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6716817 Method of treatment of female infertility  
A method of treating female infertility using a novel cetrorelix acetate lyophilizate is disclosed.
6713052 Method of mobilizing stem cells with chemokine β-8  
Novel chemokines for mobilizing stem cells are provided. Methods of mobilizing stem cells are also provided.
6703486 Peripheral nervous system specific sodium channels  
Cloning, expression, viral and delivery vectors and hosts which contain nucleic acid coding for at least one peripheral nervous system specific (PNS) sodium channel peptide (SCP), isolated PNS...
6693083 Conjugates targeted to the interleukin-2 receptor  
A composition for intracellular delivery of a chemical agent into an interleukin-2-receptor-bearing cell, e.g. an activated T cell, includes a chemical agent and at least one copy of an...
6677442 Nucleic acid encoding human REV1 protein  
The present invention relates to a human cDNA homologous to the yeast REV1 gene. The sequence of human REV1 (hREV1) gene is described.
6673897 Inhibitors of NF-&kgr B Activation  
The present invention relates to novel inhibitors of the Nuclear factor kappa B (NF-κB) activating pathway useful in the treatment of NF-κB related diseases and/or in the improvement of anti-tumor...
6673769 Lanthionine bridged peptides  
Disclosed are lanthionine bridged peptides having the structure methods of their preparation and their use as pharmacologically active agents.
6664367 Stable analogs of bioactive peptides containing disulfide linkages  
Stable analogs of cyclic peptides containing disulfide linkages are disclosed. The disulfide linkage is modified by one of four methods: (a) sulfide contraction, (b) isosteric substitution, (c)...
6660840 Methods for enhancement of protective immune responses  
Methods for eliciting or enhancing immune responses to antigens, including tumor antigens, and/or DNA vaccines are provided. The methods employ polypeptides or nucleic acid compositions that...
6642353 Peptide ligands for the erythropoietin receptor  
Clones isolated from phage display libraries that bound to an erythropoietin (EPO) receptor probe are disclosed. Peptides encoded by sequences of those clones that bound to the EPO receptor are...
6638503 STREPTOMYCES MEGASPORUS SD5, PROCESS FOR THE ISOLATION THEREOF, NOVEL FIBRINOLYTIC ENZYME PREPARED THEREFROM, PROCESS FOR THE PRODUCTION OF SAID ENZYME AND METHOD OF TREATMENT OF THROMBOLYTIC DISORDERS USING SAID ENZYME  
The present invention relates to a novel microorganism Streptomyces megasporus SD5. The present invention also relates to a process for the isolation of said Streptomyces megasporus SD5. The...
6635743 Apoptosis inducing molecule II and methods of use  
The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM...
6617423 Superpotent calcitonin analogs having greatly increased hypocalcemic action in vivo  
Calcitonins and calcitonin derivatives such as are employed for therapy for, for example, osteoporosis. Paget's disease or hypercalcemia. The calcitonins and calcitonin derivatives are...
6613887 Human ependymin-like protein  
The invention provides an ependymin-like protein derived from a mammal, or its partial peptide or its precursor protein, or a salt thereof; a signal peptide; a DNA coding for the protein, etc. a...
6599719 Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha  
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also...
6579967 Receptor-selective somatostatin analogs  
Analogs of SRIF which are selective for SSTR3 in contrast to the other cloned SRIF receptors. These analogs are useful in determining the tissue and cellular expression of the receptor SSTR3 and...
6579715 Mammalian cortexin-like proteins and polynucleotides encoding the same  
The human and murine homologues of a novel cortexin-like protein are described.
6573363 Cystine knot protein and materials and methods for making it  
The present invention relates to polynucleotide and polypeptide molecules for zsig51, a novel member of the cystine knot family of polypeptides. The polypeptides comprise a sequence of amino acid...
6571199 Method and apparatus for performing pattern dictionary formation for use in sequence homology detection  
In a dictionary formation aspect of the invention, a computer-based method of processing a plurality of sequences in a database comprises the following steps. First, the method includes evaluating...
6559289 Use of growth hormone or analogues thereof for the treatment of mammals with familial hypercholesterolemia  
The invention relates to the use of compounds selected from GH, analogues thereof, and GH-releasing compounds, optionally in combination with lipid-lowering agents or therapy, for the preparation...
6521599 Stable pharmaceutical formulation for intravenous or intramuscular administration of active peptide compounds  
A stable pharmaceutical formulation for intravenous or intramuscular administration of Octreotide, which is characterized in that the vehicle for injection of the peptide or pharmaceutically...
