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7566447 Biocides  
The present invention relates to the use of biocide (e.g., bactericidal enzyme) to target pathogens. In particular, the present invention provides biocides for use in health care (e.g., human and...
7553930 BAFF variants and methods thereof  
The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further...
7544655 Haptotactic peptides  
Novel cell attachment peptides having sequences homologous to specific portions of the carboxy terminal sequence of fibrinogen chains are disclosed. The novel peptides, derived from proteins...
7544662 Polypeptides useful for appetite suppression  
The present invention relates to polypeptides obtained from bear derivative isolate which are useful in suppressing appetite. The polypeptides of the present invention are most preferably between...
7531522 Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi  
A method for the production of fungus resistant transgenic plants, plant cells or plant tissue comprising the introduction of an Ab, rAb, rAb fragment or fusion or vector of the invention or the...
7491490 Cytomegalovirus disintegrin-like peptides  
The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain...
7485446 Stable retrovirus and methods of use  
The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold...
7449445 Conductive peptide nanofiber and method of manufacture of the same  
A peptide nanofiber having conductivity is provided. A conductive peptide nanofiber which includes a nanofiber formed through a manner of self-assembly of a peptide that has a nanofiber-forming...
7439347 Hepatitis C virus non-structural NS3/4A fusion gene  
Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the invention include HCV peptides, nucleic acids encoding said HCV peptides,...
7402558 Method for aiding implantation or decreasing miscarriage rate  
The invention provides a protocol leading to improved embryo implantation rates and/or decreased miscarriage rates in which hCG or LH, or a bio-analogue thereof, is administered during the...
7402407 Chemically targeted positional identification of post-translationally phosphorylated peptides  
Methods are provided for determining the position of a post-translationally modified (PTM) amino acid residue such as a phosphorylated amino acid residue or an O-glycosylated amino acid residue in...
7384916 Methods and compositions for preventing and treating aging or photodamaged skin  
Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods...
7381556 Nucleic acids encoding deallergenized proteins and permuteins  
Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were...
7378234 Method for isolating hepatitis C virus peptides  
Described is a method for isolating Hepatitis C Virus peptides (HPs) which have a binding capacity to a MHC/HLA molecule or a complex comprising said HCV-peptide and said MHC/HLA molecule...
7345020 Mimetics of CD4 that inhibit immune response  
The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4+ T cell immune responses by identifying compounds that block the interaction of CD4 and...
7338770 Human procalcitonin and the preparation and use thereof  
The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide...
7331920 Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same  
Methods for preparing a glycopeptide are disclosed. The methods comprise the steps of selecting a protected glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, wherein the groups A1 to A7 comprise...
7326782 Metabolic engineering of viomycin biosynthesis  
The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes...
7300772 BMP products  
Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue...
7285618 Polypeptides having neutrophil stimulating activity  
Neutrophil attracting and activating factors that may already exist in normal cells are located. Polypeptides having neutrophil stimulating activity were isolated from an extract originating from...
7285533 Apo-2 ligand  
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2...
7285534 Corticotropin-releasing hormone analogs and their uses  
This invention provides members of the corticiotropin-releasing hormone superfamily and peptide analogs thereof wherein the 38th amino acid from the N-terminus is D-Nle, i.e. [D-Nle38]-CRH...
RE39887 Dehydrodidemnin B  
Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives.
7271242 Cytotoxic cyplasin of the sea hare, aplysia punctata, cdna cloning and expression of bioreactive recombinants  
Described is a nucleic acid coding for a protein called “cyplasin” that shows a preferential toxicity to autonomously growing mammalian cells. Cell death induced by this protein differs from both...
7268118 Thymosin β4 compositions  
A composition with a polypeptide including amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, the composition further including a carrier for application to a surface of a...
7258997 Methods of increasing protein expression levels  
The present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline....
7238511 Preparation of deallergenized proteins and permuteins  
Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were...
7226910 Treatment of female sexual dysfunction with vasoactive intestinal polypeptide agonists  
Methods for treating female sexual dysfunction are provided. A pharmaceutical composition containing a vasoactive agent selected from vasoactive intestinal potypeptide (VIP) and VIP agonists is...
