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6153581 |
Drug for recovering renal function
Drug which contains human growth hormones capable of recovering the renal function when administered to a patient who has renal insufficiency but has not yet undergone kidney dialysis. By...
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6146851 |
DNA encoding NV2 (long form) and carboxy truncated fragments thereof
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other...
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6143866 |
Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
At least two substantially purified tumor necrosis factor (TNF) inhibitors are disclosed which are glycoproteins that are active against TNF. The isolation of 3O kDa and 40 KDa TNF inhibitor from...
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6143523 |
Human growth hormone variants
Human growth hormone variants and their nucleic acids are disclosed wherein the amino acid residues at positions 10, 14, 18, 21, 167, 171, 174, 176 and 179 have been replaced with other amino...
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6139832 |
Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1...
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6136563 |
Human growth hormone variants comprising amino acid substitutions
Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups,...
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6132720 |
Immunogens against gonadotropin releasing hormone
Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal...
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6127528 |
Process for adsorbing and removing tumor necrosis factor-α
The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-α (TNF-α) in a body fluid, an adsorber using the adsorbent and a process for adsorbing a...
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6123916 |
Therapeutic use of somatostatin peptides
The invention relates to a new pharmaceutical use of somatostatin peptides comprising on the terminal amino group a polyamino polycarboxylic group, in free form or in a pharmaceutically acceptable...
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6120989 |
Isolated human cytomegalovirus polypeptides and uses thereof
Diagnostically relevant polypeptides and fusion proteins comprising an amino acid sequence which originates from cytomegalovirus and corresponds to a region of the major DNA-binding protein or of...
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6117422 |
N∇2-CSF-1(long form) and carboxy truncated fragments thereof
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from...
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6114142 |
Parasitic helminth nucleic acid molecules/and uses thereof
The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to...
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6107021 |
Synthetic peptide vaccines for foot-and-mouth disease
The present invention relates to the use of a peptide composition as an immunogen, with each peptide contained therein comprising a target antigenic site derived from the VP1 capsid protein of...
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6107465 |
IL-1β and derivatives thereof and drugs
A homogeneous interleukin 1β (IL-1β), its derivative having a modified amino acid sequence of IL-1β, a gene coding for said derivative, medical composition comprising said derivative as a ph...
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6106805 |
Diagnostic composition containing an LH-RH antagonist for hysteroscopy
The invention relates to a diagnostic composition for improving the effectiveness of hysteroscopy, characterized in that it contains an LH-RH antagonist, in particular cetrorelix. The composition...
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6103224 |
N∇2 CSF-1 (short form) and carboxy truncated fragments thereof
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from...
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6103500 |
Production of tissue factor pathway inhibitor
A method for the production of Tissue Factor Pathway Inhibitor (TFPI) and Tissue Factor Pathway Inhibitor 2 (TFPI-2), and muteins thereof is disclosed wherein the protein is retained within a yeast...
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6099843 |
Parasitic helminth PLA2 proteins
The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such...
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6084071 |
Human L105 polypeptides and polynucleotides encoding same
A chemokine, human L105, is disclosed.
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6066482 |
Acyltransferase and gene encoding acyltransferase
Essentially pure acyltransferase is provided which is functional to catalyze reaction to form sugar esters. Also provided is isolated gene encoding acyltransferase. Additionally provided is method...
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6063901 |
Macrophage receptor with a collagenous domain
The present invention is directed to processes for isolating and identifying the nucleotide sequence of a gene for a novel macrophage receptor with collagenous structure, termed "MARCO". The new...
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6057292 |
Method for inhibiting growth hormone action
Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups,...
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6054556 |
Melanocortin receptor antagonists and agonists
Cyclic lactam peptides are disclosed which inhibit at various levels of antagonism the melanocortin 1 receptor (MC1R), melanocortin 3 receptor (MC3R), melanocortin 4 receptor (MC4R), and...
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6051390 |
Complex-bound inhibitors of metabolic enzymes capable of being activated, useful as molecular markers for diagnostic and therapy monitoring purposes
This invention relates to the use of an inhibitor of an activatable metabolic enzyme, which inhibitor is bound to a high molecular weight carrier, as a molecular marker for determining the...
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6034062 |
Bone morphogenetic protein (BMP)-9 compositions and their uses
Purified Bone Morphogenetic Protein (BMP)-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and...
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6028176 |
High-affinity interleukin-4 muteins
This invention is directed to recombinant human IL-4 muteins numbered in accordance with wild-type IL-4 wherein the muteins comprise at least one amino acid substitution selected from the group...
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6017523 |
Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain one to three amino acid substitutions and may also have...
