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6117422 N∇2-CSF-1(long form) and carboxy truncated fragments thereof  
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from...
6114142 Parasitic helminth nucleic acid molecules/and uses thereof  
The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and...
6106805 Diagnostic composition containing an LH-RH antagonist for hysteroscopy  
The invention relates to a diagnostic composition for improving the effectiveness of hysteroscopy, characterized in that it contains an LH-RH antagonist, in particular cetrorelix. The composition...
6107465 IL-1β and derivatives thereof and drugs  
A homogeneous interleukin 1β (IL-1β), its derivative having a modified amino acid sequence of IL-1β, a gene coding for said derivative, medical composition comprising said derivative as a...
6107021 Synthetic peptide vaccines for foot-and-mouth disease  
The present invention relates to the use of a peptide composition as an immunogen, with each peptide contained therein comprising a target antigenic site derived from the VP1 capsid protein of...
6103500 Production of tissue factor pathway inhibitor  
A method for the production of Tissue Factor Pathway Inhibitor (TFPI) and Tissue Factor Pathway Inhibitor 2 (TFPI-2), and muteins thereof is disclosed wherein the protein is retained within a...
6103224 N∇2 CSF-1 (short form) and carboxy truncated fragments thereof  
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from...
6099843 Parasitic helminth PLA2 proteins  
The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such...
6084071 Human L105 polypeptides and polynucleotides encoding same  
A chemokine, human L105, is disclosed.
6066482 Acyltransferase and gene encoding acyltransferase  
Essentially pure acyltransferase is provided which is functional to catalyze reaction to form sugar esters. Also provided is isolated gene encoding acyltransferase. Additionally provided is method...
6063901 Macrophage receptor with a collagenous domain  
The present invention is directed to processes for isolating and identifying the nucleotide sequence of a gene for a novel macrophage receptor with collagenous structure, termed "MARCO". The new...
6057292 Method for inhibiting growth hormone action  
Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups,...
6054556 Melanocortin receptor antagonists and agonists  
Cyclic lactam peptides are disclosed which inhibit at various levels of antagonism the melanocortin 1 receptor (MC1R), melanocortin 3 receptor (MC3R), melanocortin 4 receptor (MC4R), and...
6051390 Complex-bound inhibitors of metabolic enzymes capable of being activated, useful as molecular markers for diagnostic and therapy monitoring purposes  
This invention relates to the use of an inhibitor of an activatable metabolic enzyme, which inhibitor is bound to a high molecular weight carrier, as a molecular marker for determining the...
6034062 Bone morphogenetic protein (BMP)-9 compositions and their uses  
Purified Bone Morphogenetic Protein (BMP)-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing...
6028176 High-affinity interleukin-4 muteins  
This invention is directed to recombinant human IL-4 muteins numbered in accordance with wild-type IL-4 wherein the muteins comprise at least one amino acid substitution selected from the group...
6018036 Nucleic acids encoding cytokine synthesis inhibitory factor (Interleukin-10)  
Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines...
6017523 Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides  
The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain one to three amino acid substitutions and may also have...
6015883 Rantes homolog from prostate  
The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The...
6013626 Cryptophycins from synthesis  
A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals....
6013506 Feline leukemia virus vaccines  
Disclosed are recombinant baculovirus expressing the gag, gp70, and gp85 genes of feline leukemia virus. Also disclosed are vaccines based on protein expressed from these recombinants. Also...
6010700 Polypeptides p57 or p9.5 of Borna disease virus and their use for diagnosis and immunization  
The invention involves polypeptides which correspond to amino acid sequences of protein p57 or protein p9.5 of Borna disease virus. These polypeptides, as well as DNA and RNA fragments are used in...
6010704 Polypeptides and antibodies characteristic of papillomavirus, and diagnostic procedures and vaccines making use of them  
The present invention provides papillomavirus DNA, and more particularly DNA probes derived from papillomavirus. The present invention also provides procedures for the use of DNA derived from...
6007804 IL-6 as serum uric acid decreasing compound  
The present invention provides a serum uric acid decreasing agent which contains interleukin-6 (IL-6) as the active ingredient together with a pharmaceutically acceptable carrier; and a method for...
6001606 Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby  
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3...
6001960 Synthetic somatostatin mimics  
Relatively small cyclic peptides that mimic the biological and/or chemical activity of larger cyclic peptide such as somatostatin, as well as synthetic methods therefor. In certain embodiments,...