7220558 Cartilage-derived morphogenetic proteins  
Nucleotide and amino acid sequences of cartilage-derived morphogenetic proteins (CDMP-1 and CDMP-2) from human and bovine cartilage extracts. These proteins exhibit chondrogenic activity and can...
7214367 Orally-administered interferon-tau compositions and methods  
The present invention includes interferon-tau (IFNτ) pharmaceutical compositions useful for oral administration to treat cancers, autoimmune disorders (particularly multiple sclerosis), cell...
7214768 Echinocandin process  
This invention relates to an improved process for the minimization of acid-catalyzed reactions of certain echinocandins of the kind disclosed in U.S. Pat. No. 5,378,804. The process involves the...
7208486 Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof  
The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each...
7192920 Derivatives of echinocandine, their preparation process and their use as antifungals  
A subject of the invention, in all possible isomer forms as well as their mixtures, is the compounds of formula (I): in which either R1: H or CH3 andR2: cyclohexyl substituted by an amine, a...
RE39496 Kahalalide F and compositions and uses thereof  
Kalahide Kahalalide F, of formula I below, may be isolated from a sacoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral...
7176292 Ghrelin variant protein  
The present invention concerns a protein produced from an alternative splice form of the human Ghrelin gene, an obesity and/or diabetes related gene.
7169894 Methods and compositions for reverse translation  
A process is disclosed by which a polynucleotide is directly synthesized from the peptide or protein that it encodes without the need for sequencing (or sequence analysis) of the peptide or...
7166693 Ectoparasite saliva proteins  
The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an...
7148034 Bioactive whey protein hydrolysate  
The present invention relates to a process of preparing a whey protein hydrolysate from a WPI substrate having improved flavour, functionality and ACE-I inhibiting properties.
7147856 Stable radioiodine conjugates and methods of their synthesis  
Methods are described for conjugating radioiodinated peptides or carbohydrate structures to proteins with improved yields and qualities of conjugates. In one method, specially designed...
7144579 Paramyxoviruses comprising modified transcription start sequence  
The present invention provides virus vectors of the family Paramyxoviridae in which the transcription start (S) sequence has been modified so as to modify the expression of genes located...
7141262 Method for obtaining a TGF-beta enriched protein fraction in activated form, protein fraction and therapeutic applications  
The invention concerns a method for obtaining a highly enriched TGF-beta protein fraction in activated form, from a liquid solution rich in proteins said to be soluble in the aqueous phase of milk...
7129329 Heme proteins hemAT-Hs and hemAT-Bs and their use in medicine and microsensors  
The present invention provides an isolated archael and bacterial heme binding protein which reversibly binds oxygen with a low affinity. The heme binding protein may be utilized as a blood...
7128913 Erythropoietin conjugates  
The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N-terminal α-amino group and having the in vivo...
7125702 Process for the preparation of angiotensis converting enzyme (ACE) inhibitors and its use  
The invention is a process for the preparation of angiotensin converting enzyme (ACE) inhibitors and the use thereof.
7125842 Anti-fungal compounds and methods of use  
The invention relates to compounds including peptides and peptidomimetics having anti-fungal activity alone, and in combination with other agents that have anti-fungal activity. The invention...
7118749 Transferrin receptor genes  
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
7118750 Modified TNF-alpha molecules, DNA encoding such and vaccines comprising such modified TNF-alpha and DNA  
A modified human TNFα molecule is capable of raising neutralizing antibodies towards unmodified human TNFα following administration of the modified TNFα to a human host, wherein one or more...
7115268 Peptides useful for reducing symptoms of toxic shock syndrome and septic shock  
This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates...
7115562 Peptides and their use to ameliorate cell death  
The present invention relates to a method of reducing cell death in a warm-blood animal wherein said cell death associated with a neurodegenerative disorder, an immune disease, a neoplastic...
7094755 Vasoactive intestinal peptide analogs  
The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the...