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6333305 Antibiotic TKR2999, process for the preparation thereof and microbe  
The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt: (1) FAB-MS m/z 971 [M+H)]+, (2) the molecular formula: C44 H78 N10 O14, and...
6326463 Cyclic CRF agonists  
Novel cyclic CRF agonist peptides have the amino acid sequence: (cyclo 30-33)Ac-Ser-Leu-Asp-Leu-Thr-D-Phe-His-Leu-Leu-Arg-Glu-Val-L eu-Glu-Nle-Ala -Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-R32 -R33...
6326462 RibH  
The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
6323179 Chicken GNRH analogs and uses thereof in regulation of fertility and pregnancy  
Specially designed non-mammalian GnRH analog decapeptides resistant to degradation by the placental enzyme, C-ase-1, or a post-proline peptidase, are disclosed. The GnRH analogs are further...
6322779 Recombinant human CSF-1 dimer and compositions thereof  
The present invention is directed to an isolated and purified, recombinant, unglycosylated and dimeric CSF-1, the dimeric CSF-1 being biologically active and essentially endotoxin and...
6319897 Peptides which inhibit complement activation  
Peptides capable of inhibiting complement activation are provided. Methods of inhibiting complement activation and complement-mediated tissue injury using these peptides are also provided. In...
6316000 Cloning and expression of plasmodium falciparum transmission-blocking target antigen, PFS230  
Compositions comprising biologically pure Pfs230 and nucleic acids which encode them are provided. The proteins can be used induce transmission blocking immune responses in susceptible hosts.
6312686 Modulating the permeability of a physiological barrier with an agent that modulates tyrosine phosphorylation  
Permeability of the blood-brain barrier and other physiological barriers can be modulated by the degree of tyrosine phosphorylation of proteins. Agents which promote tyrosine protein...
6313272 DNA encoding high affinity interleukin-4 muteins  
A recombinant human IL-4 mutein numbered in accordance with wild-type IL-4 wherein the mutein comprises at least one amino acid substitution in the binding surface of either the A- or C-alpha...
6303123 Methods for the treatment of hormone-dependent tumors with immunogens against gonadotropin releasing hormone  
Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal...
6297357 prb2/p130 peptide inhibitors of cdk2 kinase activity  
The present invention provides peptides of pRb2/p130 or mutants or fragments thereof which inhibit cdk2 kinase activity. Method of inhibiting cdk2 kinase activity in cells with these peptides are...
6294652 Response regulator  
The invention provides Response regulator polypeptides and polynucleotides encoding Response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also...
6287816 BMP-9 compositions  
Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing...
6287566 Protective peptides neurotoxin of C. botulinum  
Methods for developing vaccines to protect from neurotoxins of C. botulinum have been developed. Truncated BoNT/A proteins of about 15-30 kDa in size produced immune responses that provided...
6287794 Factor Vlla inhibitors  
The present invention relates to novel compounds and pharmaceutical composition, their preparation, and their use, having a antithrombotic effect through reversible inhibition of activated blood...
6274551 Cytotoxic and antiviral compound  
Kalahide F, of formula I below, may be isolated from a sacoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions....
6268479 Intracellular amyloid-beta peptide binding (ERAB) polypeptide  
The present invention provides an isolated nucleic acid encoding an endoplasmic reticulum associated amyloid-beta peptide binding (ERAB) polypeptide. The ERAB polypeptide may comprise human ERAB...
6268482 Recombinant cytokine designated LERK-6  
The invention is directed to LERK-6 as a purified and isolated protein, the DNA encoding the LERK-6, host cells transfected with cDNAs encoding LERK-6.
6261549 Human mesenchymal stem cells from peripheral blood  
Disclosed is a method for recovering peripheral blood containing a population of cells enhanced in human mesenchymal stem cells from an individual by (i) administering to said individual at least...
6262235 Leptospiral outer membranes protein, LipL46  
An antigenic preparation is provided containing an outer membrane protein associated with pathogenic strains of Leptospira. The protein has been designated "LipL46" for "lipoprotein from...
6258556 cDNA and genomic clones encoding human μ opiate receptor and the purified gene product  
A human μ opiate receptor cDNA has been identified from a cerebral cortical CDNA library using sequences from the rat μ opiate receptor CDNA. The human μ opiate receptor (hμOR1) shares 95% amino...
6255281 Use of recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions  
Method for treatment of inflammatory and fibrotic conditions in vivo using pure rhUG is disclosed. Method for treating or preventing inflammatory or fibrotic conditions characterized by a...
6248574 Polypeptides selectively reactive with antibodies against human immunodeficiency virus and vaccines comprising the polypeptides  
Highly conserved polypeptide sequences derived from gp41 and gp120, preferably from eleven to twenty-one amino acids in length, are joined (for example, via DNA recombinant techniques) to a...
6238915 Mutant human growth hormones and their uses  
In accordance with the present invention, there are provided mutant human growth hormone proteins which exhibit enhanced affinity for growth hormone but lowered hormone activity, base sequences...