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6018036 |
Nucleic acids encoding cytokine synthesis inhibitory factor (Interleukin-10)
Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines...
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6015883 |
Rantes homolog from prostate
The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The...
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6013506 |
Feline leukemia virus vaccines
Disclosed are recombinant baculovirus expressing the gag, gp70, and gp85 genes of feline leukemia virus. Also disclosed are vaccines based on protein expressed from these recombinants. Also...
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6013626 |
Cryptophycins from synthesis
A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals....
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6010700 |
Polypeptides p57 or p9.5 of Borna disease virus and their use for diagnosis and immunization
The invention involves polypeptides which correspond to amino acid sequences of protein p57 or protein p9.5 of Borna disease virus. These polypeptides, as well as DNA and RNA fragments are used in...
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6010704 |
Polypeptides and antibodies characteristic of papillomavirus, and diagnostic procedures and vaccines making use of them
The present invention provides papillomavirus DNA, and more particularly DNA probes derived from papillomavirus. The present invention also provides procedures for the use of DNA derived from...
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6007804 |
IL-6 as serum uric acid decreasing compound
The present invention provides a serum uric acid decreasing agent which contains interleukin-6 (IL-6) as the active ingredient together with a pharmaceutically acceptable carrier; and a method for...
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6001606 |
Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3...
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6001960 |
Synthetic somatostatin mimics
Relatively small cyclic peptides that mimic the biological and/or chemical activity of larger cyclic peptide such as somatostatin, as well as synthetic methods therefor. In certain embodiments,...
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5998580 |
Photosensitive caged macromolecules
Disclosed is a method for preparing a photosensitive peptide which is capable of being activated or deactivated in a biological system, including the steps of: (a) providing an amino acid including...
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5998376 |
Substance P treatment for immunostimulation
Substance P aerosols are effective in replenishing immune systems compromised by environmental toxicants. They are also useful for prophylaxis against and treatment of infections and neoplasms....
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5994104 |
Interleukin-12 fusion protein
This invention relates to Interleukin-12 fusion proteins and nucleic acid constructs encoding them, and to the use of such fusion proteins and constructs in tumour therapy, especially therapy of...
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5989548 |
Peptide-based composition against papillomavirus infection
Pharmaceutical compositions comprising an antigenic amount of peptides derived from the L1 and L2 OFR's of human papillomavirus type 16 coupled to a carrier or in multimer form.
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5990276 |
Synthetic inhibitors of hepatitis C virus NS3 protease
An inhibitor of the HCV NS3 protease. The inhibitor is a subsequence of a substrate of the NS3 protease or a subsequence of the NS4A cofactor. Another inhibitor of the present invention contains a...
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5989839 |
Use of MOLT4 CD69 expression to determine the presence and activity of interferon inhibitors
Disclosed is a method of determining the presence and activity of interferon inhibitors in a test sample, preferably human blood serum. The method includes the steps of culturing cells which...
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5989836 |
Method for measuring the binding sites for macrophage-derived inflammatory mediator (MIP-1α and MIP-1β)
An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of...
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5985654 |
Recombinant poxvirus and streptococcal M protein vaccine
Viruses of the family poxviridae such as vaccinia or fowlpox viruses are modified to contain a gene which expresses a protein corresponding to the conserved exposed region of the M6 protein. The...
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5985613 |
Use of an "immunodeficiency-virus suppressing lymphokine (ISL) "to inhibit the replication of viruses, in particular of retroviruses
An isolated polypeptide which inhibits the replication of retroviruses in peripheral blood lymphocytes and i) is encoded by the DNA sequence shown in SEQ ID NO: 1 or complementary sequences; or ii)...
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5986068 |
Site-directed mutagenesis modified glycoprotein hormones and methods of use
Described are new glycoprotein hormones capable of competing with natural hormones for the normal receptor binding sites but substantially incapable of effecting post receptor activities. The...
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5985834 |
Nova- and decapeptides in the preparation of a drug for the treatment of aids
Described are LHRH-antagonistic and bombesin-antagonistic nona- and decapeptides suitable for use in the preparation of a drug for the treatment of AIDS and ARC as well as for use in the...
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5977068 |
Stabilized growth hormone compositions
The present invention relates to compositions of growth hormones and preservatives which do not interfere with the activity of the growth hormone.
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5977298 |
Calcitonin derivatives
The present invention relates to compounds represented by formula (I): ##STR1## wherein Z represents Gly or Cys; X represents an (α-amino acid residue; Y represents a natural calcitonin moiety, a ...
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5977306 |
Parasitic helminth P39 proteins, and uses thereof
The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to...
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