5998376 Substance P treatment for immunostimulation  
Substance P aerosols are effective in replenishing immune systems compromised by environmental toxicants. They are also useful for prophylaxis against and treatment of infections and neoplasms....
5998580 Photosensitive caged macromolecules  
Disclosed is a method for preparing a photosensitive peptide which is capable of being activated or deactivated in a biological system, including the steps of: (a) providing an amino acid...
5994104 Interleukin-12 fusion protein  
This invention relates to Interleukin-12 fusion proteins and nucleic acid constructs encoding them, and to the use of such fusion proteins and constructs in tumour therapy, especially therapy of...
5989836 Method for measuring the binding sites for macrophage-derived inflammatory mediator (MIP-1α and MIP-1β)  
An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of...
5989839 Use of MOLT4 CD69 expression to determine the presence and activity of interferon inhibitors  
Disclosed is a method of determining the presence and activity of interferon inhibitors in a test sample, preferably human blood serum. The method includes the steps of culturing cells which...
5990276 Synthetic inhibitors of hepatitis C virus NS3 protease  
An inhibitor of the HCV NS3 protease. The inhibitor is a subsequence of a substrate of the NS3 protease or a subsequence of the NS4A cofactor. Another inhibitor of the present invention contains a...
5989548 Peptide-based composition against papillomavirus infection  
Pharmaceutical compositions comprising an antigenic amount of peptides derived from the L1 and L2 OFR's of human papillomavirus type 16 coupled to a carrier or in multimer form.
5986068 Site-directed mutagenesis modified glycoprotein hormones and methods of use  
Described are new glycoprotein hormones capable of competing with natural hormones for the normal receptor binding sites but substantially incapable of effecting post receptor activities. The...
5985613 Use of an "immunodeficiency-virus suppressing lymphokine (ISL) "to inhibit the replication of viruses, in particular of retroviruses  
An isolated polypeptide which inhibits the replication of retroviruses in peripheral blood lymphocytes and i) is encoded by the DNA sequence shown in SEQ ID NO: 1 or complementary sequences; or...
5985654 Recombinant poxvirus and streptococcal M protein vaccine  
Viruses of the family poxviridae such as vaccinia or fowlpox viruses are modified to contain a gene which expresses a protein corresponding to the conserved exposed region of the M6 protein. The...
5985834 Nova- and decapeptides in the preparation of a drug for the treatment of aids  
Described are LHRH-antagonistic and bombesin-antagonistic nona- and decapeptides suitable for use in the preparation of a drug for the treatment of AIDS and ARC as well as for use in the...
5977306 Parasitic helminth P39 proteins, and uses thereof  
The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and...
5977068 Stabilized growth hormone compositions  
The present invention relates to compositions of growth hormones and preservatives which do not interfere with the activity of the growth hormone.
5977298 Calcitonin derivatives  
The present invention relates to compounds represented by formula (I): ##STR1## wherein Z represents Gly or Cys; X represents an (α-amino acid residue; Y represents a natural calcitonin moiety, a...
5968904 Modified arginine containing lytic peptides and method of making the same by glyoxylation  
A non-neurotoxin, arginine residue-containing non-naturally occurring lytic peptide comprising a sequence of amino acid residues in sufficient number and arrangement to confer lytic activity to...
5965699 Assay for the proteolytic activity of serotype a from clostridium botulinum  
A label-based assay is described, through modifications of substrate strure and derivatization of serum albumin, which can be used to determine type A proteolytic activity without separation of...
5965694 Somatostatin mimics and synthetic methods therefor  
Relatively small cyclic peptides that mimic the biological and/or chemical activity of larger cyclic peptide such as somatostatin, as well as synthetic methods therefor. In certain embodiments,...
5958879 Growth hormone receptor antagonists and methods of reducing growth hormone activity in a mammal  
The present invention relates to antagonists of vertebrate growth hormones obtained by mutation of the third alpha helix of such proteins (especially bovine or human GHs). These mutants have...
5955423 Cryptophycins  
A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria)....
5952461 Process for preparing human proinsulin  
The present invention relates to a process for preparing human proinsulin which is represented as a following chemical formula(I): ##STR1## wherein, R is an amino acid residue or a peptide which...
5945506 Chemokine expressed in fetal spleen and its production  
The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (FSEC) from human fetal spleen cells. The present invention also provides...
5945511 Class II cytokine receptor  
Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface...
5939386 Chimeric fatty body-pro-GRF (1-29) analogs with increased biological potency  
The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone...
5936068 Liver expressed chemokine-1  
The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also...