6235874 Production of biologically active recombinant insulin-like growth factor II polypeptides  
The present invention relates to the finding and construction of fish insulin-like growth factor II (IGF-II) cDNAs which can be cloned and expressed in cells. This invention also relates to the...
6228836 Permucous preparation  
A composition for permucosal administration characterized by containing Antago-3 or a physiologically acceptable salt thereof, and a sucrose fatty acid ester.With the composition for permucosal...
6228838 LicD1 polypeptides  
The invention provides licD1 polypeptides and polynucleotides encoding licD1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
6221577 Seroreactive regions on HPV 16-proteins E1 and E2  
The invention relates to seroreactive regions on protein E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the...
6218364 Fluorinated neurokinin A antagonists  
Peptide derivatives which are antagonists of neurokinin A. The derivatives have a modified peptide bond having a reduced amide and a fluorinated alkyl attached to the nitrogen atom of the modified...
6214969 Luteinizing hormone releasing hormone analogs with cytotoxic moiety  
The present invention deals with LHRH analogs which contain cytotoxic moieties, have influence on the release of gonadotropins from the pituitary in mammals (possess high agonistic or antagonistic...
6214798 GnRH antagonists being modified in positions 5 and 6  
Peptides are provided which have improved duration of GnRH antagonistic properties. These antagonists may be used to regulate fertility and to treat steroid-dependent tumors and for other...
6210927 Polynucleotides encoding sbGnRH, a novel reproductive hormone  
Novel peptide hormones which influence the release of gonadotropins by the pituitary gland in fish are disclosed. Methods in which such peptides may be administered to fish to control their...
6211142 Compositions comprising gas6 polypeptides and articles of manufacture comprising the same  
An activator of the Rse receptor protein tyrosine kinase has been identified which is encoded by growth arrest-specific gene 6 (gas6). Accordingly, the present invention provides compositions...
6204020 DNA encoding N∇2 CSF-1 (short form) and carboxy truncated fragment thereof  
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from...
6184351 α-synuclein super-mutants accelerate α-synuclein aggregation  
Parkinson's disease (PD) is a neurodegenerative disorder which is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of which are filaments...
6174857 Composition and method for the treatment of osteoporosis in mammals  
Pharmaceutical compositions and methods for the treatment of osteoporosis in mammals are disclosed. The compositions are suitable for parenteral administration and comprise Insulin-Like Growth...
6174995 Human chemokines, CKβ4 and CKβ10/MCP-4  
Human chemokine polypeptides and DNA/(RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods...
6160093 Compounds and methods for treatment and diagnosis of mycobacterial infections  
The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae protein and DNA molecules encoding such polypeptides, together with methods for their use in the...
6159934 Use of GHRH-RP to stimulate stem cell factor production  
Described are novel uses of GHRH-RP polypeptides for specifically activating Sertoli cell expression of stem cell factor and promoting spermatogenesis and fertility, and for inhibiting GHRH-RP...
6153587 Conformationally constrained LH-RH analogues, their uses and pharmaceutical compositions containing them  
LH-RH analogues with excellent affinity for LH-RH receptors, of the formula A1 -A2 -W-A3 -A4 -SPL-A5 -A6 -Pro-Z(I) in which: -A1 is pGlu, AcSar or an aromatic D-amino acid; -A2 is a direct bond,...
6153581 Drug for recovering renal function  
Drug which contains human growth hormones capable of recovering the renal function when administered to a patient who has renal insufficiency but has not yet undergone kidney dialysis. By...
6146851 DNA encoding NV2 (long form) and carboxy truncated fragments thereof  
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from...
6143866 Tumor necrosis factor (TNF) inhibitor and method for obtaining the same  
At least two substantially purified tumor necrosis factor (TNF) inhibitors are disclosed which are glycoproteins that are active against TNF. The isolation of 3O kDa and 40 KDa TNF inhibitor from...
6143523 Human growth hormone variants  
Human growth hormone variants and their nucleic acids are disclosed wherein the amino acid residues at positions 10, 14, 18, 21, 167, 171, 174, 176 and 179 have been replaced with other amino...
6139832 Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides  
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion...
6136563 Human growth hormone variants comprising amino acid substitutions  
Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups,...
6132720 Immunogens against gonadotropin releasing hormone  
Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal...
6127528 Process for adsorbing and removing tumor necrosis factor-α  
The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-α (TNF-α) in a body fluid, an adsorber using the adsorbent and a process for adsorbing and...
6123916 Therapeutic use of somatostatin peptides  
The invention relates to a new pharmaceutical use of somatostatin peptides comprising on the terminal amino group a polyamino polycarboxylic group, in free form or in a pharmaceutically acceptable...
6120989 Isolated human cytomegalovirus polypeptides and uses thereof  
Diagnostically relevant polypeptides and fusion proteins comprising an amino acid sequence which originates from cytomegalovirus and corresponds to a region of the major DNA-binding protein or of...