corresponding to at least a portion of a conserved transfer factor region. The amino acid and...
5880256 Factor VIIa inhibitors from Kunitz domain proteins  
A potent serine protease inhibitor capable of inhibiting Factor VIIa, Factor XIa, plasma kallikrein, or plasmin is provided. The inhibitor is provided in a pharmaceutical composition for treatment...
5876730 Heparin-binding growth factor (HBGF) polypeptides  
Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides...
5877276 Polypeptide agonists for human interleukin-8  
Polypeptides derived from human interleukin-8 (IL-8) which act as therapeutic agents for the therapy of neoplastic (both solid and leukemic) and infectious diseases such as bacterial, fungal,...
5874227 Cyclic CRF antagonists  
Novel cyclic CRF antagonist peptides have the amino acid sequence: ##STR1## wherein Y is Ac, H, Ac-Thr or H-Thr; R30 is Glu or Cys; R32 is His or preferably a basic and/or aromatic D-amino acid...
5874075 Stable protein: phospholipid compositions and methods  
The invention relates to stable compositions of proteins and related methods wherein a protein capable of transitioning into the molten globular state is contacted with a negatively charged lipid...
5871956 Recombinant methods for production of serine inhibitors and DNA sequences useful for same  
A synthetic DNA sequence and its genetic equivalents are disclosed which sequences are capable, when used in a recombinant DNA method, of directing production of a serine protease inibitor...
5871742 Recombinant Avipox virus encoding polypeptide of mycoplasma gallisepticum, and utilized a live vaccine  
A polypeptide exhibiting the antigenicity of Mycoplasma gallisepticum, a fused polypeptide comprising the above polypeptide and, connected to the N-terminus thereof, a signal membrane anchor of a...
5871740 Methods of using poxvirus p35 as a chemokine inhibitor and compositions therefore  
A protein designated p35 binds to a number of the chemotaxis-stimulating cytokines known as chemokines. p35 may be used to treat conditions that are mediated by chemokines, such as inflammation....
5869278 Process for the preparation of mature human growth hormone by enzymatic hydrolysis of a soluble precursor with immobilized factor Xa  
Mature Human Growth Hormone is prepared by enzymatic hydrolysis of a soluble precursor with immobilized Factor Xa. The soluble precursor contains a cleavage recognition sequence,...
5869449 38-decarboxy-38-hydroxymethyl derivatives of teiocoplanin antibiotics and a process for preparing them  
The present invention is directed to novel 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antiobiotics and a process for preparing them which includes submitted the corresponding lower...
5869448 Cyclic CS-1 peptidomimetics, compositions and methods of using same  
The present invention contemplates a cyclic peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on...
5866683 Isoelectric point markers for isoelectric focusing with fluorescence detection  
Provided are isoelectric point(pI) markers for isoelectric focusing with fluorescence detection. The markers are fluorescence-labeled oligopeptides which comprise a fluorescence dye bonded...
5863540 Adhesion molecule  
The present invention relates, in general, to a method of treating inflammation or inhibiting cancer cell metastasis. In particular, the present invention relates to a method of suppressing T cell...
5861485 Polypeptides involved in body weight disorders, including obesity  
The present invention relates to methods and compositions for the treatment of body weight disorders, including, but not limited to, obesity. Specifically, the present invention identifies and...
5861160 Isospora suis sporozoite antigen  
Isospora suis is propagated using a swine testicular cell line which facilitates production of sporozoites and merozoites, either or both of which can be used in a vaccine for swine. Antibodies...
5858347 Therapeutic methods using fusion proteins between interleukin-3 (IL-3) variants and other hematopoietic factors  
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF),...
5854216 Marker for growth hormone-releasing factor receptors  
The present invention relates to a compound having the formula: Ra--X--Rb Ior a pharmaceutically acceptable salt thereof,wherein, X is selected from the group consisting of ##STR1## Ra is a...
5854395 Cloned borrelia burgdorferi virulence protein  
The present invention provides EppA polypeptide, a Borrelia burgdorferi virulence protein. This 17-kD outer membrane protein has been designated EppA for exported plasmid protein A.
5849694 Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof  
The present invention provides a stable and bioactive recombinant small-loop modified somatotropin which has its small-loop cysteines changed to other amino acids or deleted altogether and a...
5849283 Human interleukin-6 receptor antagonists  
It is known that the ligands of the group of cytokines similar to Interleukin 6 (IL-6), that is Oncostatin M (OSM), Leukemia Inhibitory Factor (LIF), Ciliary Neurotrophic Factor (CNTF) and...
5849869 Delta fragments and derivatives and methods based thereon  
The present invention relates to nucleotide sequences of the Delta genes, and amino acid sequence of the encoded protein, fragments and derivatives which retain binding activity are also provided.
5846935 Modified ciliary neurotrophic factors  
Modified ciliary neurotrophic factors and methods for their production and therapeutic use. Also described is a method of screening for novel therapeutic proteins by determining altered...
5847078 Polypeptide capable of differentiating and maturing malignant cells into normal cells or capable of accelerating the formulation of erythroblasts  
A physiologically active polypeptide, BUF-3, having the ability to differentiate and maturate human leukemia cells into normal cells and of accelerating the formation of erythroblasts is...
5846936 Growth hormone releasing factor analogs  
Novel growth hormone releasing factor analogs are presented having a sequence of from about twenty-nine (29) to about forty-four (44) amino acids (SEQ ID NO: 6) wherein Xaa at position 1 is His,...
5844084 Chemokine expressed in inflamed adenoid  
The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for...
5840687 Modified ligands for receptor tyrosine kinases  
The invention provides for synthetic ligands that bind to class I receptor tyrosine kinases. The ligands are analogous in structure to naturally occurring ligands. The modified ligands however,...
5840846 Fibronectin binding protein as well as its preparation  
The present invention relates to a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from S. aureus coding for a protein, or polypeptide, having fibronectin binding properties.
5840857 Urinary follicle stimulating hormone  
Purification of human FSH from post-menopausal urine gonadogropin using immunochromatography and reverse phase HPLC steps yelds a biologically active hormone which is free from detectable traces...
5834598 Human growth hormone variants  
A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method...
5833942 Technetium-99m labeled somatostatin-derived peptides for imaging and therapeutic uses  
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to...
5831015 Colon mucosa gene having down-regulated expression in colon adenumas and adenocarcinomas  
A new down-regulated gene called DRA, for down regulated in adenoma, maps to chromosome 7 and is believed to encode a tumor suppressor. The DRA gene encodes a highly hydrophobic protein with...