6517844 Compositions and method for immunizing polutry  
The present invention is directed to vaccine compositions and methods for immunizing poultry. The vaccine compositions comprise inactivated bacterial organisms which can be administered to the...
6512014 Compositions containing bioemulsifiers and a method for their preparation  
A bioemulsifier composition useful for forming and stabilizing oil-in-water emulsions, comprising an esterase protein of 32.5 KD, found in association with emulsan in the bacteria Acinetobacter....
6504007 GDNF receptor  
GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRae (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are...
6500929 Membrane-bound C1 inhibitor  
The present invention provides an mbCRP capable of effectively suppressing complement activity and completely inhibiting generation of intermediates damaging a transplanted tissue during the...
6495661 DNA encoding the outer membrane protein of Pasteurella multocida  
An isolated nucleic acid molecule encoding the outer membrane protein of Pasteurella multocida is provided. Also provided are methods to detect the presence of the nucleic acid molecule, and...
6486302 Hm2 cDNA and related polypeptide  
The invention provides isolated Hm2 nucleic acids, and their encoded proteins. The present invention provides methods and compositions relating to altering Hm2 concentration and/or composition of...
6479630 Human purinergic P2U receptor  
The present invention provides nucleotide and amino acid sequences that identify and encode a novel purinergic PU2 receptor (PNR) expressed in human placenta. The present invention also provides...
6479254 Apoptosis inducing molecule II  
The present invention relates to a novel member of the TNF-Ligand superfamily, Apoptosis Inducing Molecule II (AIM II). In particular, isolated nucleic acid molecules are provided encoding the...
6475988 Methods to increase white blood cell survival after chemotherapy  
The present invention provides improved methods, kits, and pharmaceutical compositions for increasing white blood cell survival following chemotherapy, and mobilizing hematopoietic progenitor...
6458365 Method for treating headache  
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
6458764 GRF analogs with increased biological potency  
The present invention relates to chimeric fatty body-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone...
6458761 Synthetic, statistic thymic peptide combination and its use as a preparation with immunological and/or endocrinological effect  
Immunologically and/or endocrinologically active preparation containing as an active ingredient short-chain peptides with a weighted quantity ratio and a pattern of amino acids characteristic of...
6455499 Methods for treating disorders associated with LHRH activity  
Methods of treating a subject having a disorder associated with LHRH activity are disclosed.
RE37850 Recombinant human endothelial cell growth factor  
Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering...
6444645 Crosslink-stabilized indolicidin analogs  
The present invention relates to crosslink-stabilized analogs of indolicidin, which is a naturally occurring peptide having the amino acid sequence...
6426329 Immunosuppressant activity of insulin-like growth factor I (IGF-I)  
The invention provides a composition for improving an action of an immunosuppressant, comprising insulin-like growth factor I or its analog as an active ingredient.
6423827 Limbic system-associated membrane protein  
The present invention is directed to nucleic acid sequences encoding a limbic-system associated membrane protein (“LAMP”) and to purified proteins with LAMP activity. LAMP is a self-binding,...
6414114 Disulfides and thiol compounds  
The present invention is directed to novel disulfides and thiols that are of up to about eighteen amino acids. One example, is a compound of the formula (1): A—B—C—S—S—D—E—F, wherein: A and F are...
6406705 Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant  
The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one...
6395707 Methods of treatment utilizing variants of vascular endothelial cell growth factor  
Described herein are vascular endothelial cell growth factor (VEGF) variants having structural alterations in the C-terminus heparin binding domain and methods of use. The variants exhibit reduced...
6391633 Production of erythropoietin by endogenous gene activation  
The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a...
H002023 Streptococcus pneumoniae sequence GrpE  
The invention provides isolated nucleic acid compounds encoding GrpE of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a...
6362319 Glial cell line-derived neurotrophic factor  
A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and...
6355681 Glycine substitutes and precursors for treating a psychosis  
Process for treating psychosis such as schizophrenia using a glycine substitute or a precursor thereof to potentiate NMDA receptormediated neurotransmission.
6355774 Isolated p27 protein  
An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E-Cdk2...
6348446 Method for selectively purging CD77&plus cells from bone marrow or peripheral blood  
A method for the selective purging ex vivo of CD77 positive cells from bone marrow or peripheral blood containing stem cells prior to autologous transplantation is described. The method involves...
6344314 Determined DNA sequenced derived from a papillomavirus genome, their uses for in vitro diagnostic purposes and the production of antigenic compositions  
The invention concerns DNA fragments derived from the genomic DNA of HPV-33. These fragments are selected from the group of fragments extending between the nucleotide extremities defined hereafter...
6344192 Use of interleukin-15  
The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of...
6335424 ribG  
The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...